Pentamidine (isethionate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.083035
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0543318
TXNRD1 thioredoxin reductase 1 0.0538495
KTN1 kinectin 1 (kinesin receptor) 0.0504178
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0501807
B2M beta-2-microglobulin 0.0446907
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0419278
PTMA prothymosin, alpha 0.0410285
MT2A metallothionein 2A 0.0403145
ZNF292 zinc finger protein 292 0.037609
YBX1 Y box binding protein 1 0.0350571
TMEM41B transmembrane protein 41B 0.0336192
RPS12 ribosomal protein S12 0.0323799
GOLGA4 golgin A4 0.0302047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0293784
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0274251
PNISR PNN-interacting serine/arginine-rich protein 0.0261969
TRA2A transformer 2 alpha homolog (Drosophila) 0.0258758
WWTR1 WW domain containing transcription regulator 1 0.0252826
OGA O-GlcNAcase 0.0246958
SMAD3 SMAD family member 3 0.0245876
RPL37A ribosomal protein L37a 0.0243623
CDK19 cyclin-dependent kinase 19 0.0241283
ARRDC3 arrestin domain containing 3 0.0240397
RNF145 ring finger protein 145 0.0236917
RPS8 ribosomal protein S8 0.022487
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0220357
DGKD diacylglycerol kinase, delta 130kDa 0.021975
SET SET nuclear proto-oncogene 0.0210408
RPS2 ribosomal protein S2 0.0208642
NOP58 NOP58 ribonucleoprotein 0.0206114
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0205424
FTL ferritin, light polypeptide 0.0203886
RPS3 ribosomal protein S3 0.0201729
SPAG9 sperm associated antigen 9 0.0200932
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0196233
CHD1 chromodomain helicase DNA binding protein 1 0.0196223
ANGPTL4 angiopoietin-like 4 0.0194971
RB1CC1 RB1-inducible coiled-coil 1 0.0193391
RBM25 RNA binding motif protein 25 0.0191454
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0188782
DDIT4 DNA-damage-inducible transcript 4 0.0187889
MATR3 matrin 3 0.0187793
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187425
RTN4 reticulon 4 0.0185752
ARID4B AT rich interactive domain 4B (RBP1-like) 0.018156
RPLP2 ribosomal protein, large, P2 0.0181313
SUCO SUN domain containing ossification factor 0.0181191
FOSL1 FOS-like antigen 1 0.0180441
SNX14 sorting nexin 14 0.0178919
XPO1 exportin 1 0.0178142
JMJD1C jumonji domain containing 1C 0.0177433
NAMPT nicotinamide phosphoribosyltransferase 0.0176029
AFAP1 actin filament associated protein 1 0.0172138
ESYT2 extended synaptotagmin-like protein 2 0.017195
PCBP2 poly(rC) binding protein 2 0.0171384
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.016927
KMT2E lysine (K)-specific methyltransferase 2E 0.0167942
SEPTIN7 septin 7 0.0162483
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0161984
NAP1L1 nucleosome assembly protein 1-like 1 0.0160864
RPLP1 ribosomal protein, large, P1 0.0160077
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.015981
VEZT vezatin, adherens junctions transmembrane protein 0.015833
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0157975
EZR ezrin 0.0157772
SCAF11 SR-related CTD-associated factor 11 0.0157142
CALR calreticulin 0.0156832
RAB6A RAB6A, member RAS oncogene family 0.0154667
TBK1 TANK-binding kinase 1 0.0153905
ACBD3 acyl-CoA binding domain containing 3 0.0153751
S100A10 S100 calcium binding protein A10 0.0153608
SRP54 signal recognition particle 54kDa 0.0153596
HILPDA hypoxia inducible lipid droplet-associated 0.0152614
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0152034
TPM3 tropomyosin 3 0.0151536
PHIP pleckstrin homology domain interacting protein 0.0150809
DSTN destrin (actin depolymerizing factor) 0.0149783
APLP2 amyloid beta (A4) precursor-like protein 2 0.0148659
KDM2A lysine (K)-specific demethylase 2A 0.014858
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0145125
KDM5B lysine (K)-specific demethylase 5B 0.0144963
TNRC6A trinucleotide repeat containing 6A 0.0144409
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0140714
FAM13A family with sequence similarity 13, member A 0.0139576
TTC3 tetratricopeptide repeat domain 3 0.0138683
RSRC2 arginine/serine-rich coiled-coil 2 0.013708
PDIA3 protein disulfide isomerase family A, member 3 0.0136843
PRRC2C proline-rich coiled-coil 2C 0.0136751
PDE8A phosphodiesterase 8A 0.0136024
TFG TRK-fused gene 0.0135337
USP3 ubiquitin specific peptidase 3 0.0133234
SMAP1 small ArfGAP 1 0.0133076
PTEN phosphatase and tensin homolog 0.0132848
RPL36A ribosomal protein L36a 0.0132261
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.013172
AKAP9 A kinase (PRKA) anchor protein 9 0.0129992
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0129727
IRAK2 interleukin-1 receptor-associated kinase 2 0.0129691
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0128917

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.23456
AKAP12 A kinase (PRKA) anchor protein 12 -0.1556
