Pentamidine (isethionate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.0882338
TMSB4X thymosin beta 4, X-linked 0.0867271
B2M beta-2-microglobulin 0.0770821
IGFBP3 insulin-like growth factor binding protein 3 0.0674431
TMSB10 thymosin beta 10 0.0633931
VIM vimentin 0.0584329
ASPH aspartate beta-hydroxylase 0.0540214
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0475886
KTN1 kinectin 1 (kinesin receptor) 0.0431165
G0S2 G0/G1 switch 2 0.0420948
FMNL2 formin-like 2 0.0417269
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0394861
TPM4 tropomyosin 4 0.0391661
MAML2 mastermind-like 2 (Drosophila) 0.0388347
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0383752
EHBP1 EH domain binding protein 1 0.0377257
RPS8 ribosomal protein S8 0.0368769
LOC102724023 ES1 protein homolog, mitochondrial 0.0356873
WFDC2 WAP four-disulfide core domain 2 0.0356577
FRMD5 FERM domain containing 5 0.0345138
RPS12 ribosomal protein S12 0.0320936
SKAP2 src kinase associated phosphoprotein 2 0.031657
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0314931
MT2A metallothionein 2A 0.030952
PTMA prothymosin, alpha 0.0308561
GNPDA1 glucosamine-6-phosphate deaminase 1 0.030588
RPL14 ribosomal protein L14 0.0305314
SOX4 SRY (sex determining region Y)-box 4 0.0299121
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0297038
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296472
ESYT2 extended synaptotagmin-like protein 2 0.0294244
NPEPPS aminopeptidase puromycin sensitive 0.0293513
BACE2 beta-site APP-cleaving enzyme 2 0.0290356
AKAP12 A kinase (PRKA) anchor protein 12 0.0287334
RPS27 ribosomal protein S27 0.0281285
RPS17 ribosomal protein S17 0.0272362
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.027151
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0264546
KDM5B lysine (K)-specific demethylase 5B 0.0257207
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0257134
NCOR2 nuclear receptor corepressor 2 0.0255977
HLA-A major histocompatibility complex, class I, A 0.0255755
FTH1 ferritin, heavy polypeptide 1 0.0254698
KRT8 keratin 8, type II 0.0253363
S100A10 S100 calcium binding protein A10 0.0248491
RPL13A ribosomal protein L13a 0.0247636
CARD11 caspase recruitment domain family, member 11 0.0247325
EMP1 epithelial membrane protein 1 0.0244939
SVIL supervillin 0.0244179
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0239994
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.023769
EFNA5 ephrin-A5 0.0237303
RPS14 ribosomal protein S14 0.0235153
KPNB1 karyopherin (importin) beta 1 0.0234459
DLG1 discs, large homolog 1 (Drosophila) 0.0233919
FN1 fibronectin 1 0.0231392
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0229913
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0228568
DDIT4 DNA-damage-inducible transcript 4 0.0228453
N4BP2L2 NEDD4 binding protein 2-like 2 0.0227441
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0227371
LMO7 LIM domain 7 0.0226475
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0225976
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0225066
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0224445
CD46 CD46 molecule, complement regulatory protein 0.0221433
RAI1 retinoic acid induced 1 0.0218335
RPL36A ribosomal protein L36a 0.0217118
ITGA6 integrin, alpha 6 0.0215194
RPS19 ribosomal protein S19 0.0214652
TBC1D5 TBC1 domain family, member 5 0.0209829
HMGA2 high mobility group AT-hook 2 0.0206431
ARHGAP10 Rho GTPase activating protein 10 0.0204339
INHBA inhibin, beta A 0.0201538
SET SET nuclear proto-oncogene 0.0198562
PLEC plectin 0.0194166
DYNC2I1 dynein 2 intermediate chain 1 0.0194091
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0193554
RPL37A ribosomal protein L37a 0.0192859
RPS29 ribosomal protein S29 0.0192741
DST dystonin 0.0190706
NFE2L1 nuclear factor, erythroid 2-like 1 0.0188858
RPL23 ribosomal protein L23 0.0187947
BTG1 B-cell translocation gene 1, anti-proliferative 0.0186784
RPLP2 ribosomal protein, large, P2 0.018674
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0185823
TMEM51 transmembrane protein 51 0.0184994
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0184365
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0182242
RPS6 ribosomal protein S6 0.0179923
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0179119
KDM2A lysine (K)-specific demethylase 2A 0.0178915
ARHGAP21 Rho GTPase activating protein 21 0.0176699
PDE8A phosphodiesterase 8A 0.0176266
SACK1A scaffolding CK1 anchoring protein A 0.0176262
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0176222
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0173594
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0171708
LIMCH1 LIM and calponin homology domains 1 0.0171341
RUNX1 runt-related transcription factor 1 0.0168242

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.263997
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.112448
DSG2 desmoglein 2 -0.104672
