Pentamidine (isethionate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.137498
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.122579
ELL2 elongation factor, RNA polymerase II, 2 0.0822682
MT2A metallothionein 2A 0.0810685
LPP LIM domain containing preferred translocation partner in lipoma 0.0729602
FRMD4A FERM domain containing 4A 0.0722993
FLNB filamin B, beta 0.0712446
ZNF438 zinc finger protein 438 0.0712135
EEF2 eukaryotic translation elongation factor 2 0.0678512
PBX3 pre-B-cell leukemia homeobox 3 0.0676877
NAP1L1 nucleosome assembly protein 1-like 1 0.0667068
RPS8 ribosomal protein S8 0.0628565
CALD1 caldesmon 1 0.0581601
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0576817
NAV3 neuron navigator 3 0.0574903
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0552841
LAMB3 laminin, beta 3 0.0539473
BNC2 basonuclin 2 0.0528076
HDAC9 histone deacetylase 9 0.0527208
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0511486
RAD51B RAD51 paralog B 0.0491462
RPL14 ribosomal protein L14 0.0488467
TPM4 tropomyosin 4 0.0476067
AKAP9 A kinase (PRKA) anchor protein 9 0.0462661
HMGA2 high mobility group AT-hook 2 0.046122
RPS6 ribosomal protein S6 0.0457022
MTDH metadherin 0.0441326
ZNF292 zinc finger protein 292 0.0429282
DLC1 DLC1 Rho GTPase activating protein 0.0410404
FHIT fragile histidine triad 0.0403509
SET SET nuclear proto-oncogene 0.0400256
IARS1 isoleucyl-tRNA synthetase 1 0.0398527
OSBPL8 oxysterol binding protein-like 8 0.0397241
BIRC6 baculoviral IAP repeat containing 6 0.0396608
ZBTB20 zinc finger and BTB domain containing 20 0.0383693
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0369556
KTN1 kinectin 1 (kinesin receptor) 0.0367774
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.03584
C2CD2 C2 calcium-dependent domain containing 2 0.0358177
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0344241
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.029909
SAMD12 sterile alpha motif domain containing 12 0.0294176
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0291577
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0289499
DGKI diacylglycerol kinase, iota 0.0289265
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0280803
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0278445
PTPRF protein tyrosine phosphatase, receptor type, F 0.0271524
NAV2 neuron navigator 2 0.0269254
PHF3 PHD finger protein 3 0.0268615
FTL ferritin, light polypeptide 0.0266149
BTBD9 BTB (POZ) domain containing 9 0.0265622
EXOC4 exocyst complex component 4 0.0263099
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0262214
SRRM2 serine/arginine repetitive matrix 2 0.0261732
FAM162A family with sequence similarity 162, member A 0.0261558
PRRC2C proline-rich coiled-coil 2C 0.0259665
GCC2 GRIP and coiled-coil domain containing 2 0.0259317
MXI1 MAX interactor 1, dimerization protein 0.0248523
RPL18 ribosomal protein L18 0.0247022
MT1X metallothionein 1X 0.0245623
PIAS2 protein inhibitor of activated STAT, 2 0.0242769
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0238737
CD46 CD46 molecule, complement regulatory protein 0.02382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0235481
TMEM41B transmembrane protein 41B 0.0234345
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0233844
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0230317
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0228072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0227264
TBC1D5 TBC1 domain family, member 5 0.0225944
EEF1G eukaryotic translation elongation factor 1 gamma 0.0224569
MSI2 musashi RNA-binding protein 2 0.0224405
BLZF1 basic leucine zipper nuclear factor 1 0.0220396
TLK1 tousled-like kinase 1 0.0216951
ZNF146 zinc finger protein 146 0.021474
BABAM2 BRISC and BRCA1 A complex member 2 0.0213348
RPL30 ribosomal protein L30 0.0212749
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0212057
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0211838
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0211206
WDFY3 WD repeat and FYVE domain containing 3 0.0210156
RPL26 ribosomal protein L26 0.0208396
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0208139
CALR calreticulin 0.0206672
DLG1 discs, large homolog 1 (Drosophila) 0.020391
SMC4 structural maintenance of chromosomes 4 0.0202703
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0200366
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0199951
PCBP2 poly(rC) binding protein 2 0.0199529
S100A2 S100 calcium binding protein A2 0.0198977
SMC3 structural maintenance of chromosomes 3 0.0198569
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0198413
FOXD1 forkhead box D1 0.0197343
SBF2 SET binding factor 2 0.0196352
MED13L mediator complex subunit 13-like 0.0195826
SQSTM1 sequestosome 1 0.0195399
TCEA1 transcription elongation factor A (SII), 1 0.0192524
FMNL2 formin-like 2 0.0191364
EIF3A eukaryotic translation initiation factor 3, subunit A 0.01913

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.120366
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0985698
