| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemigatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DTNA | dystrobrevin, alpha | 0.18304 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.153864 |
| ZNF292 | zinc finger protein 292 | 0.111576 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.106914 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.102156 |
| IGF2 | insulin-like growth factor 2 | 0.101908 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0976717 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0934149 |
| FNDC3B | fibronectin type III domain containing 3B | 0.091705 |
| SETD5 | SET domain containing 5 | 0.0903465 |
| PARD3 | par-3 family cell polarity regulator | 0.0878478 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0875644 |
| NRG1 | neuregulin 1 | 0.0855206 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0852321 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0845162 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0829852 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.078413 |
| RPS6 | ribosomal protein S6 | 0.0782445 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0782232 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0740234 |
| ITSN2 | intersectin 2 | 0.0730456 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0710519 |
| SP100 | SP100 nuclear antigen | 0.0652222 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0631293 |
| HMGA2 | high mobility group AT-hook 2 | 0.0622724 |
| DST | dystonin | 0.0601831 |
| RPS19 | ribosomal protein S19 | 0.059337 |
| RPS8 | ribosomal protein S8 | 0.05867 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.057202 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0567632 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0556909 |
| ZNF638 | zinc finger protein 638 | 0.0555432 |
| RPL23 | ribosomal protein L23 | 0.0517739 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0509137 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.048788 |
| FTL | ferritin, light polypeptide | 0.0487158 |
| NFIB | nuclear factor I/B | 0.047926 |
| FHIT | fragile histidine triad | 0.0469868 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0469451 |
| PNN | pinin, desmosome associated protein | 0.0441314 |
| PCBP2 | poly(rC) binding protein 2 | 0.0425192 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0416409 |
| MLEC | malectin | 0.0403995 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0395558 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0391572 |
| MEF2A | myocyte enhancer factor 2A | 0.0380753 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0366785 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0353956 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0353746 |
| GPC6 | glypican 6 | 0.0348392 |
| PKM | pyruvate kinase, muscle | 0.0342963 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.034233 |
| FNDC3A | fibronectin type III domain containing 3A | 0.033189 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0326914 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0323321 |
| QKI | QKI, KH domain containing, RNA binding | 0.0323178 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0311599 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0310975 |
| HDAC8 | histone deacetylase 8 | 0.0309926 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0290283 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0282816 |
| USP34 | ubiquitin specific peptidase 34 | 0.0282657 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0281207 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0274181 |
| ZFHX3 | zinc finger homeobox 3 | 0.0272093 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0272011 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0271041 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0268484 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0267714 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.026642 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0259572 |
| RPL34 | ribosomal protein L34 | 0.025667 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0249695 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0227687 |
| SMYD3 | SET and MYND domain containing 3 | 0.0220922 |
| DSTN | destrin (actin depolymerizing factor) | 0.0219053 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0208688 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0208557 |
| SNX9 | sorting nexin 9 | 0.0206865 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0206577 |
| FNIP1 | folliculin interacting protein 1 | 0.0205812 |
| RPL35A | ribosomal protein L35a | 0.0204434 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0203233 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0186763 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0186118 |
| SIK3 | SIK family kinase 3 | 0.0176867 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0172663 |
| AK1 | adenylate kinase 1 | 0.0171632 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0159738 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0150998 |
| CUX1 | cut-like homeobox 1 | 0.014964 |
| NFIA | nuclear factor I/A | 0.0144338 |
| CUL3 | cullin 3 | 0.0141645 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0141119 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0139763 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.013772 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0136102 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0131866 |
| CDK6 | cyclin-dependent kinase 6 | 0.0119538 |
| MAP1B | microtubule-associated protein 1B | 0.0116383 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.132439 |
| VIM | vimentin | -0.116413 |
| POTEF | POTE ankyrin domain family, member F | -0.109014 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0907401 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0837818 |
| EFNA5 | ephrin-A5 | -0.0829078 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0829008 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0736796 |
| PTK2 | protein tyrosine kinase 2 | -0.070228 |
| ANXA2 | annexin A2 | -0.0639324 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.061889 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0581221 |
| CDH13 | cadherin 13 | -0.0579309 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0544473 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0525891 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0522139 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0518323 |
| FAM13A | family with sequence similarity 13, member A | -0.0517851 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0517156 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0496683 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0488517 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0486198 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0484511 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0481864 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.048173 |
| PRKCA | protein kinase C, alpha | -0.0480065 |
| INHBA | inhibin, beta A | -0.0466258 |
| EGFR | epidermal growth factor receptor | -0.0464468 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0463288 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0455538 |
| MSI2 | musashi RNA-binding protein 2 | -0.0445605 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0439082 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0434708 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0433402 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0428074 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0426932 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0426835 |
| HELZ | helicase with zinc finger | -0.0423998 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0420602 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0417657 |
| RPLP1 | ribosomal protein, large, P1 | -0.0413181 |
| OLA1 | Obg-like ATPase 1 | -0.041263 |
| PRRC2C | proline-rich coiled-coil 2C | -0.040366 |
| CANX | calnexin | -0.0395851 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0395361 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0390697 |
| VMP1 | vacuole membrane protein 1 | -0.0390557 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0389419 |
| RPLP2 | ribosomal protein, large, P2 | -0.0386516 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0374227 |
| FLNB | filamin B, beta | -0.0366582 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0364882 |
| CD44 | CD44 molecule (Indian blood group) | -0.0363544 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0362744 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0362376 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0355156 |
| USP3 | ubiquitin specific peptidase 3 | -0.0350378 |
| RAN | RAN, member RAS oncogene family | -0.0342566 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0339447 |
| GPHN | gephyrin | -0.0330341 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0328953 |
| TFG | TRK-fused gene | -0.0327061 |
| RCOR1 | REST corepressor 1 | -0.0321579 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0313705 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0307548 |
| ANKRD12 | ankyrin repeat domain 12 | -0.030313 |
| SF3B3 | splicing factor 3b, subunit 3, 130kDa | -0.030225 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.030123 |
| MYOF | myoferlin | -0.0301138 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0300089 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0291897 |
| TMSB10 | thymosin beta 10 | -0.0283074 |
| CD2AP | CD2-associated protein | -0.0273714 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0266747 |
| PGK1 | phosphoglycerate kinase 1 | -0.0263669 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0253898 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0247269 |
| ASPH | aspartate beta-hydroxylase | -0.0245626 |
| SBF2 | SET binding factor 2 | -0.0242402 |
| RPS12 | ribosomal protein S12 | -0.024011 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0238062 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0235333 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0232948 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0232336 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.022935 |
| PRELID2 | PRELI domain containing 2 | -0.0228582 |
| PDE10A | phosphodiesterase 10A | -0.0227577 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0227295 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0223389 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0221568 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0212353 |
| VCL | vinculin | -0.0207953 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0207316 |
| ARMH4 | armadillo like helical domain containing 4 | -0.019922 |
| NBAS | neuroblastoma amplified sequence | -0.0191181 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0189067 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0187358 |
| YEATS2 | YEATS domain containing 2 | -0.0183747 |
| SRP54 | signal recognition particle 54kDa | -0.0182221 |
| STAG2 | stromal antigen 2 | -0.0176474 |
