Pemigatinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.167894
PDE10A phosphodiesterase 10A 0.121179
DST dystonin 0.114417
ASPH aspartate beta-hydroxylase 0.105821
PDLIM5 PDZ and LIM domain 5 0.0987588
PM20D1 peptidase M20 domain containing 1 0.0927283
EFNA5 ephrin-A5 0.0911788
MYOF myoferlin 0.0886435
COL8A1 collagen, type VIII, alpha 1 0.0849444
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0842422
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0820655
TRIO trio Rho guanine nucleotide exchange factor 0.0818021
KYNU kynureninase 0.0749414
PDE4D phosphodiesterase 4D, cAMP-specific 0.0731269
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0730755
ESYT2 extended synaptotagmin-like protein 2 0.0728707
SAMD4A sterile alpha motif domain containing 4A 0.0686725
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0647465
EXT1 exostosin glycosyltransferase 1 0.0568062
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0561186
INTS6 integrator complex subunit 6 0.0552942
ELL2 elongation factor, RNA polymerase II, 2 0.0538605
LIMCH1 LIM and calponin homology domains 1 0.0534585
VCL vinculin 0.0526562
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0522543
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0521075
IGFBP3 insulin-like growth factor binding protein 3 0.0514793
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0512816
SOD2 superoxide dismutase 2, mitochondrial 0.0492635
AGTPBP1 ATP/GTP binding protein 1 0.0457949
FNDC3B fibronectin type III domain containing 3B 0.0431042
GPC6 glypican 6 0.042994
BIRC6 baculoviral IAP repeat containing 6 0.0418261
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0414888
ANKRD17 ankyrin repeat domain 17 0.0404957
LDHA lactate dehydrogenase A 0.0395837
PTEN phosphatase and tensin homolog 0.0393733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0393466
ZSWIM6 zinc finger, SWIM-type containing 6 0.0382828
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0381742
SMOC1 SPARC related modular calcium binding 1 0.0378857
GRAMD1B GRAM domain containing 1B 0.0368638
NBAS neuroblastoma amplified sequence 0.0363357
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0358418
CTIF CBP80/20-dependent translation initiation factor 0.0352387
CD109 CD109 molecule 0.0350676
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0350111
ZNF638 zinc finger protein 638 0.0349068
CLTC clathrin, heavy chain (Hc) 0.0348747
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0343308
GPHN gephyrin 0.0339399
PCBP2 poly(rC) binding protein 2 0.0333762
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0333683
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0331286
CARD16 caspase recruitment domain family, member 16 0.0330819
COL4A6 collagen, type IV, alpha 6 0.0328317
CTBP2 C-terminal binding protein 2 0.0327019
P3H2 prolyl 3-hydroxylase 2 0.0325359
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0324647
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0318593
USP9X ubiquitin specific peptidase 9, X-linked 0.0315922
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0312876
FNIP1 folliculin interacting protein 1 0.031272
ANXA2 annexin A2 0.0311281
ATXN1 ataxin 1 0.03078
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0307617
CREB3L2 cAMP responsive element binding protein 3-like 2 0.030425
HSPA8 heat shock 70kDa protein 8 0.0301061
PRELID2 PRELI domain containing 2 0.0298884
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0297058
MBD5 methyl-CpG binding domain protein 5 0.0296589
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0294535
ENAH enabled homolog (Drosophila) 0.0291902
COPA coatomer protein complex, subunit alpha 0.0291783
SEC31A SEC31 homolog A (S. cerevisiae) 0.0290979
USP34 ubiquitin specific peptidase 34 0.0290487
SMAD2 SMAD family member 2 0.0289381
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.028855
MCTP1 multiple C2 domains, transmembrane 1 0.0285367
PRRC2C proline-rich coiled-coil 2C 0.028493
MORF4L2 mortality factor 4 like 2 0.0283994
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0283222
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0278901
STRN3 striatin, calmodulin binding protein 3 0.0278669
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0277826
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0270919
ALCAM activated leukocyte cell adhesion molecule 0.0270093
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.026835
NF1 neurofibromin 1 0.0266812
TGFBR1 transforming growth factor, beta receptor 1 0.0264498
GSK3B glycogen synthase kinase 3 beta 0.0264249
DNER delta/notch-like EGF repeat containing 0.0263492
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0262017
ADARB1 adenosine deaminase, RNA-specific, B1 0.0261909
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.02605
