Pentamidine (isethionate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.106315
NDRG1 N-myc downstream regulated 1 0.078598
PSD3 pleckstrin and Sec7 domain containing 3 0.0745157
EZR ezrin 0.0666018
TSC22D2 TSC22 domain family, member 2 0.0662041
UBA6 ubiquitin-like modifier activating enzyme 6 0.0631542
FLNB filamin B, beta 0.0616122
BAIAP2L1 BAI1-associated protein 2-like 1 0.0612176
GLS2 glutaminase 2 (liver, mitochondrial) 0.059269
ERRFI1 ERBB receptor feedback inhibitor 1 0.0589003
ITGA6 integrin, alpha 6 0.0577559
MPRIP myosin phosphatase Rho interacting protein 0.0572999
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0544031
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0542133
ITPRID2 ITPR interacting domain containing 2 0.0511953
ARHGAP42 Rho GTPase activating protein 42 0.0486062
GRB10 growth factor receptor-bound protein 10 0.0467163
VIM vimentin 0.046182
PCBP2 poly(rC) binding protein 2 0.0450552
CAPRIN2 caprin family member 2 0.0418017
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0417899
KTN1 kinectin 1 (kinesin receptor) 0.0402709
APLP2 amyloid beta (A4) precursor-like protein 2 0.0398563
AKAP13 A kinase (PRKA) anchor protein 13 0.0390404
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0373253
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0369994
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.034469
RPS2 ribosomal protein S2 0.0340508
KCMF1 potassium channel modulatory factor 1 0.03373
RCOR1 REST corepressor 1 0.033674
ADAM9 ADAM metallopeptidase domain 9 0.0318567
SLC38A2 solute carrier family 38, member 2 0.0315072
EEF2 eukaryotic translation elongation factor 2 0.0312034
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0294838
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0283077
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0282712
FOSL1 FOS-like antigen 1 0.0281666
DIAPH1 diaphanous-related formin 1 0.0281296
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.027826
RIOK3 RIO kinase 3 0.0274516
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0273954
MCL1 myeloid cell leukemia 1 0.0265667
ZSWIM6 zinc finger, SWIM-type containing 6 0.026544
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0264515
LDHA lactate dehydrogenase A 0.0262145
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0260706
CCNY cyclin Y 0.0256017
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0255469
AREG amphiregulin 0.0253558
TMEM164 transmembrane protein 164 0.0249975
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0241545
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0241432
MYOF myoferlin 0.0241244
PICALM phosphatidylinositol binding clathrin assembly protein 0.0239692
SERTAD2 SERTA domain containing 2 0.0236677
SLK STE20-like kinase 0.0235655
OPTN optineurin 0.0233631
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0232739
CCDC88A coiled-coil domain containing 88A 0.0232345
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0231367
TRIO trio Rho guanine nucleotide exchange factor 0.0230304
RPS3 ribosomal protein S3 0.0226978
PEAR1 platelet endothelial aggregation receptor 1 0.0225645
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0225386
LAMA4 laminin, alpha 4 0.0224828
TPM3 tropomyosin 3 0.0223774
CD9 CD9 molecule 0.0222242
WWC1 WW and C2 domain containing 1 0.0220104
ACTN4 actinin, alpha 4 0.0218514
CCNL1 cyclin L1 0.0216365
NCOR2 nuclear receptor corepressor 2 0.0216303
KRT8 keratin 8, type II 0.0213519
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0210235
NPTN neuroplastin 0.0209677
RTN4 reticulon 4 0.0209221
INTS6 integrator complex subunit 6 0.0208757
ERBIN erbb2 interacting protein 0.0207199
MBNL1 muscleblind-like splicing regulator 1 0.0206737
CARD16 caspase recruitment domain family, member 16 0.0205824
TGM2 transglutaminase 2 0.0205697
MYO1E myosin IE 0.0202706
MED13L mediator complex subunit 13-like 0.0202547
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0201707
WASF2 WAS protein family, member 2 0.0197101
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.019534
S100A10 S100 calcium binding protein A10 0.0194662
DSPP dentin sialophosphoprotein 0.0194027
C12ORF75 chromosome 12 open reading frame 75 0.0190718
MSN moesin 0.018794
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0182106
ITGB4 integrin, beta 4 0.0180784
DPYSL2 dihydropyrimidinase-like 2 0.0179864
MEF2D myocyte enhancer factor 2D 0.0179289
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0177991
CPNE8 copine VIII 0.0177062
TOP1 topoisomerase (DNA) I 0.0175717
KMT2E lysine (K)-specific methyltransferase 2E 0.0174738
HDGF hepatoma-derived growth factor 0.0170703
TPM2 tropomyosin 2 (beta) 0.0167932
BCL2L1 BCL2-like 1 0.0166721

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.222532
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.1621
