| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | 0.0340303 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.030789 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.0286505 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0249213 |
| SNTG1 | syntrophin, gamma 1 | 0.024023 |
| GPC5 | glypican 5 | 0.0225054 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0223783 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0205775 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | 0.020156 |
| TMSB4X | thymosin beta 4, X-linked | 0.0199769 |
| ESRRG | estrogen-related receptor gamma | 0.0198021 |
| RIT2 | Ras-like without CAAX 2 | 0.0191305 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0183447 |
| RORA | RAR-related orphan receptor A | 0.0164853 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | 0.0163407 |
| KIF26B | kinesin family member 26B | 0.0162323 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0154083 |
| GPC6 | glypican 6 | 0.0151505 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0150694 |
| SCG2 | secretogranin II | 0.014564 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0144463 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0142417 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0141596 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0133289 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0124572 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0123116 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0117568 |
| LRFN2 | leucine rich repeat and fibronectin type III domain containing 2 | 0.0114456 |
| NELL1 | NEL-like 1 (chicken) | 0.0112811 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0111634 |
| NBEA | neurobeachin | 0.0103651 |
| NDRG1 | N-myc downstream regulated 1 | 0.010257 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0100943 |
| MMP26 | matrix metallopeptidase 26 | 0.0100807 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | 0.00993171 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.00981351 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | 0.00962853 |
| KLHL29 | kelch-like family member 29 | 0.00897982 |
| PAEP | progestagen-associated endometrial protein | 0.00894541 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.00892758 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.00887744 |
| FN1 | fibronectin 1 | 0.00864804 |
| F2RL3 | coagulation factor II (thrombin) receptor-like 3 | 0.00840731 |
| CNKSR3 | CNKSR family member 3 | 0.00840274 |
| CREB5 | cAMP responsive element binding protein 5 | 0.00839965 |
| MYT1L | myelin transcription factor 1-like | 0.00836273 |
| SVIL | supervillin | 0.0082014 |
| PLXNA2 | plexin A2 | 0.00813825 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.00810377 |
| RPL35A | ribosomal protein L35a | 0.0080527 |
| SCFD1 | sec1 family domain containing 1 | 0.00797683 |
| EGFR | epidermal growth factor receptor | 0.00783351 |
| GRB10 | growth factor receptor-bound protein 10 | 0.00782314 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0076878 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | 0.00760471 |
| NAV2 | neuron navigator 2 | 0.0075234 |
| BDKRB2 | bradykinin receptor B2 | 0.00741415 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.00741179 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 0.00738457 |
| PCED1B | PC-esterase domain containing 1B | 0.00719613 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.00713686 |
| FAM13A | family with sequence similarity 13, member A | 0.00709147 |
| TNS3 | tensin 3 | 0.00702934 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.00699095 |
| EFNA5 | ephrin-A5 | 0.00690933 |
| RAB3B | RAB3B, member RAS oncogene family | 0.00679229 |
| FHIT | fragile histidine triad | 0.00670883 |
| AGMO | alkylglycerol monooxygenase | 0.00664914 |
| SLC8A3 | solute carrier family 8 (sodium/calcium exchanger), member 3 | 0.00648399 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | 0.00645552 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0063748 |
| HDAC9 | histone deacetylase 9 | 0.00625057 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.00612036 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00611322 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.00607305 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | 0.00602718 |
| SEC24A | SEC24 family member A | 0.00591852 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0057968 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.00577766 |
| EPHA4 | EPH receptor A4 | 0.00564947 |
| PTPRT | protein tyrosine phosphatase, receptor type, T | 0.00563164 |
| NDST4 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 | 0.00555162 |
| VIM | vimentin | 0.00551878 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.00550806 |
| KIAA1671 | KIAA1671 | 0.00550691 |
| CHGB | chromogranin B | 0.00543598 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.00541069 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00536604 |
| KCND3 | potassium channel, voltage gated Shal related subfamily D, member 3 | 0.00531292 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | 0.00530234 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.00523786 |
| KCNMB4 | potassium channel subfamily M regulatory beta subunit 4 | 0.00511035 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.00508903 |
| YAP1 | Yes-associated protein 1 | 0.00503536 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.00502526 |
| DGKB | diacylglycerol kinase, beta 90kDa | 0.00502314 |
| RGS4 | regulator of G-protein signaling 4 | 0.00502224 |
| EPHA6 | EPH receptor A6 | 0.0049968 |
