Pemigatinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pemigatinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pemigatinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.147605
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.11596
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.11027
EREG epiregulin 0.0781786
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0721573
FNDC3B fibronectin type III domain containing 3B 0.0689866
PTPRD protein tyrosine phosphatase, receptor type, D 0.064625
TXNIP thioredoxin interacting protein 0.0600644
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0569701
FAT1 FAT atypical cadherin 1 0.0569536
GRB10 growth factor receptor-bound protein 10 0.0569353
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0559313
PALLD palladin, cytoskeletal associated protein 0.0546885
GPC6 glypican 6 0.0543449
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0529326
CXCL8 chemokine (C-X-C motif) ligand 8 0.0521688
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.0505136
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0502151
CD109 CD109 molecule 0.0496131
ELL2 elongation factor, RNA polymerase II, 2 0.048472
ZSWIM6 zinc finger, SWIM-type containing 6 0.0480276
ATF6 activating transcription factor 6 0.0478984
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.047281
CTBP2 C-terminal binding protein 2 0.0468518
MRPS6 mitochondrial ribosomal protein S6 0.044913
FAM13A family with sequence similarity 13, member A 0.0435692
SEC31A SEC31 homolog A (S. cerevisiae) 0.0417707
MYOF myoferlin 0.04128
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.040925
TAS2R14 taste receptor, type 2, member 14 0.0409114
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0405896
TTC3 tetratricopeptide repeat domain 3 0.0404764
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.039981
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0399365
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0397598
DLG1 discs, large homolog 1 (Drosophila) 0.0397171
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0392303
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0391507
SEC24A SEC24 family member A 0.0388533
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.037154
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0365241
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0363497
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0363236
SOD2 superoxide dismutase 2, mitochondrial 0.0349558
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0339928
LINGO2 leucine rich repeat and Ig domain containing 2 0.033677
DSTN destrin (actin depolymerizing factor) 0.0336654
NDRG1 N-myc downstream regulated 1 0.0334247
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0316475
TSC22D2 TSC22 domain family, member 2 0.0312408
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0309068
PCDH7 protocadherin 7 0.0304807
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0303564
COPA coatomer protein complex, subunit alpha 0.0302403
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0297886
TBC1D19 TBC1 domain family, member 19 0.0297334
DENND4C DENN/MADD domain containing 4C 0.0296036
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0295477
FRMD5 FERM domain containing 5 0.0291047
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0288056
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0287664
TNNC1 troponin C type 1 (slow) 0.0286981
COG6 component of oligomeric golgi complex 6 0.0285557
FBXW11 F-box and WD repeat domain containing 11 0.0282151
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0281548
MBNL1 muscleblind-like splicing regulator 1 0.0276441
SGMS2 sphingomyelin synthase 2 0.0274252
SUCO SUN domain containing ossification factor 0.0273749
FAM219A family with sequence similarity 219, member A 0.0270712
TRA2A transformer 2 alpha homolog (Drosophila) 0.0270576
CRY1 cryptochrome circadian clock 1 0.0269945
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0268636
PRELID2 PRELI domain containing 2 0.0267658
SCFD1 sec1 family domain containing 1 0.0266554
SIRT1 sirtuin 1 0.0264774
SEC24D SEC24 family member D 0.0264086
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0263794
MAPK8 mitogen-activated protein kinase 8 0.0261795
SCFD2 sec1 family domain containing 2 0.0259203
LIMCH1 LIM and calponin homology domains 1 0.0259178
MBNL2 muscleblind-like splicing regulator 2 0.0258046
BIRC6 baculoviral IAP repeat containing 6 0.0257162
FAM3C family with sequence similarity 3, member C 0.0257115
PEG10 paternally expressed 10 0.0256201
ZNF451 zinc finger protein 451 0.0255512
ATOSA atos homolog A 0.0255079
EXT1 exostosin glycosyltransferase 1 0.0254886
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0252923
DENND4A DENN/MADD domain containing 4A 0.0251781
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0251243
WDR33 WD repeat domain 33 0.0250557
RIMS2 regulating synaptic membrane exocytosis 2 0.0246031
