Pemigatinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator 0.172887
TXNRD1 thioredoxin reductase 1 0.101172
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0965814
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0889802
MYOF myoferlin 0.0820167
SPAG9 sperm associated antigen 9 0.0790459
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0736486
GSK3B glycogen synthase kinase 3 beta 0.0696906
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0649533
TRIO trio Rho guanine nucleotide exchange factor 0.0612419
KYNU kynureninase 0.0610995
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.059629
GRAMD1B GRAM domain containing 1B 0.0593848
RNF213 ring finger protein 213 0.0584247
SOD2 superoxide dismutase 2, mitochondrial 0.054548
RUNX1 runt-related transcription factor 1 0.0528893
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0526686
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0505423
GCLC glutamate-cysteine ligase, catalytic subunit 0.0501307
RAB7A RAB7A, member RAS oncogene family 0.0500941
DTNA dystrobrevin, alpha 0.049203
ADAM9 ADAM metallopeptidase domain 9 0.048912
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.047411
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0473476
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0467411
LRP1B low density lipoprotein receptor-related protein 1B 0.0463955
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0451418
USP9X ubiquitin specific peptidase 9, X-linked 0.0446869
LMO7 LIM domain 7 0.0437877
TES testin LIM domain protein 0.0436077
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0430798
LOC112694756 uncharaterized LOC112694756 0.0428254
USP53 ubiquitin specific peptidase 53 0.0424833
NABP1 nucleic acid binding protein 1 0.0424317
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0411014
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0397206
CCNL1 cyclin L1 0.0380458
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0380098
MACC1 metastasis associated in colon cancer 1 0.0374445
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0371627
NAMPT nicotinamide phosphoribosyltransferase 0.0367955
NSUN6 NOP2/Sun domain family, member 6 0.0366441
CXCL8 chemokine (C-X-C motif) ligand 8 0.0365702
JAK1 Janus kinase 1 0.0365354
ZNF292 zinc finger protein 292 0.0357864
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0347653
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0346038
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0345896
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0345739
CES1 carboxylesterase 1 0.0342321
LRP12 low density lipoprotein receptor-related protein 12 0.0338197
ELL2 elongation factor, RNA polymerase II, 2 0.0337766
EXT1 exostosin glycosyltransferase 1 0.0335173
CCSER1 coiled-coil serine-rich protein 1 0.0333778
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0332548
ELOVL7 ELOVL fatty acid elongase 7 0.0332347
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0330021
ABLIM1 actin binding LIM protein 1 0.0324627
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0324323
NRIP1 nuclear receptor interacting protein 1 0.0319292
GPC6 glypican 6 0.0312811
ZNF638 zinc finger protein 638 0.0311413
OSMR oncostatin M receptor 0.0310893
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0309509
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0309151
TSC22D2 TSC22 domain family, member 2 0.0305684
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.030492
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0300919
RAB10 RAB10, member RAS oncogene family 0.0298165
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0298157
SMAD3 SMAD family member 3 0.0297633
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0296634
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0295866
SMYD3 SET and MYND domain containing 3 0.0294976
ABI1 abl-interactor 1 0.0293344
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0289416
BCAR3 breast cancer anti-estrogen resistance 3 0.0289283
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0288547
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0287057
DSCAM Down syndrome cell adhesion molecule 0.0277373
INO80 INO80 complex subunit 0.0273691
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0273064
OXSR1 oxidative stress responsive 1 0.0271853
ARB2A ARB2 cotranscriptional regulator A 0.0271441
LGALS12 lectin, galactoside-binding, soluble, 12 0.0269998
ARRDC3 arrestin domain containing 3 0.0268872
ZFAND6 zinc finger, AN1-type domain 6 0.0268577
SAMD4A sterile alpha motif domain containing 4A 0.0266694
KIAA1217 KIAA1217 0.0263845
LCOR ligand dependent nuclear receptor corepressor 0.0262965
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0262273
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0262216
ITSN2 intersectin 2 0.0261533
VCL vinculin 0.025979
PDZD8 PDZ domain containing 8 0.0259415
