Pemigatinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.178115
TFPI2 tissue factor pathway inhibitor 2 0.164446
ELL2 elongation factor, RNA polymerase II, 2 0.104077
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0942379
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0807381
PDE4D phosphodiesterase 4D, cAMP-specific 0.0741008
KTN1 kinectin 1 (kinesin receptor) 0.0719029
PCBP2 poly(rC) binding protein 2 0.0685654
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.064157
VIM vimentin 0.0639411
CSDE1 cold shock domain containing E1, RNA-binding 0.0617015
YBX3 Y box binding protein 3 0.0573522
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0552025
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0542421
MCTP1 multiple C2 domains, transmembrane 1 0.0530775
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0514119
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0508812
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0493393
EXOC6B exocyst complex component 6B 0.0489478
JMJD1C jumonji domain containing 1C 0.0485223
RAB7A RAB7A, member RAS oncogene family 0.0479871
ADAR adenosine deaminase, RNA-specific 0.0476695
ETNK1 ethanolamine kinase 1 0.0473186
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.047308
SRPK1 SRSF protein kinase 1 0.0467144
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0451622
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.044578
UBE2H ubiquitin-conjugating enzyme E2H 0.0445562
TAOK1 TAO kinase 1 0.0434845
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.042904
NIPBL Nipped-B homolog (Drosophila) 0.0424467
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0422385
TXNRD1 thioredoxin reductase 1 0.0419935
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0410706
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0409081
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0406335
TPM3 tropomyosin 3 0.0399026
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0398959
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0397629
YAP1 Yes-associated protein 1 0.0395129
TRIO trio Rho guanine nucleotide exchange factor 0.0393881
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0388363
GATAD2B GATA zinc finger domain containing 2B 0.0384117
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0383012
BMAL2 basic helix-loop-helix ARNT like 2 0.0376833
CCNL1 cyclin L1 0.0376612
PLS3 plastin 3 0.0373517
CUX1 cut-like homeobox 1 0.0371102
DENND4A DENN/MADD domain containing 4A 0.0363164
RLF rearranged L-myc fusion 0.0361541
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0361424
MAP4 microtubule-associated protein 4 0.0361362
VCL vinculin 0.0358534
IPO7 importin 7 0.0357346
SFPQ splicing factor proline/glutamine-rich 0.0353343
POTEF POTE ankyrin domain family, member F 0.0350291
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0339922
NUP153 nucleoporin 153kDa 0.0338807
UBE3C ubiquitin protein ligase E3C 0.0334188
CTTNBP2NL CTTNBP2 N-terminal like 0.0333269
RBM25 RNA binding motif protein 25 0.0332286
MIPOL1 mirror-image polydactyly 1 0.033149
MARCHF4 membrane associated ring-CH-type finger 4 0.0331329
PHF20 PHD finger protein 20 0.0329604
CCND2 cyclin D2 0.0327056
TENM1 teneurin transmembrane protein 1 0.0324785
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0323772
SETD5 SET domain containing 5 0.0322717
TPI1 triosephosphate isomerase 1 0.0321888
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0320353
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0317681
APLP2 amyloid beta (A4) precursor-like protein 2 0.0317626
AHNAK AHNAK nucleoprotein 0.0317505
RAB1A RAB1A, member RAS oncogene family 0.0317146
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0316175
CXADR coxsackie virus and adenovirus receptor 0.0314534
WNK1 WNK lysine deficient protein kinase 1 0.0311187
PDE10A phosphodiesterase 10A 0.0309356
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0307647
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0306894
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0306282
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0306199
RB1CC1 RB1-inducible coiled-coil 1 0.0305671
AHCYL1 adenosylhomocysteinase-like 1 0.0303218
IRF1 interferon regulatory factor 1 0.0302137
CHD1 chromodomain helicase DNA binding protein 1 0.030184
ERRFI1 ERBB receptor feedback inhibitor 1 0.0299256
BBX bobby sox homolog (Drosophila) 0.0297562
SEPTIN2 septin 2 0.0296923
SLC38A2 solute carrier family 38, member 2 0.0296756
DGKH diacylglycerol kinase, eta 0.029504
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0293945
SIN3A SIN3 transcription regulator family member A 0.0293487
KMT2C lysine (K)-specific methyltransferase 2C 0.0293382
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.029222
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0291283
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0289455
