Penfluridol_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.223777
ENO1 enolase 1, (alpha) 0.158653
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.133766
RPS12 ribosomal protein S12 0.107449
ERRFI1 ERBB receptor feedback inhibitor 1 0.102274
DSPP dentin sialophosphoprotein 0.0814222
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0762088
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.074524
RPS6 ribosomal protein S6 0.0742915
RPL37A ribosomal protein L37a 0.0718377
PTMA prothymosin, alpha 0.0716735
PLIN2 perilipin 2 0.0666937
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0602263
CCL20 chemokine (C-C motif) ligand 20 0.060037
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0600062
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0580218
DDIT4 DNA-damage-inducible transcript 4 0.0564582
RPS27A ribosomal protein S27a 0.0547377
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0539055
RPS3 ribosomal protein S3 0.0538103
RPL11 ribosomal protein L11 0.0535822
ASPH aspartate beta-hydroxylase 0.0510886
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0494604
EIF1 eukaryotic translation initiation factor 1 0.0489461
AHSG alpha-2-HS-glycoprotein 0.0488751
ATXN1 ataxin 1 0.0488469
CANX calnexin 0.0480682
RPLP0 ribosomal protein, large, P0 0.0474121
DTNA dystrobrevin, alpha 0.0462105
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0456988
LDHA lactate dehydrogenase A 0.0456786
UBC ubiquitin C 0.0453678
B2M beta-2-microglobulin 0.0451422
MT2A metallothionein 2A 0.0450822
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0439506
TF transferrin 0.0437649
TMSB10 thymosin beta 10 0.0432859
RPL23 ribosomal protein L23 0.0421881
SAMD4A sterile alpha motif domain containing 4A 0.0417989
ZFAND3 zinc finger, AN1-type domain 3 0.0415363
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0412934
RPS19 ribosomal protein S19 0.0411961
RPLP1 ribosomal protein, large, P1 0.0411703
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0401719
RPS17 ribosomal protein S17 0.0391778
FMNL2 formin-like 2 0.0388208
RPS14 ribosomal protein S14 0.0385981
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0385439
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0366855
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0354303
RPL7 ribosomal protein L7 0.0349126
RPLP2 ribosomal protein, large, P2 0.0329435
RPS8 ribosomal protein S8 0.0329278
RPL12 ribosomal protein L12 0.0326799
PGK1 phosphoglycerate kinase 1 0.0326242
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0325449
KYNU kynureninase 0.0324491
FAM107B family with sequence similarity 107, member B 0.0319903
DST dystonin 0.0318295
RPL26 ribosomal protein L26 0.0316742
SEC31A SEC31 homolog A (S. cerevisiae) 0.0316014
RPL3 ribosomal protein L3 0.0315532
RACK1 receptor for activated C kinase 1 0.0312902
RPS24 ribosomal protein S24 0.0311735
APOA1 apolipoprotein A-I 0.0308427
GOLGA4 golgin A4 0.0308306
PCBP2 poly(rC) binding protein 2 0.0308155
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0302456
EXT1 exostosin glycosyltransferase 1 0.0299952
EPS8 epidermal growth factor receptor pathway substrate 8 0.0298935
VEGFA vascular endothelial growth factor A 0.0298589
LPP LIM domain containing preferred translocation partner in lipoma 0.0296197
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0295866
RPS23 ribosomal protein S23 0.0293884
RPS25 ribosomal protein S25 0.0293408
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0291823
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0286124
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0280267
SQSTM1 sequestosome 1 0.0276626
GRB10 growth factor receptor-bound protein 10 0.0276596
ZCCHC7 zinc finger, CCHC domain containing 7 0.0275057
FTL ferritin, light polypeptide 0.0274817
SRRM1 serine/arginine repetitive matrix 1 0.02744
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0274174
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.027269
GMDS GDP-mannose 4,6-dehydratase 0.0271418
EEF2 eukaryotic translation elongation factor 2 0.0270387
ANKRD12 ankyrin repeat domain 12 0.0269089
RPL31 ribosomal protein L31 0.0265666
KTN1 kinectin 1 (kinesin receptor) 0.0265596
RPS29 ribosomal protein S29 0.0264781
OLA1 Obg-like ATPase 1 0.0260943
CAMTA1 calmodulin binding transcription activator 1 0.0260875
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0260328
RPL5 ribosomal protein L5 0.0257778
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0257699
CALR calreticulin 0.0257177
APOA2 apolipoprotein A-II 0.0253733
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0253496
HMGA1 high mobility group AT-hook 1 0.0250751

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.309435
APOB apolipoprotein B -0.271118
FN1 fibronectin 1 -0.187909
C3 complement component 3 -0.120791
A2M alpha-2-macroglobulin -0.0893418
GPC3 glypican 3 -0.0892267
