Pentamidine (isethionate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.037541
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0122917
HMGB2 high mobility group box 2 0.00896015
RPS2 ribosomal protein S2 0.00829356
RPL35A ribosomal protein L35a 0.00764019
HILPDA hypoxia inducible lipid droplet-associated 0.00733665
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00659211
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00655246
RPS7 ribosomal protein S7 0.00623993
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00617177
RPL13A ribosomal protein L13a 0.00616163
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.00608158
COL6A1 collagen, type VI, alpha 1 0.00566591
RPL41 ribosomal protein L41 0.00541583
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00540305
BZW1 basic leucine zipper and W2 domains 1 0.00520294
RPL14 ribosomal protein L14 0.00510479
LRRC23 leucine rich repeat containing 23 0.00509075
EGR1 early growth response 1 0.00501231
GADD45B growth arrest and DNA-damage-inducible, beta 0.00493597
TPT1 tumor protein, translationally-controlled 1 0.00483383
AKAP12 A kinase (PRKA) anchor protein 12 0.00471436
RRM2 ribonucleotide reductase M2 0.00465048
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.00461713
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 0.00455801
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.00452155
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00447072
ZC3H3 zinc finger CCCH-type containing 3 0.00440527
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.00439479
CCDC200 coiled-coil domain containing 200 0.0043582
FGFR1 fibroblast growth factor receptor 1 0.00426396
MCL1 myeloid cell leukemia 1 0.00423976
FGFR2 fibroblast growth factor receptor 2 0.00422431
CDH13 cadherin 13 0.00420747
ERRFI1 ERBB receptor feedback inhibitor 1 0.00417865
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.00407612
B2M beta-2-microglobulin 0.00404994
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.00404709
COX6C cytochrome c oxidase subunit VIc 0.00403333
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.00399908
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.00399143
STC1 stanniocalcin 1 0.00392329
ZFYVE21 zinc finger, FYVE domain containing 21 0.00390393
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 0.00383309
CDPF1 cysteine-rich, DPF motif domain containing 1 0.00379633
LRRC75A leucine rich repeat containing 75A 0.00378626
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.00378581
ELOC elongin C 0.0037786
TOLLIP toll interacting protein 0.00376937
STPG4 sperm-tail PG-rich repeat containing 4 0.00373168
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.00373117
TIMP3 TIMP metallopeptidase inhibitor 3 0.00371409
PDE4D phosphodiesterase 4D, cAMP-specific 0.00370902
COX7B cytochrome c oxidase subunit VIIb 0.00370178
ZNF433 zinc finger protein 433 0.00367529
CYCS cytochrome c, somatic 0.00364809
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.00364706
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00364619
ZEB1 zinc finger E-box binding homeobox 1 0.00361796
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.00360457
UBE2I ubiquitin-conjugating enzyme E2I 0.00359698
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.00359387
SAFB2 scaffold attachment factor B2 0.00357837
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.00357736
COL6A3 collagen, type VI, alpha 3 0.00357523
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.00354215
LARS1 leucyl-tRNA synthetase 1 0.00353798
SOD2 superoxide dismutase 2, mitochondrial 0.00353544
AHDC1 AT hook, DNA binding motif, containing 1 0.00352066
DYNLL2 dynein, light chain, LC8-type 2 0.0035159
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00351046
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.00349796
AUTS2 autism susceptibility candidate 2 0.00349528
FAM53C family with sequence similarity 53, member C 0.00348716
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.00345793
MYLIP myosin regulatory light chain interacting protein 0.00344981
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.003436
RPL3 ribosomal protein L3 0.0034261
PNRC2 proline-rich nuclear receptor coactivator 2 0.00339958
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 0.00339025
MAT2A methionine adenosyltransferase II, alpha 0.00337833
ANKRD37 ankyrin repeat domain 37 0.00335633
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.00333064
FRMD4A FERM domain containing 4A 0.00331852
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 0.00331711
GCH1 GTP cyclohydrolase 1 0.00331707
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00331483
THAP12 THAP domain containing 12 0.00330384
IRF3 interferon regulatory factor 3 0.00328904
CALCOCO2 calcium binding and coiled-coil domain 2 0.00328596
H2AC6 H2A clustered histone 6 0.0032613
PTCHD4 patched domain containing 4 0.00325525
KPNA5 karyopherin alpha 5 (importin alpha 6) 0.00323995
SIRT2 sirtuin 2 0.00323991
CRYBG2 crystallin beta-gamma domain containing 2 0.00320754
FLII flightless I homolog (Drosophila) 0.00320656
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.00320382