CANX calnexin 0.0244545
SDCBP syndecan binding protein (syntenin) 0.0243789
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0243484
PICALM phosphatidylinositol binding clathrin assembly protein 0.0243044
MON2 MON2 homolog (S. cerevisiae) 0.0242797
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0242432
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0238705
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0238501

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.165955
FN1 fibronectin 1 -0.16061
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.125923
VIM vimentin -0.0943404
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0872782
IFI27 interferon, alpha-inducible protein 27 -0.0858595
HLA-B major histocompatibility complex, class I, B -0.0842043
FTL ferritin, light polypeptide -0.0839024
PTMA prothymosin, alpha -0.0836808
TPT1 tumor protein, translationally-controlled 1 -0.0808634
TMSB10 thymosin beta 10 -0.0800146
TMEM156 transmembrane protein 156 -0.0748114
HMGA2 high mobility group AT-hook 2 -0.0745612
GLIS3 GLIS family zinc finger 3 -0.0687991
MT2A metallothionein 2A -0.0629959
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.05645
RPL35A ribosomal protein L35a -0.0560353
RPL31 ribosomal protein L31 -0.0555967
SQSTM1 sequestosome 1 -0.0548859
KLHL5 kelch-like family member 5 -0.0491674
OSMR oncostatin M receptor -0.0483077
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0456651
RPL26 ribosomal protein L26 -0.0447723
RPL12 ribosomal protein L12 -0.0426734
FOXP1 forkhead box P1 -0.0426405
ETV1 ets variant 1 -0.042279
MBD5 methyl-CpG binding domain protein 5 -0.0413201
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0412558
RPL9 ribosomal protein L9 -0.0411685
AKAP12 A kinase (PRKA) anchor protein 12 -0.040889
RPL11 ribosomal protein L11 -0.0401833
RPS19 ribosomal protein S19 -0.0397036
RPS11 ribosomal protein S11 -0.0396751
S100A6 S100 calcium binding protein A6 -0.0396081
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0394472
RPL37A ribosomal protein L37a -0.0382362
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0381085
RPS6 ribosomal protein S6 -0.0380721
RPS8 ribosomal protein S8 -0.0372294
HLA-A major histocompatibility complex, class I, A -0.0371872
DNAH5 dynein, axonemal, heavy chain 5 -0.0369461
RPS3 ribosomal protein S3 -0.0368296
HMGA1 high mobility group AT-hook 1 -0.0367575
RPLP1 ribosomal protein, large, P1 -0.0360646
EFNA5 ephrin-A5 -0.0352083
RPL37 ribosomal protein L37 -0.0344034
RPS27A ribosomal protein S27a -0.0342521
SOX4 SRY (sex determining region Y)-box 4 -0.033212
HPCAL1 hippocalcin-like 1 -0.0321797
EIF1 eukaryotic translation initiation factor 1 -0.0321656
TMSB4X thymosin beta 4, X-linked -0.0320406
RPL23 ribosomal protein L23 -0.0319981
SOS1 son of sevenless homolog 1 (Drosophila) -0.0314803
RPS21 ribosomal protein S21 -0.0310705
FNBP1 formin binding protein 1 -0.0304881
KTN1 kinectin 1 (kinesin receptor) -0.0304429
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0293579
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0293068
FTH1 ferritin, heavy polypeptide 1 -0.0291645
ENO1 enolase 1, (alpha) -0.0290779
RACK1 receptor for activated C kinase 1 -0.0288708
NTN4 netrin 4 -0.0287143
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0285852
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0284083
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0282092
TSC22D1 TSC22 domain family, member 1 -0.0276657
SEPTIN9 septin 9 -0.0271895
ZMYND8 zinc finger, MYND-type containing 8 -0.0271848
RPS12 ribosomal protein S12 -0.0270089
NRP1 neuropilin 1 -0.0268853
RPL34 ribosomal protein L34 -0.0268525
DPYD dihydropyrimidine dehydrogenase -0.026779
RPS25 ribosomal protein S25 -0.0267564
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0266282
SKAP2 src kinase associated phosphoprotein 2 -0.0265332
LTBP1 latent transforming growth factor beta binding protein 1 -0.0264394
ACTG1 actin gamma 1 -0.0263785
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0261199
RPS29 ribosomal protein S29 -0.0260955
RPLP2 ribosomal protein, large, P2 -0.026006
RPS5 ribosomal protein S5 -0.0257488
RPL36 ribosomal protein L36 -0.0257198
RPL19 ribosomal protein L19 -0.0257092
RPS23 ribosomal protein S23 -0.0256925
SMOX spermine oxidase -0.0256023
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0251875
RPS16 ribosomal protein S16 -0.0248121
CD63 CD63 molecule -0.0246703
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0244863
LDHA lactate dehydrogenase A -0.0244733
CENPF centromere protein F, 350/400kDa -0.0244548
TMEM131 transmembrane protein 131 -0.0240874
TPI1 triosephosphate isomerase 1 -0.0240356
CD44 CD44 molecule (Indian blood group) -0.0238476
B2M beta-2-microglobulin -0.0238472
RPS27 ribosomal protein S27 -0.02367
ADAM8 ADAM metallopeptidase domain 8 -0.0234029
ITGB5 integrin, beta 5 -0.0231674
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0231125
RPL28 ribosomal protein L28 -0.0228902