| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0264401 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0263671 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0228463 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0215533 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0215164 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0214595 |
| VCL | vinculin | 0.0211366 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0210234 |
| INTS6 | integrator complex subunit 6 | 0.0209526 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0204039 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0191603 |
| PM20D1 | peptidase M20 domain containing 1 | 0.018637 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0182078 |
| HOMER1 | homer scaffolding protein 1 | 0.0171942 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0171792 |
| PLEC | plectin | 0.0168835 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0162077 |
| MCL1 | myeloid cell leukemia 1 | 0.0161124 |
| SPAG9 | sperm associated antigen 9 | 0.0160522 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0157822 |
| LDHA | lactate dehydrogenase A | 0.0153907 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0135797 |
| TUFT1 | tuftelin 1 | 0.0128055 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0120864 |
| AREG | amphiregulin | 0.011597 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0114146 |
| SYAP1 | synapse associated protein 1 | 0.0107035 |
| SIK3 | SIK family kinase 3 | 0.0106634 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0106585 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0105434 |
| SFPQ | splicing factor proline/glutamine-rich | 0.010503 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.010217 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0098503 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.00970989 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00960354 |
| SLTM | SAFB-like, transcription modulator | 0.00958842 |
| SEPTIN10 | septin 10 | 0.00949913 |
| TOP1 | topoisomerase (DNA) I | 0.00945518 |
| IRS2 | insulin receptor substrate 2 | 0.0093331 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.00926914 |
| BMP6 | bone morphogenetic protein 6 | 0.00926697 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.00917001 |
| NME7 | NME/NM23 family member 7 | 0.00906848 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.00904622 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0089752 |
| DOCK1 | dedicator of cytokinesis 1 | 0.00891289 |
| FERMT2 | fermitin family member 2 | 0.00888948 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00874745 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.00830001 |
| GPATCH2L | G patch domain containing 2-like | 0.00828859 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00821807 |
| YTHDC1 | YTH domain containing 1 | 0.00817397 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.00810242 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.00797003 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.00789403 |
| RPS3 | ribosomal protein S3 | 0.00789286 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00770248 |
| EZR | ezrin | 0.00769857 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00752305 |
| RTN4 | reticulon 4 | 0.00744189 |
| TMEM184B | transmembrane protein 184B | 0.00736472 |
| DUSP6 | dual specificity phosphatase 6 | 0.00729263 |
| TLE4 | transducin-like enhancer of split 4 | 0.00728222 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.00718097 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.00706558 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.00705245 |
| RUNX1 | runt-related transcription factor 1 | 0.00700989 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.00698387 |
| OXSR1 | oxidative stress responsive 1 | 0.00670616 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.00660836 |
| AFDN | afadin, adherens junction formation factor | 0.00655592 |
| ERI2 | ERI1 exoribonuclease family member 2 | 0.00654967 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00652752 |
| WDR26 | WD repeat domain 26 | 0.00651583 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.00632162 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.00631177 |
| FLNA | filamin A, alpha | 0.00629069 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.00627888 |
| RPL3 | ribosomal protein L3 | 0.00627626 |
| FAT1 | FAT atypical cadherin 1 | 0.00623309 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.00614967 |
| STK38L | serine/threonine kinase 38 like | 0.00613383 |
| HDAC4 | histone deacetylase 4 | 0.00611447 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.00611267 |
| RRM2 | ribonucleotide reductase M2 | 0.00603928 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.00600952 |
| ACTN1 | actinin, alpha 1 | 0.00598269 |
| FTL | ferritin, light polypeptide | 0.00595444 |
| SON | SON DNA binding protein | 0.00593408 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.00590762 |
| MAGEA4 | melanoma antigen family A4 | 0.00583064 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.00575614 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.00575165 |
| MRPS35 | mitochondrial ribosomal protein S35 | 0.00573686 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.00572424 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0056814 |
| FNDC3A | fibronectin type III domain containing 3A | 0.00563334 |