AHNAK AHNAK nucleoprotein -0.127925
SLC35F3 solute carrier family 35, member F3 -0.117129
THSD4 thrombospondin, type I, domain containing 4 -0.101927
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.09851
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0921591
TRIO trio Rho guanine nucleotide exchange factor -0.0852638
EGFR epidermal growth factor receptor -0.0774977
DST dystonin -0.0707618
RPS16 ribosomal protein S16 -0.0628756
EGR1 early growth response 1 -0.0593414
TM4SF1 transmembrane 4 L six family member 1 -0.0586641
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0571492
ERRFI1 ERBB receptor feedback inhibitor 1 -0.055246
ACTG1 actin gamma 1 -0.0540406
MACF1 microtubule-actin crosslinking factor 1 -0.0539699
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0528887
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0521612
HMGA2 high mobility group AT-hook 2 -0.0513308
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0509008
ATG7 autophagy related 7 -0.0482845
INTS6 integrator complex subunit 6 -0.0479793
TPM1 tropomyosin 1 (alpha) -0.0469565
ATXN1 ataxin 1 -0.046846
MAP1B microtubule-associated protein 1B -0.0468418
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0442432
EXT1 exostosin glycosyltransferase 1 -0.0441098
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0438049
EHBP1 EH domain binding protein 1 -0.0436727
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0420065
LPP LIM domain containing preferred translocation partner in lipoma -0.0412858
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0411272
MCL1 myeloid cell leukemia 1 -0.04085
MYO1E myosin IE -0.040053
TMSB10 thymosin beta 10 -0.039742
CARD18 caspase recruitment domain family, member 18 -0.0369454
RASAL2 RAS protein activator like 2 -0.0369411
NUP98 nucleoporin 98kDa -0.0366724
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0342576
EXOC4 exocyst complex component 4 -0.0335764
ZSWIM6 zinc finger, SWIM-type containing 6 -0.032847
CTSD cathepsin D -0.0326069
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0320723
ZNF780B zinc finger protein 780B -0.0319096
SBF2 SET binding factor 2 -0.0315002
MSRB3 methionine sulfoxide reductase B3 -0.0313977
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0311033
IGF1R insulin-like growth factor 1 receptor -0.0307309
MAML3 mastermind-like 3 (Drosophila) -0.0306439
DIAPH2 diaphanous-related formin 2 -0.0302757
TNS3 tensin 3 -0.0301144
RPS24 ribosomal protein S24 -0.0298506
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0295796
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0288352
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.028506
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0284452
DOCK1 dedicator of cytokinesis 1 -0.0279468
H1-0 H1.0 linker histone -0.0279228
ASPH aspartate beta-hydroxylase -0.0277926
UBASH3B ubiquitin associated and SH3 domain containing B -0.0274734
NCOA7 nuclear receptor coactivator 7 -0.0273966
RNF213 ring finger protein 213 -0.0272792
ZNF407 zinc finger protein 407 -0.0272041
PDLIM5 PDZ and LIM domain 5 -0.0267209
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0265459
ZFAND3 zinc finger, AN1-type domain 3 -0.0264139
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262863
SLC38A2 solute carrier family 38, member 2 -0.0259902
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0255378
NF1 neurofibromin 1 -0.0255033
NPAS2 neuronal PAS domain protein 2 -0.0253473
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.025212
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0249795
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0248653
HDAC9 histone deacetylase 9 -0.024791
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0241676
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0240674
TCF12 transcription factor 12 -0.0236685
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0236671
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.023501
RSU1 Ras suppressor protein 1 -0.0231128
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0231017
ZNF644 zinc finger protein 644 -0.0230991
SAMD4A sterile alpha motif domain containing 4A -0.0228963
RNF220 ring finger protein 220 -0.022838
TTC28 tetratricopeptide repeat domain 28 -0.0227677
BMAL2 basic helix-loop-helix ARNT like 2 -0.0226569
SDK1 sidekick cell adhesion molecule 1 -0.0223936
SYT1 synaptotagmin I -0.0220654
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0219623
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0215848
DSCAM Down syndrome cell adhesion molecule -0.021581
FHL2 four and a half LIM domains 2 -0.0215717
TRIP12 thyroid hormone receptor interactor 12 -0.0214988
THSD7A thrombospondin, type I, domain containing 7A -0.0214253
SAMD4B sterile alpha motif domain containing 4B -0.0214114
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0213564
UBC ubiquitin C -0.0210404
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0210065