Penfluridol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.141525
ZFAND3 zinc finger, AN1-type domain 3 0.0788201
TRIO trio Rho guanine nucleotide exchange factor 0.07296
ERRFI1 ERBB receptor feedback inhibitor 1 0.0667635
GRAMD1B GRAM domain containing 1B 0.0664364
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0490777
MARCHF4 membrane associated ring-CH-type finger 4 0.0481279
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0476268
RTN4 reticulon 4 0.0470882
ZCCHC7 zinc finger, CCHC domain containing 7 0.0456888
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0445162
KDM2A lysine (K)-specific demethylase 2A 0.0440537
PUM2 pumilio RNA-binding family member 2 0.0437286
XPO1 exportin 1 0.0421567
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0402766
CAMKMT calmodulin-lysine N-methyltransferase 0.0378152
CAMTA1 calmodulin binding transcription activator 1 0.0377343
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0370952
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0365655
ZNF292 zinc finger protein 292 0.0363129
EXOC4 exocyst complex component 4 0.0361628
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0358136
EIF4B eukaryotic translation initiation factor 4B 0.0350041
GPHN gephyrin 0.0349694
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0342954
FAM168A family with sequence similarity 168, member A 0.0337304
FMNL2 formin-like 2 0.0335385
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0332311
ZFC3H1 zinc finger, C3H1-type containing 0.0331166
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0330276
WDR43 WD repeat domain 43 0.0323761
PTK2 protein tyrosine kinase 2 0.0321666
DENND5B DENN/MADD domain containing 5B 0.0320749
MED13L mediator complex subunit 13-like 0.031704
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0312935
ADAM17 ADAM metallopeptidase domain 17 0.031227
JMJD1C jumonji domain containing 1C 0.0309972
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0308403
GATAD2B GATA zinc finger domain containing 2B 0.0306638
RNF145 ring finger protein 145 0.0305916
PHIP pleckstrin homology domain interacting protein 0.0303553
COG5 component of oligomeric golgi complex 5 0.0301844
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0296789
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0295427
THOC1 THO complex 1 0.0293483
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0293175
PCNX1 pecanex 1 0.0292403
NCKAP1 NCK-associated protein 1 0.02908
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0290289
CDYL chromodomain protein, Y-like 0.0285944
BBX bobby sox homolog (Drosophila) 0.0284908
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0284849
NUP153 nucleoporin 153kDa 0.0284813
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0283334
CKAP5 cytoskeleton associated protein 5 0.0280285
LRPPRC leucine-rich pentatricopeptide repeat containing 0.027874
RUSC2 RUN and SH3 domain containing 2 0.0278327
EXT1 exostosin glycosyltransferase 1 0.0277255
SINHCAF SIN3-HDAC complex associated factor 0.0275308
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0273762
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0271217
MAPK8 mitogen-activated protein kinase 8 0.0270022
EXOC6B exocyst complex component 6B 0.026892
RAD51B RAD51 paralog B 0.0267857
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0267019
RNF38 ring finger protein 38 0.0266453
RLF rearranged L-myc fusion 0.0264814
NCAPD2 non-SMC condensin I complex, subunit D2 0.0263786
LATS2 large tumor suppressor kinase 2 0.0262204
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0259696
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0259042
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0256235
CSDE1 cold shock domain containing E1, RNA-binding 0.0254069
OSBPL8 oxysterol binding protein-like 8 0.0254045
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0253823
PPME1 protein phosphatase methylesterase 1 0.0250099
RFX7 regulatory factor X, 7 0.0250043
ANXA5 annexin A5 0.0248869
AVL9 AVL9 homolog (S. cerevisiase) 0.0247906
BIRC6 baculoviral IAP repeat containing 6 0.0247359
ITCH itchy E3 ubiquitin protein ligase 0.0246798
PGK1 phosphoglycerate kinase 1 0.0246232
OLA1 Obg-like ATPase 1 0.0245635
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0245482
MATR3 matrin 3 0.0241816
SRSF4 serine/arginine-rich splicing factor 4 0.0240304
SRPK2 SRSF protein kinase 2 0.0239105
FBXO11 F-box protein 11 0.0238605
KDM3A lysine (K)-specific demethylase 3A 0.0235908
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0235797
MEMO1 mediator of cell motility 1 0.0235362
MKI67 marker of proliferation Ki-67 0.0235294
TAS2R14 taste receptor, type 2, member 14 0.0235026
SFPQ splicing factor proline/glutamine-rich 0.0234676
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0233813
