Pentamidine (isethionate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0638839
VCL vinculin 0.0604378
ADARB1 adenosine deaminase, RNA-specific, B1 0.0573324
FTL ferritin, light polypeptide 0.0557286
INTS6 integrator complex subunit 6 0.0532246
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0477922
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0470458
PCBP2 poly(rC) binding protein 2 0.0445468
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0408121
MCL1 myeloid cell leukemia 1 0.0391027
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0390128
AREG amphiregulin 0.0390066
SMAD3 SMAD family member 3 0.0383499
DSCAM Down syndrome cell adhesion molecule 0.0383289
VMP1 vacuole membrane protein 1 0.0373857
RPL21 ribosomal protein L21 0.0358914
RPL23 ribosomal protein L23 0.0356666
VIM vimentin 0.0354923
PLEC plectin 0.0349824
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0346454
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0345612
ARHGAP23 Rho GTPase activating protein 23 0.0332934
B2M beta-2-microglobulin 0.0320025
RPS12 ribosomal protein S12 0.0314365
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0314335
RPL37A ribosomal protein L37a 0.0313618
RPLP2 ribosomal protein, large, P2 0.0308566
BRD2 bromodomain containing 2 0.0304572
TRA2A transformer 2 alpha homolog (Drosophila) 0.0303955
MYH9 myosin, heavy chain 9, non-muscle 0.0302072
TSC22D2 TSC22 domain family, member 2 0.0301743
CTBP2 C-terminal binding protein 2 0.0299759
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0298211
GOLGA4 golgin A4 0.029722
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0288965
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0287463
SUCO SUN domain containing ossification factor 0.0286796
YBX1 Y box binding protein 1 0.0283469
RTN4 reticulon 4 0.0281017
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0279833
CCNYL1 cyclin Y-like 1 0.0277908
MSN moesin 0.0275792
CCNL1 cyclin L1 0.0264546
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0262218
RPS3 ribosomal protein S3 0.0259833
APLP2 amyloid beta (A4) precursor-like protein 2 0.0255854
MYOF myoferlin 0.0254339
EPS8L1 EPS8-like 1 0.0253523
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0253071
RPL31 ribosomal protein L31 0.0248511
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0245858
CEMIP2 cell migration inducing hyaluronidase 2 0.024484
RPS2 ribosomal protein S2 0.0240646
EZR ezrin 0.0235609
RPL9 ribosomal protein L9 0.0234779
RPS17 ribosomal protein S17 0.0230756
KTN1 kinectin 1 (kinesin receptor) 0.0228166
MT2A metallothionein 2A 0.0225124
SET SET nuclear proto-oncogene 0.0223644
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0219844
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0218201
ATAD2 ATPase family, AAA domain containing 2 0.0218058
VEGFA vascular endothelial growth factor A 0.0217361
STK24 serine/threonine kinase 24 0.0216973
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0213426
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0212393
RNF145 ring finger protein 145 0.0199253
SPRED2 sprouty-related, EVH1 domain containing 2 0.0197856
FN1 fibronectin 1 0.0197237
FLNA filamin A, alpha 0.0194856
RPS29 ribosomal protein S29 0.0194764
NTN4 netrin 4 0.0194118
CCDC200 coiled-coil domain containing 200 0.0192263
SMC4 structural maintenance of chromosomes 4 0.019194
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0190534
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0190102
RBM39 RNA binding motif protein 39 0.0188528
SHB Src homology 2 domain containing adaptor protein B 0.0188082
FOSL1 FOS-like antigen 1 0.0187213
RPS19 ribosomal protein S19 0.0186483
KMT2E lysine (K)-specific methyltransferase 2E 0.0186088
HOMER1 homer scaffolding protein 1 0.0185947
RPL5 ribosomal protein L5 0.0184514
TMEM41B transmembrane protein 41B 0.018431
PRR5L proline rich 5 like 0.0184248
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.018285
UBA6 ubiquitin-like modifier activating enzyme 6 0.0182707
USP47 ubiquitin specific peptidase 47 0.0181921
NAP1L1 nucleosome assembly protein 1-like 1 0.0179704
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0179284
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0177505
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0175491
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0174251
ARF4 ADP-ribosylation factor 4 0.0170031
WNK1 WNK lysine deficient protein kinase 1 0.0169629
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0169152
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0169004
ITPRID2 ITPR interacting domain containing 2 0.0168803
FBXO32 F-box protein 32 0.0167582
CUL3 cullin 3 0.0167496

decreased expression

Symbol Name Standardized Value
FRY furry homolog (Drosophila) -0.152042
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.142739
TPT1 tumor protein, translationally-controlled 1 -0.124912
