Pemigatinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pemigatinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.121317
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.11823
ERRFI1 ERBB receptor feedback inhibitor 1 0.0839928
NPAS2 neuronal PAS domain protein 2 0.0817974
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0690985
CADM2 cell adhesion molecule 2 0.0677353
MACF1 microtubule-actin crosslinking factor 1 0.0550125
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0535136
WARS1 tryptophanyl-tRNA synthetase 1 0.0530336
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0493904
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0492677
JMJD1C jumonji domain containing 1C 0.0469896
SDK1 sidekick cell adhesion molecule 1 0.0462639
CAPRIN2 caprin family member 2 0.0400604
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0381026
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0350894
USP9X ubiquitin specific peptidase 9, X-linked 0.0346346
SOD2 superoxide dismutase 2, mitochondrial 0.0337426
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0334679
KLF6 Kruppel-like factor 6 0.0323776
TXNIP thioredoxin interacting protein 0.0320753
TXNRD1 thioredoxin reductase 1 0.0319468
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0317547
RSAD2 radical S-adenosyl methionine domain containing 2 0.0312162
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.030326
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.029828
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0294883
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0283671
RAB7A RAB7A, member RAS oncogene family 0.0282729
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0281135
CRY1 cryptochrome circadian clock 1 0.0276429
PLK2 polo-like kinase 2 0.0273544
SEPTIN9 septin 9 0.0267671
IFIH1 interferon induced with helicase C domain 1 0.0267061
APLP2 amyloid beta (A4) precursor-like protein 2 0.0262186
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0257106
ESYT2 extended synaptotagmin-like protein 2 0.0257089
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0249137
TAOK1 TAO kinase 1 0.0248955
SGMS2 sphingomyelin synthase 2 0.0247745
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0243566
SRPK2 SRSF protein kinase 2 0.0242628
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0242185
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0240189
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0233024
MAST2 microtubule associated serine/threonine kinase 2 0.0230597
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0229775
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0228655
CCDC57 coiled-coil domain containing 57 0.0228249
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0226396
TENM1 teneurin transmembrane protein 1 0.0223209
CEP192 centrosomal protein 192kDa 0.0223089
ANKRD36C ankyrin repeat domain 36C 0.0219496
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0215453
RNF213 ring finger protein 213 0.0214748
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0213177
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.021312
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0212375
HIP1 huntingtin interacting protein 1 0.021237
DNER delta/notch-like EGF repeat containing 0.0211027
ZNF638 zinc finger protein 638 0.0210557
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0208015
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0207935
HDLBP high density lipoprotein binding protein 0.020609
BLZF1 basic leucine zipper nuclear factor 1 0.0204017
ECT2 epithelial cell transforming 2 0.0203318
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0202003
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0201936
WTIP Wilms tumor 1 interacting protein 0.0198051
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0194487
CTBP2 C-terminal binding protein 2 0.0193799
TPST1 tyrosylprotein sulfotransferase 1 0.0193709
FAM107B family with sequence similarity 107, member B 0.0193459
LRRC23 leucine rich repeat containing 23 0.0192993
S100A6 S100 calcium binding protein A6 0.0192173
ATXN2 ataxin 2 0.019115
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0190896
TBC1D32 TBC1 domain family, member 32 0.019073
IRF1 interferon regulatory factor 1 0.0190276
PCGF5 polycomb group ring finger 5 0.0189854
FRMD8 FERM domain containing 8 0.0189499
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0189301
SRPK1 SRSF protein kinase 1 0.0188603
KMT2C lysine (K)-specific methyltransferase 2C 0.018789
USP34 ubiquitin specific peptidase 34 0.0185422
SEC24A SEC24 family member A 0.0184715
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0184217
LYRM4 LYR motif containing 4 0.0183935
OSBPL8 oxysterol binding protein-like 8 0.0183885
BIRC3 baculoviral IAP repeat containing 3 0.0183156
INTS6 integrator complex subunit 6 0.0181781
TMSB4X thymosin beta 4, X-linked 0.0181597
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.018067
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0178004