TPT1 tumor protein, translationally-controlled 1 -0.161161
TXNRD1 thioredoxin reductase 1 -0.149001
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.145365
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.120138
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.113807
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.097684
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0862818
TMSB10 thymosin beta 10 -0.0860739
F3 coagulation factor III (thromboplastin, tissue factor) -0.0773125
AHNAK AHNAK nucleoprotein -0.0695419
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0674167
TM4SF1 transmembrane 4 L six family member 1 -0.0670889
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0653006
ZMYND8 zinc finger, MYND-type containing 8 -0.0630211
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0594335
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0583134
FTL ferritin, light polypeptide -0.0576173
LMO7 LIM domain 7 -0.0526472
SACK1A scaffolding CK1 anchoring protein A -0.0524835
RRBP1 ribosome binding protein 1 -0.0513338
BZW1 basic leucine zipper and W2 domains 1 -0.0509164
TPM4 tropomyosin 4 -0.0499053
KDM3A lysine (K)-specific demethylase 3A -0.0496092
KLK10 kallikrein-related peptidase 10 -0.0493204
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0490785
CLMP CXADR-like membrane protein -0.0478827
TXNIP thioredoxin interacting protein -0.0477836
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0459904
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0454258
RPS24 ribosomal protein S24 -0.0439347
EXT1 exostosin glycosyltransferase 1 -0.0433624
ANTXR2 anthrax toxin receptor 2 -0.0430608
FERMT1 fermitin family member 1 -0.0427428
DSG2 desmoglein 2 -0.0419976
WSB1 WD repeat and SOCS box containing 1 -0.0417762
RAD21 RAD21 homolog (S. pombe) -0.0408643
RPL35A ribosomal protein L35a -0.0405331
PLAUR plasminogen activator, urokinase receptor -0.0392982
CD2AP CD2-associated protein -0.0382966
SEC31A SEC31 homolog A (S. cerevisiae) -0.0382181
PGK1 phosphoglycerate kinase 1 -0.0370411
HDLBP high density lipoprotein binding protein -0.0369801
RSL1D1 ribosomal L1 domain containing 1 -0.036593
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0360171
RPLP1 ribosomal protein, large, P1 -0.0357657
AK1 adenylate kinase 1 -0.0356868
KLF6 Kruppel-like factor 6 -0.0352591
ARF1 ADP-ribosylation factor 1 -0.0351867
CALU calumenin -0.0343517
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.033761
TMEM263 transmembrane protein 263 -0.0334299
GCC2 GRIP and coiled-coil domain containing 2 -0.0332465
UBC ubiquitin C -0.0319775
IER3 immediate early response 3 -0.0315988
HLA-E major histocompatibility complex, class I, E -0.0308868
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0305427
LMTK2 lemur tyrosine kinase 2 -0.0300106
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0297596
CDCP1 CUB domain containing protein 1 -0.029363
CANX calnexin -0.0293408
THBD thrombomodulin -0.028988
NDFIP1 Nedd4 family interacting protein 1 -0.0283447
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0281759
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0281212
SEPTIN10 septin 10 -0.0278054
UBE2I ubiquitin-conjugating enzyme E2I -0.0277719
MTDH metadherin -0.0275654
COG5 component of oligomeric golgi complex 5 -0.0275277
NT5C2 5'-nucleotidase, cytosolic II -0.0272391
USP34 ubiquitin specific peptidase 34 -0.0271159
UBE2B ubiquitin-conjugating enzyme E2B -0.0270406
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0268621
PRSS3 protease, serine, 3 -0.0267812
TAOK3 TAO kinase 3 -0.0267354
COPB1 coatomer protein complex, subunit beta 1 -0.0266674
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0265433
NPC1 Niemann-Pick disease, type C1 -0.0265383
MORF4L2 mortality factor 4 like 2 -0.0263491
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0261474
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0257972
MIDN midnolin -0.0255853
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0251328
CD63 CD63 molecule -0.0250308
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0249441
HM13 histocompatibility (minor) 13 -0.0248573
IFI16 interferon, gamma-inducible protein 16 -0.0248299
THSD4 thrombospondin, type I, domain containing 4 -0.024762
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0247598
CLINT1 clathrin interactor 1 -0.0247216
NFE2L2 nuclear factor, erythroid 2-like 2 -0.024701
SKAP2 src kinase associated phosphoprotein 2 -0.0246501
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0245197
PTMA prothymosin, alpha -0.0243841
SAMD9 sterile alpha motif domain containing 9 -0.0243799
RPL34 ribosomal protein L34 -0.0243691
SP100 SP100 nuclear antigen -0.0242939
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0240644
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0240411