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.121539
AHNAK AHNAK nucleoprotein -0.107287
MYH14 myosin, heavy chain 14, non-muscle -0.0986093
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0965649
KRT18 keratin 18, type I -0.08696
ZMYND8 zinc finger, MYND-type containing 8 -0.0861156
SAMD12 sterile alpha motif domain containing 12 -0.0838771
GMDS GDP-mannose 4,6-dehydratase -0.0813636
KRT20 keratin 20, type I -0.0808531
PGK1 phosphoglycerate kinase 1 -0.0770772
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0763875
MMP7 matrix metallopeptidase 7 -0.0757709
LOC102724023 ES1 protein homolog, mitochondrial -0.07385
PTPRK protein tyrosine phosphatase, receptor type, K -0.0736399
TMC5 transmembrane channel-like 5 -0.0709853
NDRG1 N-myc downstream regulated 1 -0.0701373
MAML3 mastermind-like 3 (Drosophila) -0.0694378
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0690338
CCSER1 coiled-coil serine-rich protein 1 -0.0681613
DIAPH2 diaphanous-related formin 2 -0.0676548
KRT8 keratin 8, type II -0.0666995
ZBTB20 zinc finger and BTB domain containing 20 -0.0656212
ITPKC inositol-trisphosphate 3-kinase C -0.064972
PATJ PATJ crumbs cell polarity complex component -0.0628188
NECTIN2 nectin cell adhesion molecule 2 -0.062605
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0624519
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0614139
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0604678
KRT19 keratin 19, type I -0.0595914
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0567048
ACACA acetyl-CoA carboxylase alpha -0.0566091
JUN jun proto-oncogene -0.0555109
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.054761
ANXA2 annexin A2 -0.0542446
PTK2 protein tyrosine kinase 2 -0.054182
S100A6 S100 calcium binding protein A6 -0.05417
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0539948
PRKN parkin RBR E3 ubiquitin protein ligase -0.0535621
TRIB1 tribbles pseudokinase 1 -0.0533809
PTMA prothymosin, alpha -0.0531805
LAMA4 laminin, alpha 4 -0.0525374
ACTG1 actin gamma 1 -0.0521856
RAD21 RAD21 homolog (S. pombe) -0.0512667
FNDC3B fibronectin type III domain containing 3B -0.0512143
POF1B premature ovarian failure, 1B -0.050931
SLC45A4 solute carrier family 45, member 4 -0.0493686
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0483739
RRBP1 ribosome binding protein 1 -0.0477142
CD2AP CD2-associated protein -0.047668
DGKH diacylglycerol kinase, eta -0.04759
ETV6 ets variant 6 -0.0469629
RNF213 ring finger protein 213 -0.0469489
NF1 neurofibromin 1 -0.0468098
TM4SF4 transmembrane 4 L six family member 4 -0.0465783
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0465326
TMEM123 transmembrane protein 123 -0.0464479
TMEM45B transmembrane protein 45B -0.0462383
PLAUR plasminogen activator, urokinase receptor -0.0460196
GCC2 GRIP and coiled-coil domain containing 2 -0.0456132
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0442415
ACTN4 actinin, alpha 4 -0.044018
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0438212
SOX4 SRY (sex determining region Y)-box 4 -0.0434159
HDLBP high density lipoprotein binding protein -0.0427221
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.040779
PRELID2 PRELI domain containing 2 -0.0406119
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0404842
TRAPPC9 trafficking protein particle complex 9 -0.0401965
TRIM56 tripartite motif containing 56 -0.0399529
PPARD peroxisome proliferator-activated receptor delta -0.0399195
NPC1 Niemann-Pick disease, type C1 -0.0382359
FTH1 ferritin, heavy polypeptide 1 -0.0379558
LCN2 lipocalin 2 -0.0372497
EXOC4 exocyst complex component 4 -0.0369659
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.036531
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0364457
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0363731
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0363394
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0362595
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0359636
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.035938
SDC4 syndecan 4 -0.035599
KLF5 Kruppel-like factor 5 (intestinal) -0.035521
CUX1 cut-like homeobox 1 -0.0354761
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0349314
LYZ lysozyme -0.0348302
RPS24 ribosomal protein S24 -0.0345566
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0345491
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0341025
IGF1R insulin-like growth factor 1 receptor -0.0331369
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0330867
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0330383
ITGA1 integrin, alpha 1 -0.0328761
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0328373
KLK10 kallikrein-related peptidase 10 -0.0327668
ASPH aspartate beta-hydroxylase -0.0325959
PDE4D phosphodiesterase 4D, cAMP-specific -0.0324772