Penfluridol_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.164456
PDE4B phosphodiesterase 4B, cAMP-specific 0.107372
TMSB4X thymosin beta 4, X-linked 0.093726
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0716022
SOX6 SRY (sex determining region Y)-box 6 0.0707021
ZNF292 zinc finger protein 292 0.0661678
PDGFC platelet derived growth factor C 0.066083
HDAC9 histone deacetylase 9 0.0582855
RTN4 reticulon 4 0.0535442
DSCAM Down syndrome cell adhesion molecule 0.0525208
JMJD1C jumonji domain containing 1C 0.0518541
NAMPT nicotinamide phosphoribosyltransferase 0.0502205
ZFAND3 zinc finger, AN1-type domain 3 0.049978
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0487603
ZEB1 zinc finger E-box binding homeobox 1 0.0485611
NCKAP1 NCK-associated protein 1 0.0481268
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0469279
GSK3B glycogen synthase kinase 3 beta 0.0468275
KDM3A lysine (K)-specific demethylase 3A 0.0464416
CCNL1 cyclin L1 0.0444918
EFNA5 ephrin-A5 0.0439535
EIF4A2 eukaryotic translation initiation factor 4A2 0.0419318
ZNF608 zinc finger protein 608 0.0390342
CAMTA1 calmodulin binding transcription activator 1 0.0388531
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0369931
CDC73 cell division cycle 73 0.036569
FLNB filamin B, beta 0.0365202
KDM6A lysine (K)-specific demethylase 6A 0.036519
KMT2E lysine (K)-specific methyltransferase 2E 0.0354281
PGK1 phosphoglycerate kinase 1 0.0348235
SMYD3 SET and MYND domain containing 3 0.0343022
PICALM phosphatidylinositol binding clathrin assembly protein 0.0341146
TGFBR3 transforming growth factor, beta receptor III 0.0332224
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0331523
SSBP2 single-stranded DNA binding protein 2 0.0329439
SQSTM1 sequestosome 1 0.0328625
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0323793
ADAM9 ADAM metallopeptidase domain 9 0.0311721
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0304062
SAMD4A sterile alpha motif domain containing 4A 0.0302586
CASC3 cancer susceptibility candidate 3 0.0299434
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0296842
YAP1 Yes-associated protein 1 0.0294298
SLMAP sarcolemma associated protein 0.0291699
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0291253
FHIT fragile histidine triad 0.0288411
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0285496
ANK2 ankyrin 2, neuronal 0.0281477
IGF1R insulin-like growth factor 1 receptor 0.0281084
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0280798
EML4 echinoderm microtubule associated protein like 4 0.0278734
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0276328
QKI QKI, KH domain containing, RNA binding 0.0274955
ELOVL5 ELOVL fatty acid elongase 5 0.0266429
NUP58 nucleoporin 58 0.0261637
DENND4A DENN/MADD domain containing 4A 0.0259523
NBAS neuroblastoma amplified sequence 0.0255669
GLS2 glutaminase 2 (liver, mitochondrial) 0.0255264
MED13L mediator complex subunit 13-like 0.0254456
FAR1 fatty acyl CoA reductase 1 0.0254446
EZR ezrin 0.0254399
FXR1 fragile X mental retardation, autosomal homolog 1 0.0253317
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0251198
EPS8 epidermal growth factor receptor pathway substrate 8 0.0250958
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0249152
BTBD9 BTB (POZ) domain containing 9 0.0247618
PUM1 pumilio RNA-binding family member 1 0.0247019
TMEM65 transmembrane protein 65 0.0247012
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0244649
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0243263
MAST2 microtubule associated serine/threonine kinase 2 0.0241972
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0241476
RAB27B RAB27B, member RAS oncogene family 0.0240719
TTC28 tetratricopeptide repeat domain 28 0.0239821
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0238152
ECT2 epithelial cell transforming 2 0.0236118
BCLAF1 BCL2-associated transcription factor 1 0.0234861
PTBP2 polypyrimidine tract binding protein 2 0.0230055
PYGB phosphorylase, glycogen; brain 0.0228542
RYBP RING1 and YY1 binding protein 0.0228516
CRY1 cryptochrome circadian clock 1 0.0228512
TFG TRK-fused gene 0.0227619
RBM33 RNA binding motif protein 33 0.0225983
CTNND1 catenin (cadherin-associated protein), delta 1 0.0225877
BRWD1 bromodomain and WD repeat domain containing 1 0.0222097
ADAM10 ADAM metallopeptidase domain 10 0.0221733
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0221181
PUM2 pumilio RNA-binding family member 2 0.0219019
VMP1 vacuole membrane protein 1 0.0218814
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0213953
ZNF644 zinc finger protein 644 0.0211055
USP3 ubiquitin specific peptidase 3 0.0207377
USP9X ubiquitin specific peptidase 9, X-linked 0.0207002
STRN3 striatin, calmodulin binding protein 3 0.0205826
RPL3 ribosomal protein L3 0.0203879
