Pentamidine (isethionate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.216739
ITGB8 integrin, beta 8 0.124523
B2M beta-2-microglobulin 0.0822331
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0784664
FTL ferritin, light polypeptide 0.0713443
POTEF POTE ankyrin domain family, member F 0.0684382
WWC1 WW and C2 domain containing 1 0.0682671
VMP1 vacuole membrane protein 1 0.0656888
VCL vinculin 0.0588254
SNX9 sorting nexin 9 0.0581066
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0581047
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0559428
DIAPH1 diaphanous-related formin 1 0.0518767
FLNA filamin A, alpha 0.0499854
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0462104
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0458386
NCEH1 neutral cholesterol ester hydrolase 1 0.0453895
ECT2 epithelial cell transforming 2 0.0439003
EGR1 early growth response 1 0.0438361
EZR ezrin 0.0429411
MPRIP myosin phosphatase Rho interacting protein 0.0408754
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0408017
UGCG UDP-glucose ceramide glucosyltransferase 0.0405807
MYEOV myeloma overexpressed 0.0403697
ANXA11 annexin A11 0.0401464
MYH9 myosin, heavy chain 9, non-muscle 0.0399447
TJP1 tight junction protein 1 0.0398971
CCDC200 coiled-coil domain containing 200 0.0369012
MACC1 metastasis associated in colon cancer 1 0.0368359
RUNX1 runt-related transcription factor 1 0.0357582
PDE4D phosphodiesterase 4D, cAMP-specific 0.0347651
APLP2 amyloid beta (A4) precursor-like protein 2 0.0345284
ADAM9 ADAM metallopeptidase domain 9 0.0343644
AXL AXL receptor tyrosine kinase 0.0339653
SMAD3 SMAD family member 3 0.0339202
PDLIM5 PDZ and LIM domain 5 0.0335514
FTH1 ferritin, heavy polypeptide 1 0.0333658
IRS2 insulin receptor substrate 2 0.0330985
PCBP2 poly(rC) binding protein 2 0.0325555
MACROD2 MACRO domain containing 2 0.0306228
RAB3IP RAB3A interacting protein 0.0293476
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0289852
CYSTM1 cysteine-rich transmembrane module containing 1 0.0288541
EEF2 eukaryotic translation elongation factor 2 0.0285831
BCAR3 breast cancer anti-estrogen resistance 3 0.0283588
KRT86 keratin 86, type II 0.028271
FOSL1 FOS-like antigen 1 0.0279814
MIDEAS mitotic deacetylase associated SANT domain protein 0.0271929
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.026988
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0267875
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261703
ZNF644 zinc finger protein 644 0.0254426
INTS6 integrator complex subunit 6 0.025267
CENPF centromere protein F, 350/400kDa 0.0251484
ZFP36L1 ZFP36 ring finger protein-like 1 0.0250936
UBA6 ubiquitin-like modifier activating enzyme 6 0.0248334
EXT1 exostosin glycosyltransferase 1 0.0247796
SVIL supervillin 0.02453
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0243374
CCNL1 cyclin L1 0.0240724
BIRC3 baculoviral IAP repeat containing 3 0.02383
UPP1 uridine phosphorylase 1 0.0230487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0230341
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0226799
LAMA5 laminin, alpha 5 0.0226308
CLDN4 claudin 4 0.0225779
NFIB nuclear factor I/B 0.0225181
SGMS2 sphingomyelin synthase 2 0.0225057
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0224525
ANKRD33B ankyrin repeat domain 33B 0.0221611
SHB Src homology 2 domain containing adaptor protein B 0.0221432
RPS11 ribosomal protein S11 0.0218987
ATAD2 ATPase family, AAA domain containing 2 0.0216575
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0213127
RND3 Rho family GTPase 3 0.0212858
ANKRD36C ankyrin repeat domain 36C 0.0212576
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.021226
AFDN afadin, adherens junction formation factor 0.0211107
RRM2 ribonucleotide reductase M2 0.0210372
ACTG1 actin gamma 1 0.0209656
TBCD tubulin folding cofactor D 0.0206801
TFDP1 transcription factor Dp-1 0.0206293
LDHA lactate dehydrogenase A 0.020609
ACTN4 actinin, alpha 4 0.0204901
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0202899
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0199869
WASF2 WAS protein family, member 2 0.0199496
RPS5 ribosomal protein S5 0.0199333
CREB5 cAMP responsive element binding protein 5 0.0198734
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0198394
SRRM2 serine/arginine repetitive matrix 2 0.0197313
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0197271
SQSTM1 sequestosome 1 0.019698
KIF5C kinesin family member 5C 0.0195788
S100A10 S100 calcium binding protein A10 0.0193129
PTBP3 polypyrimidine tract binding protein 3 0.0192547
RPS23 ribosomal protein S23 0.0191737
PARD6B par-6 family cell polarity regulator beta 0.019003
PCM1 pericentriolar material 1 0.0189029
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0187663

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.288768
AHNAK AHNAK nucleoprotein -0.128547
TMSB10 thymosin beta 10 -0.118249