AGO2 argonaute RISC catalytic component 2 0.0177667
DGLUCY D-glutamate cyclase 0.0177665
TRIM9 tripartite motif containing 9 0.0177325
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0176013
EIF3M eukaryotic translation initiation factor 3, subunit M 0.0175666
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0174383

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.168713
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.112478
CD44 CD44 molecule (Indian blood group) -0.0996817
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0915352
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0872768
DST dystonin -0.0813554
RUNX1 runt-related transcription factor 1 -0.0775806
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0634941
TPT1 tumor protein, translationally-controlled 1 -0.0606227
MT2A metallothionein 2A -0.0603324
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0601644
EHBP1 EH domain binding protein 1 -0.0591115
TSC22D1 TSC22 domain family, member 1 -0.0576075
RPS6 ribosomal protein S6 -0.0568404
PSD3 pleckstrin and Sec7 domain containing 3 -0.055637
ARHGAP5 Rho GTPase activating protein 5 -0.0520591
TMSB10 thymosin beta 10 -0.0515325
HDAC9 histone deacetylase 9 -0.0496353
HMGA1 high mobility group AT-hook 1 -0.0456442
CSMD3 CUB and Sushi multiple domains 3 -0.0451831
RPS8 ribosomal protein S8 -0.0438847
RPL26 ribosomal protein L26 -0.0434077
RPL37A ribosomal protein L37a -0.042993
RPL9 ribosomal protein L9 -0.0415558
THSD4 thrombospondin, type I, domain containing 4 -0.0397431
RPS29 ribosomal protein S29 -0.0397336
RPS12 ribosomal protein S12 -0.0390157
RPL35A ribosomal protein L35a -0.0385415
TRIO trio Rho guanine nucleotide exchange factor -0.0378832
RPS19 ribosomal protein S19 -0.0374954
BICD1 bicaudal D homolog 1 (Drosophila) -0.0371888
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0361677
RPS13 ribosomal protein S13 -0.0346635
SMAD3 SMAD family member 3 -0.0345492
RPL19 ribosomal protein L19 -0.0332659
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0324424
FLNB filamin B, beta -0.0323801
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0322941
EFNA5 ephrin-A5 -0.0321941
ZMYND8 zinc finger, MYND-type containing 8 -0.0321143
RPL31 ribosomal protein L31 -0.0320349
RPL28 ribosomal protein L28 -0.0315867
SP100 SP100 nuclear antigen -0.0314351
RPL34 ribosomal protein L34 -0.0310836
ENO1 enolase 1, (alpha) -0.0309471
HLA-B major histocompatibility complex, class I, B -0.0307237
RPS25 ribosomal protein S25 -0.0304438
ZNF292 zinc finger protein 292 -0.0301248
PMP22 peripheral myelin protein 22 -0.0293365
RPL36A ribosomal protein L36a -0.0289847
COL5A2 collagen, type V, alpha 2 -0.0279681
RPS14 ribosomal protein S14 -0.0278
TRIM56 tripartite motif containing 56 -0.0274189
RPL23 ribosomal protein L23 -0.0271797
CANX calnexin -0.0268762
GSK3B glycogen synthase kinase 3 beta -0.0266806
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0265228
DOCK11 dedicator of cytokinesis 11 -0.0265053
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0257354
GNAS GNAS complex locus -0.0257267
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0256962
RPLP2 ribosomal protein, large, P2 -0.0256129
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.025412
RPS16 ribosomal protein S16 -0.0253461
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0252679
RPL7A ribosomal protein L7a -0.0250524
ANKRD12 ankyrin repeat domain 12 -0.0250481
RPL38 ribosomal protein L38 -0.0249922
ZEB1 zinc finger E-box binding homeobox 1 -0.0249688
ADAM10 ADAM metallopeptidase domain 10 -0.0249258
RPS27 ribosomal protein S27 -0.0247651
MBNL2 muscleblind-like splicing regulator 2 -0.024538
ANXA2 annexin A2 -0.0244197
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0244175
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0242997
RPS3 ribosomal protein S3 -0.0239118
CFAP299 cilia and flagella associated protein 299 -0.0235296
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0233669
DNAH14 dynein, axonemal, heavy chain 14 -0.0230253
TAS2R14 taste receptor, type 2, member 14 -0.0229118
KAT6B K(lysine) acetyltransferase 6B -0.0223456
TBC1D5 TBC1 domain family, member 5 -0.0221977
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0221617
PTPRF protein tyrosine phosphatase, receptor type, F -0.021833
RAD51B RAD51 paralog B -0.0217279
ARB2A ARB2 cotranscriptional regulator A -0.0216927
HLA-A major histocompatibility complex, class I, A -0.0214884
PODXL podocalyxin-like -0.0214406
CDCP1 CUB domain containing protein 1 -0.0213457
TTC17 tetratricopeptide repeat domain 17 -0.0212796
RPS17 ribosomal protein S17 -0.0211476
PIAS2 protein inhibitor of activated STAT, 2 -0.021055
PTMA prothymosin, alpha -0.0209442
RTTN rotatin -0.0208746
RPS10 ribosomal protein S10 -0.0207626
IFI6 interferon, alpha-inducible protein 6 -0.0207162
ENO2 enolase 2 (gamma, neuronal) -0.0207106
FTL ferritin, light polypeptide -0.0206035
RPLP1 ribosomal protein, large, P1 -0.0205471
TM4SF1 transmembrane 4 L six family member 1 -0.0205286