| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemigatinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.19064 |
| KRT17 | keratin 17, type I | 0.159131 |
| CMIP | c-Maf inducing protein | 0.11646 |
| MYOF | myoferlin | 0.111603 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.104761 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.100742 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0979703 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0958196 |
| TXNRD1 | thioredoxin reductase 1 | 0.0943226 |
| DSPP | dentin sialophosphoprotein | 0.0923429 |
| MYO1E | myosin IE | 0.0807724 |
| FTO | fat mass and obesity associated | 0.0710225 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.06608 |
| ANXA1 | annexin A1 | 0.0637562 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0617639 |
| UBC | ubiquitin C | 0.0593508 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.0567333 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0562095 |
| TMEM87A | transmembrane protein 87A | 0.0529596 |
| MAP7 | microtubule-associated protein 7 | 0.0525625 |
| ADM | adrenomedullin | 0.0521624 |
| CXXC1 | CXXC finger protein 1 | 0.0516422 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0512282 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0505909 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.050111 |
| HOMER2 | homer scaffolding protein 2 | 0.0497987 |
| RSPRY1 | ring finger and SPRY domain containing 1 | 0.049075 |
| S100A6 | S100 calcium binding protein A6 | 0.0480381 |
| EFNA5 | ephrin-A5 | 0.0477623 |
| SREK1IP1 | SREK1-interacting protein 1 | 0.0462945 |
| FOXQ1 | forkhead box Q1 | 0.0459579 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0454976 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0452163 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0452058 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0451287 |
| STK17A | serine/threonine kinase 17a | 0.0449624 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0424866 |
| RNF103-CHMP3 | RNF103-CHMP3 readthrough | 0.0421823 |
| S100A9 | S100 calcium binding protein A9 | 0.0421397 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0420894 |
| STC1 | stanniocalcin 1 | 0.0418214 |
| MT2A | metallothionein 2A | 0.040605 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0405876 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0400869 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0398201 |
| S100A11 | S100 calcium binding protein A11 | 0.0398081 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.038683 |
| GSE1 | Gse1 coiled-coil protein | 0.0381064 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0376126 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0376057 |
| FTL | ferritin, light polypeptide | 0.0373586 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0371406 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0366101 |
| MXD1 | MAX dimerization protein 1 | 0.0362285 |
| CYTH1 | cytohesin 1 | 0.0356282 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0355655 |
| SLMAP | sarcolemma associated protein | 0.034533 |
| IRS2 | insulin receptor substrate 2 | 0.0344961 |
| IER3 | immediate early response 3 | 0.0344092 |
| GLCCI1 | glucocorticoid induced 1 | 0.0335707 |
| CD44 | CD44 molecule (Indian blood group) | 0.0331611 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0331596 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0328445 |
| CPE | carboxypeptidase E | 0.0325766 |
| PCBP3 | poly(rC) binding protein 3 | 0.0324154 |
| CDCP1 | CUB domain containing protein 1 | 0.032171 |
| PERP | PERP, TP53 apoptosis effector | 0.0320577 |
| RACK1 | receptor for activated C kinase 1 | 0.0319235 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0317498 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0316397 |
| TXNIP | thioredoxin interacting protein | 0.0314887 |
| TOP1 | topoisomerase (DNA) I | 0.0312191 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.031139 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0310973 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0307633 |
| CD58 | CD58 molecule | 0.0305668 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.03043 |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 0.0300311 |
| INPP4A | inositol polyphosphate-4-phosphatase, type I, 107kDa | 0.0298789 |
| RPL28 | ribosomal protein L28 | 0.0297044 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0284967 |
| PKM | pyruvate kinase, muscle | 0.0281963 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0278486 |
| STK24 | serine/threonine kinase 24 | 0.0277981 |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide | 0.0275966 |
| ASPH | aspartate beta-hydroxylase | 0.0271341 |
| ATAD1 | ATPase family, AAA domain containing 1 | 0.0269433 |
| LAMB3 | laminin, beta 3 | 0.0266197 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.0260586 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0260407 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0259616 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0259582 |
| TLK1 | tousled-like kinase 1 | 0.0255931 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0255384 |
| PHACTR2 | phosphatase and actin regulator 2 | 0.0255284 |
| WDR59 | WD repeat domain 59 | 0.0255267 |
