| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemigatinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.222007 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.173372 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.137538 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.120535 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.119427 |
| FNDC3B | fibronectin type III domain containing 3B | 0.082007 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0752382 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0742802 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0657611 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.064834 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0640041 |
| RBM25 | RNA binding motif protein 25 | 0.0638063 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0626281 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0625108 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0620354 |
| COPA | coatomer protein complex, subunit alpha | 0.0604123 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0594563 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.057901 |
| GLG1 | golgi glycoprotein 1 | 0.0576729 |
| RBM39 | RNA binding motif protein 39 | 0.0570594 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0550169 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0541986 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0537538 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0534481 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.053292 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.052673 |
| LDHA | lactate dehydrogenase A | 0.0515008 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0511038 |
| CCNL1 | cyclin L1 | 0.0497464 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0492549 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0491311 |
| NF1 | neurofibromin 1 | 0.04909 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0476754 |
| HLA-B | major histocompatibility complex, class I, B | 0.0470069 |
| TPD52 | tumor protein D52 | 0.0463765 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0461446 |
| EZR | ezrin | 0.0455108 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0454561 |
| CUL3 | cullin 3 | 0.0453934 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0434901 |
| PSEN1 | presenilin 1 | 0.0428133 |
| SLMAP | sarcolemma associated protein | 0.042707 |
| FAM107B | family with sequence similarity 107, member B | 0.0423921 |
| GOLGA4 | golgin A4 | 0.0421617 |
| FLNB | filamin B, beta | 0.0418332 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0417372 |
| BRD2 | bromodomain containing 2 | 0.041356 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0409074 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0408722 |
| USP36 | ubiquitin specific peptidase 36 | 0.0408622 |
| IL6 | interleukin 6 | 0.0404729 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.040389 |
| ATP13A3 | ATPase type 13A3 | 0.0401337 |
| NRG1 | neuregulin 1 | 0.0394549 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0393104 |
| COG5 | component of oligomeric golgi complex 5 | 0.0388501 |
| NEK7 | NIMA-related kinase 7 | 0.0384879 |
| MED13 | mediator complex subunit 13 | 0.0382992 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0379582 |
| LAMC2 | laminin, gamma 2 | 0.0373782 |
| YME1L1 | YME1-like 1 ATPase | 0.0371809 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0369947 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0368445 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.036796 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0364008 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0362676 |
| RUNX1 | runt-related transcription factor 1 | 0.0361608 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.035942 |
| SIK3 | SIK family kinase 3 | 0.0353723 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0351028 |
| MORF4L2 | mortality factor 4 like 2 | 0.0348659 |
| CDC73 | cell division cycle 73 | 0.0339425 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0338847 |
| USP3 | ubiquitin specific peptidase 3 | 0.0336921 |
| KIF13A | kinesin family member 13A | 0.0334805 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0333622 |
| GDA | guanine deaminase | 0.033291 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.0330863 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0330794 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0330024 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.032938 |
| SRP54 | signal recognition particle 54kDa | 0.0328584 |
| INO80 | INO80 complex subunit | 0.0328176 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0326391 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0324106 |
| RNF145 | ring finger protein 145 | 0.0320921 |
| FOCAD | focadhesin | 0.0319468 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.031676 |
| TPI1 | triosephosphate isomerase 1 | 0.0316615 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0315074 |
| MCL1 | myeloid cell leukemia 1 | 0.0314942 |
| SCFD1 | sec1 family domain containing 1 | 0.0312535 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0311601 |
| CDCP1 | CUB domain containing protein 1 | 0.0310193 |
| CDK13 | cyclin-dependent kinase 13 | 0.0308524 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0308457 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0306621 |
| SBF2 | SET binding factor 2 | 0.0306137 |
