| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pentamidine (isethionate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.093244 |
| OGA | O-GlcNAcase | 0.0772481 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0729117 |
| RRM2 | ribonucleotide reductase M2 | 0.0697826 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0689784 |
| HMGB2 | high mobility group box 2 | 0.0666441 |
| GOLGA4 | golgin A4 | 0.0648904 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0619166 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0581194 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0576073 |
| MT2A | metallothionein 2A | 0.0569304 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0562914 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0550502 |
| TPR | translocated promoter region, nuclear basket protein | 0.0542369 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0522353 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0521605 |
| RPS3 | ribosomal protein S3 | 0.0499811 |
| RPS12 | ribosomal protein S12 | 0.0483383 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0476813 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0470104 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0454659 |
| PCBP2 | poly(rC) binding protein 2 | 0.0448256 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0443254 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.043203 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0429527 |
| ANKRD12 | ankyrin repeat domain 12 | 0.042557 |
| CENPF | centromere protein F, 350/400kDa | 0.0413506 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0409819 |
| RBM25 | RNA binding motif protein 25 | 0.0407578 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0406289 |
| SUCO | SUN domain containing ossification factor | 0.0392536 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0391155 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0384521 |
| TXNRD1 | thioredoxin reductase 1 | 0.0375403 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0375041 |
| YBX3 | Y box binding protein 3 | 0.0373486 |
| ZNF654 | zinc finger protein 654 | 0.0369287 |
| NUP58 | nucleoporin 58 | 0.0364685 |
| JMJD1C | jumonji domain containing 1C | 0.0364447 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0362331 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.035718 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.035613 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.03548 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0353283 |
| YTHDC1 | YTH domain containing 1 | 0.0350559 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0347847 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0347751 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0331102 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0326709 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0322407 |
| PNN | pinin, desmosome associated protein | 0.0321537 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0321187 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0318571 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0318169 |
| MYO6 | myosin VI | 0.0315171 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0313282 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | 0.0312789 |
| UTRN | utrophin | 0.0297494 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0297429 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0296754 |
| ANLN | anillin, actin binding protein | 0.0296743 |
| WDR26 | WD repeat domain 26 | 0.0296302 |
| TMF1 | TATA element modulatory factor 1 | 0.0295027 |
| FANCI | Fanconi anemia, complementation group I | 0.0294307 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0292817 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0290459 |
| TMEM41B | transmembrane protein 41B | 0.0289655 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0287013 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0286851 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0284974 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0284391 |
| ZNF292 | zinc finger protein 292 | 0.0283996 |
| SET | SET nuclear proto-oncogene | 0.0283627 |
| YEATS2 | YEATS domain containing 2 | 0.0282431 |
| TMSB4X | thymosin beta 4, X-linked | 0.0282351 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0282133 |
| THOC2 | THO complex 2 | 0.0281082 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0279568 |
| RBM26 | RNA binding motif protein 26 | 0.0278321 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0277963 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0277017 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0276945 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0276595 |
| RPL18 | ribosomal protein L18 | 0.0272162 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0270297 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0268973 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0267073 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0266512 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0266096 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0265963 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0265694 |
| RASA2 | RAS p21 protein activator 2 | 0.0263242 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.025989 |
| DIAPH3 | diaphanous-related formin 3 | 0.0256062 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0256012 |
| CEP95 | centrosomal protein 95kDa | 0.0253998 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0252882 |