| SRGN | serglycin | 0.0253888 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0252279 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0251359 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0251098 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.106614 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0940372 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0899162 |
| EGFR | epidermal growth factor receptor | -0.0866444 |
| ATOSA | atos homolog A | -0.0854847 |
| NEK7 | NIMA-related kinase 7 | -0.0809084 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0781113 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0741988 |
| JMJD1C | jumonji domain containing 1C | -0.0739277 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0713987 |
| ERBIN | erbb2 interacting protein | -0.070466 |
| KYNU | kynureninase | -0.068858 |
| VIM | vimentin | -0.067521 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0670718 |
| HMGA2 | high mobility group AT-hook 2 | -0.0651037 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0644456 |
| FN1 | fibronectin 1 | -0.0639152 |
| OSMR | oncostatin M receptor | -0.0635168 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0633487 |
| MUC16 | mucin 16, cell surface associated | -0.0627728 |
| SPAG9 | sperm associated antigen 9 | -0.0621841 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0590733 |
| RPS6 | ribosomal protein S6 | -0.0570501 |
| PRKCA | protein kinase C, alpha | -0.0569344 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0546401 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0523673 |
| ACTG1 | actin gamma 1 | -0.0522135 |
| RPL37 | ribosomal protein L37 | -0.052002 |
| MED13L | mediator complex subunit 13-like | -0.0517864 |
| RPS8 | ribosomal protein S8 | -0.049378 |
| GRB10 | growth factor receptor-bound protein 10 | -0.048537 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0468546 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.046572 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0461577 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0457116 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0453637 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0448632 |
| RPS20 | ribosomal protein S20 | -0.0448631 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0437838 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0436828 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0430629 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0430259 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0429635 |
| EXOC6B | exocyst complex component 6B | -0.042944 |
| NBEAL1 | neurobeachin-like 1 | -0.0427128 |
| PTEN | phosphatase and tensin homolog | -0.0424314 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0423446 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0421998 |
| AFAP1 | actin filament associated protein 1 | -0.0421602 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0418125 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0417894 |
| IGF2 | insulin-like growth factor 2 | -0.040906 |
| ZNF292 | zinc finger protein 292 | -0.0408386 |
| RPL11 | ribosomal protein L11 | -0.0406698 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0405921 |
| RNF145 | ring finger protein 145 | -0.0402829 |
| SFTPA2 | surfactant protein A2 | -0.0402393 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0395805 |
| FRYL | FRY-like | -0.0393001 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0386506 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0384263 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.038389 |
| NF1 | neurofibromin 1 | -0.0383601 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0383562 |
| CALU | calumenin | -0.0383176 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0382938 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0380654 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379242 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0379109 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0377738 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0373208 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0370588 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0367855 |
| GPC6 | glypican 6 | -0.0365866 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0365167 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0363517 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0361839 |
| RPS11 | ribosomal protein S11 | -0.0349997 |
| RPL9 | ribosomal protein L9 | -0.0348691 |
| ABHD17C | abhydrolase domain containing 17C | -0.0339339 |
| MED13 | mediator complex subunit 13 | -0.0337194 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0336553 |
| CD109 | CD109 molecule | -0.0333476 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0328188 |
| PBRM1 | polybromo 1 | -0.0328157 |
| RPL31 | ribosomal protein L31 | -0.0325237 |
| SRPK2 | SRSF protein kinase 2 | -0.0321774 |
| EZR | ezrin | -0.0321176 |
| PTMA | prothymosin, alpha | -0.031728 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.031468 |
| RPS19 | ribosomal protein S19 | -0.0307975 |
| RTN4 | reticulon 4 | -0.0307001 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0302293 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0301481 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0299171 |
| GOLGA4 | golgin A4 | -0.0298631 |
| RIGI | RNA sensor RIG-I | -0.0294645 |
| JUP | junction plakoglobin | -0.029333 |
| GNAS | GNAS complex locus | -0.0290257 |
| RAI14 | retinoic acid induced 14 | -0.028997 |
