Penfluridol_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Penfluridol perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Penfluridol_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.140558
TOP2A topoisomerase (DNA) II alpha 170kDa 0.084348
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0718684
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.066171
CENPF centromere protein F, 350/400kDa 0.0650049
NAMPT nicotinamide phosphoribosyltransferase 0.0620629
CANX calnexin 0.0615295
TPX2 TPX2, microtubule-associated 0.0612143
BIRC3 baculoviral IAP repeat containing 3 0.0583215
TXNRD1 thioredoxin reductase 1 0.0569326
PUM2 pumilio RNA-binding family member 2 0.0564883
ZNF292 zinc finger protein 292 0.0562833
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0550861
NAP1L1 nucleosome assembly protein 1-like 1 0.0543864
ECT2 epithelial cell transforming 2 0.0538174
NUP58 nucleoporin 58 0.0511643
MYH9 myosin, heavy chain 9, non-muscle 0.0504243
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0489722
WAC WW domain containing adaptor with coiled-coil 0.0474172
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0471441
CKAP5 cytoskeleton associated protein 5 0.0471036
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0470318
PDE4D phosphodiesterase 4D, cAMP-specific 0.0464174
MKI67 marker of proliferation Ki-67 0.0455611
HMGB2 high mobility group box 2 0.0448473
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0443981
MIS18BP1 MIS18 binding protein 1 0.0412674
FXR1 fragile X mental retardation, autosomal homolog 1 0.0399324
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0398961
KIF4A kinesin family member 4A 0.0386638
TNPO1 transportin 1 0.0386255
RNF145 ring finger protein 145 0.0381476
SMYD3 SET and MYND domain containing 3 0.0381008
SET SET nuclear proto-oncogene 0.0380816
SOD2 superoxide dismutase 2, mitochondrial 0.0380495
XPO1 exportin 1 0.0379119
KIAA1328 KIAA1328 0.0374815
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0374511
CKAP2 cytoskeleton associated protein 2 0.0358451
TOP2B topoisomerase (DNA) II beta 180kDa 0.0356102
NFE2L2 nuclear factor, erythroid 2-like 2 0.0353054
SEC23A Sec23 homolog A (S. cerevisiae) 0.034992
KIF5B kinesin family member 5B 0.0346878
GOLGA4 golgin A4 0.0344619
RPL7 ribosomal protein L7 0.0340693
DIAPH3 diaphanous-related formin 3 0.0340652
RPL4 ribosomal protein L4 0.0339831
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0338712
SMC4 structural maintenance of chromosomes 4 0.0337784
HSPA8 heat shock 70kDa protein 8 0.0334091
CLTC clathrin, heavy chain (Hc) 0.0328217
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0326952
YAP1 Yes-associated protein 1 0.0326578
PDE8A phosphodiesterase 8A 0.0323119
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0316398
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0312453
ANLN anillin, actin binding protein 0.0308086
NCKAP1 NCK-associated protein 1 0.0306878
CALR calreticulin 0.0304687
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.030441
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0300673
TOP1 topoisomerase (DNA) I 0.0295163
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0294369
SGO2 shugoshin 2 0.0292852
CSNK1A1 casein kinase 1, alpha 1 0.0292551
STAU1 staufen double-stranded RNA binding protein 1 0.0291343
NSD2 nuclear receptor binding SET domain protein 2 0.0289597
RBM39 RNA binding motif protein 39 0.0284347
ACSL3 acyl-CoA synthetase long-chain family member 3 0.028193
KDM3A lysine (K)-specific demethylase 3A 0.0281504
CENPE centromere protein E, 312kDa 0.0278473
ITCH itchy E3 ubiquitin protein ligase 0.0269161
CELF1 CUGBP, Elav-like family member 1 0.0268447
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0268424
UBQLN1 ubiquilin 1 0.0267803
BSG basigin (Ok blood group) 0.026752
CCNB1 cyclin B1 0.0266474
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0264894
STAG2 stromal antigen 2 0.026385
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0262993
NBAS neuroblastoma amplified sequence 0.0262086
RAD23B RAD23 homolog B (S. cerevisiae) 0.0261922
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0261569
UVRAG UV radiation resistance associated 0.026021
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0259498
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.025687
LCORL ligand dependent nuclear receptor corepressor-like 0.025675
EXOC4 exocyst complex component 4 0.0255734
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0255393
COG5 component of oligomeric golgi complex 5 0.0255264
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0253593
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0253043
RPL12 ribosomal protein L12 0.0250993
CXCL8 chemokine (C-X-C motif) ligand 8 0.0250186
CHD1 chromodomain helicase DNA binding protein 1 0.0249902
YME1L1 YME1-like 1 ATPase 0.0249866
CEP295 centrosomal protein 295kDa 0.0249293
TMEM39A transmembrane protein 39A 0.0247027
RPL23 ribosomal protein L23 0.0246809
YTHDC1 YTH domain containing 1 0.0246457