PTK2 protein tyrosine kinase 2 0.026007
SH3KBP1 SH3-domain kinase binding protein 1 0.0258421
CREB5 cAMP responsive element binding protein 5 0.0255325
WDFY2 WD repeat and FYVE domain containing 2 0.0254175
SCFD1 sec1 family domain containing 1 0.0250979

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.163398
VIM vimentin -0.129838
TPT1 tumor protein, translationally-controlled 1 -0.122031
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.110195
FN1 fibronectin 1 -0.100839
TMSB10 thymosin beta 10 -0.0997441
NALF1 NALCN channel auxiliary factor 1 -0.0844199
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0841392
PTMA prothymosin, alpha -0.0747669
RPLP1 ribosomal protein, large, P1 -0.0725377
RPS6 ribosomal protein S6 -0.0618415
S100A6 S100 calcium binding protein A6 -0.0603593
SOX4 SRY (sex determining region Y)-box 4 -0.059529
RPL31 ribosomal protein L31 -0.054703
CTSL cathepsin L -0.0496822
RPL35A ribosomal protein L35a -0.0495847
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0471834
RPS12 ribosomal protein S12 -0.0460228
RPS8 ribosomal protein S8 -0.0460119
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0449841
RPS24 ribosomal protein S24 -0.0435543
HLA-B major histocompatibility complex, class I, B -0.043381
RPS19 ribosomal protein S19 -0.0427062
RPL26 ribosomal protein L26 -0.0414319
RPS27A ribosomal protein S27a -0.0410883
RPL19 ribosomal protein L19 -0.0409126
RPL36A ribosomal protein L36a -0.0408778
STC1 stanniocalcin 1 -0.0404561
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0402455
RPL9 ribosomal protein L9 -0.0399462
RPS29 ribosomal protein S29 -0.0395605
GNAS GNAS complex locus -0.0383899
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0380879
RPL37A ribosomal protein L37a -0.0372529
RPS13 ribosomal protein S13 -0.0371648
KIAA0825 KIAA0825 -0.0365773
PCBP3 poly(rC) binding protein 3 -0.0365325
RPS3 ribosomal protein S3 -0.0364269
RPL37 ribosomal protein L37 -0.0356288
FTL ferritin, light polypeptide -0.0353203
RPL12 ribosomal protein L12 -0.0349147
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0346032
RPL38 ribosomal protein L38 -0.0342884
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0338876
HLA-A major histocompatibility complex, class I, A -0.0334833
RPL36 ribosomal protein L36 -0.0333837
RTN1 reticulon 1 -0.0333435
TBXT T-box transcription factor T -0.0332053
INHBA inhibin, beta A -0.0331059
TMSB4X thymosin beta 4, X-linked -0.0327464
RPS14 ribosomal protein S14 -0.032168
RPLP0 ribosomal protein, large, P0 -0.0319971
RPLP2 ribosomal protein, large, P2 -0.0308809
RPL11 ribosomal protein L11 -0.0305656
RPS27 ribosomal protein S27 -0.0305002
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0298155
RPL13A ribosomal protein L13a -0.0297582
RPL23 ribosomal protein L23 -0.0296596
RPS16 ribosomal protein S16 -0.0294977
FOXC1 forkhead box C1 -0.0293695
RPS21 ribosomal protein S21 -0.0290725
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0286106
RPL39 ribosomal protein L39 -0.028079
TPM4 tropomyosin 4 -0.0279027
RPS23 ribosomal protein S23 -0.0277136
RPS25 ribosomal protein S25 -0.027216
OASL 2'-5'-oligoadenylate synthetase-like -0.0270625
SMYD3 SET and MYND domain containing 3 -0.026457
SLC16A6 solute carrier family 16, member 6 -0.025457
RPH3AL rabphilin 3A-like (without C2 domains) -0.0249284
WSB1 WD repeat and SOCS box containing 1 -0.024813
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0244352
RPL34 ribosomal protein L34 -0.0239157
THSD4 thrombospondin, type I, domain containing 4 -0.0238423
RPL7A ribosomal protein L7a -0.0234896
CRLF2 cytokine receptor-like factor 2 -0.0233741
RPS17 ribosomal protein S17 -0.0232821
B2M beta-2-microglobulin -0.0232425
RPL27A ribosomal protein L27a -0.0227877
MT2A metallothionein 2A -0.0227727
CHL1 cell adhesion molecule L1-like -0.0227486
ZMYND8 zinc finger, MYND-type containing 8 -0.0227455
CCDC68 coiled-coil domain containing 68 -0.0224699
TM4SF1 transmembrane 4 L six family member 1 -0.0223981
BASP1 brain abundant, membrane attached signal protein 1 -0.0218072
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0215528
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0211839
S100A10 S100 calcium binding protein A10 -0.0209913
BCAS3 breast carcinoma amplified sequence 3 -0.0200529
TGFBI transforming growth factor, beta-induced, 68kDa -0.0199073
PYGL phosphorylase, glycogen, liver -0.0198832
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0197921
SRGN serglycin -0.0197489
RPL8 ribosomal protein L8 -0.0196049
TFPI2 tissue factor pathway inhibitor 2 -0.0193318
LAMB1 laminin, beta 1 -0.0192292
KTN1 kinectin 1 (kinesin receptor) -0.019174
STEAP1B STEAP family member 1B -0.0191141
IL6 interleukin 6 -0.0190671
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0190095