Penfluridol_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.109054
FNDC3B fibronectin type III domain containing 3B 0.107897
SOD2 superoxide dismutase 2, mitochondrial 0.101275
FAM13A family with sequence similarity 13, member A 0.0954807
GRB10 growth factor receptor-bound protein 10 0.0763344
ATP13A3 ATPase type 13A3 0.074225
GOLGA4 golgin A4 0.0692804
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0678313
PCBP2 poly(rC) binding protein 2 0.0671742
TRIO trio Rho guanine nucleotide exchange factor 0.0617922
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0606767
RICTOR RPTOR independent companion of MTOR, complex 2 0.0583133
KDM3A lysine (K)-specific demethylase 3A 0.0566305
USP3 ubiquitin specific peptidase 3 0.0527447
CXCL8 chemokine (C-X-C motif) ligand 8 0.0527153
SPAG9 sperm associated antigen 9 0.0523814
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0498096
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0484631
WAC WW domain containing adaptor with coiled-coil 0.0467411
RAB8B RAB8B, member RAS oncogene family 0.0452989
ZFAND3 zinc finger, AN1-type domain 3 0.043956
UBA6 ubiquitin-like modifier activating enzyme 6 0.0435905
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0431606
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.042688
RNF145 ring finger protein 145 0.0408375
NAV2 neuron navigator 2 0.040822
QKI QKI, KH domain containing, RNA binding 0.0400404
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0393155
HELZ helicase with zinc finger 0.0392361
NGLY1 N-glycanase 1 0.038977
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0389309
CDC73 cell division cycle 73 0.0388152
FMNL2 formin-like 2 0.0384792
NBAS neuroblastoma amplified sequence 0.0384188
ANKRD11 ankyrin repeat domain 11 0.0369433
SIK3 SIK family kinase 3 0.0361296
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0361091
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0353344
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0351507
MARCHF6 membrane associated ring-CH-type finger 6 0.034887
KMT2C lysine (K)-specific methyltransferase 2C 0.0348731
PARD3 par-3 family cell polarity regulator 0.0345618
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0343225
PIAS2 protein inhibitor of activated STAT, 2 0.0333004
ZNF292 zinc finger protein 292 0.032898
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0326964
COG5 component of oligomeric golgi complex 5 0.0326582
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0325521
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0323976
MEF2A myocyte enhancer factor 2A 0.0322276
CCNY cyclin Y 0.0311588
ELL2 elongation factor, RNA polymerase II, 2 0.0305866
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0304568
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0299031
RUNX2 runt-related transcription factor 2 0.029547
MATR3 matrin 3 0.0294161
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0293674
FXR1 fragile X mental retardation, autosomal homolog 1 0.0290455
APP amyloid beta (A4) precursor protein 0.0289411
STRN3 striatin, calmodulin binding protein 3 0.0286525
TNIP1 TNFAIP3 interacting protein 1 0.0284515
MYH9 myosin, heavy chain 9, non-muscle 0.0282969
ARHGAP32 Rho GTPase activating protein 32 0.0280749
NCKAP1 NCK-associated protein 1 0.0280225
NUP58 nucleoporin 58 0.0276048
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.027302
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0271113
RBM39 RNA binding motif protein 39 0.0271018
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0270901
RAB18 RAB18, member RAS oncogene family 0.026654
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0264145
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0264086
TOP2B topoisomerase (DNA) II beta 180kDa 0.0262763
OGA O-GlcNAcase 0.0262247
ZEB1 zinc finger E-box binding homeobox 1 0.026142
PID1 phosphotyrosine interaction domain containing 1 0.0260006
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0259452
ITCH itchy E3 ubiquitin protein ligase 0.0259429
RBM33 RNA binding motif protein 33 0.0258035
SUCO SUN domain containing ossification factor 0.0257694
COPA coatomer protein complex, subunit alpha 0.0257273
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256918
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0256798
RIOK3 RIO kinase 3 0.0256752
KDM6A lysine (K)-specific demethylase 6A 0.0253167
BHLHE40 basic helix-loop-helix family, member e40 0.0252272
GPC6 glypican 6 0.0251084
ARL8B ADP-ribosylation factor-like 8B 0.0250941
JMJD1C jumonji domain containing 1C 0.0248602
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0243871
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0241116
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0239396
SLTM SAFB-like, transcription modulator 0.0239268
SETD5 SET domain containing 5 0.023836
YEATS2 YEATS domain containing 2 0.0238334
