Penfluridol_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.207221
TRIO trio Rho guanine nucleotide exchange factor 0.17559
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.163819
CD44 CD44 molecule (Indian blood group) 0.148024
EXT1 exostosin glycosyltransferase 1 0.131262
CDH13 cadherin 13 0.119154
MYH9 myosin, heavy chain 9, non-muscle 0.116979
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.115439
ENO1 enolase 1, (alpha) 0.11188
CXCL8 chemokine (C-X-C motif) ligand 8 0.106257
FN1 fibronectin 1 0.0798596
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0780028
TIMP3 TIMP metallopeptidase inhibitor 3 0.077414
MTSS1 metastasis suppressor 1 0.0754628
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0754626
INHBA inhibin, beta A 0.0750906
PSD3 pleckstrin and Sec7 domain containing 3 0.0747036
TM4SF1 transmembrane 4 L six family member 1 0.0739094
SOD2 superoxide dismutase 2, mitochondrial 0.0731278
ZBTB20 zinc finger and BTB domain containing 20 0.0689107
STC1 stanniocalcin 1 0.0665339
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0662827
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0652071
TMSB4X thymosin beta 4, X-linked 0.0633886
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0630794
LOXL2 lysyl oxidase-like 2 0.0626896
PDE10A phosphodiesterase 10A 0.0604393
FNDC3B fibronectin type III domain containing 3B 0.0599751
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0598668
NAV2 neuron navigator 2 0.0589354
SMYD3 SET and MYND domain containing 3 0.0585246
APP amyloid beta (A4) precursor protein 0.0555538
DST dystonin 0.0550484
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0508639
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0506891
CANX calnexin 0.0488537
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0482014
ERRFI1 ERBB receptor feedback inhibitor 1 0.0473923
ATXN1 ataxin 1 0.0470083
UBC ubiquitin C 0.0466837
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0461221
ALCAM activated leukocyte cell adhesion molecule 0.0460192
LPP LIM domain containing preferred translocation partner in lipoma 0.0455501
NAMPT nicotinamide phosphoribosyltransferase 0.0453212
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0452009
GPC6 glypican 6 0.0444923
PRELID2 PRELI domain containing 2 0.0444581
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0435155
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0428761
GLIS3 GLIS family zinc finger 3 0.0428145
SMAD3 SMAD family member 3 0.0424111
ASPH aspartate beta-hydroxylase 0.0417821
ZBTB38 zinc finger and BTB domain containing 38 0.0416663
ELL2 elongation factor, RNA polymerase II, 2 0.0414343
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0405592
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405113
ATP13A3 ATPase type 13A3 0.0403714
HMGA2 high mobility group AT-hook 2 0.0401645
IER3 immediate early response 3 0.0398109
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0395679
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0391353
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0376843
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0376826
FMNL2 formin-like 2 0.0371931
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0367454
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0361372
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0360074
SDC2 syndecan 2 0.0358226
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0356056
AHNAK AHNAK nucleoprotein 0.0353421
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0351333
MACF1 microtubule-actin crosslinking factor 1 0.0351146
RAD21 RAD21 homolog (S. pombe) 0.0333723
CTSB cathepsin B 0.0332282
FBN1 fibrillin 1 0.0327021
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0326607
LTBP1 latent transforming growth factor beta binding protein 1 0.0325239
DPYSL3 dihydropyrimidinase-like 3 0.0325002
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0324242
ARRDC3 arrestin domain containing 3 0.0323463
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0323253
LDHA lactate dehydrogenase A 0.0319314
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0316686
VCAN versican 0.0313375
KDM7A lysine (K)-specific demethylase 7A 0.0311091
JARID2 jumonji, AT rich interactive domain 2 0.0307444
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0304173
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0295999
HAS2 hyaluronan synthase 2 0.0288764
DPYD dihydropyrimidine dehydrogenase 0.028516
TNIP1 TNFAIP3 interacting protein 1 0.0282701
ANO6 anoctamin 6 0.0278596
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0277003
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0275477
SQSTM1 sequestosome 1 0.0273813
RND3 Rho family GTPase 3 0.0271739
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0271645
FBXO32 F-box protein 32 0.0270988