| CCDC200 | coiled-coil domain containing 200 | 0.00558418 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00558163 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.00556217 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.253076 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.17946 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.15773 |
| TMSB10 | thymosin beta 10 | -0.126952 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0683419 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0672293 |
| NDRG1 | N-myc downstream regulated 1 | -0.0598755 |
| LAMC2 | laminin, gamma 2 | -0.0592677 |
| TXNRD1 | thioredoxin reductase 1 | -0.0587892 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.057457 |
| PKM | pyruvate kinase, muscle | -0.0569018 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0558107 |
| EFNA5 | ephrin-A5 | -0.0489599 |
| ANKRD12 | ankyrin repeat domain 12 | -0.045766 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0445893 |
| CST3 | cystatin C | -0.0434491 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.04211 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0418956 |
| S100A10 | S100 calcium binding protein A10 | -0.0404011 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0401759 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0397971 |
| ACTG1 | actin gamma 1 | -0.0386928 |
| KRT7 | keratin 7, type II | -0.0386848 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0370937 |
| LMO7 | LIM domain 7 | -0.0364436 |
| ANXA2 | annexin A2 | -0.0360765 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0352226 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0351943 |
| ASPH | aspartate beta-hydroxylase | -0.0351238 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0349444 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0345096 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0341128 |
| CES1 | carboxylesterase 1 | -0.0338871 |
| PTMA | prothymosin, alpha | -0.0333495 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0331299 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0321301 |
| HDLBP | high density lipoprotein binding protein | -0.031531 |
| RPS6 | ribosomal protein S6 | -0.0312206 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0306844 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0298017 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0296604 |
| EGR1 | early growth response 1 | -0.028041 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0269331 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0268699 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0267277 |
| AHNAK | AHNAK nucleoprotein | -0.0255585 |
| FAM13A | family with sequence similarity 13, member A | -0.0252989 |
| CCND1 | cyclin D1 | -0.0252798 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0246743 |
| RNF213 | ring finger protein 213 | -0.024485 |
| TMEM165 | transmembrane protein 165 | -0.0236241 |
| SMAD3 | SMAD family member 3 | -0.0230635 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0228864 |
| TNS3 | tensin 3 | -0.0227306 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0221728 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0221484 |
| RPLP1 | ribosomal protein, large, P1 | -0.0219303 |
| PARD3 | par-3 family cell polarity regulator | -0.0217686 |
| KRT8 | keratin 8, type II | -0.0216618 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0215996 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0214094 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0213335 |
| RAB10 | RAB10, member RAS oncogene family | -0.0210693 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.021025 |
| PDE8A | phosphodiesterase 8A | -0.0210239 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0208568 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0208146 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0207342 |
| RIN2 | Ras and Rab interactor 2 | -0.0206594 |
| HLA-B | major histocompatibility complex, class I, B | -0.0199617 |
| TRIM56 | tripartite motif containing 56 | -0.0198655 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0198144 |
| MT2A | metallothionein 2A | -0.019655 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0196298 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0194526 |
| TPD52 | tumor protein D52 | -0.0193469 |
| WASF2 | WAS protein family, member 2 | -0.0193348 |
| S100A9 | S100 calcium binding protein A9 | -0.0191331 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0189802 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0189214 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.018912 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0188158 |
| KRT18 | keratin 18, type I | -0.0187843 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.018767 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0187534 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0184997 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0184423 |
| CD99 | CD99 molecule | -0.0183976 |
| RPL34 | ribosomal protein L34 | -0.0183839 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0182352 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0177322 |
| H1-0 | H1.0 linker histone | -0.0176892 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0176816 |
| CAV2 | caveolin 2 | -0.0175414 |
| USP34 | ubiquitin specific peptidase 34 | -0.0172302 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0171556 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0168763 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0168412 |
| SLMAP | sarcolemma associated protein | -0.0168264 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0166726 |