| RALYL | RALY RNA binding protein-like | 0.00498426 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.00497775 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.213431 |
| ENO1 | enolase 1, (alpha) | -0.112538 |
| TENM1 | teneurin transmembrane protein 1 | -0.0920281 |
| PTMA | prothymosin, alpha | -0.0918895 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.081156 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0774598 |
| VGF | VGF nerve growth factor inducible | -0.0719583 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0666184 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0648519 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0624876 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0622388 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0614589 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0564207 |
| UBC | ubiquitin C | -0.0559883 |
| RPS27A | ribosomal protein S27a | -0.0556398 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0520456 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0508642 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0466813 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0455521 |
| PEG10 | paternally expressed 10 | -0.0449847 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0442034 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0424992 |
| MATR3 | matrin 3 | -0.0420589 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0412252 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0411921 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0404946 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0401585 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0390345 |
| PCBP2 | poly(rC) binding protein 2 | -0.0389454 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0388384 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0385213 |
| PKM | pyruvate kinase, muscle | -0.0376598 |
| CENPF | centromere protein F, 350/400kDa | -0.0372419 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0343353 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0324091 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0312271 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0310853 |
| RPS3 | ribosomal protein S3 | -0.0310129 |
| SMC1A | structural maintenance of chromosomes 1A | -0.0308758 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0300429 |
| TPM3 | tropomyosin 3 | -0.0300399 |
| SET | SET nuclear proto-oncogene | -0.0299654 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0298963 |
| POTEF | POTE ankyrin domain family, member F | -0.0297622 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0297297 |
| FAT1 | FAT atypical cadherin 1 | -0.0295539 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0292633 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0289373 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0286533 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0281024 |
| RPL23 | ribosomal protein L23 | -0.027752 |
| MED13L | mediator complex subunit 13-like | -0.0275395 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0274029 |
| CALCA | calcitonin-related polypeptide alpha | -0.0273301 |
| PCM1 | pericentriolar material 1 | -0.0265564 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0262136 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0261127 |
| MCL1 | myeloid cell leukemia 1 | -0.0258601 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0256007 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0252102 |
| PRPF8 | pre-mRNA processing factor 8 | -0.0246567 |
| XPO1 | exportin 1 | -0.0246444 |
| TPX2 | TPX2, microtubule-associated | -0.02463 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0245396 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.023943 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0237909 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.023423 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0231172 |
| INHBA | inhibin, beta A | -0.0225838 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0225451 |
| MKI67 | marker of proliferation Ki-67 | -0.0224938 |
| ZNF292 | zinc finger protein 292 | -0.0223685 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0222372 |
| HMGB2 | high mobility group box 2 | -0.0220863 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0220629 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0220532 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0218794 |
| FTL | ferritin, light polypeptide | -0.0218319 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0217517 |
| LDHA | lactate dehydrogenase A | -0.0216438 |
| RTN4 | reticulon 4 | -0.0215337 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0213605 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0213135 |
| RPL26 | ribosomal protein L26 | -0.0213058 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0212212 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0208511 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0207094 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0206705 |
| CADM1 | cell adhesion molecule 1 | -0.0205104 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0205003 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0204618 |
| DST | dystonin | -0.0201344 |
| CPE | carboxypeptidase E | -0.0200851 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0200058 |
| PCBP3 | poly(rC) binding protein 3 | -0.0199979 |
| PTK2 | protein tyrosine kinase 2 | -0.0199949 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0199947 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0199372 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0199123 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0198733 |