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.00320134
GPN3 GPN-loop GTPase 3 0.0031983
CAB39L calcium binding protein 39-like 0.00319718

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182848
POTEF POTE ankyrin domain family, member F -0.168587
FN1 fibronectin 1 -0.16838
UBC ubiquitin C -0.145122
TMSB10 thymosin beta 10 -0.139928
ACTG1 actin gamma 1 -0.117984
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.110856
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0978448
PTMA prothymosin, alpha -0.0961186
LPP LIM domain containing preferred translocation partner in lipoma -0.0931453
NDRG1 N-myc downstream regulated 1 -0.0886825
FNDC3B fibronectin type III domain containing 3B -0.0868333
LIMCH1 LIM and calponin homology domains 1 -0.0752028
SAMD4A sterile alpha motif domain containing 4A -0.0724669
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.072345
ASPH aspartate beta-hydroxylase -0.0714672
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0645516
S100A6 S100 calcium binding protein A6 -0.0635969
FBXO32 F-box protein 32 -0.0621721
ERBIN erbb2 interacting protein -0.0591841
MYO6 myosin VI -0.0577086
EXT1 exostosin glycosyltransferase 1 -0.0573187
TRIO trio Rho guanine nucleotide exchange factor -0.0571356
GOLGA4 golgin A4 -0.0541248
KRT7 keratin 7, type II -0.0509272
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0499892
LMO7 LIM domain 7 -0.0485926
EFNA5 ephrin-A5 -0.0482841
ALCAM activated leukocyte cell adhesion molecule -0.0469548
ENO1 enolase 1, (alpha) -0.0469073
PTK2 protein tyrosine kinase 2 -0.0464051
CD2AP CD2-associated protein -0.0459012
NPEPPS aminopeptidase puromycin sensitive -0.0453387
FAM3C family with sequence similarity 3, member C -0.0445313
AHNAK AHNAK nucleoprotein -0.0444748
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0438998
P4HB prolyl 4-hydroxylase, beta polypeptide -0.043755
FTH1 ferritin, heavy polypeptide 1 -0.0436674
TM4SF1 transmembrane 4 L six family member 1 -0.043191
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0427367
DSCAM Down syndrome cell adhesion molecule -0.0422693
RBM25 RNA binding motif protein 25 -0.0415004
AKAP13 A kinase (PRKA) anchor protein 13 -0.0413263
PKM pyruvate kinase, muscle -0.0401411
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0399211
TOP1 topoisomerase (DNA) I -0.0394264
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0393624
SOX4 SRY (sex determining region Y)-box 4 -0.0384469
RPL8 ribosomal protein L8 -0.0381526
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0380225
STRN3 striatin, calmodulin binding protein 3 -0.0374934
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0368036
RBM39 RNA binding motif protein 39 -0.0367099
MDK midkine (neurite growth-promoting factor 2) -0.0366797
LY6E lymphocyte antigen 6 complex, locus E -0.0365721
PRRC2C proline-rich coiled-coil 2C -0.0364315
RCOR1 REST corepressor 1 -0.0363921
FTL ferritin, light polypeptide -0.0360693
PCBP2 poly(rC) binding protein 2 -0.0354473
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0347972
MAP4 microtubule-associated protein 4 -0.0347315
ZBTB20 zinc finger and BTB domain containing 20 -0.0344985
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0333613
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0332835
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0329726
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0328057
IFI27 interferon, alpha-inducible protein 27 -0.0327902
ADAM9 ADAM metallopeptidase domain 9 -0.0325264
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0321751
S100A10 S100 calcium binding protein A10 -0.0321235
NAV2 neuron navigator 2 -0.0320047
TMEM165 transmembrane protein 165 -0.0317085
RPS23 ribosomal protein S23 -0.0315963
CANX calnexin -0.031341
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0311076
SLC38A1 solute carrier family 38, member 1 -0.0310435
CALR calreticulin -0.0308532
SH3KBP1 SH3-domain kinase binding protein 1 -0.0307848
ZFAND3 zinc finger, AN1-type domain 3 -0.0306254
ITCH itchy E3 ubiquitin protein ligase -0.0305147
KMT2E lysine (K)-specific methyltransferase 2E -0.0302218
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0296147
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0295881
GNAS GNAS complex locus -0.0293613
COPA coatomer protein complex, subunit alpha -0.0293236
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0293045
KMT2C lysine (K)-specific methyltransferase 2C -0.0290395
CALU calumenin -0.0287724
RPS27A ribosomal protein S27a -0.0287165
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0285555
BASP1 brain abundant, membrane attached signal protein 1 -0.0284969
SEC31A SEC31 homolog A (S. cerevisiae) -0.0284201
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.028311
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0282392
MAP1B microtubule-associated protein 1B -0.0280601
UBE2H ubiquitin-conjugating enzyme E2H -0.0280513
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0279826
PGK1 phosphoglycerate kinase 1 -0.0278748
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0277343
WASF2 WAS protein family, member 2 -0.0276201