NKD1 naked cuticle homolog 1 (Drosophila) -0.0870593
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0855533
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0783658
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0632832
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0593421
FBF1 Fas (TNFRSF6) binding factor 1 -0.0579828
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0500393
ACTN4 actinin, alpha 4 -0.0440821
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0389585
MBNL3 muscleblind-like splicing regulator 3 -0.0389208
MAML2 mastermind-like 2 (Drosophila) -0.0356858
EML4 echinoderm microtubule associated protein like 4 -0.0345894
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0344452
DNAH17 dynein, axonemal, heavy chain 17 -0.0328844
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0321374
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0316274
PEG10 paternally expressed 10 -0.0314374
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0311297
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0310858
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0294567
PTCHD4 patched domain containing 4 -0.0288902
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0288368
CFB complement factor B -0.0285241
EPAS1 endothelial PAS domain protein 1 -0.0281986
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0280149
ITGB5 integrin, beta 5 -0.0278804
OSMR oncostatin M receptor -0.0276638
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0276636
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0274765
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0273254
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.026571
TGFBI transforming growth factor, beta-induced, 68kDa -0.0260003
ITGAV integrin, alpha V -0.025966
TM4SF1 transmembrane 4 L six family member 1 -0.0259027
RBM39 RNA binding motif protein 39 -0.0255014
ARL5A ADP-ribosylation factor-like 5A -0.0251477
ZMYND8 zinc finger, MYND-type containing 8 -0.0251237
RRBP1 ribosome binding protein 1 -0.0243646
KIAA1217 KIAA1217 -0.023608
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0235815
MALT1 MALT1 paracaspase -0.0227923
HLF hepatic leukemia factor -0.0222196
AGO2 argonaute RISC catalytic component 2 -0.0218041
NCOA7 nuclear receptor coactivator 7 -0.0216906
LMCD1 LIM and cysteine-rich domains 1 -0.0215885
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.0213961
NPAS2 neuronal PAS domain protein 2 -0.0213878
FGG fibrinogen gamma chain -0.020647
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0206183
PEG3 paternally expressed 3 -0.0205395
ELL2 elongation factor, RNA polymerase II, 2 -0.0205226
ECE1 endothelin converting enzyme 1 -0.0204812
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.020234
IGF1R insulin-like growth factor 1 receptor -0.020022
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0198654
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0197581
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.01949
CHD6 chromodomain helicase DNA binding protein 6 -0.0191228
PDGFB platelet-derived growth factor beta polypeptide -0.0188475
ICAM1 intercellular adhesion molecule 1 -0.018777
FOXN3 forkhead box N3 -0.0187103
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0185808
FGA fibrinogen alpha chain -0.018099
FAM135A family with sequence similarity 135, member A -0.0178696
TMEM181 transmembrane protein 181 -0.0178388
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0176294
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.017619
SYN3 synapsin III -0.0175133
TGFBR3 transforming growth factor, beta receptor III -0.0174166
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -0.0171571
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0170075
ACOX3 acyl-CoA oxidase 3, pristanoyl -0.0168804
EGR1 early growth response 1 -0.0167557
RNF43 ring finger protein 43 -0.0166969
IQSEC1 IQ motif and Sec7 domain 1 -0.0165186
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.016517
CCDC146 coiled-coil domain containing 146 -0.0164911
ARHGAP18 Rho GTPase activating protein 18 -0.0163179
KAZN kazrin, periplakin interacting protein -0.0161879
PLEC plectin -0.0161704
ITGA1 integrin, alpha 1 -0.0161667
ALPK2 alpha-kinase 2 -0.0158451
PPARD peroxisome proliferator-activated receptor delta -0.0156445
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0154644
DOCK4 dedicator of cytokinesis 4 -0.0154553
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0153026
DOCK1 dedicator of cytokinesis 1 -0.0151612
TRIM26 tripartite motif containing 26 -0.0151544
SCARB1 scavenger receptor class B, member 1 -0.015066
ATP10A ATPase, class V, type 10A -0.0149419
KIF21A kinesin family member 21A -0.0148684
TBCK TBC1 domain containing kinase -0.0148638
WNK2 WNK lysine deficient protein kinase 2 -0.0147689
AGXT alanine-glyoxylate aminotransferase -0.0147465