| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.309999 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.148209 |
| RRM2 | ribonucleotide reductase M2 | 0.119489 |
| AREG | amphiregulin | 0.108071 |
| YAP1 | Yes-associated protein 1 | 0.0824752 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0701758 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0700461 |
| RPS12 | ribosomal protein S12 | 0.0637287 |
| PCBP2 | poly(rC) binding protein 2 | 0.0635104 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0584939 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0574418 |
| YBX3 | Y box binding protein 3 | 0.057354 |
| TPI1 | triosephosphate isomerase 1 | 0.0519823 |
| PDGFC | platelet derived growth factor C | 0.0513688 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0507289 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0451792 |
| RPS3 | ribosomal protein S3 | 0.0432114 |
| CENPF | centromere protein F, 350/400kDa | 0.0411214 |
| SET | SET nuclear proto-oncogene | 0.0404543 |
| EPHA6 | EPH receptor A6 | 0.0400195 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0386192 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0379038 |
| DIAPH3 | diaphanous-related formin 3 | 0.0366629 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0359828 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0356695 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0338511 |
| TPM3 | tropomyosin 3 | 0.0334087 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0332938 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0330051 |
| PNN | pinin, desmosome associated protein | 0.0322368 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0317239 |
| RPS17 | ribosomal protein S17 | 0.0311965 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0310058 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0307878 |
| B2M | beta-2-microglobulin | 0.0307343 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.0304491 |
| CBX3 | chromobox homolog 3 | 0.0302129 |
| TENM3 | teneurin transmembrane protein 3 | 0.0301782 |
| MSH6 | mutS homolog 6 | 0.0301275 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0299697 |
| RPL23 | ribosomal protein L23 | 0.0299408 |
| RPL3 | ribosomal protein L3 | 0.0298004 |
| TUBA1B | tubulin, alpha 1b | 0.0297569 |
| CPOX | coproporphyrinogen oxidase | 0.0295151 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0293532 |
| MGAT4C | MGAT4 family, member C | 0.0288803 |
| MED13L | mediator complex subunit 13-like | 0.0287623 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0286205 |
| PFN1 | profilin 1 | 0.0285261 |
| PRELID2 | PRELI domain containing 2 | 0.0273085 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0269533 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.026307 |
| RPL37A | ribosomal protein L37a | 0.0260675 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0259509 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0257242 |
| RPL9 | ribosomal protein L9 | 0.0255963 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0253131 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0252498 |
| HMGB2 | high mobility group box 2 | 0.0252043 |
| TUBA1C | tubulin, alpha 1c | 0.0251495 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0249668 |
| HDAC9 | histone deacetylase 9 | 0.0247257 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0246594 |
| RPS21 | ribosomal protein S21 | 0.0245691 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.024437 |
| CEP192 | centrosomal protein 192kDa | 0.0243763 |
| RTN4 | reticulon 4 | 0.024308 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0242134 |
| TBK1 | TANK-binding kinase 1 | 0.0238612 |
| CIP2A | cellular inhibitor of PP2A | 0.0236322 |
| CCDC200 | coiled-coil domain containing 200 | 0.0235764 |
| WWOX | WW domain containing oxidoreductase | 0.023359 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0230712 |
| DEPDC1B | DEP domain containing 1B | 0.0228861 |
| HELLS | helicase, lymphoid-specific | 0.0227262 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0226444 |
| NEK7 | NIMA-related kinase 7 | 0.0223445 |
| PHF3 | PHD finger protein 3 | 0.021928 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.021723 |
| LDHA | lactate dehydrogenase A | 0.0215813 |
| SON | SON DNA binding protein | 0.0214811 |
| LMNB1 | lamin B1 | 0.0210946 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0209962 |
| BRD2 | bromodomain containing 2 | 0.0205467 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0203547 |
| HDGF | hepatoma-derived growth factor | 0.020299 |
| SP3 | Sp3 transcription factor | 0.0202521 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0202062 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0201974 |
| KCMF1 | potassium channel modulatory factor 1 | 0.020085 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0200721 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0197449 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0196311 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0195225 |
| PCM1 | pericentriolar material 1 | 0.0194738 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0194519 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0194218 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0194173 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0193255 |
| DIAPH1 | diaphanous-related formin 1 | 0.0192706 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.304756 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.171327 |
