| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.143977 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.122259 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.114269 |
| RPS6 | ribosomal protein S6 | 0.111167 |
| RPL37A | ribosomal protein L37a | 0.0917884 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.091095 |
| B2M | beta-2-microglobulin | 0.0748124 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0726775 |
| JMJD1C | jumonji domain containing 1C | 0.0661749 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0615982 |
| APOA2 | apolipoprotein A-II | 0.0614447 |
| RPS17 | ribosomal protein S17 | 0.0607969 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0583191 |
| RBM39 | RNA binding motif protein 39 | 0.0560524 |
| RPL14 | ribosomal protein L14 | 0.0554349 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0546224 |
| RPS19 | ribosomal protein S19 | 0.0536769 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0533843 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0512341 |
| RPS8 | ribosomal protein S8 | 0.0509101 |
| SDC4 | syndecan 4 | 0.0505894 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0504255 |
| RPS27A | ribosomal protein S27a | 0.0461498 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0457858 |
| MYO6 | myosin VI | 0.0452911 |
| RPL5 | ribosomal protein L5 | 0.0449866 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0437392 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0433322 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0433128 |
| GOLGA4 | golgin A4 | 0.0429159 |
| SBF2 | SET binding factor 2 | 0.0428408 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.042531 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0416968 |
| RPL19 | ribosomal protein L19 | 0.0416346 |
| ZNF292 | zinc finger protein 292 | 0.0413247 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.040405 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0400449 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0398199 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0396241 |
| DENND4A | DENN/MADD domain containing 4A | 0.0384912 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0383522 |
| RBM25 | RNA binding motif protein 25 | 0.0373094 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0363645 |
| RPS29 | ribosomal protein S29 | 0.0361503 |
| KIF5B | kinesin family member 5B | 0.0344601 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0340211 |
| CCNY | cyclin Y | 0.0336964 |
| AFDN | afadin, adherens junction formation factor | 0.0333099 |
| OGA | O-GlcNAcase | 0.0331852 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0326119 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0323919 |
| TOP1 | topoisomerase (DNA) I | 0.0323465 |
| RPL37 | ribosomal protein L37 | 0.0317412 |
| PTMA | prothymosin, alpha | 0.0316678 |
| WTAP | Wilms tumor 1 associated protein | 0.031622 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0313827 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0313767 |
| RPS3 | ribosomal protein S3 | 0.0311961 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0308825 |
| SET | SET nuclear proto-oncogene | 0.0308491 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0308056 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0305909 |
| FMNL2 | formin-like 2 | 0.0305289 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0302706 |
| PTK2 | protein tyrosine kinase 2 | 0.0302491 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0300115 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0299798 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0299449 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0297303 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0297206 |
| RTN4 | reticulon 4 | 0.0292111 |
| RPL9 | ribosomal protein L9 | 0.0289782 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0288016 |
| RPL36 | ribosomal protein L36 | 0.0287857 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0285415 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.028404 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0283697 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0283139 |
| FBXO11 | F-box protein 11 | 0.028253 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0279728 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0279535 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0275696 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0275084 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0274523 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0274393 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0272622 |
| SPAG9 | sperm associated antigen 9 | 0.0270668 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0270604 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.02692 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0268735 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0268614 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0268529 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0263585 |
| RPL36A | ribosomal protein L36a | 0.0261937 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0261188 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0260259 |
| RPL38 | ribosomal protein L38 | 0.0258639 |
| UBE3A | ubiquitin protein ligase E3A | 0.0254592 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0254499 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0254245 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.239465 |
| FN1 | fibronectin 1 | -0.193154 |
| APOB | apolipoprotein B | -0.163572 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.11217 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101877 |
| GPC3 | glypican 3 | -0.094056 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0931078 |
| EHBP1 | EH domain binding protein 1 | -0.0890159 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0871353 |
| LOC112694756 | uncharaterized LOC112694756 | -0.079307 |
| PTCHD4 | patched domain containing 4 | -0.0646878 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0645332 |
| AHSG | alpha-2-HS-glycoprotein | -0.0596176 |
| ITGAV | integrin, alpha V | -0.0594889 |
| SVIL | supervillin | -0.0527128 |
| CFB | complement factor B | -0.0502048 |
| DST | dystonin | -0.0490272 |
| GPC6 | glypican 6 | -0.0481418 |
| RPLP0 | ribosomal protein, large, P0 | -0.0477105 |
| IGF2 | insulin-like growth factor 2 | -0.0457324 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0455821 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0440102 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0436796 |
| ENO1 | enolase 1, (alpha) | -0.0425946 |
| KYNU | kynureninase | -0.042093 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0419201 |
| FTL | ferritin, light polypeptide | -0.0418744 |
| INTS6 | integrator complex subunit 6 | -0.0416142 |
| CP | ceruloplasmin (ferroxidase) | -0.0413494 |
| PEG3 | paternally expressed 3 | -0.0399946 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0395885 |
| KLF6 | Kruppel-like factor 6 | -0.0388583 |
| HDAC4 | histone deacetylase 4 | -0.0381322 |
| EGR1 | early growth response 1 | -0.0372264 |
| CTSB | cathepsin B | -0.0370238 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0364663 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0362937 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0361583 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0359447 |
| FAT1 | FAT atypical cadherin 1 | -0.0357923 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0353837 |
| ATXN1 | ataxin 1 | -0.0339302 |
| FAM107B | family with sequence similarity 107, member B | -0.0335555 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0324872 |
| ZFHX3 | zinc finger homeobox 3 | -0.0320344 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0316076 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0305436 |
| TXNIP | thioredoxin interacting protein | -0.0303209 |
| TRAM1 | translocation associated membrane protein 1 | -0.0301605 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.029825 |
| RHOB | ras homolog family member B | -0.0296471 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0296149 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0291113 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0283272 |
| NDRG1 | N-myc downstream regulated 1 | -0.0282997 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0279756 |
| ATP11A | ATPase, class VI, type 11A | -0.0277667 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.027733 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0273711 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0270666 |
| ITGA1 | integrin, alpha 1 | -0.0269758 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0263599 |
| ACYP2 | acylphosphatase 2, muscle type | -0.0262474 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0261693 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0259898 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0257113 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0257108 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0256427 |
| JUN | jun proto-oncogene | -0.0255084 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0255049 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0254178 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0250933 |
| PKM | pyruvate kinase, muscle | -0.0246947 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0245383 |
| PLEC | plectin | -0.0243083 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.0238194 |
| HMGA1 | high mobility group AT-hook 1 | -0.0235786 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0235584 |
| H1-0 | H1.0 linker histone | -0.0235545 |
| RNF213 | ring finger protein 213 | -0.0235232 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0235162 |
| UBC | ubiquitin C | -0.0232397 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0231724 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0231073 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.0228982 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0227423 |
| USP34 | ubiquitin specific peptidase 34 | -0.022661 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0226355 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0220852 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0218154 |
| PATJ | PATJ crumbs cell polarity complex component | -0.02137 |
| GDF15 | growth differentiation factor 15 | -0.0207824 |
| TF | transferrin | -0.0205661 |
| WDR1 | WD repeat domain 1 | -0.0204873 |
| PRKCA | protein kinase C, alpha | -0.0204488 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0204074 |
| EXOC4 | exocyst complex component 4 | -0.0202997 |
| TMEM181 | transmembrane protein 181 | -0.0202021 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0201801 |
| PDHX | pyruvate dehydrogenase complex, component X | -0.0198776 |
