Penfluridol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRXN3 neurexin 3 0.0727558
KMT2C lysine (K)-specific methyltransferase 2C 0.058757
ELL2 elongation factor, RNA polymerase II, 2 0.0539916
RICTOR RPTOR independent companion of MTOR, complex 2 0.0523317
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0497447
LAMB3 laminin, beta 3 0.045942
RNF145 ring finger protein 145 0.0456332
CSNK1A1 casein kinase 1, alpha 1 0.0449508
FMNL2 formin-like 2 0.0418116
SDK1 sidekick cell adhesion molecule 1 0.0417116
DLG1 discs, large homolog 1 (Drosophila) 0.0405084
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0396262
TENT5A terminal nucleotidyltransferase 5A 0.0388514
MBNL1 muscleblind-like splicing regulator 1 0.0386743
UBA6 ubiquitin-like modifier activating enzyme 6 0.0382821
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0381172
BIRC6 baculoviral IAP repeat containing 6 0.0372641
RSRC1 arginine/serine-rich coiled-coil 1 0.0354377
CELF1 CUGBP, Elav-like family member 1 0.0350275
PARD3 par-3 family cell polarity regulator 0.0347275
EFNA5 ephrin-A5 0.0334813
GPC6 glypican 6 0.0330781
SLMAP sarcolemma associated protein 0.0325176
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0323828
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0319516
USP32 ubiquitin specific peptidase 32 0.0317626
CDH13 cadherin 13 0.03146
WASL Wiskott-Aldrich syndrome-like 0.0312769
RPL7 ribosomal protein L7 0.0310345
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0309013
RAB6A RAB6A, member RAS oncogene family 0.0305595
YBX1 Y box binding protein 1 0.0303357
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0303021
TTC3 tetratricopeptide repeat domain 3 0.0298945
MON2 MON2 homolog (S. cerevisiae) 0.029723
WDR26 WD repeat domain 26 0.0295567
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0294057
RPS12 ribosomal protein S12 0.0290953
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0289443
PTK2 protein tyrosine kinase 2 0.0288873
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0287934
NAV2 neuron navigator 2 0.0286546
PICALM phosphatidylinositol binding clathrin assembly protein 0.0284996
PSD3 pleckstrin and Sec7 domain containing 3 0.0284394
RAD51B RAD51 paralog B 0.0281312
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0280033
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0278475
WDFY3 WD repeat and FYVE domain containing 3 0.0278092
TM4SF1 transmembrane 4 L six family member 1 0.0274301
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0273087
CAB39 calcium binding protein 39 0.0271795
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0271495
PAWR PRKC, apoptosis, WT1, regulator 0.0271337
RPL31 ribosomal protein L31 0.0270633
LPP LIM domain containing preferred translocation partner in lipoma 0.0268968
NECTIN3 nectin cell adhesion molecule 3 0.026806
SAMD4A sterile alpha motif domain containing 4A 0.0267964
CD47 CD47 molecule 0.026702
CYLD cylindromatosis (turban tumor syndrome) 0.0266935
ETV6 ets variant 6 0.0266422
HIPK2 homeodomain interacting protein kinase 2 0.0265641
GRK5 G protein-coupled receptor kinase 5 0.0262662
MED13L mediator complex subunit 13-like 0.0262443
FOXJ3 forkhead box J3 0.0259831
RBAK-RBAKDN RBAK-RBAKDN readthrough 0.0258777
YEATS2 YEATS domain containing 2 0.025801
EPS8 epidermal growth factor receptor pathway substrate 8 0.0257379
SCAF11 SR-related CTD-associated factor 11 0.0255661
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0255598
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.025515
ZFYVE16 zinc finger, FYVE domain containing 16 0.0254957
AGO3 argonaute RISC catalytic component 3 0.0252581
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0251106
TMEM123 transmembrane protein 123 0.0250404
CADM1 cell adhesion molecule 1 0.0250142
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0250048
LRMDA leucine rich melanocyte differentiation associated 0.0248518
FAM13B family with sequence similarity 13, member B 0.0246593
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0246075
ZNF438 zinc finger protein 438 0.0245904
RIN2 Ras and Rab interactor 2 0.0245524
DSPP dentin sialophosphoprotein 0.0244985
BACE2 beta-site APP-cleaving enzyme 2 0.02418
NLGN1 neuroligin 1 0.0241581
ZMIZ1 zinc finger, MIZ-type containing 1 0.0241175
PDE4D phosphodiesterase 4D, cAMP-specific 0.024006
FOSL1 FOS-like antigen 1 0.0239465
NCOR2 nuclear receptor corepressor 2 0.0239149
RPS14 ribosomal protein S14 0.0235749
NSD3 nuclear receptor binding SET domain protein 3 0.0235384
FHIT fragile histidine triad 0.0235182
USP9X ubiquitin specific peptidase 9, X-linked 0.023511
ECT2 epithelial cell transforming 2 0.0233149
ZMYND8 zinc finger, MYND-type containing 8 0.0232341
KRIT1 KRIT1, ankyrin repeat containing 0.0232123
NCKAP1 NCK-associated protein 1 0.023187
MARCHF7 membrane associated ring-CH-type finger 7 0.0231579
PTBP3 polypyrimidine tract binding protein 3 0.0231275
MIMS1 mitochondrial inner membrane scaffold 1 0.0231248
