Penfluridol_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

84 genes differentially expressed following the Penfluridol_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RUNX1 runt-related transcription factor 1 0.188254
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.166369
STK24 serine/threonine kinase 24 0.148716
SND1 staphylococcal nuclease and tudor domain containing 1 0.146781
SPATS2L spermatogenesis associated, serine-rich 2-like 0.143836
NDRG1 N-myc downstream regulated 1 0.133578
LMO7 LIM domain 7 0.129052
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.128856
NAMPT nicotinamide phosphoribosyltransferase 0.126207
HELZ helicase with zinc finger 0.108799
SAMD4A sterile alpha motif domain containing 4A 0.0892376
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0883091
TRIO trio Rho guanine nucleotide exchange factor 0.0881191
FTH1 ferritin, heavy polypeptide 1 0.0828098
AKAP12 A kinase (PRKA) anchor protein 12 0.0764965
RAP1B RAP1B, member of RAS oncogene family 0.0764247
SMAD3 SMAD family member 3 0.0717095
MYOF myoferlin 0.0649069
PRELID2 PRELI domain containing 2 0.0641209
INHBA inhibin, beta A 0.0578635
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0554138
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0530977
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0510576
MAML3 mastermind-like 3 (Drosophila) 0.0478207
EXT1 exostosin glycosyltransferase 1 0.0470697
DST dystonin 0.0439204
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0382789
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0365065
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0354727
ZFR zinc finger RNA binding protein 0.0333293
TJP1 tight junction protein 1 0.0326234
NEK7 NIMA-related kinase 7 0.0314099
WSB1 WD repeat and SOCS box containing 1 0.0283299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.028137
OGA O-GlcNAcase 0.0276408
PGK1 phosphoglycerate kinase 1 0.025302
GOLGA4 golgin A4 0.0239185
RPS6 ribosomal protein S6 0.0214474
RPL35A ribosomal protein L35a 0.0208447
CD44 CD44 molecule (Indian blood group) 0.0204774
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0143374
LIMS1 LIM and senescent cell antigen-like domains 1 0.0113437
ENO1 enolase 1, (alpha) 0.0094892
RPS12 ribosomal protein S12 0.00766599
RBM39 RNA binding motif protein 39 0.00659654
DLG1 discs, large homolog 1 (Drosophila) 0.00488591
FNDC3B fibronectin type III domain containing 3B 0.00487152
NAP1L1 nucleosome assembly protein 1-like 1 0.00396257
CDH13 cadherin 13 0.00200443

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.312492
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.169753
VIM vimentin -0.154993
FN1 fibronectin 1 -0.143398
TPT1 tumor protein, translationally-controlled 1 -0.131198
EGFR epidermal growth factor receptor -0.130889
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.130663
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.116186
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.106146
EFNA5 ephrin-A5 -0.104305
IGF2 insulin-like growth factor 2 -0.0955298
ZNF292 zinc finger protein 292 -0.0881841
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0829203
PDE4D phosphodiesterase 4D, cAMP-specific -0.0780997
NALF1 NALCN channel auxiliary factor 1 -0.0726104
PTMA prothymosin, alpha -0.0698722
ANKRD12 ankyrin repeat domain 12 -0.0670958
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.062044
ASPH aspartate beta-hydroxylase -0.0553616
PRKCA protein kinase C, alpha -0.0413938
HDLBP high density lipoprotein binding protein -0.0384397
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0337929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.033746
MT2A metallothionein 2A -0.0311982
PSD3 pleckstrin and Sec7 domain containing 3 -0.0304801
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0301617
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0202869
SMYD3 SET and MYND domain containing 3 -0.0188338
TMSB10 thymosin beta 10 -0.0161489
CANX calnexin -0.0161197
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0120672
DSCAM Down syndrome cell adhesion molecule -0.00580158
MACF1 microtubule-actin crosslinking factor 1 -0.00307144
PRRC2C proline-rich coiled-coil 2C -0.00267052
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -3.71036E-6