Penfluridol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0917224
FXR1 fragile X mental retardation, autosomal homolog 1 0.0586228
NAMPT nicotinamide phosphoribosyltransferase 0.0550556
FAM13A family with sequence similarity 13, member A 0.0538783
PTMA prothymosin, alpha 0.0482385
SQSTM1 sequestosome 1 0.0459408
CCNL1 cyclin L1 0.0430806
BHLHE40 basic helix-loop-helix family, member e40 0.0424452
TSC22D2 TSC22 domain family, member 2 0.0422618
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.041742
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0412808
RNF145 ring finger protein 145 0.040733
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0406478
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0388672
MYH9 myosin, heavy chain 9, non-muscle 0.0373917
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0324449
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0318815
SLC38A1 solute carrier family 38, member 1 0.0312247
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0297478
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0292384
QKI QKI, KH domain containing, RNA binding 0.0287793
RHEB Ras homolog enriched in brain 0.028718
RPS3 ribosomal protein S3 0.0286758
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0285321
GARS1 glycyl-tRNA synthetase 1 0.0278014
PCBP2 poly(rC) binding protein 2 0.0268155
MSMO1 methylsterol monooxygenase 1 0.0258372
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0258363
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251738
MSN moesin 0.0249687
HMGB2 high mobility group box 2 0.0246937
SOD2 superoxide dismutase 2, mitochondrial 0.0245507
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0238544
EEF2 eukaryotic translation elongation factor 2 0.0228345
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0227766
EPS8 epidermal growth factor receptor pathway substrate 8 0.0222091
SSBP2 single-stranded DNA binding protein 2 0.0221723
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0214892
CD109 CD109 molecule 0.0214262
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0213305
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.021188
MATR3 matrin 3 0.0207165
GRB10 growth factor receptor-bound protein 10 0.0194763
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0188874
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0186832
TMEM131L transmembrane 131 like 0.0186266
TNIP1 TNFAIP3 interacting protein 1 0.0185251
RPLP0 ribosomal protein, large, P0 0.0181843
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0181113
RPS12 ribosomal protein S12 0.0180428
ELOVL5 ELOVL fatty acid elongase 5 0.0177692
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0177134
APP amyloid beta (A4) precursor protein 0.0176707
ENAH enabled homolog (Drosophila) 0.0175998
ANKRD11 ankyrin repeat domain 11 0.0175639
CANX calnexin 0.0173738
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0173248
LRRC1 leucine rich repeat containing 1 0.0172999
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0170504
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0170193
KMT2E lysine (K)-specific methyltransferase 2E 0.01692
DENND4A DENN/MADD domain containing 4A 0.0166686
ENO1 enolase 1, (alpha) 0.016295
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0160135
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0159172
ZBTB10 zinc finger and BTB domain containing 10 0.0154591
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0154571
AHDC1 AT hook, DNA binding motif, containing 1 0.0151836
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0149741
CALR calreticulin 0.0148437
RPL4 ribosomal protein L4 0.0147917
CXCL2 chemokine (C-X-C motif) ligand 2 0.0147891
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0147826
YBX1 Y box binding protein 1 0.0147347
PDS5B PDS5 cohesin associated factor B 0.0146817
RBM33 RNA binding motif protein 33 0.0146073
MBNL2 muscleblind-like splicing regulator 2 0.0145671
USP3 ubiquitin specific peptidase 3 0.0144667
RYBP RING1 and YY1 binding protein 0.0143746
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0142331
FHIT fragile histidine triad 0.013941
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0138264
IPO7 importin 7 0.0138215
PARD3 par-3 family cell polarity regulator 0.0137051
EFNA1 ephrin-A1 0.0136942
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0136855
FAM168A family with sequence similarity 168, member A 0.0135966
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0135956
CXCL8 chemokine (C-X-C motif) ligand 8 0.0134648
CD83 CD83 molecule 0.0134337
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0133138
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0133083
TFG TRK-fused gene 0.0133067
EIF5 eukaryotic translation initiation factor 5 0.0132107
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0131161
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0128558
TBC1D12 TBC1 domain family, member 12 0.0128493
