Pentamidine (isethionate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.239122
VIM vimentin 0.237599
B2M beta-2-microglobulin 0.145904
COL8A1 collagen, type VIII, alpha 1 0.118877
AKAP12 A kinase (PRKA) anchor protein 12 0.10949
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.102779
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.101974
DLG1 discs, large homolog 1 (Drosophila) 0.0991555
TRIO trio Rho guanine nucleotide exchange factor 0.0784212
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0718768
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0698183
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0682238
ELL2 elongation factor, RNA polymerase II, 2 0.0646989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0629293
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0583849
TMSB10 thymosin beta 10 0.057735
MT2A metallothionein 2A 0.0452827
ZFP36L1 ZFP36 ring finger protein-like 1 0.0448758
FTH1 ferritin, heavy polypeptide 1 0.0443059
DCLK2 doublecortin-like kinase 2 0.0404675
SOX9 SRY (sex determining region Y)-box 9 0.0397812
HILPDA hypoxia inducible lipid droplet-associated 0.0383618
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.037439
GARS1 glycyl-tRNA synthetase 1 0.0374003
TMSB4X thymosin beta 4, X-linked 0.036428
CD109 CD109 molecule 0.0348567
RAI1 retinoic acid induced 1 0.0334759
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0316514
ZEB1 zinc finger E-box binding homeobox 1 0.0316498
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.031211
VEGFC vascular endothelial growth factor C 0.0307358
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0307265
MMP12 matrix metallopeptidase 12 0.0306919
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0278164
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0277735
ANXA1 annexin A1 0.0275953
EZR ezrin 0.0269125
DDIT4 DNA-damage-inducible transcript 4 0.026624
EEF2 eukaryotic translation elongation factor 2 0.025364
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0252911
COPA coatomer protein complex, subunit alpha 0.0250869
RND3 Rho family GTPase 3 0.0250868
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.024589
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0243162
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0242892
EGFR epidermal growth factor receptor 0.0235252
S100A10 S100 calcium binding protein A10 0.02351
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0232613
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0231412
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0227994
FTL ferritin, light polypeptide 0.0220704
ADAM9 ADAM metallopeptidase domain 9 0.0220321
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.0219488
RNF169 ring finger protein 169 0.0218902
TRA2A transformer 2 alpha homolog (Drosophila) 0.021833
FBXO11 F-box protein 11 0.021769
RAB18 RAB18, member RAS oncogene family 0.0213225
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0207998
MBNL2 muscleblind-like splicing regulator 2 0.0206777
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0204999
GADD45B growth arrest and DNA-damage-inducible, beta 0.0203014
BASP1 brain abundant, membrane attached signal protein 1 0.0200627
CDH13 cadherin 13 0.0199942
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.01956
MSI2 musashi RNA-binding protein 2 0.0194973
FAM107B family with sequence similarity 107, member B 0.0194324
KDM5B lysine (K)-specific demethylase 5B 0.019397
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0192415
FAM13A family with sequence similarity 13, member A 0.0190711
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0189673
MRPS6 mitochondrial ribosomal protein S6 0.0189481
BIRC6 baculoviral IAP repeat containing 6 0.0187671
HDAC9 histone deacetylase 9 0.0187296
JUN jun proto-oncogene 0.018543
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0184128
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0178175
ACBD3 acyl-CoA binding domain containing 3 0.0177632
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0177346
FNBP1L formin binding protein 1-like 0.0175984
ADM adrenomedullin 0.0174993
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0171782
FAM193B family with sequence similarity 193, member B 0.0171706
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0166836
LOC102724023 ES1 protein homolog, mitochondrial 0.0166458
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165949
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0165359
ZBTB7C zinc finger and BTB domain containing 7C 0.0165287
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0164721
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0163541
GPBP1 GC-rich promoter binding protein 1 0.0162238
RNF11 ring finger protein 11 0.0162201
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0160933
BHLHE40 basic helix-loop-helix family, member e40 0.0160537
SLC39A11 solute carrier family 39, member 11 0.01603
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0160142
IFITM3 interferon induced transmembrane protein 3 0.0159805
GRB10 growth factor receptor-bound protein 10 0.0159197