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0268674
MYOF myoferlin 0.02684

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.126447
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.121383
IGFBP3 insulin-like growth factor binding protein 3 -0.104395
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0504334
TMSB10 thymosin beta 10 -0.0485844
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0485107
EGR1 early growth response 1 -0.0464402
COL1A1 collagen, type I, alpha 1 -0.0428331
PKM pyruvate kinase, muscle -0.0396083
CYB5R3 cytochrome b5 reductase 3 -0.0331121
MYADM myeloid-associated differentiation marker -0.0308485
VIM vimentin -0.028458
FTH1 ferritin, heavy polypeptide 1 -0.0278513
MT2A metallothionein 2A -0.0277992
TMEM165 transmembrane protein 165 -0.0277196
HLA-A major histocompatibility complex, class I, A -0.0275201
RPL35A ribosomal protein L35a -0.0272919
COL6A1 collagen, type VI, alpha 1 -0.0250236
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0242313
HLA-B major histocompatibility complex, class I, B -0.024084
IFI6 interferon, alpha-inducible protein 6 -0.0237901
VEGFA vascular endothelial growth factor A -0.0235
HMGA1 high mobility group AT-hook 1 -0.0211287
FOSL1 FOS-like antigen 1 -0.0211006
TAPBP TAP binding protein (tapasin) -0.0206364
PFN1 profilin 1 -0.0201054
RPL28 ribosomal protein L28 -0.0196371
LAMA5 laminin, alpha 5 -0.0189198
TFG TRK-fused gene -0.0187749
TGFBI transforming growth factor, beta-induced, 68kDa -0.0180152
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0178632
FTL ferritin, light polypeptide -0.0175723
S100A9 S100 calcium binding protein A9 -0.0175659
RPL5 ribosomal protein L5 -0.0175588
RPL9 ribosomal protein L9 -0.0174897
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0170558
NUCB2 nucleobindin 2 -0.016839
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0162637
AGRN agrin -0.0157798
PALLD palladin, cytoskeletal associated protein -0.0155434
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0154357
RPS8 ribosomal protein S8 -0.0154353
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0151209
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0149681
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0149223
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.014882
LIMS1 LIM and senescent cell antigen-like domains 1 -0.014783
RPS12 ribosomal protein S12 -0.0146323
MYO9B myosin IXB -0.0145325
POTEF POTE ankyrin domain family, member F -0.0142622
RAB22A RAB22A, member RAS oncogene family -0.0141069
RRBP1 ribosome binding protein 1 -0.0140736
RPS19 ribosomal protein S19 -0.0138604
SESN2 sestrin 2 -0.0136403
MRPS6 mitochondrial ribosomal protein S6 -0.013539
NLRP1 NLR family, pyrin domain containing 1 -0.0134423
AGO3 argonaute RISC catalytic component 3 -0.0133626
AXL AXL receptor tyrosine kinase -0.0133281
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0132672
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0132044
GANAB glucosidase, alpha; neutral AB -0.0131037
CABIN1 calcineurin binding protein 1 -0.0130348
SHISA5 shisa family member 5 -0.0129411
FBXO11 F-box protein 11 -0.0128592
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0126121
BRD2 bromodomain containing 2 -0.0125308
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0125195
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0124953
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0124266
NEK10 NIMA-related kinase 10 -0.0122596
RPS20 ribosomal protein S20 -0.012256
RPS6 ribosomal protein S6 -0.012065
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0120618
FNBP4 formin binding protein 4 -0.0119005
WDR27 WD repeat domain 27 -0.0118016
MAGT1 magnesium transporter 1 -0.0117114
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0114971
TENT4A terminal nucleotidyltransferase 4A -0.0114248
EHD2 EH-domain containing 2 -0.0113308
RPS2 ribosomal protein S2 -0.0110214
PDLIM7 PDZ and LIM domain 7 (enigma) -0.0109662
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0109635
DPYSL2 dihydropyrimidinase-like 2 -0.0107728
RPL36 ribosomal protein L36 -0.0107407
TAGLN2 transgelin 2 -0.0104876
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -0.010382
MCPH1 microcephalin 1 -0.0101147
LY6E lymphocyte antigen 6 complex, locus E -0.010108
UGCG UDP-glucose ceramide glucosyltransferase -0.0101006
RPLP1 ribosomal protein, large, P1 -0.0100984
RAB6A RAB6A, member RAS oncogene family -0.0100009
FBXL2 F-box and leucine-rich repeat protein 2 -0.00996312
FAM120A family with sequence similarity 120A -0.0098957
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.00988375
CALD1 caldesmon 1 -0.00983214
PLBD2 phospholipase B domain containing 2 -0.0097254
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.00968907
NCOA1 nuclear receptor coactivator 1 -0.00968065
SRGN serglycin -0.00958633
ATL1 atlastin GTPase 1 -0.00957686