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0128393
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0128326
CPNE8 copine VIII 0.012798

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.326323
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220613
ACTG1 actin gamma 1 -0.164892
LAMB3 laminin, beta 3 -0.133891
NDRG1 N-myc downstream regulated 1 -0.108158
TMSB10 thymosin beta 10 -0.106759
FN1 fibronectin 1 -0.0968255
FTL ferritin, light polypeptide -0.0934503
LMO7 LIM domain 7 -0.0848769
IFI27 interferon, alpha-inducible protein 27 -0.081737
CSTB cystatin B (stefin B) -0.070014
LAMC2 laminin, gamma 2 -0.0672729
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0653743
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0645417
FBXO32 F-box protein 32 -0.0643456
LPP LIM domain containing preferred translocation partner in lipoma -0.0606871
S100A6 S100 calcium binding protein A6 -0.060484
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0593138
IGFBP3 insulin-like growth factor binding protein 3 -0.0591141
FAM3C family with sequence similarity 3, member C -0.0589176
ERBIN erbb2 interacting protein -0.0571544
SOX4 SRY (sex determining region Y)-box 4 -0.0568554
NPEPPS aminopeptidase puromycin sensitive -0.0563836
DTNA dystrobrevin, alpha -0.0562966
CCND1 cyclin D1 -0.0557827
POTEF POTE ankyrin domain family, member F -0.0552958
HMGA1 high mobility group AT-hook 1 -0.0545025
IFI6 interferon, alpha-inducible protein 6 -0.0540625
DSG2 desmoglein 2 -0.0537789
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0531184
LY6E lymphocyte antigen 6 complex, locus E -0.0525153
TRIO trio Rho guanine nucleotide exchange factor -0.0513756
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0512459
MYO6 myosin VI -0.0485615
S100A10 S100 calcium binding protein A10 -0.0483341
MDK midkine (neurite growth-promoting factor 2) -0.0480077
EFNA5 ephrin-A5 -0.0478269
WSB1 WD repeat and SOCS box containing 1 -0.0477833
EXT1 exostosin glycosyltransferase 1 -0.04715
AHNAK AHNAK nucleoprotein -0.0470443
TMEM165 transmembrane protein 165 -0.0468278
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0465681
ELL2 elongation factor, RNA polymerase II, 2 -0.0460481
CDCP1 CUB domain containing protein 1 -0.0446979
ITCH itchy E3 ubiquitin protein ligase -0.0446438
MAP1B microtubule-associated protein 1B -0.0445878
TMSB4X thymosin beta 4, X-linked -0.0443212
CD2AP CD2-associated protein -0.0442374
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0439766
KRT7 keratin 7, type II -0.0431797
RPL34 ribosomal protein L34 -0.0430419
TPT1 tumor protein, translationally-controlled 1 -0.0429641
UBE2H ubiquitin-conjugating enzyme E2H -0.0426668
RBM25 RNA binding motif protein 25 -0.0424561
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0415118
ARHGAP5 Rho GTPase activating protein 5 -0.0408946
SDC4 syndecan 4 -0.0408585
GOLGA4 golgin A4 -0.040502
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0400361
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0398103
AKAP13 A kinase (PRKA) anchor protein 13 -0.0393452
JUP junction plakoglobin -0.0387156
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0386596
TPM4 tropomyosin 4 -0.0384059
BASP1 brain abundant, membrane attached signal protein 1 -0.0382336
MT2A metallothionein 2A -0.0366834
RCOR1 REST corepressor 1 -0.0360248
NIPBL Nipped-B homolog (Drosophila) -0.0359422
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0355546
VGLL3 vestigial-like family member 3 -0.0350412
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0349628
RPL8 ribosomal protein L8 -0.0347338
S100A9 S100 calcium binding protein A9 -0.0345477
HLA-B major histocompatibility complex, class I, B -0.034073
TXNIP thioredoxin interacting protein -0.0339494
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0338273
IFITM3 interferon induced transmembrane protein 3 -0.0334394
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0334181
MACC1 metastasis associated in colon cancer 1 -0.0333034
SH3KBP1 SH3-domain kinase binding protein 1 -0.033256
PLSCR1 phospholipid scramblase 1 -0.0331938
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0325864
MCTP2 multiple C2 domains, transmembrane 2 -0.0320426
KRT8 keratin 8, type II -0.0318067
NF1 neurofibromin 1 -0.0317728
IFITM1 interferon induced transmembrane protein 1 -0.0316926
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0313331
RRBP1 ribosome binding protein 1 -0.0312768
F11R F11 receptor -0.03122
RAB7A RAB7A, member RAS oncogene family -0.031188
H1-0 H1.0 linker histone -0.0311024
ESYT2 extended synaptotagmin-like protein 2 -0.0308163
MYO1E myosin IE -0.0307736
LMNA lamin A/C -0.0307301
IFI16 interferon, gamma-inducible protein 16 -0.0304586
RASAL2 RAS protein activator like 2 -0.0304427
BLZF1 basic leucine zipper nuclear factor 1 -0.0302447
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0300825
MACF1 microtubule-actin crosslinking factor 1 -0.0298866
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0297217