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0258767
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0255687
SON SON DNA binding protein 0.0255616
MAST4 microtubule associated serine/threonine kinase family member 4 0.0253655
ACBD6 acyl-CoA binding domain containing 6 0.025333

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.122242
ACTG1 actin gamma 1 -0.0931054
MT2A metallothionein 2A -0.0832246
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.082389
STC1 stanniocalcin 1 -0.0784402
TPT1 tumor protein, translationally-controlled 1 -0.0755337
NDRG1 N-myc downstream regulated 1 -0.0735345
CAV1 caveolin 1, caveolae protein, 22kDa -0.0630867
RPL35A ribosomal protein L35a -0.061844
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0605963
PTPRM protein tyrosine phosphatase, receptor type, M -0.0574393
PDE4D phosphodiesterase 4D, cAMP-specific -0.0566547
RPS3 ribosomal protein S3 -0.049917
KRT18 keratin 18, type I -0.0478838
RPL37A ribosomal protein L37a -0.0473284
S100P S100 calcium binding protein P -0.0469787
S100A10 S100 calcium binding protein A10 -0.0462973
PTMA prothymosin, alpha -0.0441302
RPS12 ribosomal protein S12 -0.0423211
THSD4 thrombospondin, type I, domain containing 4 -0.0418729
EGR1 early growth response 1 -0.0417064
RPLP1 ribosomal protein, large, P1 -0.040005
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0399893
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0384704
RPS24 ribosomal protein S24 -0.0382252
ASPH aspartate beta-hydroxylase -0.0377357
ZBTB20 zinc finger and BTB domain containing 20 -0.0376924
CAV2 caveolin 2 -0.0374805
HMGA1 high mobility group AT-hook 1 -0.0372139
RPL31 ribosomal protein L31 -0.0371158
TPM4 tropomyosin 4 -0.0369387
S100A6 S100 calcium binding protein A6 -0.0361153
RPL34 ribosomal protein L34 -0.034786
FTL ferritin, light polypeptide -0.0340838
RPS25 ribosomal protein S25 -0.0340732
RPS6 ribosomal protein S6 -0.033778
GNAS GNAS complex locus -0.0335891
SEC61G Sec61 gamma subunit -0.0326263
AGR2 anterior gradient 2 -0.0320989
RPL37 ribosomal protein L37 -0.0318487
CPE carboxypeptidase E -0.0318241
PKM pyruvate kinase, muscle -0.0307859
CST3 cystatin C -0.0301988
RPS8 ribosomal protein S8 -0.0292447
MKI67 marker of proliferation Ki-67 -0.0292196
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0291938
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0290378
RPS27A ribosomal protein S27a -0.0289653
CUX1 cut-like homeobox 1 -0.0287715
RPS27 ribosomal protein S27 -0.0282607
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0278878
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0278217
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0277332
RPL12 ribosomal protein L12 -0.0276697
S100A11 S100 calcium binding protein A11 -0.0272233
CEMIP cell migration inducing protein, hyaluronan binding -0.0263322
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0260358
RPL11 ribosomal protein L11 -0.0260258
MCL1 myeloid cell leukemia 1 -0.0256797
FOXP1 forkhead box P1 -0.0254046
MAML3 mastermind-like 3 (Drosophila) -0.0248691
RPL38 ribosomal protein L38 -0.0247966
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0240738
KRT8 keratin 8, type II -0.0239003
RPS29 ribosomal protein S29 -0.0236794
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0236127
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0235129
TNS3 tensin 3 -0.0233665
KRT7 keratin 7, type II -0.0230923
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0229873
IGFBP5 insulin-like growth factor binding protein 5 -0.0229134
RPLP0 ribosomal protein, large, P0 -0.022465
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0224306
SMIM14 small integral membrane protein 14 -0.0223024
RPS13 ribosomal protein S13 -0.0222172
CP ceruloplasmin (ferroxidase) -0.0221274
PYGL phosphorylase, glycogen, liver -0.0219466
KPNB1 karyopherin (importin) beta 1 -0.0218209
RNF149 ring finger protein 149 -0.0217913
RPL19 ribosomal protein L19 -0.0217899
PSD3 pleckstrin and Sec7 domain containing 3 -0.0215067
DOCK4 dedicator of cytokinesis 4 -0.0214329
RPL9 ribosomal protein L9 -0.0213814
ACTN1 actinin, alpha 1 -0.0213002
AKAP9 A kinase (PRKA) anchor protein 9 -0.021244
RPS17 ribosomal protein S17 -0.0210605
IFI6 interferon, alpha-inducible protein 6 -0.0209996
RPL23 ribosomal protein L23 -0.020923
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0208631
RPS15 ribosomal protein S15 -0.0207369
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0207312
EIF1 eukaryotic translation initiation factor 1 -0.0203151
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0200037
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0197362
NTSR1 neurotensin receptor 1 (high affinity) -0.0195175
FBXO11 F-box protein 11 -0.0194532
CD99 CD99 molecule -0.0193491
CDCP1 CUB domain containing protein 1 -0.0192239
CATSPERB catsper channel auxiliary subunit beta -0.0191564
SPIRE1 spire-type actin nucleation factor 1 -0.019027