Penfluridol_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.219855
EREG epiregulin 0.101719
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0991585
WAC WW domain containing adaptor with coiled-coil 0.0878277
FAM13A family with sequence similarity 13, member A 0.0860488
RNF145 ring finger protein 145 0.0852683
MED13L mediator complex subunit 13-like 0.0828796
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0808938
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0759746
PGK1 phosphoglycerate kinase 1 0.0697608
GARS1 glycyl-tRNA synthetase 1 0.0688872
KDM3A lysine (K)-specific demethylase 3A 0.0664665
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0661941
NAMPT nicotinamide phosphoribosyltransferase 0.0650421
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0637306
DSCAM Down syndrome cell adhesion molecule 0.0609966
ANKRD11 ankyrin repeat domain 11 0.0596874
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0591836
ZFAND3 zinc finger, AN1-type domain 3 0.0591717
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0560623
FTH1 ferritin, heavy polypeptide 1 0.0529236
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0525084
RBM39 RNA binding motif protein 39 0.0524416
NUP58 nucleoporin 58 0.0521151
RNF43 ring finger protein 43 0.0511454
TFG TRK-fused gene 0.0509897
PTMA prothymosin, alpha 0.0507528
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0506067
KMT2E lysine (K)-specific methyltransferase 2E 0.0499752
PUM1 pumilio RNA-binding family member 1 0.0486715
PUM2 pumilio RNA-binding family member 2 0.0482566
TMSB4X thymosin beta 4, X-linked 0.0480958
ZNF292 zinc finger protein 292 0.0443579
ENO1 enolase 1, (alpha) 0.0439118
RAB1A RAB1A, member RAS oncogene family 0.0435344
NCKAP1 NCK-associated protein 1 0.043417
UBA6 ubiquitin-like modifier activating enzyme 6 0.0426766
MATR3 matrin 3 0.0422125
USP3 ubiquitin specific peptidase 3 0.0416015
TRA2A transformer 2 alpha homolog (Drosophila) 0.040285
KDM6A lysine (K)-specific demethylase 6A 0.0402246
TXNIP thioredoxin interacting protein 0.0400742
YME1L1 YME1-like 1 ATPase 0.0396279
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0395246
WDR43 WD repeat domain 43 0.0393823
FNDC3B fibronectin type III domain containing 3B 0.0393467
H2AC6 H2A clustered histone 6 0.0388264
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0385967
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0382478
MBNL2 muscleblind-like splicing regulator 2 0.0376933
FNBP1L formin binding protein 1-like 0.0376222
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0375436
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0373404
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0371891
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.037184
FXR1 fragile X mental retardation, autosomal homolog 1 0.0365633
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0360319
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0359834
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0357804
MYH9 myosin, heavy chain 9, non-muscle 0.0356616
CDC73 cell division cycle 73 0.0354607
CCNL1 cyclin L1 0.035325
GPHN gephyrin 0.0353246
CCNY cyclin Y 0.0352318
GOLGA4 golgin A4 0.0350049
MARCHF6 membrane associated ring-CH-type finger 6 0.0347047
DDIT4 DNA-damage-inducible transcript 4 0.0343161
COPA coatomer protein complex, subunit alpha 0.0342034
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0339045
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0332439
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0330408
NEK7 NIMA-related kinase 7 0.0329515
CANX calnexin 0.0328718
EPS8 epidermal growth factor receptor pathway substrate 8 0.0325855
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0324989
STRN3 striatin, calmodulin binding protein 3 0.0320484
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0319806
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0311052
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0311014
EWSR1 EWS RNA-binding protein 1 0.0310544
RPLP0 ribosomal protein, large, P0 0.0308792
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0308758
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0307413
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0306197
COG5 component of oligomeric golgi complex 5 0.0305896
ADAM17 ADAM metallopeptidase domain 17 0.0302891
GSK3B glycogen synthase kinase 3 beta 0.0302716
ESRP1 epithelial splicing regulatory protein 1 0.0300361
TFRC transferrin receptor 0.0295796
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0294145
EEF2 eukaryotic translation elongation factor 2 0.0293228
YTHDC1 YTH domain containing 1 0.0293108
XPO1 exportin 1 0.0291252
RLF rearranged L-myc fusion 0.028793
AFDN afadin, adherens junction formation factor 0.0286981
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0286931
SERINC5 serine incorporator 5 0.0283945
