Pemigatinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.178868
DTNA dystrobrevin, alpha 0.114965
FNDC3B fibronectin type III domain containing 3B 0.0892188
TSC22D2 TSC22 domain family, member 2 0.0854568
PTK2 protein tyrosine kinase 2 0.0774993
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0755163
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0723401
ZSWIM6 zinc finger, SWIM-type containing 6 0.0709641
ASPH aspartate beta-hydroxylase 0.0694848
ERBIN erbb2 interacting protein 0.0679752
MACC1 metastasis associated in colon cancer 1 0.0659695
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0652942
ELL2 elongation factor, RNA polymerase II, 2 0.0647721
MYO5B myosin VB 0.0637425
PDLIM5 PDZ and LIM domain 5 0.0622045
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0621132
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0601984
MARCHF6 membrane associated ring-CH-type finger 6 0.0597959
DST dystonin 0.0581545
GOLGA4 golgin A4 0.0573959
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.056094
LMO7 LIM domain 7 0.0552341
LAMC2 laminin, gamma 2 0.0544984
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0540227
IGFBP3 insulin-like growth factor binding protein 3 0.0538208
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0537019
VGLL3 vestigial-like family member 3 0.052618
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0523059
RUNX1 runt-related transcription factor 1 0.0511143
AKAP13 A kinase (PRKA) anchor protein 13 0.0508688
OSMR oncostatin M receptor 0.0495556
GRAMD2B GRAM domain containing 2B 0.0495214
WWC1 WW and C2 domain containing 1 0.0493831
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0490249
DSPP dentin sialophosphoprotein 0.0482711
AFF1 AF4/FMR2 family, member 1 0.048016
FLNB filamin B, beta 0.0474194
EXT1 exostosin glycosyltransferase 1 0.0471087
SMAD3 SMAD family member 3 0.0468306
NDRG1 N-myc downstream regulated 1 0.0467232
PPARD peroxisome proliferator-activated receptor delta 0.0459806
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0459012
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0455968
JMJD1C jumonji domain containing 1C 0.0455563
CERT1 ceramide transporter 1 0.0454459
TJP1 tight junction protein 1 0.0453576
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0452177
USP15 ubiquitin specific peptidase 15 0.0449146
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0448255
ZNF292 zinc finger protein 292 0.0415309
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0414314
USP9X ubiquitin specific peptidase 9, X-linked 0.0413752
LDHA lactate dehydrogenase A 0.0411709
MYO6 myosin VI 0.0411149
NUP153 nucleoporin 153kDa 0.0409605
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0409192
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0403424
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0403004
TNPO1 transportin 1 0.0401786
MYOF myoferlin 0.0397265
ANKRD28 ankyrin repeat domain 28 0.0396218
RCOR1 REST corepressor 1 0.0394053
XPO1 exportin 1 0.0393707
MBNL1 muscleblind-like splicing regulator 1 0.0391082
NABP1 nucleic acid binding protein 1 0.0388621
CD109 CD109 molecule 0.0387478
OCLN occludin 0.0386707
ANXA2 annexin A2 0.0383511
BBX bobby sox homolog (Drosophila) 0.0383389
GRB10 growth factor receptor-bound protein 10 0.0379251
NAV2 neuron navigator 2 0.0378927
ALCAM activated leukocyte cell adhesion molecule 0.0377744
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0374427
TFRC transferrin receptor 0.0372628
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0364518
CD2AP CD2-associated protein 0.0363619
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.036301
LPP LIM domain containing preferred translocation partner in lipoma 0.0362234
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0360024
WWTR1 WW domain containing transcription regulator 1 0.0358139
GPBP1 GC-rich promoter binding protein 1 0.0356217
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0354376
CDC73 cell division cycle 73 0.0352621
MED13 mediator complex subunit 13 0.0344995
APP amyloid beta (A4) precursor protein 0.0343407
TPD52 tumor protein D52 0.0341876
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0341298
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0338438
ARL8B ADP-ribosylation factor-like 8B 0.0334981
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0334483
DSG2 desmoglein 2 0.0334075
VCL vinculin 0.0333062
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0330349
MSI2 musashi RNA-binding protein 2 0.0327095
PCBP2 poly(rC) binding protein 2 0.0326757
NUP98 nucleoporin 98kDa 0.0324438
ATAD2 ATPase family, AAA domain containing 2 0.0323805
EZR ezrin 0.0322023