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0892419
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0844353
POTEF POTE ankyrin domain family, member F -0.0812759
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0615763
RPL7 ribosomal protein L7 -0.0516025
UBC ubiquitin C -0.049867
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0496361
AHNAK AHNAK nucleoprotein -0.044783
BIRC2 baculoviral IAP repeat containing 2 -0.0436686
TXNRD1 thioredoxin reductase 1 -0.0430262
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0429927
ATP13A3 ATPase type 13A3 -0.0409756
MCTP1 multiple C2 domains, transmembrane 1 -0.0405349
RBM39 RNA binding motif protein 39 -0.0400344
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0399414
EXT1 exostosin glycosyltransferase 1 -0.0394808
RPL11 ribosomal protein L11 -0.0394615
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0384049
CD44 CD44 molecule (Indian blood group) -0.0371238
CLTC clathrin, heavy chain (Hc) -0.037115
NABP1 nucleic acid binding protein 1 -0.0359538
RAD21 RAD21 homolog (S. pombe) -0.03586
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0351927
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0351825
GPHN gephyrin -0.0351431
SPAG9 sperm associated antigen 9 -0.0350358
PKM pyruvate kinase, muscle -0.03482
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.034671
SPRY4 sprouty homolog 4 (Drosophila) -0.0342259
KMT2E lysine (K)-specific methyltransferase 2E -0.0336332
TOP1 topoisomerase (DNA) I -0.0327742
PRRC2B proline-rich coiled-coil 2B -0.032693
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0326401
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0326327
ADAR adenosine deaminase, RNA-specific -0.0323911
CREB5 cAMP responsive element binding protein 5 -0.0320782
MYH9 myosin, heavy chain 9, non-muscle -0.0319643
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0319026
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0308478
KDM6A lysine (K)-specific demethylase 6A -0.0308236
SAMD9 sterile alpha motif domain containing 9 -0.0301111
RPS2 ribosomal protein S2 -0.0296059
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0293576
TASOR2 transcription activation suppressor family member 2 -0.0292203
AKAP12 A kinase (PRKA) anchor protein 12 -0.0292067
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0291796
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0290154
AGO2 argonaute RISC catalytic component 2 -0.0286747
SCLT1 sodium channel and clathrin linker 1 -0.0279341
RECQL RecQ helicase-like -0.0276252
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0273868
H1-4 H1.4 linker histone, cluster member -0.0272946
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0271492
ECPAS Ecm29 proteasome adaptor and scaffold -0.0269565
RPS20 ribosomal protein S20 -0.0269329
TARS1 threonyl-tRNA synthetase 1 -0.0265432
PDE4D phosphodiesterase 4D, cAMP-specific -0.0262895
FUBP3 far upstream element (FUSE) binding protein 3 -0.0260124
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0258427
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0255456
KAT6A K(lysine) acetyltransferase 6A -0.0255149
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0254414
RPL38 ribosomal protein L38 -0.0252022
TPT1 tumor protein, translationally-controlled 1 -0.025041
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0248363
ATP5F1B ATP synthase F1 subunit beta -0.024718
BHLHE40 basic helix-loop-helix family, member e40 -0.0247129
BRD4 bromodomain containing 4 -0.0246909
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0245782
RUNX1 runt-related transcription factor 1 -0.0244354
PAPOLA poly(A) polymerase alpha -0.0242433
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0242127
TM4SF1 transmembrane 4 L six family member 1 -0.0241859
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0241754
SGMS2 sphingomyelin synthase 2 -0.0241445
SAMD4A sterile alpha motif domain containing 4A -0.0240553
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0239899
RCC1 regulator of chromosome condensation 1 -0.0239294
TUBB4B tubulin, beta 4B class IVb -0.0238203
RAB10 RAB10, member RAS oncogene family -0.0238191
EIF1 eukaryotic translation initiation factor 1 -0.0238152
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0237719
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0236285
CDCP1 CUB domain containing protein 1 -0.0234063
ZFAND3 zinc finger, AN1-type domain 3 -0.0233265
TPX2 TPX2, microtubule-associated -0.0233118
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0229666
WAPL WAPL cohesin release factor -0.0227873
PA2G4 proliferation-associated 2G4, 38kDa -0.022709
KDM5A lysine (K)-specific demethylase 5A -0.0225918
GNAS GNAS complex locus -0.0225447
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0223748
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0223478
RNF24 ring finger protein 24 -0.0223067
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0222319
PUM2 pumilio RNA-binding family member 2 -0.022131
RIOK3 RIO kinase 3 -0.0220952
SPIDR scaffolding protein involved in DNA repair -0.0220553