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.110869
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0885679
FNDC3B fibronectin type III domain containing 3B -0.0874007
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0850023
TPT1 tumor protein, translationally-controlled 1 -0.0708326
ASPH aspartate beta-hydroxylase -0.0682853
MAP4 microtubule-associated protein 4 -0.0663107
PTMA prothymosin, alpha -0.0655904
RPL35A ribosomal protein L35a -0.0623924
CANX calnexin -0.0605834
BICD1 bicaudal D homolog 1 (Drosophila) -0.0597345
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0594999
LAMB3 laminin, beta 3 -0.056034
TTC3 tetratricopeptide repeat domain 3 -0.0546233
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0529365
HMGA2 high mobility group AT-hook 2 -0.0498445
H1-0 H1.0 linker histone -0.0492993
RAD51B RAD51 paralog B -0.047967
PCED1B PC-esterase domain containing 1B -0.0471704
ATG7 autophagy related 7 -0.0460388
PATJ PATJ crumbs cell polarity complex component -0.0456339
TBC1D22A TBC1 domain family, member 22A -0.0453394
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0442151
PDIA5 protein disulfide isomerase family A, member 5 -0.0430561
IARS1 isoleucyl-tRNA synthetase 1 -0.0429988
EGFR epidermal growth factor receptor -0.0422577
GARS1 glycyl-tRNA synthetase 1 -0.0421937
ZFAND3 zinc finger, AN1-type domain 3 -0.0417965
LIMCH1 LIM and calponin homology domains 1 -0.0415483
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0413881
TMSB4X thymosin beta 4, X-linked -0.0410919
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0410756
SMYD3 SET and MYND domain containing 3 -0.0410434
DLC1 DLC1 Rho GTPase activating protein -0.0409467
TAS2R14 taste receptor, type 2, member 14 -0.040829
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0401859
ANKRD11 ankyrin repeat domain 11 -0.0390667
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0381514
ZBTB20 zinc finger and BTB domain containing 20 -0.0379709
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0378885
LARP1B La ribonucleoprotein domain family, member 1B -0.0373277
LARP1 La ribonucleoprotein domain family, member 1 -0.0371294
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0367251
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.036647
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0361318
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0358365
CALR calreticulin -0.0357781
LAMA4 laminin, alpha 4 -0.0352365
FNIP1 folliculin interacting protein 1 -0.0348663
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0348143
ZNF609 zinc finger protein 609 -0.0346406
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0343778
ANK2 ankyrin 2, neuronal -0.0343196
WSB1 WD repeat and SOCS box containing 1 -0.0336238
ANKRD10 ankyrin repeat domain 10 -0.0324881
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0319303
RPS24 ribosomal protein S24 -0.03147
GNAS GNAS complex locus -0.0312281
PDIA4 protein disulfide isomerase family A, member 4 -0.0311854
EHBP1 EH domain binding protein 1 -0.0310905
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0308763
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0306594
PSD3 pleckstrin and Sec7 domain containing 3 -0.0306027
LASP1 LIM and SH3 protein 1 -0.0304895
LPP LIM domain containing preferred translocation partner in lipoma -0.0303114
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0298982
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0298806
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0297104
DOCK4 dedicator of cytokinesis 4 -0.0297023
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0292478
ENOSF1 enolase superfamily member 1 -0.0291011
NF1 neurofibromin 1 -0.0290575
NFX1 nuclear transcription factor, X-box binding 1 -0.0289705
MTDH metadherin -0.0288004
SEC24D SEC24 family member D -0.0285151
ALCAM activated leukocyte cell adhesion molecule -0.0284106
CLINT1 clathrin interactor 1 -0.0283871
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0283369
PTK2 protein tyrosine kinase 2 -0.0283044
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0282485
RPL4 ribosomal protein L4 -0.0281818
SEC63 SEC63 homolog (S. cerevisiae) -0.0280204
RTN3 reticulon 3 -0.0279047
RPL23 ribosomal protein L23 -0.0276966
CAPN2 calpain 2, (m/II) large subunit -0.0276636
THSD4 thrombospondin, type I, domain containing 4 -0.0273975
MON2 MON2 homolog (S. cerevisiae) -0.0273085
GOLGA4 golgin A4 -0.0272957
PLCB4 phospholipase C, beta 4 -0.0271341
MBD5 methyl-CpG binding domain protein 5 -0.0267895
RAB10 RAB10, member RAS oncogene family -0.0266134
HMGB1 high mobility group box 1 -0.0263459
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0260469
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0258565
SH3KBP1 SH3-domain kinase binding protein 1 -0.0258535
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0258451
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0258072