| PHF20 | PHD finger protein 20 | 0.0303243 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0300274 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.219754 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.142784 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0735854 |
| CMIP | c-Maf inducing protein | -0.073228 |
| RAD51B | RAD51 paralog B | -0.0728076 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0687467 |
| FTL | ferritin, light polypeptide | -0.0637537 |
| BICC1 | BicC family RNA binding protein 1 | -0.0619738 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0581454 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0544001 |
| NEGR1 | neuronal growth regulator 1 | -0.0537044 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0512464 |
| PTMA | prothymosin, alpha | -0.0494819 |
| DST | dystonin | -0.0481033 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0478565 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0478228 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0463604 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0449022 |
| EXOC4 | exocyst complex component 4 | -0.0427914 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0416371 |
| EFNA5 | ephrin-A5 | -0.0395755 |
| ACTG1 | actin gamma 1 | -0.0384744 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0382083 |
| AHNAK | AHNAK nucleoprotein | -0.0379107 |
| HMGA2 | high mobility group AT-hook 2 | -0.0367078 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0362445 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0342745 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.033485 |
| UTRN | utrophin | -0.0333427 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0332794 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0330188 |
| EHBP1 | EH domain binding protein 1 | -0.0319868 |
| AK1 | adenylate kinase 1 | -0.0318111 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0316746 |
| TPM3 | tropomyosin 3 | -0.0315876 |
| PDE8A | phosphodiesterase 8A | -0.0313251 |
| SMAD3 | SMAD family member 3 | -0.0310799 |
| GLIS3 | GLIS family zinc finger 3 | -0.0309866 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0304954 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0294197 |
| FRMD5 | FERM domain containing 5 | -0.0292416 |
| CUX1 | cut-like homeobox 1 | -0.0284781 |
| TPM1 | tropomyosin 1 (alpha) | -0.0283879 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.027627 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.02728 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0270612 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0265117 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0264622 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0260414 |
| AHR | aryl hydrocarbon receptor | -0.0255694 |
| HDAC9 | histone deacetylase 9 | -0.0252602 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0246894 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0245646 |
| CNKSR3 | CNKSR family member 3 | -0.0242218 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0241023 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0238555 |
| FLNA | filamin A, alpha | -0.0235388 |
| PKM | pyruvate kinase, muscle | -0.0233035 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0232681 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0231163 |
| CAVIN1 | caveolae associated protein 1 | -0.0230803 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0230173 |
| DIAPH3 | diaphanous-related formin 3 | -0.0227249 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.022668 |
| IGF1R | insulin-like growth factor 1 receptor | -0.022658 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0224974 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0218196 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0216778 |
| YBX1 | Y box binding protein 1 | -0.0215527 |
| RTN4 | reticulon 4 | -0.0214237 |
| RNF213 | ring finger protein 213 | -0.0213381 |
| STC1 | stanniocalcin 1 | -0.0213252 |
| DNMBP | dynamin binding protein | -0.0211452 |
| TMEM123 | transmembrane protein 123 | -0.0210239 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0209743 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0205395 |
| WWOX | WW domain containing oxidoreductase | -0.0203697 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0202944 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0198634 |
| YBX3 | Y box binding protein 3 | -0.0191659 |
| PRR16 | proline rich 16 | -0.0191134 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0190311 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0189955 |
| RGS20 | regulator of G-protein signaling 20 | -0.0188138 |
| ATM | ATM serine/threonine kinase | -0.0187924 |
| RRM2 | ribonucleotide reductase M2 | -0.0187548 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0185846 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0185029 |
| HMGA1 | high mobility group AT-hook 1 | -0.0184716 |
| FGB | fibrinogen beta chain | -0.0184072 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0183167 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.01823 |
| CANX | calnexin | -0.0182152 |
| CCDC7 | coiled-coil domain containing 7 | -0.0179879 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0179347 |
| RPS27A | ribosomal protein S27a | -0.0179294 |
| JAZF1 | JAZF zinc finger 1 | -0.0178641 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0178477 |
| LDHB | lactate dehydrogenase B | -0.0177919 |
| BPTF | bromodomain PHD finger transcription factor | -0.0177886 |