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0230261
FXR1 fragile X mental retardation, autosomal homolog 1 0.0229575
TPM3 tropomyosin 3 0.0228376
CAPRIN1 cell cycle associated protein 1 0.0227849
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.022445

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.315292
EGR1 early growth response 1 -0.112507
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0921553
VIM vimentin -0.0828751
TMSB10 thymosin beta 10 -0.078371
MCL1 myeloid cell leukemia 1 -0.0772308
YBX3 Y box binding protein 3 -0.0745658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0660284
PTMA prothymosin, alpha -0.0608785
MT2A metallothionein 2A -0.0577849
RPL35A ribosomal protein L35a -0.0524126
RPS8 ribosomal protein S8 -0.0479425
ACTG1 actin gamma 1 -0.0468188
RPS3 ribosomal protein S3 -0.0456039
RPLP1 ribosomal protein, large, P1 -0.0455998
INTS6 integrator complex subunit 6 -0.0429907
TFPI2 tissue factor pathway inhibitor 2 -0.0413043
RPL12 ribosomal protein L12 -0.0385898
TPI1 triosephosphate isomerase 1 -0.0385733
RPL37A ribosomal protein L37a -0.0378543
TPT1 tumor protein, translationally-controlled 1 -0.0372191
AEBP2 AE binding protein 2 -0.0369781
WNT2B wingless-type MMTV integration site family, member 2B -0.0362684
ATXN1 ataxin 1 -0.036081
RPL37 ribosomal protein L37 -0.0353648
FTL ferritin, light polypeptide -0.0344654
PFN1 profilin 1 -0.0343975
RPS29 ribosomal protein S29 -0.033875
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0338197
RPS15 ribosomal protein S15 -0.0333242
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.033277
AFF3 AF4/FMR2 family, member 3 -0.0330021
PRH1 proline-rich protein HaeIII subfamily 1 -0.0320363
POTEF POTE ankyrin domain family, member F -0.0318184
RPL31 ribosomal protein L31 -0.0315841
RPL26 ribosomal protein L26 -0.031234
RPS19 ribosomal protein S19 -0.0299258
RPL5 ribosomal protein L5 -0.0298783
RPLP2 ribosomal protein, large, P2 -0.0292408
RPL9 ribosomal protein L9 -0.0291177
RPL34 ribosomal protein L34 -0.0284606
HLA-B major histocompatibility complex, class I, B -0.0283547
HMGA2 high mobility group AT-hook 2 -0.0276367
OSMR oncostatin M receptor -0.0272726
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0271513
PDLIM5 PDZ and LIM domain 5 -0.0270536
TLN1 talin 1 -0.0270191
RPL28 ribosomal protein L28 -0.0268623
RPS13 ribosomal protein S13 -0.0266744
RPS12 ribosomal protein S12 -0.0266503
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0264419
NABP1 nucleic acid binding protein 1 -0.0263702
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0262683
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0262469
NAP1L1 nucleosome assembly protein 1-like 1 -0.025902
VCL vinculin -0.0256072
NEK10 NIMA-related kinase 10 -0.025484
GPATCH2L G patch domain containing 2-like -0.0252575
MYL12B myosin, light chain 12B, regulatory -0.0252313
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0250994
RYR3 ryanodine receptor 3 -0.0247346
RPS27 ribosomal protein S27 -0.0243027
RACK1 receptor for activated C kinase 1 -0.0240497
RPS10 ribosomal protein S10 -0.02401
RPS24 ribosomal protein S24 -0.0238395
RPL23 ribosomal protein L23 -0.0235716
RPL19 ribosomal protein L19 -0.0230889
RPL36 ribosomal protein L36 -0.022952
EIF1 eukaryotic translation initiation factor 1 -0.022756
RPS4X ribosomal protein S4, X-linked -0.0226868
RPS17 ribosomal protein S17 -0.0225378
VDAC1 voltage-dependent anion channel 1 -0.0224887
RPS20 ribosomal protein S20 -0.0221516
RPLP0 ribosomal protein, large, P0 -0.0220554
PYGL phosphorylase, glycogen, liver -0.0217875
CALR calreticulin -0.0216396
TAPBP TAP binding protein (tapasin) -0.0215071
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0212626
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0211316
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0208843
CAVIN1 caveolae associated protein 1 -0.0204851
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0203396
RPS25 ribosomal protein S25 -0.020121
TPM2 tropomyosin 2 (beta) -0.0200009
WWTR1 WW domain containing transcription regulator 1 -0.0199327
TPM4 tropomyosin 4 -0.0194753
RPL32 ribosomal protein L32 -0.0194553
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.019452
RPL7A ribosomal protein L7a -0.0194209
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0193308
TRIM59 tripartite motif containing 59 -0.0192055
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0192037
IFI6 interferon, alpha-inducible protein 6 -0.0190747
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0189601
RPL8 ribosomal protein L8 -0.0188301
NACA nascent polypeptide-associated complex alpha subunit -0.0188039
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.018803
RPS21 ribosomal protein S21 -0.0187168
RPL18 ribosomal protein L18 -0.0186569
ATP5F1E ATP synthase F1 subunit epsilon -0.0186402