AHR aryl hydrocarbon receptor 0.0236019
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0235336
PTBP2 polypyrimidine tract binding protein 2 0.0235144
ADAM17 ADAM metallopeptidase domain 17 0.0234237
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0233624

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.344126
VIM vimentin -0.17556
TMSB10 thymosin beta 10 -0.145372
MT2A metallothionein 2A -0.11879
FTL ferritin, light polypeptide -0.116683
FN1 fibronectin 1 -0.0819718
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.067883
RPLP1 ribosomal protein, large, P1 -0.0669676
EGR1 early growth response 1 -0.0585029
AKAP12 A kinase (PRKA) anchor protein 12 -0.0575361
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0553197
RPS19 ribosomal protein S19 -0.0542345
LOX lysyl oxidase -0.0541326
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0532131
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0514094
RPL35A ribosomal protein L35a -0.0497369
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0496307
OSMR oncostatin M receptor -0.0487513
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0456266
EFNA5 ephrin-A5 -0.045287
RPL32 ribosomal protein L32 -0.0449595
GLCCI1 glucocorticoid induced 1 -0.0432399
C15ORF48 chromosome 15 open reading frame 48 -0.0414886
CD44 CD44 molecule (Indian blood group) -0.0412818
IER3 immediate early response 3 -0.0393711
RPS21 ribosomal protein S21 -0.038812
NCOA7 nuclear receptor coactivator 7 -0.0384081
RPS8 ribosomal protein S8 -0.0383131
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0381835
HMGA1 high mobility group AT-hook 1 -0.0377734
HMGA2 high mobility group AT-hook 2 -0.0369322
RPL34 ribosomal protein L34 -0.0368956
RPLP2 ribosomal protein, large, P2 -0.0365687
S100A10 S100 calcium binding protein A10 -0.0362167
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0354278
IFI6 interferon, alpha-inducible protein 6 -0.0345536
RPS29 ribosomal protein S29 -0.0343325
RPL36 ribosomal protein L36 -0.0343132
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0332373
RPL28 ribosomal protein L28 -0.0324461
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0313577
DPYD dihydropyrimidine dehydrogenase -0.0308627
RPL31 ribosomal protein L31 -0.0300459
HLA-B major histocompatibility complex, class I, B -0.0299483
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0296191
PKM pyruvate kinase, muscle -0.0296068
IFITM3 interferon induced transmembrane protein 3 -0.0293565
RPS24 ribosomal protein S24 -0.029299
NDRG1 N-myc downstream regulated 1 -0.0290753
B2M beta-2-microglobulin -0.0289982
RPS13 ribosomal protein S13 -0.0281785
TPT1 tumor protein, translationally-controlled 1 -0.0280998
TNNC1 troponin C type 1 (slow) -0.027825
MAP1B microtubule-associated protein 1B -0.027697
S100A6 S100 calcium binding protein A6 -0.0276649
IFI16 interferon, gamma-inducible protein 16 -0.0275393
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0265318
RPS11 ribosomal protein S11 -0.0262453
LOC102724023 ES1 protein homolog, mitochondrial -0.0261089
LMAN1 lectin, mannose-binding, 1 -0.0258449
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.025747
S100A9 S100 calcium binding protein A9 -0.025594
EIF1 eukaryotic translation initiation factor 1 -0.0253689
NTN4 netrin 4 -0.0252494
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0251949
VDAC1 voltage-dependent anion channel 1 -0.0245572
RAD51B RAD51 paralog B -0.0243212
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0242459
RPL23 ribosomal protein L23 -0.0239428
BPTF bromodomain PHD finger transcription factor -0.0238932
RPL19 ribosomal protein L19 -0.0233682
IGFBP3 insulin-like growth factor binding protein 3 -0.0232535
TMEM263 transmembrane protein 263 -0.0231406
EMP1 epithelial membrane protein 1 -0.0225846
RNF213 ring finger protein 213 -0.0223192
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0221273
SDK1 sidekick cell adhesion molecule 1 -0.0220985
PFN1 profilin 1 -0.0217898
RPS6 ribosomal protein S6 -0.0215792
MYADM myeloid-associated differentiation marker -0.0215365
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0215273
TGM2 transglutaminase 2 -0.0214519
VCL vinculin -0.0214008
EXT1 exostosin glycosyltransferase 1 -0.0213858
PDE4D phosphodiesterase 4D, cAMP-specific -0.02125
RPS5 ribosomal protein S5 -0.0210389
RPL12 ribosomal protein L12 -0.0210375
SEC61G Sec61 gamma subunit -0.0206871
AHNAK AHNAK nucleoprotein -0.0206274
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0206264
CCNI cyclin I -0.0201332
CUX1 cut-like homeobox 1 -0.020095
LOXL2 lysyl oxidase-like 2 -0.0200698
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0199967
RPS25 ribosomal protein S25 -0.0199789
CA12 carbonic anhydrase XII -0.0199286
SAMD9 sterile alpha motif domain containing 9 -0.0199181
RPS15 ribosomal protein S15 -0.0196266
RPL9 ribosomal protein L9 -0.0196163
PHF14 PHD finger protein 14 -0.0191732