| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.250565 |
| GRAMD1B | GRAM domain containing 1B | 0.20332 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.161654 |
| VIM | vimentin | 0.0843004 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0714482 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0701348 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0677472 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.065928 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0618112 |
| B2M | beta-2-microglobulin | 0.0617253 |
| RPS12 | ribosomal protein S12 | 0.0591441 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0554404 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0511895 |
| ERBIN | erbb2 interacting protein | 0.0479173 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0474358 |
| TMSB4X | thymosin beta 4, X-linked | 0.0468336 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0455641 |
| TPM3 | tropomyosin 3 | 0.0448718 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0446801 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0442196 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0436919 |
| RPS21 | ribosomal protein S21 | 0.0431184 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0428722 |
| RPS3 | ribosomal protein S3 | 0.0416608 |
| RPS17 | ribosomal protein S17 | 0.041587 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.040778 |
| CENPF | centromere protein F, 350/400kDa | 0.0399345 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0398646 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0397129 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0393397 |
| RPL14 | ribosomal protein L14 | 0.0387281 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0378714 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0376845 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0373343 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0365096 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.036342 |
| RBM25 | RNA binding motif protein 25 | 0.0360395 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0360238 |
| FMNL2 | formin-like 2 | 0.0356816 |
| KIF5B | kinesin family member 5B | 0.0355195 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0354251 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0354067 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.035114 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.034915 |
| RRM2 | ribonucleotide reductase M2 | 0.0348557 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.034701 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0335292 |
| HDGF | hepatoma-derived growth factor | 0.0334129 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0331946 |
| RPS2 | ribosomal protein S2 | 0.0330098 |
| FAM107B | family with sequence similarity 107, member B | 0.0326994 |
| ANLN | anillin, actin binding protein | 0.0326585 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0320294 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0320186 |
| RPL37A | ribosomal protein L37a | 0.0315986 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0310551 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0309878 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0302822 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.030221 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0301103 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.0299953 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0297327 |
| WDR43 | WD repeat domain 43 | 0.0295285 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0293733 |
| PHIP | pleckstrin homology domain interacting protein | 0.0291765 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0291022 |
| PTK2 | protein tyrosine kinase 2 | 0.0289071 |
| RPL36AL | ribosomal protein L36a-like | 0.0287628 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0284668 |
| GOLGA4 | golgin A4 | 0.0284167 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0284038 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0283941 |
| RPS8 | ribosomal protein S8 | 0.0283126 |
| TPX2 | TPX2, microtubule-associated | 0.0279568 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0279506 |
| RPL37 | ribosomal protein L37 | 0.0278393 |
| MKI67 | marker of proliferation Ki-67 | 0.0277834 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0275997 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0275664 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.027184 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0271196 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0265843 |
| ECT2 | epithelial cell transforming 2 | 0.0264875 |
| NF1 | neurofibromin 1 | 0.0264228 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0262512 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0262064 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0260631 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0259834 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0259394 |
| PRR16 | proline rich 16 | 0.0259367 |
| TPD52 | tumor protein D52 | 0.0253593 |
| CMIP | c-Maf inducing protein | 0.0253576 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0253427 |
| UBE2V2 | ubiquitin-conjugating enzyme E2 variant 2 | 0.0251226 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0250289 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0244908 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0243071 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0242472 |
| CEP192 | centrosomal protein 192kDa | 0.0241077 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0239812 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.315082 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.150054 |
| POTEF | POTE ankyrin domain family, member F | -0.103841 |
| FTL | ferritin, light polypeptide | -0.102987 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0936843 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0899165 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0763593 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0722401 |
| STC1 | stanniocalcin 1 | -0.0686958 |
| RPLP1 | ribosomal protein, large, P1 | -0.0684592 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0646699 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0573203 |
| IGF2 | insulin-like growth factor 2 | -0.0567585 |
| RPLP0 | ribosomal protein, large, P0 | -0.0560124 |
| ANXA2 | annexin A2 | -0.0556907 |
| UBC | ubiquitin C | -0.0540495 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.052163 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0507843 |
| IER3 | immediate early response 3 | -0.0503797 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0454316 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0436655 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0425095 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0405497 |
| HMGA1 | high mobility group AT-hook 1 | -0.0395105 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0394169 |
| AHNAK | AHNAK nucleoprotein | -0.038817 |
| ACTG1 | actin gamma 1 | -0.0382544 |
| SQSTM1 | sequestosome 1 | -0.0377722 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0371289 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0369399 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0365943 |
| PKM | pyruvate kinase, muscle | -0.035623 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0355223 |
| TMSB10 | thymosin beta 10 | -0.0350202 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0348478 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0345426 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0321541 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0320126 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0317658 |
| RPS16 | ribosomal protein S16 | -0.0316296 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0307181 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.030332 |
| MCL1 | myeloid cell leukemia 1 | -0.0297735 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.029603 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0295687 |
| EGR1 | early growth response 1 | -0.0292032 |
| NDRG1 | N-myc downstream regulated 1 | -0.0288825 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0278002 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.027719 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0276956 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0270693 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0266029 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0263047 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0256947 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0254525 |
| FGG | fibrinogen gamma chain | -0.0253305 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0246226 |
| EXT1 | exostosin glycosyltransferase 1 | -0.024384 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0243709 |
| NABP1 | nucleic acid binding protein 1 | -0.024182 |
| CCNL1 | cyclin L1 | -0.0241249 |
| RPS20 | ribosomal protein S20 | -0.0240456 |
| RPS25 | ribosomal protein S25 | -0.0237573 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0237448 |
| INTS6 | integrator complex subunit 6 | -0.0237414 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0235764 |
| IL6 | interleukin 6 | -0.0234957 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0234259 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0232706 |
| RPL7 | ribosomal protein L7 | -0.0226406 |
| PARK7 | parkinson protein 7 | -0.0225987 |
| CDK6 | cyclin-dependent kinase 6 | -0.022543 |
| ARF1 | ADP-ribosylation factor 1 | -0.0224834 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.022192 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0221514 |
| CTSL | cathepsin L | -0.0219803 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0218519 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0218105 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0216601 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0214237 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0213924 |
| TXNRD1 | thioredoxin reductase 1 | -0.0213643 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0213468 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0212555 |
| TMEM87A | transmembrane protein 87A | -0.0212152 |
| ZFHX3 | zinc finger homeobox 3 | -0.0211011 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0207959 |
| RPS6 | ribosomal protein S6 | -0.020666 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0206125 |
| RPS24 | ribosomal protein S24 | -0.020576 |
| RPS5 | ribosomal protein S5 | -0.0203824 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0203784 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0203668 |
| MYOF | myoferlin | -0.0202435 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0201796 |
| S100A10 | S100 calcium binding protein A10 | -0.0200794 |
| UTRN | utrophin | -0.0200317 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0199455 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0199047 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0198283 |
