Penfluridol_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.171248
SOD2 superoxide dismutase 2, mitochondrial 0.121422
CEMIP cell migration inducing protein, hyaluronan binding 0.0980335
ASPH aspartate beta-hydroxylase 0.0942935
THSD4 thrombospondin, type I, domain containing 4 0.0931317
NAMPT nicotinamide phosphoribosyltransferase 0.0866808
FAM13A family with sequence similarity 13, member A 0.0838078
PGK1 phosphoglycerate kinase 1 0.0829626
LAMC2 laminin, gamma 2 0.0807079
ELL2 elongation factor, RNA polymerase II, 2 0.0765162
FNDC3B fibronectin type III domain containing 3B 0.0707525
TOP1 topoisomerase (DNA) I 0.0676017
MACF1 microtubule-actin crosslinking factor 1 0.0666128
SLTM SAFB-like, transcription modulator 0.0650455
MYH9 myosin, heavy chain 9, non-muscle 0.0644884
ENO1 enolase 1, (alpha) 0.0630191
ERRFI1 ERBB receptor feedback inhibitor 1 0.0623966
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0584249
GRAMD1B GRAM domain containing 1B 0.0581281
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0570464
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0570131
PUM2 pumilio RNA-binding family member 2 0.0570093
GRB10 growth factor receptor-bound protein 10 0.0564727
NGLY1 N-glycanase 1 0.0562959
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0532015
APP amyloid beta (A4) precursor protein 0.0510611
ATP13A3 ATPase type 13A3 0.0507435
PTPRM protein tyrosine phosphatase, receptor type, M 0.048918
GPC6 glypican 6 0.0486193
KDM6A lysine (K)-specific demethylase 6A 0.0479479
PTK2 protein tyrosine kinase 2 0.0478441
AKAP13 A kinase (PRKA) anchor protein 13 0.0477581
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0460939
NCKAP1 NCK-associated protein 1 0.0458919
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0458778
GSK3B glycogen synthase kinase 3 beta 0.0455669
BCAR3 breast cancer anti-estrogen resistance 3 0.0434748
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0423734
HSPA8 heat shock 70kDa protein 8 0.0404513
ANXA5 annexin A5 0.0403968
RUNX1 runt-related transcription factor 1 0.0400684
CANX calnexin 0.0397775
HELZ helicase with zinc finger 0.0397698
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0396588
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0394748
HOOK2 hook microtubule-tethering protein 2 0.0394683
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0393791
SAMD4A sterile alpha motif domain containing 4A 0.038773
SMAD3 SMAD family member 3 0.0385813
SPAG9 sperm associated antigen 9 0.0383032
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0380736
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0373881
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0373286
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0368899
NPAS2 neuronal PAS domain protein 2 0.0364954
MYOF myoferlin 0.0361974
RASA2 RAS p21 protein activator 2 0.0359948
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0359114
ANKRD11 ankyrin repeat domain 11 0.0358292
ARRDC3 arrestin domain containing 3 0.0355936
UVRAG UV radiation resistance associated 0.0355075
TSC22D2 TSC22 domain family, member 2 0.035041
ADAM9 ADAM metallopeptidase domain 9 0.0347292
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0340213
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0332934
RNF145 ring finger protein 145 0.0330515
MED13L mediator complex subunit 13-like 0.0326845
KMT2E lysine (K)-specific methyltransferase 2E 0.0326379
ADAM17 ADAM metallopeptidase domain 17 0.0325391
DTNA dystrobrevin, alpha 0.0323711
CAMTA1 calmodulin binding transcription activator 1 0.0323133
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0322832
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0320255
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.031939
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0312892
STC1 stanniocalcin 1 0.0310659
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0309148
ZMYM2 zinc finger, MYM-type 2 0.0308693
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0306877
BZW1 basic leucine zipper and W2 domains 1 0.0304245
NRIP1 nuclear receptor interacting protein 1 0.0300857
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0299777
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0299526
UBC ubiquitin C 0.0299517
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0299486
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0294612
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0292443
TAS2R14 taste receptor, type 2, member 14 0.0289811
ZNF638 zinc finger protein 638 0.0288938
KDM3A lysine (K)-specific demethylase 3A 0.0286994
MSN moesin 0.0284736
ARHGAP21 Rho GTPase activating protein 21 0.0284579
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0282144
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0281785
PDIA6 protein disulfide isomerase family A, member 6 0.0281049
SUMF1 sulfatase modifying factor 1 0.0279246