| VIM | vimentin | -0.132225 |
| ACTG1 | actin gamma 1 | -0.106048 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0993915 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0870232 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0848593 |
| MMP12 | matrix metallopeptidase 12 | -0.0832057 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0831819 |
| CLDN1 | claudin 1 | -0.0821731 |
| AHNAK | AHNAK nucleoprotein | -0.0717073 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0665728 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0612978 |
| EHBP1 | EH domain binding protein 1 | -0.0612083 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0606915 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0540992 |
| CCND1 | cyclin D1 | -0.0492647 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0464215 |
| MAP1B | microtubule-associated protein 1B | -0.0462347 |
| TMEM123 | transmembrane protein 123 | -0.0458914 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0433454 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0430744 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0420449 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0412999 |
| TMSB10 | thymosin beta 10 | -0.0396873 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0388113 |
| RAB1A | RAB1A, member RAS oncogene family | -0.038756 |
| S100A6 | S100 calcium binding protein A6 | -0.0386752 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0379416 |
| BCHE | butyrylcholinesterase | -0.036825 |
| ZNF804A | zinc finger protein 804A | -0.0361493 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0350245 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0348857 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0344766 |
| H1-0 | H1.0 linker histone | -0.0342665 |
| MKI67 | marker of proliferation Ki-67 | -0.0341829 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0341133 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0340677 |
| KLF6 | Kruppel-like factor 6 | -0.0339812 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0336855 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0333999 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0333481 |
| NF1 | neurofibromin 1 | -0.0324556 |
| RPLP1 | ribosomal protein, large, P1 | -0.032088 |
| CLTC | clathrin, heavy chain (Hc) | -0.0311897 |
| CANX | calnexin | -0.0310933 |
| HMGA1 | high mobility group AT-hook 1 | -0.0310497 |
| BPTF | bromodomain PHD finger transcription factor | -0.0307071 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0303814 |
| TMEM131 | transmembrane protein 131 | -0.030343 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.029996 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0299178 |
| MAP4 | microtubule-associated protein 4 | -0.0296357 |
| S100A10 | S100 calcium binding protein A10 | -0.0294732 |
| PCDH7 | protocadherin 7 | -0.0294001 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0291047 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0287842 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0286348 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0282849 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0281065 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.028056 |
| SRP72 | signal recognition particle 72kDa | -0.0266887 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0266274 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0264392 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0262336 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0262264 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0262071 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0261551 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0260773 |
| RPL35A | ribosomal protein L35a | -0.0260452 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0258602 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0258168 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0256425 |
| PREPL | prolyl endopeptidase-like | -0.025354 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0251324 |
| CDK12 | cyclin-dependent kinase 12 | -0.0250331 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0250219 |
| FBXO11 | F-box protein 11 | -0.0250143 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0250004 |
| DENND5B | DENN/MADD domain containing 5B | -0.0249726 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.024866 |
| ATG12 | autophagy related 12 | -0.0248619 |
| CUX1 | cut-like homeobox 1 | -0.0248393 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | -0.0245057 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0241554 |
| ZFR | zinc finger RNA binding protein | -0.0241423 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0240677 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0239218 |
| RAB10 | RAB10, member RAS oncogene family | -0.0238572 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0237128 |
| AK1 | adenylate kinase 1 | -0.0234955 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0234671 |
| VGLL4 | vestigial-like family member 4 | -0.0233567 |
| ANXA1 | annexin A1 | -0.0233244 |
| RPL6 | ribosomal protein L6 | -0.0228878 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0226786 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0223616 |
| NLGN1 | neuroligin 1 | -0.0220764 |
| ENOSF1 | enolase superfamily member 1 | -0.0216199 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0215688 |