FAM13A family with sequence similarity 13, member A 0.0203401
SFPQ splicing factor proline/glutamine-rich 0.0201735
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.020154
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201454
MEF2A myocyte enhancer factor 2A 0.0201125

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.360684
PTMA prothymosin, alpha -0.246451
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124049
PKM pyruvate kinase, muscle -0.104036
RPS6 ribosomal protein S6 -0.0998514
ACTG1 actin gamma 1 -0.0818871
RPL35A ribosomal protein L35a -0.0814858
RPS8 ribosomal protein S8 -0.080805
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0706102
PFN1 profilin 1 -0.0634315
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0613483
S100A6 S100 calcium binding protein A6 -0.0598763
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0527892
TPT1 tumor protein, translationally-controlled 1 -0.0520726
POTEF POTE ankyrin domain family, member F -0.0516998
FOXP1 forkhead box P1 -0.0515284
RPLP1 ribosomal protein, large, P1 -0.0502908
HSPB1 heat shock 27kDa protein 1 -0.0488865
EEF2 eukaryotic translation elongation factor 2 -0.0486606
RPS19 ribosomal protein S19 -0.0473751
FTL ferritin, light polypeptide -0.0473327
RPL8 ribosomal protein L8 -0.0455286
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0452188
RPL19 ribosomal protein L19 -0.0443465
RPL12 ribosomal protein L12 -0.043146
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0429532
CCND1 cyclin D1 -0.04242
MT2A metallothionein 2A -0.0421609
RPL34 ribosomal protein L34 -0.0414516
PRDX2 peroxiredoxin 2 -0.0411429
BMP10 bone morphogenetic protein 10 -0.0402201
CPED1 cadherin-like and PC-esterase domain containing 1 -0.038813
RPL36 ribosomal protein L36 -0.0382789
RPL31 ribosomal protein L31 -0.0381621
RPL32 ribosomal protein L32 -0.0365599
RPL23 ribosomal protein L23 -0.0361549
RPS13 ribosomal protein S13 -0.0359356
RPL28 ribosomal protein L28 -0.0356611
TPM4 tropomyosin 4 -0.0350397
RPLP2 ribosomal protein, large, P2 -0.0350343
RPS3 ribosomal protein S3 -0.0348357
B2M beta-2-microglobulin -0.0346365
HMGA1 high mobility group AT-hook 1 -0.0345474
RPLP0 ribosomal protein, large, P0 -0.0344408
RACK1 receptor for activated C kinase 1 -0.0343082
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0341227
RPL7A ribosomal protein L7a -0.0340924
DLG1 discs, large homolog 1 (Drosophila) -0.0340163
RPL26 ribosomal protein L26 -0.0339269
P4HB prolyl 4-hydroxylase, beta polypeptide -0.033821
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0336183
S100A9 S100 calcium binding protein A9 -0.0332463
RPL9 ribosomal protein L9 -0.0329903
LOC102724023 ES1 protein homolog, mitochondrial -0.032961
GNAS GNAS complex locus -0.0327698
RPL11 ribosomal protein L11 -0.0327164
EGFR epidermal growth factor receptor -0.0326976
RPS23 ribosomal protein S23 -0.0324559
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0324218
RPS25 ribosomal protein S25 -0.0315464
LDHA lactate dehydrogenase A -0.0312144
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0303604
RPS11 ribosomal protein S11 -0.0296325
RPS29 ribosomal protein S29 -0.0293212
S100A4 S100 calcium binding protein A4 -0.0290334
ARL4C ADP-ribosylation factor-like 4C -0.0287807
RPL13A ribosomal protein L13a -0.0287007
RPL27A ribosomal protein L27a -0.0286939
PDIA3 protein disulfide isomerase family A, member 3 -0.028455
RPS14 ribosomal protein S14 -0.0280856
DUSP6 dual specificity phosphatase 6 -0.0280194
RPS5 ribosomal protein S5 -0.0272236
DPYD dihydropyrimidine dehydrogenase -0.0272228
S100A10 S100 calcium binding protein A10 -0.0265792
RPS27 ribosomal protein S27 -0.0262742
AHNAK AHNAK nucleoprotein -0.026187
BPTF bromodomain PHD finger transcription factor -0.0260278
RPS2 ribosomal protein S2 -0.0257009
RPS17 ribosomal protein S17 -0.0254909
EIF5B eukaryotic translation initiation factor 5B -0.0254585
RPL37A ribosomal protein L37a -0.0253676
RPS16 ribosomal protein S16 -0.0253125
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0252949
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0251734
VDAC1 voltage-dependent anion channel 1 -0.0250421
CALR calreticulin -0.0249117
TMSB10 thymosin beta 10 -0.0248573
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.024402
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0243472
RPS21 ribosomal protein S21 -0.0242617
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0241805
TPI1 triosephosphate isomerase 1 -0.0235243
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0230567
RPS27A ribosomal protein S27a -0.0229504
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0229138
TTC3 tetratricopeptide repeat domain 3 -0.0228424
RPS12 ribosomal protein S12 -0.0224513
GLI3 GLI family zinc finger 3 -0.0221912
SMC4 structural maintenance of chromosomes 4 -0.0220682
RRBP1 ribosome binding protein 1 -0.0218767