Penfluridol_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.208128
DST dystonin 0.178232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.116499
TMSB4X thymosin beta 4, X-linked 0.0969972
ENO1 enolase 1, (alpha) 0.0831404
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0723384
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0717934
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0690885
FMNL2 formin-like 2 0.0676422
EFNA5 ephrin-A5 0.0610418
RPS12 ribosomal protein S12 0.0607085
POTEF POTE ankyrin domain family, member F 0.0599008
SOD2 superoxide dismutase 2, mitochondrial 0.0574199
PCBP2 poly(rC) binding protein 2 0.0549768
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0547425
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0504747
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0478756
RPL3 ribosomal protein L3 0.0471448
CCNL1 cyclin L1 0.0464831
PGK1 phosphoglycerate kinase 1 0.045768
ENO2 enolase 2 (gamma, neuronal) 0.044942
MYH9 myosin, heavy chain 9, non-muscle 0.0440485
PLK2 polo-like kinase 2 0.0437287
SET SET nuclear proto-oncogene 0.0435253
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0434639
B2M beta-2-microglobulin 0.0425199
RPS6 ribosomal protein S6 0.0420857
MSN moesin 0.0420729
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0413965
MATR3 matrin 3 0.0413829
TSC22D1 TSC22 domain family, member 1 0.0404606
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0394541
CENPF centromere protein F, 350/400kDa 0.0389693
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0383729
FXR1 fragile X mental retardation, autosomal homolog 1 0.038339
RAD51B RAD51 paralog B 0.0377889
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.036968
SRPK2 SRSF protein kinase 2 0.0367662
PUM2 pumilio RNA-binding family member 2 0.0363796
RNF145 ring finger protein 145 0.0358137
RPS18 ribosomal protein S18 0.0356481
SQSTM1 sequestosome 1 0.0353576
RPS3 ribosomal protein S3 0.0345156
XPO1 exportin 1 0.0339593
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0336101
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0319828
ADAM17 ADAM metallopeptidase domain 17 0.0319813
SLK STE20-like kinase 0.0319809
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0311648
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0308788
DDIT4 DNA-damage-inducible transcript 4 0.0306937
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0304875
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.030309
ZNF292 zinc finger protein 292 0.0301932
CKAP5 cytoskeleton associated protein 5 0.0301903
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0297581
GARS1 glycyl-tRNA synthetase 1 0.0291138
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0291101
TPM3 tropomyosin 3 0.0289434
NUP58 nucleoporin 58 0.0288619
GOLGA4 golgin A4 0.0288245
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0287921
FNIP1 folliculin interacting protein 1 0.0283488
FAM13B family with sequence similarity 13, member B 0.028219
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0281776
MYOF myoferlin 0.0281265
UBA6 ubiquitin-like modifier activating enzyme 6 0.0280747
FAR1 fatty acyl CoA reductase 1 0.0279076
RASAL2 RAS protein activator like 2 0.0274961
PIAS2 protein inhibitor of activated STAT, 2 0.0274886
SPIRE1 spire-type actin nucleation factor 1 0.0274249
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0271905
HMGB2 high mobility group box 2 0.0267128
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0261218
RPS17 ribosomal protein S17 0.0256109
HDGF hepatoma-derived growth factor 0.0248287
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0244719
ZDHHC14 zinc finger, DHHC-type containing 14 0.0240209
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0239407
APP amyloid beta (A4) precursor protein 0.0239275
CDK19 cyclin-dependent kinase 19 0.0238508
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0238253
FAF1 Fas (TNFRSF6) associated factor 1 0.0238207
RAB18 RAB18, member RAS oncogene family 0.0238181
SRSF11 serine/arginine-rich splicing factor 11 0.0235672
ASPH aspartate beta-hydroxylase 0.0234213
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0233791
WDR43 WD repeat domain 43 0.0233567
MEF2A myocyte enhancer factor 2A 0.0232232
EIF5 eukaryotic translation initiation factor 5 0.023087
ARRDC3 arrestin domain containing 3 0.0229549
OSBPL8 oxysterol binding protein-like 8 0.0228486
BCLAF1 BCL2-associated transcription factor 1 0.0228321
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0227027
VMP1 vacuole membrane protein 1 0.0226577
NCKAP1 NCK-associated protein 1 0.0223029
ZNF148 zinc finger protein 148 0.0222572
CDC73 cell division cycle 73 0.0221732
SFPQ splicing factor proline/glutamine-rich 0.0221247
ZCCHC7 zinc finger, CCHC domain containing 7 0.0220593

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.371933
VIM vimentin -0.195104