MTCL1 microtubule crosslinking factor 1 0.0158909
RSRC2 arginine/serine-rich coiled-coil 2 0.0158447
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0155815

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.197848
PODXL podocalyxin-like -0.189922
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.130262
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122243
CD44 CD44 molecule (Indian blood group) -0.117089
PLAT plasminogen activator, tissue -0.105981
FBN1 fibrillin 1 -0.0964784
FNDC3B fibronectin type III domain containing 3B -0.0829014
STAT1 signal transducer and activator of transcription 1, 91kDa -0.078497
NDRG1 N-myc downstream regulated 1 -0.0775124
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0749044
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0706316
FSTL1 follistatin-like 1 -0.0672791
NAV1 neuron navigator 1 -0.0646905
RHOBTB3 Rho-related BTB domain containing 3 -0.0584967
COL3A1 collagen, type III, alpha 1 -0.0572294
MAP1B microtubule-associated protein 1B -0.0556136
MX2 MX dynamin-like GTPase 2 -0.0529592
CLTC clathrin, heavy chain (Hc) -0.0481104
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0468964
COL5A1 collagen, type V, alpha 1 -0.045917
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0453674
CTSB cathepsin B -0.0448318
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0443978
ADAR adenosine deaminase, RNA-specific -0.0440523
FBXL7 F-box and leucine-rich repeat protein 7 -0.0425817
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0414239
SMYD3 SET and MYND domain containing 3 -0.04137
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0412022
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0400094
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0390672
CENPF centromere protein F, 350/400kDa -0.0387254
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.038668
SFTPA2 surfactant protein A2 -0.0385564
AHNAK AHNAK nucleoprotein -0.0375732
GLG1 golgi glycoprotein 1 -0.0369879
ECM1 extracellular matrix protein 1 -0.0363645
USP34 ubiquitin specific peptidase 34 -0.0362238
NAV2 neuron navigator 2 -0.0357437
ACTG1 actin gamma 1 -0.0354635
SBF2 SET binding factor 2 -0.0350251
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0340311
HIP1 huntingtin interacting protein 1 -0.0335763
SVIL supervillin -0.0333764
NAP1L1 nucleosome assembly protein 1-like 1 -0.0330294
ATP13A3 ATPase type 13A3 -0.0329653
STC1 stanniocalcin 1 -0.0328981
CDK6 cyclin-dependent kinase 6 -0.0328848
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0328222
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0323209
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.031963
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0318168
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0317146
TUBB4B tubulin, beta 4B class IVb -0.0317064
POTEF POTE ankyrin domain family, member F -0.0313981
CD59 CD59 molecule, complement regulatory protein -0.031081
MAP4 microtubule-associated protein 4 -0.0307396
IFIH1 interferon induced with helicase C domain 1 -0.0306788
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0303217
ZNF217 zinc finger protein 217 -0.0298014
IGF2R insulin-like growth factor 2 receptor -0.0294706
ANXA2 annexin A2 -0.029415
RUNX1 runt-related transcription factor 1 -0.0293142
RIGI RNA sensor RIG-I -0.0290361
ANXA4 annexin A4 -0.0290305
SAMD9 sterile alpha motif domain containing 9 -0.0289128
MYH9 myosin, heavy chain 9, non-muscle -0.028844
BACE2 beta-site APP-cleaving enzyme 2 -0.0287277
FLNB filamin B, beta -0.0284043
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0282161
TPT1 tumor protein, translationally-controlled 1 -0.0281389
RPS24 ribosomal protein S24 -0.028048
IPO9 importin 9 -0.0280078
LOXL2 lysyl oxidase-like 2 -0.0279725
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0279554
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0272041
PKM pyruvate kinase, muscle -0.0272005
TLE4 transducin-like enhancer of split 4 -0.0271282
RPS2 ribosomal protein S2 -0.0270569
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0264977
ANTXR1 anthrax toxin receptor 1 -0.0263846
WARS1 tryptophanyl-tRNA synthetase 1 -0.0257758
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0257648
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0256856
TAGLN2 transgelin 2 -0.0254214
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0253956
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0252585
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0252395
FER fer (fps/fes related) tyrosine kinase -0.0252243
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0249952
MTDH metadherin -0.0249353
SNX14 sorting nexin 14 -0.0247975
HLA-C major histocompatibility complex, class I, C -0.0245891
ANKRD36 ankyrin repeat domain 36 -0.024509
TNIP1 TNFAIP3 interacting protein 1 -0.0244958
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0243776
PSD3 pleckstrin and Sec7 domain containing 3 -0.0240461
SQSTM1 sequestosome 1 -0.0240292
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0239983
ANTXR2 anthrax toxin receptor 2 -0.0238189