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0231194

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.37547
TMSB10 thymosin beta 10 -0.180701
COL6A3 collagen, type VI, alpha 3 -0.174022
MT2A metallothionein 2A -0.158773
UBC ubiquitin C -0.132099
VIM vimentin -0.120228
FN1 fibronectin 1 -0.114488
SDC4 syndecan 4 -0.106114
TGFBI transforming growth factor, beta-induced, 68kDa -0.103327
COL1A2 collagen, type I, alpha 2 -0.101478
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0945737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0933276
ENO1 enolase 1, (alpha) -0.0821558
AHNAK AHNAK nucleoprotein -0.0749096
TXNIP thioredoxin interacting protein -0.0742502
CCNI cyclin I -0.0724681
CALU calumenin -0.0723854
CALD1 caldesmon 1 -0.0710147
B2M beta-2-microglobulin -0.0709917
LOX lysyl oxidase -0.0696245
COL1A1 collagen, type I, alpha 1 -0.0679466
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0675034
LDHA lactate dehydrogenase A -0.0667247
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0629679
PDIA3 protein disulfide isomerase family A, member 3 -0.0627202
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.058143
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0564884
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0535705
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0531888
HDLBP high density lipoprotein binding protein -0.0514362
RTN4 reticulon 4 -0.0510551
POTEF POTE ankyrin domain family, member F -0.0489739
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0485171
HLA-B major histocompatibility complex, class I, B -0.0484718
FNDC3B fibronectin type III domain containing 3B -0.0475368
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0473629
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0469258
SEPTIN7 septin 7 -0.0453855
SEC31A SEC31 homolog A (S. cerevisiae) -0.0453105
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0450772
GRB10 growth factor receptor-bound protein 10 -0.0427125
WTAP Wilms tumor 1 associated protein -0.0417233
GLG1 golgi glycoprotein 1 -0.0416561
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0400343
COL6A1 collagen, type VI, alpha 1 -0.0397436
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.039036
SEC24D SEC24 family member D -0.038927
EEF2 eukaryotic translation elongation factor 2 -0.0384045
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0378218
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.037497
CDK6 cyclin-dependent kinase 6 -0.0371978
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0369519
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0369018
SPAG9 sperm associated antigen 9 -0.0366357
FTL ferritin, light polypeptide -0.0362364
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0360577
MEF2A myocyte enhancer factor 2A -0.0355704
JUN jun proto-oncogene -0.0348091
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0346913
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0345551
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0340502
ANXA5 annexin A5 -0.034027
RPL37A ribosomal protein L37a -0.033634
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0335842
FLNA filamin A, alpha -0.0332523
COL5A1 collagen, type V, alpha 1 -0.0324966
GANAB glucosidase, alpha; neutral AB -0.0324557
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0323882
FLNB filamin B, beta -0.032305
RRBP1 ribosome binding protein 1 -0.0319892
RAB1A RAB1A, member RAS oncogene family -0.0318714
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0318417
WAC WW domain containing adaptor with coiled-coil -0.0318139
DSCAM Down syndrome cell adhesion molecule -0.0316791
LONP2 lon peptidase 2, peroxisomal -0.0315439
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313324
TPM2 tropomyosin 2 (beta) -0.0312921
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0309809
SRRM2 serine/arginine repetitive matrix 2 -0.030157
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0300984
AKAP9 A kinase (PRKA) anchor protein 9 -0.0297942
ZNF207 zinc finger protein 207 -0.0288179
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0287924
SOS2 son of sevenless homolog 2 (Drosophila) -0.0286953
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0283135
RIGI RNA sensor RIG-I -0.0280604
IARS1 isoleucyl-tRNA synthetase 1 -0.02759
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0273978
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0269349
ARB2A ARB2 cotranscriptional regulator A -0.0269052
RPS8 ribosomal protein S8 -0.0268325
SCARB2 scavenger receptor class B, member 2 -0.0267027
SEC61G Sec61 gamma subunit -0.0265603
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0265581
MTPN myotrophin -0.0259187
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0257457
SOD2 superoxide dismutase 2, mitochondrial -0.0256638
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0255912
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0255818
H3-3B H3.3 histone B -0.0253505