Pentamidine (isethionate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.240709
B2M beta-2-microglobulin 0.139534
MTSS1 metastasis suppressor 1 0.134193
MEF2A myocyte enhancer factor 2A 0.101658
TPT1 tumor protein, translationally-controlled 1 0.0960091
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0861945
PLEC plectin 0.0790946
PTMA prothymosin, alpha 0.0740406
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0725348
RPS8 ribosomal protein S8 0.0646903
LAMC2 laminin, gamma 2 0.0642078
TMSB4X thymosin beta 4, X-linked 0.0637659
RPS3 ribosomal protein S3 0.0593237
RPS12 ribosomal protein S12 0.0592972
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0492009
TPM3 tropomyosin 3 0.049148
SLC35F3 solute carrier family 35, member F3 0.0436262
NAV2 neuron navigator 2 0.0421311
MYH9 myosin, heavy chain 9, non-muscle 0.0412736
CSTB cystatin B (stefin B) 0.0395426
HLA-E major histocompatibility complex, class I, E 0.0394352
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0392487
LMNA lamin A/C 0.0385747
TPM4 tropomyosin 4 0.0384619
SQLE squalene epoxidase 0.0370315
PDE4D phosphodiesterase 4D, cAMP-specific 0.0358163
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0353962
RPL37A ribosomal protein L37a 0.0346593
RRBP1 ribosome binding protein 1 0.0342248
IFI44L interferon-induced protein 44-like 0.0341608
FTL ferritin, light polypeptide 0.0341481
RPS25 ribosomal protein S25 0.0341329
RPS6 ribosomal protein S6 0.0332929
KRT6A keratin 6A, type II 0.0331308
SET SET nuclear proto-oncogene 0.0331057
CALB1 calbindin 1, 28kDa 0.032837
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0325244
RPS27 ribosomal protein S27 0.0325197
RPL35A ribosomal protein L35a 0.0315799
RPS17 ribosomal protein S17 0.0312037
RPL26 ribosomal protein L26 0.0300545
BCAR3 breast cancer anti-estrogen resistance 3 0.0300213
RPL23 ribosomal protein L23 0.029625
RPL37 ribosomal protein L37 0.028701
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0286066
RPS13 ribosomal protein S13 0.0285499
RPS14 ribosomal protein S14 0.0277875
RPL36A ribosomal protein L36a 0.0275161
IFI6 interferon, alpha-inducible protein 6 0.0273905
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0264403
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0262314
IFI27 interferon, alpha-inducible protein 27 0.0260958
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0256892
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0256828
SQSTM1 sequestosome 1 0.0250507
MT2A metallothionein 2A 0.0249444
PGK1 phosphoglycerate kinase 1 0.0248744
RPL31 ribosomal protein L31 0.0247578
RNF217 ring finger protein 217 0.0246205
PLS3 plastin 3 0.0244413
COL17A1 collagen, type XVII, alpha 1 0.0242715
MEGF6 multiple EGF-like-domains 6 0.0242555
MCL1 myeloid cell leukemia 1 0.0242414
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0242204
HM13 histocompatibility (minor) 13 0.0242093
RPS21 ribosomal protein S21 0.0239796
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0239322
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0236175
RPLP2 ribosomal protein, large, P2 0.0233596
VIM vimentin 0.0230843
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.022932
OXR1 oxidation resistance 1 0.0226474
S100A9 S100 calcium binding protein A9 0.02242
PPARG peroxisome proliferator-activated receptor gamma 0.0223793
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0221737
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0221488
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0220982
KISS1 KiSS-1 metastasis-suppressor 0.0220874
SLK STE20-like kinase 0.0219553
MT1E metallothionein 1E 0.0218342
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.021795
PODXL podocalyxin-like 0.0215729
DUSP6 dual specificity phosphatase 6 0.0209314
EHBP1L1 EH domain binding protein 1-like 1 0.020324
TMEM41B transmembrane protein 41B 0.0202858
RPS27A ribosomal protein S27a 0.0201758
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0201115
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0200801
RPL12 ribosomal protein L12 0.0200601
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0200168
TNIP1 TNFAIP3 interacting protein 1 0.0197827
ANGPTL4 angiopoietin-like 4 0.0197687
EIF1 eukaryotic translation initiation factor 1 0.0196798
AKAP12 A kinase (PRKA) anchor protein 12 0.0193612
RNF220 ring finger protein 220 0.0193342
IFI44 interferon-induced protein 44 0.0191429
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0191089
CSDE1 cold shock domain containing E1, RNA-binding 0.0190444
CANX calnexin 0.0188697
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0187723

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228323
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.17619
MBNL1 muscleblind-like splicing regulator 1 -0.126063