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0279065
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0277285
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0275542
RPL4 ribosomal protein L4 0.0275389

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.224044
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.128338
TMSB10 thymosin beta 10 -0.115816
EGR1 early growth response 1 -0.109629
FTL ferritin, light polypeptide -0.0790982
NDRG1 N-myc downstream regulated 1 -0.0717834
MT2A metallothionein 2A -0.0677972
FTH1 ferritin, heavy polypeptide 1 -0.0639523
PKM pyruvate kinase, muscle -0.0564095
RPL35A ribosomal protein L35a -0.0516759
AKR1C1 aldo-keto reductase family 1, member C1 -0.0483014
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0481534
RPLP1 ribosomal protein, large, P1 -0.0476211
TPT1 tumor protein, translationally-controlled 1 -0.04255
GCLC glutamate-cysteine ligase, catalytic subunit -0.0409891
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0396883
NSUN6 NOP2/Sun domain family, member 6 -0.0377095
RPS3 ribosomal protein S3 -0.0370742
NABP1 nucleic acid binding protein 1 -0.035659
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0341114
CST3 cystatin C -0.0332331
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0320212
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0311641
RNF213 ring finger protein 213 -0.0308501
BLZF1 basic leucine zipper nuclear factor 1 -0.0306685
CAV1 caveolin 1, caveolae protein, 22kDa -0.0302997
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0302853
CCNL1 cyclin L1 -0.0289045
RPS8 ribosomal protein S8 -0.0286974
S100A10 S100 calcium binding protein A10 -0.0286164
RPL37A ribosomal protein L37a -0.0283129
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0265984
EIF1 eukaryotic translation initiation factor 1 -0.0259711
RPS6 ribosomal protein S6 -0.0254549
RPS25 ribosomal protein S25 -0.0251632
RPL31 ribosomal protein L31 -0.024679
RPL30 ribosomal protein L30 -0.0243537
RPS27 ribosomal protein S27 -0.0239453
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0232839
EMP1 epithelial membrane protein 1 -0.0230927
BRD2 bromodomain containing 2 -0.0223011
RPS12 ribosomal protein S12 -0.0220137
HMGA1 high mobility group AT-hook 1 -0.0220011
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0218754
SON SON DNA binding protein -0.0217566
LOC102724023 ES1 protein homolog, mitochondrial -0.0215409
AGR2 anterior gradient 2 -0.0215162
B2M beta-2-microglobulin -0.0214025
RPS14 ribosomal protein S14 -0.0213806
GUK1 guanylate kinase 1 -0.0212704
RPS29 ribosomal protein S29 -0.0209608
TMEM165 transmembrane protein 165 -0.0209157
JUP junction plakoglobin -0.0207152
IFI6 interferon, alpha-inducible protein 6 -0.0203367
RPS24 ribosomal protein S24 -0.020288
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0202431
HLA-B major histocompatibility complex, class I, B -0.0201868
RPLP2 ribosomal protein, large, P2 -0.019643
RPL34 ribosomal protein L34 -0.0196044
SLC38A1 solute carrier family 38, member 1 -0.0190373
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0190306
RPS19 ribosomal protein S19 -0.0188433
AREG amphiregulin -0.0186916
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0186651
RPL36 ribosomal protein L36 -0.0186429
SEC61G Sec61 gamma subunit -0.0182963
RPS17 ribosomal protein S17 -0.0181449
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0180436
RPL8 ribosomal protein L8 -0.0179756
ECD ecdysoneless homolog (Drosophila) -0.0178951
ARL5B ADP-ribosylation factor-like 5B -0.0178445
RNASEH2A ribonuclease H2, subunit A -0.0176664
BTG1 B-cell translocation gene 1, anti-proliferative -0.0175915
S100A9 S100 calcium binding protein A9 -0.0175368
S100A6 S100 calcium binding protein A6 -0.0174355
PER2 period circadian clock 2 -0.0174043
IGFBP3 insulin-like growth factor binding protein 3 -0.0172431
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.017234
RPL5 ribosomal protein L5 -0.0170464
S100P S100 calcium binding protein P -0.0170245
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0167384
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0164437
VMP1 vacuole membrane protein 1 -0.0163885
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0162063
EZR ezrin -0.0161655
NCOA7 nuclear receptor coactivator 7 -0.0161049
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.016016
AKAP9 A kinase (PRKA) anchor protein 9 -0.0159437
CPE carboxypeptidase E -0.0158834
IER3 immediate early response 3 -0.0158104
KMT2D lysine (K)-specific methyltransferase 2D -0.0156174
SYAP1 synapse associated protein 1 -0.0154197
RPL19 ribosomal protein L19 -0.0154116
ARF4 ADP-ribosylation factor 4 -0.0153837
RPL12 ribosomal protein L12 -0.0153412
FOSL1 FOS-like antigen 1 -0.0152863
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0152818
RPL28 ribosomal protein L28 -0.0151228
MT1X metallothionein 1X -0.0151179
LRP1B low density lipoprotein receptor-related protein 1B -0.0150424