| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.135068 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0980126 |
| B2M | beta-2-microglobulin | 0.0949521 |
| MT2A | metallothionein 2A | 0.0905603 |
| VIM | vimentin | 0.0881459 |
| VEGFA | vascular endothelial growth factor A | 0.0824853 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.052161 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0498167 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0497837 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0479196 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0447757 |
| RPS8 | ribosomal protein S8 | 0.0431332 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0430732 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0394706 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0384811 |
| RPS3 | ribosomal protein S3 | 0.0360934 |
| PTMA | prothymosin, alpha | 0.0352039 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0347284 |
| COPA | coatomer protein complex, subunit alpha | 0.0346164 |
| VMP1 | vacuole membrane protein 1 | 0.0338892 |
| MSN | moesin | 0.0328328 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0320203 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0317952 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0314656 |
| RPS12 | ribosomal protein S12 | 0.0306691 |
| RASA2 | RAS p21 protein activator 2 | 0.0302531 |
| TFG | TRK-fused gene | 0.0299797 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0287729 |
| TMF1 | TATA element modulatory factor 1 | 0.0283424 |
| BRD2 | bromodomain containing 2 | 0.0275106 |
| TPM3 | tropomyosin 3 | 0.0274275 |
| LDHA | lactate dehydrogenase A | 0.0270943 |
| RPL14 | ribosomal protein L14 | 0.0267576 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0264232 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0262093 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0261916 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0260309 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.025931 |
| EGR1 | early growth response 1 | 0.0246428 |
| EFNA5 | ephrin-A5 | 0.0242049 |
| SQLE | squalene epoxidase | 0.0241591 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.024067 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0240133 |
| TPM4 | tropomyosin 4 | 0.0235699 |
| TPM2 | tropomyosin 2 (beta) | 0.023501 |
| RAB7A | RAB7A, member RAS oncogene family | 0.023064 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0230562 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0230547 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0220199 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0219251 |
| PGM3 | phosphoglucomutase 3 | 0.0219238 |
| AXL | AXL receptor tyrosine kinase | 0.0214693 |
| YBX1 | Y box binding protein 1 | 0.02129 |
| RPS2 | ribosomal protein S2 | 0.0206012 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0205829 |
| ASPH | aspartate beta-hydroxylase | 0.020495 |
| RPS23 | ribosomal protein S23 | 0.0201199 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0199073 |
| RND3 | Rho family GTPase 3 | 0.0196619 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0195625 |
| FLNB | filamin B, beta | 0.01947 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0193969 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0193688 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0191483 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0191335 |
| NRDC | nardilysin convertase | 0.0190444 |
| TMSB4X | thymosin beta 4, X-linked | 0.0189437 |
| PFN1 | profilin 1 | 0.0188509 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.018836 |
| RPL37A | ribosomal protein L37a | 0.0188251 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | 0.0186552 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.018585 |
| MYO10 | myosin X | 0.0184865 |
| FAM107B | family with sequence similarity 107, member B | 0.0182969 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0181175 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0179471 |
| VCL | vinculin | 0.0179396 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0179234 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0178813 |
| SET | SET nuclear proto-oncogene | 0.0177707 |
| SUCO | SUN domain containing ossification factor | 0.0177582 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0174489 |
| RPS17 | ribosomal protein S17 | 0.0173771 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0172993 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.017241 |
| RPL18 | ribosomal protein L18 | 0.0171677 |
| RPL7A | ribosomal protein L7a | 0.0171159 |
| SLC25A32 | solute carrier family 25 (mitochondrial folate carrier), member 32 | 0.0170962 |
| CCNY | cyclin Y | 0.0170777 |
| RPL3 | ribosomal protein L3 | 0.0169981 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0169824 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0169807 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0169419 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0169346 |
| RPL36 | ribosomal protein L36 | 0.0169335 |
| ARF4 | ADP-ribosylation factor 4 | 0.0166635 |
| MED13L | mediator complex subunit 13-like | 0.0166143 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0165289 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0165148 |
| TMEM165 | transmembrane protein 165 | 0.0164844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.432584 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.373258 |
