| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pemigatinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pemigatinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.135068 |
| PDE10A | phosphodiesterase 10A | 0.123793 |
| GPC6 | glypican 6 | 0.11769 |
| HDAC9 | histone deacetylase 9 | 0.113073 |
| VCL | vinculin | 0.103125 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0958503 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0940838 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0924523 |
| VCAN | versican | 0.0672118 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0626758 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0604939 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0591238 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0543718 |
| TMEM132D | transmembrane protein 132D | 0.0526786 |
| FNIP1 | folliculin interacting protein 1 | 0.0511358 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0501221 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.046742 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.04672 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0466804 |
| CDH13 | cadherin 13 | 0.0456709 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0437859 |
| FMN1 | formin 1 | 0.0424923 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0422737 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0420389 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0403728 |
| SYNJ2 | synaptojanin 2 | 0.0403448 |
| PRELID2 | PRELI domain containing 2 | 0.0363423 |
| DTNA | dystrobrevin, alpha | 0.0349808 |
| GPHN | gephyrin | 0.0343766 |
| GPR176 | G protein-coupled receptor 176 | 0.0342702 |
| ERBIN | erbb2 interacting protein | 0.0338488 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0330657 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0322992 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0316914 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0316796 |
| PALLD | palladin, cytoskeletal associated protein | 0.0305033 |
| EGR1 | early growth response 1 | 0.0301795 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0296964 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0296767 |
| WWOX | WW domain containing oxidoreductase | 0.0294685 |
| MORF4L2 | mortality factor 4 like 2 | 0.0292055 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0287209 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0283135 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0281869 |
| FRMD4A | FERM domain containing 4A | 0.0281575 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0279084 |
| CTBP2 | C-terminal binding protein 2 | 0.0277227 |
| IRS2 | insulin receptor substrate 2 | 0.0275327 |
| HOMER1 | homer scaffolding protein 1 | 0.0273127 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0267432 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.026283 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0261684 |
| MYOF | myoferlin | 0.0260522 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0258858 |
| KLHL29 | kelch-like family member 29 | 0.0255146 |
| FHIT | fragile histidine triad | 0.0254773 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0249839 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0246537 |
| KIAA1217 | KIAA1217 | 0.0246033 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0244415 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0241263 |
| CRY1 | cryptochrome circadian clock 1 | 0.0240899 |
| TUSC3 | tumor suppressor candidate 3 | 0.0239208 |
| ANO6 | anoctamin 6 | 0.0238673 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0236789 |
| HKDC1 | hexokinase domain containing 1 | 0.0236781 |
| PDLIM5 | PDZ and LIM domain 5 | 0.023294 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0231322 |
| ATXN1 | ataxin 1 | 0.0230164 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0229212 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.022858 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0228109 |
| SLIT3 | slit homolog 3 (Drosophila) | 0.0225152 |
| RUNX1 | runt-related transcription factor 1 | 0.0224859 |
| RPS6 | ribosomal protein S6 | 0.0223709 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0223543 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0223291 |
| TENM2 | teneurin transmembrane protein 2 | 0.0223027 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.022141 |
| DUSP10 | dual specificity phosphatase 10 | 0.0220945 |
| NRXN3 | neurexin 3 | 0.0220843 |
| LYST | lysosomal trafficking regulator | 0.0220079 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0219504 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0217561 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0217445 |
| LSAMP | limbic system-associated membrane protein | 0.0216969 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0212376 |
| CCNL1 | cyclin L1 | 0.0208277 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0206135 |
| ASPH | aspartate beta-hydroxylase | 0.0205951 |
| CORO1C | coronin, actin binding protein, 1C | 0.0204018 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0203216 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0202275 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0201864 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0199306 |
| IER3 | immediate early response 3 | 0.0199024 |
| PCDH7 | protocadherin 7 | 0.0198837 |
| TRAM2 | translocation associated membrane protein 2 | 0.019847 |
| SFRP1 | secreted frizzled-related protein 1 | 0.0197786 |
