Penfluridol_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0534788
HELZ helicase with zinc finger 0.0532791
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0481863
WAC WW domain containing adaptor with coiled-coil 0.04156
NALF1 NALCN channel auxiliary factor 1 0.0410327
FNDC3B fibronectin type III domain containing 3B 0.0392243
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0367967
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0355047
KDM3A lysine (K)-specific demethylase 3A 0.0334414
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0333464
NDRG1 N-myc downstream regulated 1 0.0326651
CDC73 cell division cycle 73 0.0312135
SSBP2 single-stranded DNA binding protein 2 0.0294525
PDE4D phosphodiesterase 4D, cAMP-specific 0.0289235
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0281212
ECT2 epithelial cell transforming 2 0.0260062
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.024511
NUP58 nucleoporin 58 0.0243353
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0241363
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0239988
KMT2C lysine (K)-specific methyltransferase 2C 0.0234905
RNF145 ring finger protein 145 0.0234848
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0232726
MSI2 musashi RNA-binding protein 2 0.0231828
NAMPT nicotinamide phosphoribosyltransferase 0.0231413
PGK1 phosphoglycerate kinase 1 0.0230341
USP3 ubiquitin specific peptidase 3 0.0230111
QKI QKI, KH domain containing, RNA binding 0.0225001
ZNF148 zinc finger protein 148 0.0221743
MSMO1 methylsterol monooxygenase 1 0.0221288
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0220063
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0219645
TOP2B topoisomerase (DNA) II beta 180kDa 0.0217986
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0217618
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0209555
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0208185
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0205166
INSIG2 insulin induced gene 2 0.0201737
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0200542
GPBP1 GC-rich promoter binding protein 1 0.019695
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0196373
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.019599
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.019518
XPO1 exportin 1 0.0192966
CKAP5 cytoskeleton associated protein 5 0.0190976
SRPK2 SRSF protein kinase 2 0.0187598
RYBP RING1 and YY1 binding protein 0.0186793
MEF2A myocyte enhancer factor 2A 0.0185442
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0184991
YAP1 Yes-associated protein 1 0.0184557
TNIP1 TNFAIP3 interacting protein 1 0.0177896
ATXN1 ataxin 1 0.0177579
SERTAD2 SERTA domain containing 2 0.0174825
CD46 CD46 molecule, complement regulatory protein 0.0172472
DLG1 discs, large homolog 1 (Drosophila) 0.0172131
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.017175
CCNL1 cyclin L1 0.0169114
BRD4 bromodomain containing 4 0.0167437
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0166703
RAD23B RAD23 homolog B (S. cerevisiae) 0.0166015
ADAM17 ADAM metallopeptidase domain 17 0.0164935
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0163961
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0163944
BIRC6 baculoviral IAP repeat containing 6 0.0163456
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0163205
ADAM9 ADAM metallopeptidase domain 9 0.0160496
AFF4 AF4/FMR2 family, member 4 0.015986
CDH13 cadherin 13 0.0157803
UBA6 ubiquitin-like modifier activating enzyme 6 0.0157333
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0157137
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0155823
TNPO1 transportin 1 0.0155006
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0154954
SEC23A Sec23 homolog A (S. cerevisiae) 0.0154328
OSBPL8 oxysterol binding protein-like 8 0.0153713
SIK3 SIK family kinase 3 0.0152834
DIAPH1 diaphanous-related formin 1 0.0150825
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0150718
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0148531
MARCHF6 membrane associated ring-CH-type finger 6 0.0145691
TLK2 tousled-like kinase 2 0.014564
KMT2E lysine (K)-specific methyltransferase 2E 0.0145426
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0145307
AKAP13 A kinase (PRKA) anchor protein 13 0.0145208
KIAA1958 KIAA1958 0.0144628
MYO1B myosin IB 0.0144232
RBM39 RNA binding motif protein 39 0.0141621
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0140869
CEP152 centrosomal protein 152kDa 0.0140188
USP9X ubiquitin specific peptidase 9, X-linked 0.0139942
NGLY1 N-glycanase 1 0.013955
ATP13A3 ATPase type 13A3 0.013822
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0138172
LBR lamin B receptor 0.0137996
AFDN afadin, adherens junction formation factor 0.0137874
