Pentamidine (isethionate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.22268
NLGN1 neuroligin 1 0.196701
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.144149
VIM vimentin 0.133732
AKAP12 A kinase (PRKA) anchor protein 12 0.130349
LSAMP limbic system-associated membrane protein 0.116356
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0836657
FHIT fragile histidine triad 0.0700593
RAD51B RAD51 paralog B 0.0666878
NRG3 neuregulin 3 0.0644973
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0586758
EHBP1 EH domain binding protein 1 0.0549053
IGFBP3 insulin-like growth factor binding protein 3 0.0547346
SLC39A11 solute carrier family 39, member 11 0.0542617
ANGPTL4 angiopoietin-like 4 0.0531401
LINGO2 leucine rich repeat and Ig domain containing 2 0.0506011
RPS3 ribosomal protein S3 0.0487741
PRELID2 PRELI domain containing 2 0.0447555
KDM4C lysine (K)-specific demethylase 4C 0.0410062
RPS6 ribosomal protein S6 0.0408149
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0407227
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0386693
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.036485
SEPTIN9 septin 9 0.0360343
RPS12 ribosomal protein S12 0.0357113
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0353532
ZBTB20 zinc finger and BTB domain containing 20 0.0351011
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0349124
PHF14 PHD finger protein 14 0.0337452
RPS8 ribosomal protein S8 0.0335989
SREBF2 sterol regulatory element binding transcription factor 2 0.0333692
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0332175
ZNF638 zinc finger protein 638 0.03277
FMNL2 formin-like 2 0.0326223
JMJD1C jumonji domain containing 1C 0.032399
MMP12 matrix metallopeptidase 12 0.0322303
SQSTM1 sequestosome 1 0.0319625
FOXP1 forkhead box P1 0.0312204
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0311876
BACE2 beta-site APP-cleaving enzyme 2 0.0306928
SET SET nuclear proto-oncogene 0.0305867
CADM1 cell adhesion molecule 1 0.0304081
FLNB filamin B, beta 0.0300989
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0300149
B2M beta-2-microglobulin 0.029467
PRKCE protein kinase C, epsilon 0.0293695
NSUN6 NOP2/Sun domain family, member 6 0.0289338
SMYD3 SET and MYND domain containing 3 0.0285768
AKAP9 A kinase (PRKA) anchor protein 9 0.0282983
KTN1 kinectin 1 (kinesin receptor) 0.0282768
MSI2 musashi RNA-binding protein 2 0.0281422
TENM3 teneurin transmembrane protein 3 0.0279484
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0271015
ASPH aspartate beta-hydroxylase 0.0269699
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0269316
ARFGEF3 ARFGEF family member 3 0.0266369
NAV2 neuron navigator 2 0.0264478
RPL37A ribosomal protein L37a 0.0262739
FNIP1 folliculin interacting protein 1 0.0262366
RPL14 ribosomal protein L14 0.0262144
YEATS2 YEATS domain containing 2 0.0260839
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026046
TAS2R14 taste receptor, type 2, member 14 0.0259141
AFF3 AF4/FMR2 family, member 3 0.0258769
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0257435
NFE2L1 nuclear factor, erythroid 2-like 1 0.0255149
MAP2K1 mitogen-activated protein kinase kinase 1 0.0250865
EXOC4 exocyst complex component 4 0.0247497
ZCCHC7 zinc finger, CCHC domain containing 7 0.0246542
DST dystonin 0.024497
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0241319
TMEM51 transmembrane protein 51 0.0238829
SOX5 SRY (sex determining region Y)-box 5 0.0238539
SBF2 SET binding factor 2 0.0236864
RPS17 ribosomal protein S17 0.0234946
FGGY FGGY carbohydrate kinase domain containing 0.0231881
MFGE8 milk fat globule-EGF factor 8 protein 0.0229682
ADAM10 ADAM metallopeptidase domain 10 0.0228837
ZNF292 zinc finger protein 292 0.021968
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0217045
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0212859
BABAM2 BRISC and BRCA1 A complex member 2 0.0212069
C1ORF21 chromosome 1 open reading frame 21 0.021061
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.020841
GOLGB1 golgin B1 0.0208086
IFI6 interferon, alpha-inducible protein 6 0.0206736
FAM219A family with sequence similarity 219, member A 0.0206396
ULK4 unc-51 like kinase 4 0.0206195
CALD1 caldesmon 1 0.0206013
NRDC nardilysin convertase 0.0205295
AGTPBP1 ATP/GTP binding protein 1 0.0205163
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.0203766
LITAF lipopolysaccharide-induced TNF factor 0.0203532
RPS13 ribosomal protein S13 0.0203263
CHD9 chromodomain helicase DNA binding protein 9 0.0202883
EPN2 epsin 2 0.0202787
DCAF7 DDB1 and CUL4 associated factor 7 0.0201663
CNKSR3 CNKSR family member 3 0.0200828
IGF1R insulin-like growth factor 1 receptor 0.0200828