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206286
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.13726
IGFBP3 insulin-like growth factor binding protein 3 -0.101598
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.101018
PRKCA protein kinase C, alpha -0.0741898
AKAP12 A kinase (PRKA) anchor protein 12 -0.0696397
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0690304
MACF1 microtubule-actin crosslinking factor 1 -0.0674799
TMSB10 thymosin beta 10 -0.0665698
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0663944
IGF2 insulin-like growth factor 2 -0.0659373
TPT1 tumor protein, translationally-controlled 1 -0.0632905
ESYT2 extended synaptotagmin-like protein 2 -0.0599322
HILPDA hypoxia inducible lipid droplet-associated -0.0590572
FNDC3B fibronectin type III domain containing 3B -0.0582419
LDHA lactate dehydrogenase A -0.0580783
FLNB filamin B, beta -0.0579296
NDRG1 N-myc downstream regulated 1 -0.0555768
MT2A metallothionein 2A -0.0551002
MYO9B myosin IXB -0.0550726
ANGPTL4 angiopoietin-like 4 -0.0549399
RIGI RNA sensor RIG-I -0.053909
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0530668
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0530117
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0520598
CD44 CD44 molecule (Indian blood group) -0.0505244
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0500476
RAI14 retinoic acid induced 14 -0.047693
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0461707
CAPRIN2 caprin family member 2 -0.0457881
PKM pyruvate kinase, muscle -0.0447543
ERBIN erbb2 interacting protein -0.0439501
EGR1 early growth response 1 -0.0437809
GPC6 glypican 6 -0.0435227
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.043418
EFNA5 ephrin-A5 -0.0423231
ATXN1 ataxin 1 -0.0419785
PDGFA platelet-derived growth factor alpha polypeptide -0.0396205
FNDC3A fibronectin type III domain containing 3A -0.0391268
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0390365
BPTF bromodomain PHD finger transcription factor -0.0386882
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0383862
FTH1 ferritin, heavy polypeptide 1 -0.0376217
DTNA dystrobrevin, alpha -0.0375525
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0370313
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0362089
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0352736
DGKD diacylglycerol kinase, delta 130kDa -0.0348039
SASH1 SAM and SH3 domain containing 1 -0.0341637
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0337489
ADM adrenomedullin -0.0331785
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0331616
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0331547
PRSS23 protease, serine, 23 -0.0328036
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0322775
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0320946
OSMR oncostatin M receptor -0.0317696
GPC5 glypican 5 -0.0316876
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0311351
HMGA2 high mobility group AT-hook 2 -0.0310713
BTG1 B-cell translocation gene 1, anti-proliferative -0.0310152
PTK2 protein tyrosine kinase 2 -0.0309431
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0307597
IER3 immediate early response 3 -0.0305205
KTN1 kinectin 1 (kinesin receptor) -0.0303852
ASPH aspartate beta-hydroxylase -0.030339
FMN1 formin 1 -0.0300317
NPAS2 neuronal PAS domain protein 2 -0.0300223
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0296872
NALCN sodium leak channel, non selective -0.0296769
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0295117
CEMIP2 cell migration inducing hyaluronidase 2 -0.0293156
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0291881
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0290665
UGCG UDP-glucose ceramide glucosyltransferase -0.0290303
MAP1B microtubule-associated protein 1B -0.0289649
KIAA1671 KIAA1671 -0.0288768
GLG1 golgi glycoprotein 1 -0.0287306
DPYD dihydropyrimidine dehydrogenase -0.0286026
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0284537
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0282657
ANXA2 annexin A2 -0.0281738
EXT1 exostosin glycosyltransferase 1 -0.0281437
GLS2 glutaminase 2 (liver, mitochondrial) -0.028113
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.028035
EMP1 epithelial membrane protein 1 -0.0276588
SAMD4A sterile alpha motif domain containing 4A -0.0274905
ZFHX3 zinc finger homeobox 3 -0.027462
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0273743
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0272983
PYGL phosphorylase, glycogen, liver -0.0271503
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0268819
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0267796
JUN jun proto-oncogene -0.0267793
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0267074
COL5A1 collagen, type V, alpha 1 -0.026707
PFN1 profilin 1 -0.0265557
RIN2 Ras and Rab interactor 2 -0.0264759
ARHGAP26 Rho GTPase activating protein 26 -0.0263833
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0263764