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0320675
MAP2K1 mitogen-activated protein kinase kinase 1 0.0320459

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.120515
POTEF POTE ankyrin domain family, member F -0.0855101
TMSB10 thymosin beta 10 -0.0789419
RPL35A ribosomal protein L35a -0.0761827
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0649076
S100A6 S100 calcium binding protein A6 -0.050296
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0501113
FN1 fibronectin 1 -0.0500596
IFI27 interferon, alpha-inducible protein 27 -0.0489876
TPT1 tumor protein, translationally-controlled 1 -0.0456359
RPS13 ribosomal protein S13 -0.0441143
FTH1 ferritin, heavy polypeptide 1 -0.0424027
HMGA1 high mobility group AT-hook 1 -0.0391781
ISG15 ISG15 ubiquitin-like modifier -0.0390905
RPL34 ribosomal protein L34 -0.0381896
IFI6 interferon, alpha-inducible protein 6 -0.0375809
IFITM3 interferon induced transmembrane protein 3 -0.0373993
RPL23 ribosomal protein L23 -0.036351
RPLP1 ribosomal protein, large, P1 -0.0357746
RPS29 ribosomal protein S29 -0.0351484
RPL9 ribosomal protein L9 -0.0340758
IFITM1 interferon induced transmembrane protein 1 -0.0337363
RPS25 ribosomal protein S25 -0.0324593
RPS8 ribosomal protein S8 -0.0321411
AKAP9 A kinase (PRKA) anchor protein 9 -0.0316011
RAB2A RAB2A, member RAS oncogene family -0.030874
MDK midkine (neurite growth-promoting factor 2) -0.0307691
EIF1 eukaryotic translation initiation factor 1 -0.0305434
LIMCH1 LIM and calponin homology domains 1 -0.0299673
VIM vimentin -0.0299299
CALR calreticulin -0.0296504
SOX4 SRY (sex determining region Y)-box 4 -0.0295255
RPS23 ribosomal protein S23 -0.0294835
RPL19 ribosomal protein L19 -0.0287962
TM4SF1 transmembrane 4 L six family member 1 -0.0277244
TMEM165 transmembrane protein 165 -0.0275867
SACK1A scaffolding CK1 anchoring protein A -0.0267791
S100A10 S100 calcium binding protein A10 -0.0254021
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0244249
HSPB1 heat shock 27kDa protein 1 -0.0230942
RPL37 ribosomal protein L37 -0.0228293
RPS6 ribosomal protein S6 -0.022419
UBC ubiquitin C -0.0223786
RPL11 ribosomal protein L11 -0.0221156
ANTXR2 anthrax toxin receptor 2 -0.0220734
RPS16 ribosomal protein S16 -0.0220229
VEGFA vascular endothelial growth factor A -0.0211765
IFI16 interferon, gamma-inducible protein 16 -0.0210157
ACTG1 actin gamma 1 -0.0209604
RPL31 ribosomal protein L31 -0.0208646
RPL28 ribosomal protein L28 -0.020755
GPX4 glutathione peroxidase 4 -0.0204822
RIOK3 RIO kinase 3 -0.0203689
HLA-A major histocompatibility complex, class I, A -0.0202416
RPS19 ribosomal protein S19 -0.0201733
RPL12 ribosomal protein L12 -0.0200201
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0199484
RACK1 receptor for activated C kinase 1 -0.0199215
RPS12 ribosomal protein S12 -0.0198264
TMEM263 transmembrane protein 263 -0.0197558
RPL30 ribosomal protein L30 -0.0194834
ACBD3 acyl-CoA binding domain containing 3 -0.0194723
RPL26 ribosomal protein L26 -0.0194532
RPL15 ribosomal protein L15 -0.0193538
CIB1 calcium and integrin binding 1 (calmyrin) -0.0193002
LY6E lymphocyte antigen 6 complex, locus E -0.0191519
RPS27A ribosomal protein S27a -0.0189148
RPL37A ribosomal protein L37a -0.0185597
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0185027
GOLGB1 golgin B1 -0.0185003
RPL27A ribosomal protein L27a -0.018204
EGR1 early growth response 1 -0.0177283
CTSD cathepsin D -0.0177191
MT2A metallothionein 2A -0.0176736
RPS15 ribosomal protein S15 -0.0176019
TPM4 tropomyosin 4 -0.0173415
RPL36A ribosomal protein L36a -0.0172123
RPS21 ribosomal protein S21 -0.0171387
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.016979
BASP1 brain abundant, membrane attached signal protein 1 -0.0168184
TPI1 triosephosphate isomerase 1 -0.0166414
MAML3 mastermind-like 3 (Drosophila) -0.0163087
FBXO32 F-box protein 32 -0.0162623
CTSB cathepsin B -0.0162084
CAB39 calcium binding protein 39 -0.0162026
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0161721
ZBTB20 zinc finger and BTB domain containing 20 -0.0161455
CD63 CD63 molecule -0.0159128
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0157949
RPS3 ribosomal protein S3 -0.0157629
SYT1 synaptotagmin I -0.0156777
RPS17 ribosomal protein S17 -0.0155107
MARCKS myristoylated alanine-rich protein kinase C substrate -0.015493
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0152548
WFDC2 WAP four-disulfide core domain 2 -0.0151279
B2M beta-2-microglobulin -0.0148894
LMNA lamin A/C -0.0148683
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.01481
BCAS3 breast carcinoma amplified sequence 3 -0.0146839
RPLP2 ribosomal protein, large, P2 -0.0145329