| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pentamidine (isethionate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.120114 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0805059 |
| EZR | ezrin | 0.0796107 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0777726 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0728144 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0639817 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0614735 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0607031 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0591624 |
| PLEC | plectin | 0.0555165 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.055299 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0544275 |
| RIGI | RNA sensor RIG-I | 0.0543522 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0538557 |
| COL6A3 | collagen, type VI, alpha 3 | 0.053609 |
| MYO10 | myosin X | 0.0534439 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0527776 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0520644 |
| SMAD3 | SMAD family member 3 | 0.051845 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0510502 |
| ATP11A | ATPase, class VI, type 11A | 0.0505328 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0491802 |
| APP | amyloid beta (A4) precursor protein | 0.0491677 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.048076 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0467778 |
| PTK2 | protein tyrosine kinase 2 | 0.0458836 |
| KRT18 | keratin 18, type I | 0.0450464 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0449043 |
| TLN1 | talin 1 | 0.0448315 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0441863 |
| RPS12 | ribosomal protein S12 | 0.0438835 |
| CDK6 | cyclin-dependent kinase 6 | 0.0426669 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0423512 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0417997 |
| YEATS2 | YEATS domain containing 2 | 0.0406757 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0390949 |
| PDE10A | phosphodiesterase 10A | 0.0390714 |
| VCL | vinculin | 0.0385419 |
| KIAA1958 | KIAA1958 | 0.0384758 |
| TP53BP2 | tumor protein p53 binding protein 2 | 0.0384108 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0381389 |
| SEPTIN9 | septin 9 | 0.0381023 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0380891 |
| PCBP2 | poly(rC) binding protein 2 | 0.0380665 |
| CMIP | c-Maf inducing protein | 0.0378012 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.03729 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0372144 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0368686 |
| YBX1 | Y box binding protein 1 | 0.0367237 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0365112 |
| CAPRIN2 | caprin family member 2 | 0.0364964 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0363497 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0363152 |
| NPTN | neuroplastin | 0.0362359 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0361722 |
| JUN | jun proto-oncogene | 0.0359471 |
| UVRAG | UV radiation resistance associated | 0.0352493 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0347085 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0344331 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0342931 |
| ATP13A3 | ATPase type 13A3 | 0.0341833 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0341823 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0340754 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0338299 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0338089 |
| NME7 | NME/NM23 family member 7 | 0.0335972 |
| ZNF609 | zinc finger protein 609 | 0.0333868 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0333142 |
| SLTM | SAFB-like, transcription modulator | 0.0328942 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0322619 |
| RPL4 | ribosomal protein L4 | 0.0320194 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0319656 |
| RND3 | Rho family GTPase 3 | 0.0319609 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0317755 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0316822 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0316655 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.031643 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0313462 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0312872 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0312267 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0311777 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0311252 |
| CHD6 | chromodomain helicase DNA binding protein 6 | 0.0310628 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0309542 |
| CHMP2B | charged multivesicular body protein 2B | 0.0308818 |
| NOP58 | NOP58 ribonucleoprotein | 0.0308455 |
| NAV2 | neuron navigator 2 | 0.0307766 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0304273 |
| RPS3 | ribosomal protein S3 | 0.0303725 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0303224 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0299701 |
| TCERG1 | transcription elongation regulator 1 | 0.029939 |
| PGK1 | phosphoglycerate kinase 1 | 0.0298315 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0297198 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0296176 |
| CCNY | cyclin Y | 0.0295232 |
| DIAPH3 | diaphanous-related formin 3 | 0.0294641 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0293815 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0292868 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0291739 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.193491 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.152283 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.147993 |
| ATOSA | atos homolog A | -0.126482 |
| GRB10 | growth factor receptor-bound protein 10 | -0.113666 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.10833 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.108325 |
| S100A9 | S100 calcium binding protein A9 | -0.106965 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0988795 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.098165 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0978202 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.096813 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0941047 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0913226 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0884947 |
| OSMR | oncostatin M receptor | -0.0847417 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0790197 |
| KRT17 | keratin 17, type I | -0.0743121 |
| SBF2 | SET binding factor 2 | -0.0734078 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0718163 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0708279 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0683736 |
| POTEF | POTE ankyrin domain family, member F | -0.0672725 |
| RPL19 | ribosomal protein L19 | -0.062822 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0626664 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0625857 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0624207 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0618756 |
| FNIP1 | folliculin interacting protein 1 | -0.061207 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0611679 |
| RAD51B | RAD51 paralog B | -0.0605495 |
| TXNIP | thioredoxin interacting protein | -0.0600371 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0586502 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.058562 |
| TXNRD1 | thioredoxin reductase 1 | -0.0578076 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0573468 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.057324 |
| TMSB10 | thymosin beta 10 | -0.0567468 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0564098 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.055599 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0547238 |
| RBM47 | RNA binding motif protein 47 | -0.0545079 |
| FN1 | fibronectin 1 | -0.0543226 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0527664 |
| LAMC2 | laminin, gamma 2 | -0.0520552 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0520528 |
| FMNL2 | formin-like 2 | -0.0493307 |
| MXD1 | MAX dimerization protein 1 | -0.0481265 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0475248 |
| TMEM87A | transmembrane protein 87A | -0.0472189 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0471468 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0468667 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0467882 |
| CDK13 | cyclin-dependent kinase 13 | -0.045817 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0456876 |
| PARD3 | par-3 family cell polarity regulator | -0.0443677 |
| GRAMD1B | GRAM domain containing 1B | -0.0440398 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0434002 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0426176 |
| HLA-A | major histocompatibility complex, class I, A | -0.0419276 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0417273 |
| FOXP1 | forkhead box P1 | -0.0409111 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0399502 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0395149 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0394722 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0392216 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0390195 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0389757 |
| FOXO3 | forkhead box O3 | -0.0386133 |
| RAI14 | retinoic acid induced 14 | -0.0382778 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0379813 |
| CCNI | cyclin I | -0.0375431 |
| WASF2 | WAS protein family, member 2 | -0.0375425 |
| RNF213 | ring finger protein 213 | -0.0374424 |
| S100A10 | S100 calcium binding protein A10 | -0.0371341 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0370547 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0365914 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0362822 |
| RREB1 | ras responsive element binding protein 1 | -0.0362052 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0361166 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0359308 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0357561 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0357543 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0356925 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0355699 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0353614 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0352545 |
| AHNAK | AHNAK nucleoprotein | -0.0350358 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.034831 |
| SLMAP | sarcolemma associated protein | -0.0347572 |
| KLF6 | Kruppel-like factor 6 | -0.0345685 |
| RSF1 | remodeling and spacing factor 1 | -0.034555 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0343369 |
| FBXO11 | F-box protein 11 | -0.0339361 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0339311 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0337891 |
| CSTB | cystatin B (stefin B) | -0.0336492 |
| ZNF638 | zinc finger protein 638 | -0.0335932 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0334695 |
| KYNU | kynureninase | -0.0334544 |