| EPHA5 | EPH receptor A5 | 0.0197622 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.312346 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0847673 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0697085 |
| PTMA | prothymosin, alpha | -0.0676845 |
| HLA-E | major histocompatibility complex, class I, E | -0.0651075 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0641061 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0639013 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0628657 |
| HLA-B | major histocompatibility complex, class I, B | -0.0624678 |
| CD44 | CD44 molecule (Indian blood group) | -0.0577394 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0557315 |
| CENPF | centromere protein F, 350/400kDa | -0.055445 |
| GLIS3 | GLIS family zinc finger 3 | -0.0541608 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0539927 |
| PGK1 | phosphoglycerate kinase 1 | -0.0513908 |
| MT2A | metallothionein 2A | -0.0511878 |
| OGA | O-GlcNAcase | -0.047922 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.047518 |
| AHNAK | AHNAK nucleoprotein | -0.0460528 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0458475 |
| ANLN | anillin, actin binding protein | -0.0442755 |
| STC1 | stanniocalcin 1 | -0.0440701 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0431788 |
| RAI14 | retinoic acid induced 14 | -0.0426784 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0418786 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0400894 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0387449 |
| VEGFA | vascular endothelial growth factor A | -0.0384265 |
| THBS1 | thrombospondin 1 | -0.0381185 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0380851 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0376142 |
| KIF4A | kinesin family member 4A | -0.037283 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0367378 |
| TPM4 | tropomyosin 4 | -0.0366032 |
| SBF2 | SET binding factor 2 | -0.0363679 |
| UBC | ubiquitin C | -0.0362395 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0356622 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0353891 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0345467 |
| TMSB4X | thymosin beta 4, X-linked | -0.0340802 |
| ENO1 | enolase 1, (alpha) | -0.0337025 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0327062 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0326536 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0324846 |
| MMP12 | matrix metallopeptidase 12 | -0.0324279 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0322919 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0320576 |
| PTK2 | protein tyrosine kinase 2 | -0.0317746 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0316487 |
| ZNF292 | zinc finger protein 292 | -0.0313351 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0310759 |
| RPS3 | ribosomal protein S3 | -0.0309727 |
| NDRG1 | N-myc downstream regulated 1 | -0.0308586 |
| FLNB | filamin B, beta | -0.0308522 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0306071 |
| HMGA2 | high mobility group AT-hook 2 | -0.0305692 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0302485 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0302354 |
| TAPBP | TAP binding protein (tapasin) | -0.0298213 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0293305 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0291672 |
| FOXP1 | forkhead box P1 | -0.0290974 |
| HMGA1 | high mobility group AT-hook 1 | -0.0288998 |
| RPS27A | ribosomal protein S27a | -0.0287056 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0285183 |
| TMSB10 | thymosin beta 10 | -0.0285036 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0283054 |
| APP | amyloid beta (A4) precursor protein | -0.0282693 |
| RPL36A | ribosomal protein L36a | -0.0282079 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.028021 |
| SEPTIN7 | septin 7 | -0.0279619 |
| RAI1 | retinoic acid induced 1 | -0.0279334 |
| RPL31 | ribosomal protein L31 | -0.0276789 |
| TPX2 | TPX2, microtubule-associated | -0.0275721 |
| LDHA | lactate dehydrogenase A | -0.0275648 |
| PCBP2 | poly(rC) binding protein 2 | -0.0274447 |
| RPL27A | ribosomal protein L27a | -0.0273612 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0272964 |
| DIAPH3 | diaphanous-related formin 3 | -0.0271513 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0268915 |
| HLA-A | major histocompatibility complex, class I, A | -0.0268033 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0266487 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0265451 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0265176 |
| TOX2 | TOX high mobility group box family member 2 | -0.0264432 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0263026 |
| TPR | translocated promoter region, nuclear basket protein | -0.0257209 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0254366 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0253935 |
| SDC4 | syndecan 4 | -0.0253409 |
| RTN4 | reticulon 4 | -0.0251232 |
| SET | SET nuclear proto-oncogene | -0.0248696 |
| RBMX | RNA binding motif protein, X-linked | -0.0245524 |
| TMEM123 | transmembrane protein 123 | -0.0244793 |
| ACTG1 | actin gamma 1 | -0.0243582 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0242968 |
| AFDN | afadin, adherens junction formation factor | -0.0242085 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0239622 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0239002 |
| RPL9 | ribosomal protein L9 | -0.023828 |