| ATF4 | activating transcription factor 4 | 0.0252516 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0250495 |
| FAM13B | family with sequence similarity 13, member B | 0.0249634 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.205602 |
| AHNAK | AHNAK nucleoprotein | -0.181227 |
| FAT1 | FAT atypical cadherin 1 | -0.148378 |
| NDRG1 | N-myc downstream regulated 1 | -0.139798 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.107167 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.100174 |
| POTEF | POTE ankyrin domain family, member F | -0.0979406 |
| ENO1 | enolase 1, (alpha) | -0.0924053 |
| ACTG1 | actin gamma 1 | -0.0921394 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0909933 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0784379 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0687107 |
| PKM | pyruvate kinase, muscle | -0.0669722 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0619465 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0609208 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0607974 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0584929 |
| UBC | ubiquitin C | -0.0558977 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0558089 |
| HMGA1 | high mobility group AT-hook 1 | -0.0540557 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0535106 |
| CCND1 | cyclin D1 | -0.0515727 |
| CTBP2 | C-terminal binding protein 2 | -0.0514624 |
| KRT19 | keratin 19, type I | -0.0507333 |
| CANX | calnexin | -0.049656 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0491322 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0478674 |
| S100A6 | S100 calcium binding protein A6 | -0.0471708 |
| EGFR | epidermal growth factor receptor | -0.0463412 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0461512 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.045067 |
| PARD3 | par-3 family cell polarity regulator | -0.0447868 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0440693 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0431413 |
| EGR1 | early growth response 1 | -0.0426384 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0423231 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0423142 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0402111 |
| KRT18 | keratin 18, type I | -0.0399403 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0397286 |
| HDLBP | high density lipoprotein binding protein | -0.0395795 |
| DIAPH2 | diaphanous-related formin 2 | -0.0387959 |
| HLA-A | major histocompatibility complex, class I, A | -0.0385564 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0384876 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0384456 |
| RPL7 | ribosomal protein L7 | -0.0382381 |
| RPS11 | ribosomal protein S11 | -0.0375869 |
| RPS6 | ribosomal protein S6 | -0.0370096 |
| TUBA1B | tubulin, alpha 1b | -0.0369689 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0369063 |
| ARF1 | ADP-ribosylation factor 1 | -0.0362476 |
| SH3BP4 | SH3-domain binding protein 4 | -0.0352476 |
| DENND1A | DENN/MADD domain containing 1A | -0.0342871 |
| LDHB | lactate dehydrogenase B | -0.0336173 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0330064 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0329368 |
| RAB1A | RAB1A, member RAS oncogene family | -0.032917 |
| SERINC5 | serine incorporator 5 | -0.0322829 |
| RPL35 | ribosomal protein L35 | -0.031993 |
| MKI67 | marker of proliferation Ki-67 | -0.0317432 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0315027 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0314985 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0314255 |
| RPLP0 | ribosomal protein, large, P0 | -0.0311369 |
| SRP72 | signal recognition particle 72kDa | -0.0308223 |
| MTDH | metadherin | -0.030681 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0304419 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0296056 |
| LRRC23 | leucine rich repeat containing 23 | -0.0294946 |
| HMGA2 | high mobility group AT-hook 2 | -0.0294036 |
| DSG2 | desmoglein 2 | -0.0292978 |
| RPS14 | ribosomal protein S14 | -0.0292315 |
| INTS6 | integrator complex subunit 6 | -0.0290181 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.029006 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0289565 |
| FDPS | farnesyl diphosphate synthase | -0.0286221 |
| TPM4 | tropomyosin 4 | -0.0284464 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0279429 |
| WWC2 | WW and C2 domain containing 2 | -0.0278581 |
| HMGB1 | high mobility group box 1 | -0.0277523 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0277196 |
| JUN | jun proto-oncogene | -0.0276387 |
| MORF4L2 | mortality factor 4 like 2 | -0.0275748 |
| RPL38 | ribosomal protein L38 | -0.02756 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274218 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0273054 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0271809 |
| TUBB | tubulin, beta class I | -0.0271727 |
| INSIG1 | insulin induced gene 1 | -0.0269655 |
| RPS16 | ribosomal protein S16 | -0.0269341 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0266636 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0266324 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0265307 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0265275 |
| SUN1 | Sad1 and UNC84 domain containing 1 | -0.0262311 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0261458 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0260866 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0260379 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0256058 |
| EREG | epiregulin | -0.0253936 |