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0137865
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.0137485
DTNA dystrobrevin, alpha 0.0137176
ALCAM activated leukocyte cell adhesion molecule 0.0136679
PANK3 pantothenate kinase 3 0.0136188

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.323561
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220976
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.168916
VIM vimentin -0.157854
RPS6 ribosomal protein S6 -0.0917034
AKAP12 A kinase (PRKA) anchor protein 12 -0.0916327
PTMA prothymosin, alpha -0.0906205
RPL19 ribosomal protein L19 -0.0788582
RPL23 ribosomal protein L23 -0.0765883
RPL35A ribosomal protein L35a -0.0700633
RPLP1 ribosomal protein, large, P1 -0.0684449
VCL vinculin -0.0678213
ACTG1 actin gamma 1 -0.0630213
COL1A1 collagen, type I, alpha 1 -0.0607068
BPTF bromodomain PHD finger transcription factor -0.0589334
RPL38 ribosomal protein L38 -0.0572364
RPL34 ribosomal protein L34 -0.0518642
EIF1 eukaryotic translation initiation factor 1 -0.0501579
TMSB10 thymosin beta 10 -0.0460388
RPL37A ribosomal protein L37a -0.0435221
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0425634
PTPRD protein tyrosine phosphatase, receptor type, D -0.0420754
TLE4 transducin-like enhancer of split 4 -0.0406369
TPT1 tumor protein, translationally-controlled 1 -0.0403692
PLAT plasminogen activator, tissue -0.0400993
RACK1 receptor for activated C kinase 1 -0.0400839
RPS19 ribosomal protein S19 -0.0393871
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0393557
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0390964
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0385423
RPS3 ribosomal protein S3 -0.037747
RPL12 ribosomal protein L12 -0.0374545
S100A6 S100 calcium binding protein A6 -0.0369582
LMNA lamin A/C -0.0366719
BCAS3 breast carcinoma amplified sequence 3 -0.0366645
IFI16 interferon, gamma-inducible protein 16 -0.0354627
RPL36 ribosomal protein L36 -0.0345026
RPL26 ribosomal protein L26 -0.0344226
FTL ferritin, light polypeptide -0.0337534
RPL7A ribosomal protein L7a -0.033588
RPL18 ribosomal protein L18 -0.0335804
MED13 mediator complex subunit 13 -0.0335124
RPS29 ribosomal protein S29 -0.0331828
RPS24 ribosomal protein S24 -0.0330722
SYT1 synaptotagmin I -0.0329942
RPL32 ribosomal protein L32 -0.0329462
HAND2 heart and neural crest derivatives expressed 2 -0.0325932
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0323765
FNBP1 formin binding protein 1 -0.0318767
DCAF7 DDB1 and CUL4 associated factor 7 -0.0317198
VMP1 vacuole membrane protein 1 -0.0311859
RNF213 ring finger protein 213 -0.0293197
MBTD1 mbt domain containing 1 -0.029279
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0292045
RPS12 ribosomal protein S12 -0.0290524
B2M beta-2-microglobulin -0.0289259
RPL31 ribosomal protein L31 -0.0289246
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0286585
FMN1 formin 1 -0.0284575
RPL28 ribosomal protein L28 -0.0282353
LPIN1 lipin 1 -0.027792
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0277633
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0276006
PRRC2C proline-rich coiled-coil 2C -0.0274577
GOLGA4 golgin A4 -0.0267964
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0265781
RPS27A ribosomal protein S27a -0.0262537
TRIB2 tribbles pseudokinase 2 -0.0259218
EGR1 early growth response 1 -0.025152
RPS23 ribosomal protein S23 -0.0249795
FNDC3A fibronectin type III domain containing 3A -0.0249242
RPS2 ribosomal protein S2 -0.0246205
RAB7A RAB7A, member RAS oncogene family -0.0242273
RSL1D1 ribosomal L1 domain containing 1 -0.0242235
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0239382
TRIO trio Rho guanine nucleotide exchange factor -0.0238042
RPS14 ribosomal protein S14 -0.0234807
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0232292
FBXL20 F-box and leucine-rich repeat protein 20 -0.0232212
RPL11 ribosomal protein L11 -0.0231954
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0231363
RPL7 ribosomal protein L7 -0.0230108
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.022838
GPATCH8 G patch domain containing 8 -0.0226154
FKBP10 FK506 binding protein 10, 65 kDa -0.0224891
RPS21 ribosomal protein S21 -0.0224715
EEF2 eukaryotic translation elongation factor 2 -0.0224695
RPS5 ribosomal protein S5 -0.0216807
RPL37 ribosomal protein L37 -0.021657
RPL9 ribosomal protein L9 -0.0215368
AKAP9 A kinase (PRKA) anchor protein 9 -0.0212115
PRPF3 pre-mRNA processing factor 3 -0.0208894
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0207736
ANTXR1 anthrax toxin receptor 1 -0.0207171
RPS27 ribosomal protein S27 -0.0206194
TPST1 tyrosylprotein sulfotransferase 1 -0.0205897
RPLP2 ribosomal protein, large, P2 -0.020583
RSF1 remodeling and spacing factor 1 -0.0202978
SEPTIN2 septin 2 -0.0202467
GATA3 GATA binding protein 3 -0.0200295