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0951418
TPT1 tumor protein, translationally-controlled 1 -0.0841203
MUC4 mucin 4, cell surface associated -0.0833677
FAM3C family with sequence similarity 3, member C -0.0773936
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0731136
FNDC3B fibronectin type III domain containing 3B -0.0727293
WWC1 WW and C2 domain containing 1 -0.072379
CANX calnexin -0.0707741
CLTC clathrin, heavy chain (Hc) -0.0701918
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0689945
CCNL1 cyclin L1 -0.0678632
KRT19 keratin 19, type I -0.0648035
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0623084
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.060729
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0605049
ARHGAP26 Rho GTPase activating protein 26 -0.0589531
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0572786
SPAG9 sperm associated antigen 9 -0.0570346
LAMC2 laminin, gamma 2 -0.0569184
RYBP RING1 and YY1 binding protein -0.0561596
MKI67 marker of proliferation Ki-67 -0.0552569
POTEF POTE ankyrin domain family, member F -0.0551705
RBM39 RNA binding motif protein 39 -0.0542407
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0540173
SMAD3 SMAD family member 3 -0.0525987
AFDN afadin, adherens junction formation factor -0.052348
ZFAND3 zinc finger, AN1-type domain 3 -0.0521697
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0518655
VCL vinculin -0.0511294
PCLO piccolo presynaptic cytomatrix protein -0.050384
IL6ST interleukin 6 signal transducer -0.0499726
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0494289
PICALM phosphatidylinositol binding clathrin assembly protein -0.049294
THBS1 thrombospondin 1 -0.0481917
NIPBL Nipped-B homolog (Drosophila) -0.0481049
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0478409
DIAPH3 diaphanous-related formin 3 -0.0472458
TSC22D2 TSC22 domain family, member 2 -0.0466418
INTS6 integrator complex subunit 6 -0.046312
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0461856
MACF1 microtubule-actin crosslinking factor 1 -0.0459101
ATP13A3 ATPase type 13A3 -0.0458207
LAMA4 laminin, alpha 4 -0.0453489
NAMPT nicotinamide phosphoribosyltransferase -0.0450247
NDRG1 N-myc downstream regulated 1 -0.0447015
NAP1L1 nucleosome assembly protein 1-like 1 -0.0445546
ECT2 epithelial cell transforming 2 -0.0442812
NRIP1 nuclear receptor interacting protein 1 -0.0442638
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0438453
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0434759
TRA2B transformer 2 beta homolog (Drosophila) -0.042806
BIRC3 baculoviral IAP repeat containing 3 -0.0426875
H1-4 H1.4 linker histone, cluster member -0.0425626
RPS24 ribosomal protein S24 -0.0425187
NCEH1 neutral cholesterol ester hydrolase 1 -0.0414766
SENP6 SUMO1/sentrin specific peptidase 6 -0.0411579
TNIP1 TNFAIP3 interacting protein 1 -0.0405632
KDM6A lysine (K)-specific demethylase 6A -0.040356
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0402968
UBE2H ubiquitin-conjugating enzyme E2H -0.0402744
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0402394
OSBPL3 oxysterol binding protein-like 3 -0.0399909
KRT17 keratin 17, type I -0.0399466
SHROOM3 shroom family member 3 -0.0396762
MBNL1 muscleblind-like splicing regulator 1 -0.0395233
ETNK1 ethanolamine kinase 1 -0.0392952
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.039186
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.038755
STAT1 signal transducer and activator of transcription 1, 91kDa -0.038627
RPS2 ribosomal protein S2 -0.0385236
ARRDC3 arrestin domain containing 3 -0.0377553
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0377244
TM4SF1 transmembrane 4 L six family member 1 -0.0376831
KLF5 Kruppel-like factor 5 (intestinal) -0.0376781
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0376644
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0376602
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0376464
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0375338
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0372121
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0371668
LIMA1 LIM domain and actin binding 1 -0.0371644
RCOR1 REST corepressor 1 -0.0369392
ARL15 ADP-ribosylation factor-like 15 -0.0368796
KDM3A lysine (K)-specific demethylase 3A -0.0365989
KRT18 keratin 18, type I -0.0362898
MAPK8 mitogen-activated protein kinase 8 -0.0362808
ELL2 elongation factor, RNA polymerase II, 2 -0.0362026
DSPP dentin sialophosphoprotein -0.0360404
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0352412
TFRC transferrin receptor -0.0350195
EIF1 eukaryotic translation initiation factor 1 -0.0349803
ANLN anillin, actin binding protein -0.0348777
TPI1 triosephosphate isomerase 1 -0.0347513
ARHGAP29 Rho GTPase activating protein 29 -0.0346563
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0345787
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0345097
ACTN4 actinin, alpha 4 -0.0344343