| COL1A1 | collagen, type I, alpha 1 | -0.228731 |
| NDRG1 | N-myc downstream regulated 1 | -0.170146 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.133514 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0884382 |
| AHNAK | AHNAK nucleoprotein | -0.0850917 |
| LOXL2 | lysyl oxidase-like 2 | -0.0848085 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0817752 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0797064 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0763206 |
| COL1A2 | collagen, type I, alpha 2 | -0.0693147 |
| IER3 | immediate early response 3 | -0.0679796 |
| CD44 | CD44 molecule (Indian blood group) | -0.0668904 |
| COL5A1 | collagen, type V, alpha 1 | -0.0624941 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0619015 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0616989 |
| RRBP1 | ribosome binding protein 1 | -0.0592162 |
| PRELID2 | PRELI domain containing 2 | -0.0586808 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0556802 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.054574 |
| ACTG1 | actin gamma 1 | -0.0536507 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0529152 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0515315 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0499365 |
| ATP13A3 | ATPase type 13A3 | -0.0482038 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.047489 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0472606 |
| DST | dystonin | -0.0466427 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0458404 |
| TMSB10 | thymosin beta 10 | -0.0445313 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0444594 |
| FBN1 | fibrillin 1 | -0.0443583 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0441008 |
| CANX | calnexin | -0.0437403 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0426323 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0415732 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0407308 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0406235 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0400784 |
| CAVIN1 | caveolae associated protein 1 | -0.0396744 |
| PGK1 | phosphoglycerate kinase 1 | -0.039376 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0387936 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0382667 |
| ANXA2 | annexin A2 | -0.0381088 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0379565 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0371562 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0361228 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0358579 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0352714 |
| H1-0 | H1.0 linker histone | -0.0351533 |
| CADM1 | cell adhesion molecule 1 | -0.0336296 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0334815 |
| ATXN1 | ataxin 1 | -0.0333126 |
| NREP | neuronal regeneration related protein | -0.033268 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.033248 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0330785 |
| CTSB | cathepsin B | -0.0325081 |
| MAP1B | microtubule-associated protein 1B | -0.0319344 |
| KLF6 | Kruppel-like factor 6 | -0.0317442 |
| POSTN | periostin, osteoblast specific factor | -0.0312524 |
| CNTN5 | contactin 5 | -0.0312255 |
| RPL35A | ribosomal protein L35a | -0.0311214 |
| GLIS3 | GLIS family zinc finger 3 | -0.0309508 |
| TRAM2 | translocation associated membrane protein 2 | -0.0309077 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0307127 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0306822 |
| MAP4 | microtubule-associated protein 4 | -0.0303869 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0297472 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0297431 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0295022 |
| GPC6 | glypican 6 | -0.0294536 |
| FOXP1 | forkhead box P1 | -0.028841 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0285451 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0283726 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0282463 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0275339 |
| RUNX1 | runt-related transcription factor 1 | -0.0271819 |
| PXDN | peroxidasin | -0.0271238 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0270024 |
| SH3PXD2B | SH3 and PX domains 2B | -0.0268573 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.02615 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0259718 |
| ENO1 | enolase 1, (alpha) | -0.025914 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0258972 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0257333 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0256149 |
| CALD1 | caldesmon 1 | -0.0243485 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0239187 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0237793 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0236581 |
| PFKP | phosphofructokinase, platelet | -0.023628 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0232815 |
| ZFHX3 | zinc finger homeobox 3 | -0.0232782 |
| TRAM1 | translocation associated membrane protein 1 | -0.0232773 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0231742 |
| TENM1 | teneurin transmembrane protein 1 | -0.0228965 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0228257 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0227543 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0227425 |