TXNRD1 thioredoxin reductase 1 -0.133979
TM4SF1 transmembrane 4 L six family member 1 -0.132169
MT2A metallothionein 2A -0.120931
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0846797
AHNAK AHNAK nucleoprotein -0.0724471
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.068114
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0548825
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0537184
MT1E metallothionein 1E -0.0527969
ACTG1 actin gamma 1 -0.0508519
EGR1 early growth response 1 -0.0492465
SRGN serglycin -0.0486612
CD44 CD44 molecule (Indian blood group) -0.0486132
GCLM glutamate-cysteine ligase, modifier subunit -0.0483493
EMP1 epithelial membrane protein 1 -0.047946
ARHGAP5 Rho GTPase activating protein 5 -0.0465444
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0464564
WWTR1 WW domain containing transcription regulator 1 -0.0456281
HDLBP high density lipoprotein binding protein -0.0423895
MT1X metallothionein 1X -0.0409576
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0399138
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0386904
TMSB10 thymosin beta 10 -0.038636
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.038551
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0383319
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0382493
TPT1 tumor protein, translationally-controlled 1 -0.0371489
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0364164
OSMR oncostatin M receptor -0.0359109
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0352092
RGS4 regulator of G-protein signaling 4 -0.0346687
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0344566
CAPN2 calpain 2, (m/II) large subunit -0.0339892
PYGL phosphorylase, glycogen, liver -0.0332946
BMERB1 bMERB domain containing 1 -0.0331058
RRBP1 ribosome binding protein 1 -0.0326695
PYGB phosphorylase, glycogen; brain -0.032348
NPAS2 neuronal PAS domain protein 2 -0.0321919
SLC38A2 solute carrier family 38, member 2 -0.0318757
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0317945
ZBTB38 zinc finger and BTB domain containing 38 -0.0315133
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0310619
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0309589
KPNB1 karyopherin (importin) beta 1 -0.0307331
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0306212
NT5E 5'-nucleotidase, ecto (CD73) -0.0297423
LMAN1 lectin, mannose-binding, 1 -0.0296202
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0293456
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0292771
RAI1 retinoic acid induced 1 -0.0289223
SPRY4 sprouty homolog 4 (Drosophila) -0.0286632
SDCCAG8 serologically defined colon cancer antigen 8 -0.0285493
CAVIN1 caveolae associated protein 1 -0.0285074
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0284
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.027947
DPYSL2 dihydropyrimidinase-like 2 -0.0275359
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0272654
USP34 ubiquitin specific peptidase 34 -0.0271304
TMEM263 transmembrane protein 263 -0.027075
PAIP2 poly(A) binding protein interacting protein 2 -0.0269096
LOXL2 lysyl oxidase-like 2 -0.0265927
STK17A serine/threonine kinase 17a -0.0264411
FKBP10 FK506 binding protein 10, 65 kDa -0.0264212
ARF1 ADP-ribosylation factor 1 -0.0263794
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0260323
RIGI RNA sensor RIG-I -0.0256633
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0254409
CMIP c-Maf inducing protein -0.025437
S100A10 S100 calcium binding protein A10 -0.0246876
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0246036
HMGA1 high mobility group AT-hook 1 -0.0244017
FERMT1 fermitin family member 1 -0.0241739
LOC112694756 uncharaterized LOC112694756 -0.0238304
ERCC1 excision repair cross-complementation group 1 -0.0237352
GNAS GNAS complex locus -0.0237186
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0235026
CALU calumenin -0.0234394
ZMYND8 zinc finger, MYND-type containing 8 -0.0233905
RPS8 ribosomal protein S8 -0.0230168
ADGRG6 adhesion G protein-coupled receptor G6 -0.022909
PTPRF protein tyrosine phosphatase, receptor type, F -0.0227924
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.022783
RPL35A ribosomal protein L35a -0.0227778
ANTXR2 anthrax toxin receptor 2 -0.0227528
EHBP1 EH domain binding protein 1 -0.0226792
NCEH1 neutral cholesterol ester hydrolase 1 -0.0226396
RAP2B RAP2B, member of RAS oncogene family -0.0224712
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0223482
ANXA2 annexin A2 -0.0221883
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0219586
FBXO11 F-box protein 11 -0.0217332
IARS1 isoleucyl-tRNA synthetase 1 -0.0216324
ARHGAP29 Rho GTPase activating protein 29 -0.0216288
PSD3 pleckstrin and Sec7 domain containing 3 -0.0214713
YBX3 Y box binding protein 3 -0.0214711
BPTF bromodomain PHD finger transcription factor -0.0214253
YEATS2 YEATS domain containing 2 -0.0213333