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0288199
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0286858
KDM3B lysine (K)-specific demethylase 3B 0.0284363

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.0897243
RPL35A ribosomal protein L35a -0.0816763
AKAP12 A kinase (PRKA) anchor protein 12 -0.0731711
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0714594
TPT1 tumor protein, translationally-controlled 1 -0.053132
RPL37 ribosomal protein L37 -0.050822
RPL37A ribosomal protein L37a -0.0505418
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0467075
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0466737
HMGA2 high mobility group AT-hook 2 -0.0464531
ATG7 autophagy related 7 -0.0444518
AFF3 AF4/FMR2 family, member 3 -0.0443317
OSMR oncostatin M receptor -0.0437713
RPS27A ribosomal protein S27a -0.0427491
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0419865
RPL38 ribosomal protein L38 -0.0417895
RPL9 ribosomal protein L9 -0.0413257
TMSB10 thymosin beta 10 -0.0408209
RPS21 ribosomal protein S21 -0.0399555
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0383024
PDLIM5 PDZ and LIM domain 5 -0.0373726
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0370882
RPL5 ribosomal protein L5 -0.0351786
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0348022
DOCK5 dedicator of cytokinesis 5 -0.0345047
RPS13 ribosomal protein S13 -0.033882
FMNL2 formin-like 2 -0.033218
USP34 ubiquitin specific peptidase 34 -0.0331622
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0323833
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0319506
RPL12 ribosomal protein L12 -0.0311682
CAVIN1 caveolae associated protein 1 -0.0310261
RYK receptor-like tyrosine kinase -0.0305337
RPS24 ribosomal protein S24 -0.0300532
POMP proteasome maturation protein -0.0295156
S100A11 S100 calcium binding protein A11 -0.0294279
RAD51B RAD51 paralog B -0.028687
TM4SF1 transmembrane 4 L six family member 1 -0.0284401
THADA thyroid adenoma associated -0.0282947
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0279273
EXOC4 exocyst complex component 4 -0.0278871
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0274003
RPL26 ribosomal protein L26 -0.0272123
RPS3 ribosomal protein S3 -0.0270692
RPS23 ribosomal protein S23 -0.0270349
RPS6 ribosomal protein S6 -0.0270012
RNF213 ring finger protein 213 -0.0269758
RPLP1 ribosomal protein, large, P1 -0.0268023
MT2A metallothionein 2A -0.0264064
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0263933
RPS27 ribosomal protein S27 -0.0260383
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0258418
PRRC2B proline-rich coiled-coil 2B -0.0255082
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0253488
DENND5B DENN/MADD domain containing 5B -0.025144
RAB10 RAB10, member RAS oncogene family -0.0249488
TBCA tubulin folding cofactor A -0.0248687
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0247781
RPS29 ribosomal protein S29 -0.0246133
RPS8 ribosomal protein S8 -0.0242587
NPAS2 neuronal PAS domain protein 2 -0.0241213
EIF5B eukaryotic translation initiation factor 5B -0.023702
NT5E 5'-nucleotidase, ecto (CD73) -0.0233109
CD109 CD109 molecule -0.0232449
RPS17 ribosomal protein S17 -0.0229071
HLA-B major histocompatibility complex, class I, B -0.022705
EGFR epidermal growth factor receptor -0.0225274
RPS25 ribosomal protein S25 -0.0224547
ENOSF1 enolase superfamily member 1 -0.022395
GCC2 GRIP and coiled-coil domain containing 2 -0.0220354
RPS11 ribosomal protein S11 -0.0218277
COMMD1 copper metabolism (Murr1) domain containing 1 -0.0217906
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0216717
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0215502
RPL31 ribosomal protein L31 -0.0212691
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0211909
NDRG1 N-myc downstream regulated 1 -0.0210847
ATF6 activating transcription factor 6 -0.0207324
NACA nascent polypeptide-associated complex alpha subunit -0.0206505
TUBA1C tubulin, alpha 1c -0.020617
UBC ubiquitin C -0.0205942
WNT2B wingless-type MMTV integration site family, member 2B -0.0205708
CDCP1 CUB domain containing protein 1 -0.0205627
ZNF609 zinc finger protein 609 -0.0204109
KIAA1958 KIAA1958 -0.0202105
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0201977
H3-3B H3.3 histone B -0.0200497
CFAP44 cilia and flagella associated protein 44 -0.0200019
MCL1 myeloid cell leukemia 1 -0.0199314
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0198945
RPL32 ribosomal protein L32 -0.0197938
CERT1 ceramide transporter 1 -0.0197047
RPS15 ribosomal protein S15 -0.019577
NCOA7 nuclear receptor coactivator 7 -0.0195347
PATJ PATJ crumbs cell polarity complex component -0.0194638
LOXL2 lysyl oxidase-like 2 -0.0192562
RHBDD1 rhomboid domain containing 1 -0.0190892
MYOM1 myomesin 1 -0.0189428
MYL12B myosin, light chain 12B, regulatory -0.0188883
BBS9 Bardet-Biedl syndrome 9 -0.0187422