ASPH aspartate beta-hydroxylase -0.089883
INTS6 integrator complex subunit 6 -0.0857602
FNDC3B fibronectin type III domain containing 3B -0.085085
FLNB filamin B, beta -0.0848137
CD44 CD44 molecule (Indian blood group) -0.0840827
POTEF POTE ankyrin domain family, member F -0.0806187
ARHGAP29 Rho GTPase activating protein 29 -0.0764884
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0717845
IGF2 insulin-like growth factor 2 -0.0662456
CLU clusterin -0.0623462
MBNL2 muscleblind-like splicing regulator 2 -0.0619423
FOXO1 forkhead box O1 -0.0580836
SULF1 sulfatase 1 -0.0552234
CYB5R3 cytochrome b5 reductase 3 -0.0533969
NDRG1 N-myc downstream regulated 1 -0.0519783
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0515784
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0514266
SMAD3 SMAD family member 3 -0.0507109
CUL4B cullin 4B -0.0484503
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0475758
KMT2E lysine (K)-specific methyltransferase 2E -0.0472659
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0466
ANKRD28 ankyrin repeat domain 28 -0.0457686
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0428422
FN1 fibronectin 1 -0.0421502
DST dystonin -0.0419698
SLC38A2 solute carrier family 38, member 2 -0.0415962
CAV1 caveolin 1, caveolae protein, 22kDa -0.0414929
STC1 stanniocalcin 1 -0.0414912
MAML2 mastermind-like 2 (Drosophila) -0.0407056
H1-0 H1.0 linker histone -0.0406986
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0405381
ANO6 anoctamin 6 -0.0403986
TRIO trio Rho guanine nucleotide exchange factor -0.0393568
NEK7 NIMA-related kinase 7 -0.0382199
EXT1 exostosin glycosyltransferase 1 -0.0378474
MECOM MDS1 and EVI1 complex locus -0.0376071
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0371804
WASF2 WAS protein family, member 2 -0.0367417
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.035515
LIFR leukemia inhibitory factor receptor alpha -0.0345583
PALLD palladin, cytoskeletal associated protein -0.0342068
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0341822
DOCK5 dedicator of cytokinesis 5 -0.0341666
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0341551
SSBP2 single-stranded DNA binding protein 2 -0.0337872
IGFBP4 insulin-like growth factor binding protein 4 -0.033327
MRPS6 mitochondrial ribosomal protein S6 -0.0323704
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0317261
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0317169
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0312208
AOPEP aminopeptidase O (putative) -0.0309104
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0303201
TNS4 tensin 4 -0.0300849
FNDC3A fibronectin type III domain containing 3A -0.029888
KLF5 Kruppel-like factor 5 (intestinal) -0.0297213
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0296168
SERTAD2 SERTA domain containing 2 -0.0294771
CHD6 chromodomain helicase DNA binding protein 6 -0.0294349
ANLN anillin, actin binding protein -0.0290946
CDK6 cyclin-dependent kinase 6 -0.0286815
LOC112694756 uncharaterized LOC112694756 -0.0285711
ZNF217 zinc finger protein 217 -0.0275085
LRRC8C leucine rich repeat containing 8 family, member C -0.0274936
DPYD dihydropyrimidine dehydrogenase -0.02745
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0272791
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0271749
PLAT plasminogen activator, tissue -0.0271182
ATXN1 ataxin 1 -0.0270183
PRELID2 PRELI domain containing 2 -0.0268328
SEC31A SEC31 homolog A (S. cerevisiae) -0.0263826
LNPEP leucyl/cystinyl aminopeptidase -0.0261708
ANKRD33B ankyrin repeat domain 33B -0.0260598
SVIL supervillin -0.0260078
TBC1D5 TBC1 domain family, member 5 -0.0258965
GNAS GNAS complex locus -0.0255509
SULF2 sulfatase 2 -0.0251099
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0250451
VMP1 vacuole membrane protein 1 -0.0249878
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0248747
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0248173
PIBF1 progesterone immunomodulatory binding factor 1 -0.0245966
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0239875
DOCK4 dedicator of cytokinesis 4 -0.0237965
BHLHE40 basic helix-loop-helix family, member e40 -0.0237207
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0236957
DUSP4 dual specificity phosphatase 4 -0.0236618
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0235951
ZNFX1 zinc finger, NFX1-type containing 1 -0.0234636
MACF1 microtubule-actin crosslinking factor 1 -0.0234339
NAMPT nicotinamide phosphoribosyltransferase -0.0234174
DYNLRB1 dynein, light chain, roadblock-type 1 -0.023367
CDK17 cyclin-dependent kinase 17 -0.0232683
NBEA neurobeachin -0.023176
ADAM10 ADAM metallopeptidase domain 10 -0.0231598
SAMD9 sterile alpha motif domain containing 9 -0.0230922
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0230389