CTBP2 C-terminal binding protein 2 0.0283755
ZMYM2 zinc finger, MYM-type 2 0.0283748
PCBP2 poly(rC) binding protein 2 0.0282226

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145155
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.118952
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.116609
NPSR1 neuropeptide S receptor 1 -0.104529
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0964102
MYO1E myosin IE -0.0898707
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0778807
ITGA6 integrin, alpha 6 -0.0709844
GREB1L growth regulation by estrogen in breast cancer-like -0.0599893
EZR ezrin -0.0585232
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0558676
TPT1 tumor protein, translationally-controlled 1 -0.0556331
LMO7 LIM domain 7 -0.0541941
RPS2 ribosomal protein S2 -0.053682
ANTXR2 anthrax toxin receptor 2 -0.0524922
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0517835
FLNB filamin B, beta -0.0452424
FAT1 FAT atypical cadherin 1 -0.0447051
MT2A metallothionein 2A -0.0445747
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0442672
RPS8 ribosomal protein S8 -0.0420317
PTPRK protein tyrosine phosphatase, receptor type, K -0.0418426
ACTG1 actin gamma 1 -0.0404186
MUC17 mucin 17, cell surface associated -0.0404043
PATJ PATJ crumbs cell polarity complex component -0.0399427
LOC102724023 ES1 protein homolog, mitochondrial -0.0397827
LAMA4 laminin, alpha 4 -0.0387131
TMSB10 thymosin beta 10 -0.0382979
RPS6 ribosomal protein S6 -0.0367174
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.036393
ONECUT3 one cut homeobox 3 -0.0356879
RNF217 ring finger protein 217 -0.0345736
EXT1 exostosin glycosyltransferase 1 -0.0345696
SH3D19 SH3 domain containing 19 -0.0332142
GCC2 GRIP and coiled-coil domain containing 2 -0.0330579
LMNA lamin A/C -0.0327592
GOLGB1 golgin B1 -0.0316787
AGR2 anterior gradient 2 -0.0310665
POTEF POTE ankyrin domain family, member F -0.030609
FTL ferritin, light polypeptide -0.030298
KTN1 kinectin 1 (kinesin receptor) -0.0302911
SVIL supervillin -0.0286052
TPM4 tropomyosin 4 -0.0280874
EGFR epidermal growth factor receptor -0.0280763
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0278254
AHNAK AHNAK nucleoprotein -0.0270446
CALB1 calbindin 1, 28kDa -0.0263513
HMGA1 high mobility group AT-hook 1 -0.0255872
RIN2 Ras and Rab interactor 2 -0.0252852
SOX4 SRY (sex determining region Y)-box 4 -0.0252358
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0251816
SLC35F3 solute carrier family 35, member F3 -0.0251063
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0250511
TMEM165 transmembrane protein 165 -0.0250363
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0247019
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0245065
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0238634
AKAP9 A kinase (PRKA) anchor protein 9 -0.0234557
ASPH aspartate beta-hydroxylase -0.0232946
PTPRR protein tyrosine phosphatase, receptor type, R -0.0232738
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0226003
NALF1 NALCN channel auxiliary factor 1 -0.0224651
ATP5F1B ATP synthase F1 subunit beta -0.0224103
MARCHF3 membrane associated ring-CH-type finger 3 -0.0223781
TFF1 trefoil factor 1 -0.0223105
UBXN4 UBX domain protein 4 -0.0221468
BPTF bromodomain PHD finger transcription factor -0.0220262
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0216672
KRT19 keratin 19, type I -0.0213445
S100A10 S100 calcium binding protein A10 -0.0211804
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0211726
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0211453
TRIM2 tripartite motif containing 2 -0.0211251
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0210141
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0206888
TUBB4B tubulin, beta 4B class IVb -0.0204193
LAMC2 laminin, gamma 2 -0.020108
TMEM45B transmembrane protein 45B -0.0200442
MED13 mediator complex subunit 13 -0.0199019
BACE2 beta-site APP-cleaving enzyme 2 -0.0196428
FERMT1 fermitin family member 1 -0.0193687
AHI1 Abelson helper integration site 1 -0.0192221
FHL2 four and a half LIM domains 2 -0.0191336
PKM pyruvate kinase, muscle -0.0191136
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0190907
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0190415
PRSS3 protease, serine, 3 -0.0189827
TUBA1B tubulin, alpha 1b -0.0189394
MT1X metallothionein 1X -0.0187802
MUC13 mucin 13, cell surface associated -0.0187528
CCND1 cyclin D1 -0.0185876
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0185833
EMP1 epithelial membrane protein 1 -0.0184321
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0181933
PERP PERP, TP53 apoptosis effector -0.0181272
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0181201
PPARD peroxisome proliferator-activated receptor delta -0.018022
ATXN1 ataxin 1 -0.0179818
DSG2 desmoglein 2 -0.0179281
SBF2 SET binding factor 2 -0.0179223