ENO2 enolase 2 (gamma, neuronal) 0.0199108

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.247253
FN1 fibronectin 1 -0.128771
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102426
GARS1 glycyl-tRNA synthetase 1 -0.0852587
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0765023
ANKRD28 ankyrin repeat domain 28 -0.0716433
FRMD5 FERM domain containing 5 -0.0682624
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0667077
NAMPT nicotinamide phosphoribosyltransferase -0.0610595
TXNRD1 thioredoxin reductase 1 -0.0578237
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0502102
EIF1 eukaryotic translation initiation factor 1 -0.0460671
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0457738
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0453815
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0440249
TSC22D2 TSC22 domain family, member 2 -0.0434451
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0416371
TKT transketolase -0.0410718
SPAG9 sperm associated antigen 9 -0.0408199
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0400082
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0395114
ANXA2 annexin A2 -0.0394997
QKI QKI, KH domain containing, RNA binding -0.0380304
MBNL1 muscleblind-like splicing regulator 1 -0.0370634
RAD21 RAD21 homolog (S. pombe) -0.0367707
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0366227
MORF4L2 mortality factor 4 like 2 -0.0364619
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0364215
ZNF697 zinc finger protein 697 -0.0360162
CLINT1 clathrin interactor 1 -0.0358579
RPL35A ribosomal protein L35a -0.0352242
RPL23 ribosomal protein L23 -0.0350164
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0348016
MATR3 matrin 3 -0.0347874
TPT1 tumor protein, translationally-controlled 1 -0.0346145
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0345888
FRMD4A FERM domain containing 4A -0.0342142
CCND1 cyclin D1 -0.0339212
LOC112694756 uncharaterized LOC112694756 -0.0331364
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0331036
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0329143
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0328159
EXT1 exostosin glycosyltransferase 1 -0.0326858
TENM1 teneurin transmembrane protein 1 -0.0321848
TNNC1 troponin C type 1 (slow) -0.0319366
ZFAND3 zinc finger, AN1-type domain 3 -0.0310533
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0310175
RAB1A RAB1A, member RAS oncogene family -0.0309571
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0308582
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0307661
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0306918
ELL2 elongation factor, RNA polymerase II, 2 -0.0305629
TFPI2 tissue factor pathway inhibitor 2 -0.0305043
VDAC1 voltage-dependent anion channel 1 -0.0304653
WWTR1 WW domain containing transcription regulator 1 -0.0304619
CD44 CD44 molecule (Indian blood group) -0.0303185
ADAM17 ADAM metallopeptidase domain 17 -0.0298844
TM4SF1 transmembrane 4 L six family member 1 -0.0296069
UBC ubiquitin C -0.0296037
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0296
ANLN anillin, actin binding protein -0.0294236
ACTG1 actin gamma 1 -0.0294216
WAC WW domain containing adaptor with coiled-coil -0.0290777
RNF213 ring finger protein 213 -0.0284312
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0280292
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0277294
CLTC clathrin, heavy chain (Hc) -0.027726
PDIA3 protein disulfide isomerase family A, member 3 -0.0276629
ZFAND6 zinc finger, AN1-type domain 6 -0.0275447
ANKRD11 ankyrin repeat domain 11 -0.0274556
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0274281
ICAM1 intercellular adhesion molecule 1 -0.0273381
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0270806
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0270111
SOD2 superoxide dismutase 2, mitochondrial -0.02666
OLA1 Obg-like ATPase 1 -0.026414
KDM3A lysine (K)-specific demethylase 3A -0.0262263
USP3 ubiquitin specific peptidase 3 -0.0261987
FTL ferritin, light polypeptide -0.0257813
VMP1 vacuole membrane protein 1 -0.0253823
ZC3H15 zinc finger CCCH-type containing 15 -0.025381
AFF4 AF4/FMR2 family, member 4 -0.0252509
XRN2 5'-3' exoribonuclease 2 -0.0250396
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.024915
USP9X ubiquitin specific peptidase 9, X-linked -0.0248566
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0247754
TRIO trio Rho guanine nucleotide exchange factor -0.0244893
ABI1 abl-interactor 1 -0.0244857
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0244207
CSDE1 cold shock domain containing E1, RNA-binding -0.0244003
RPS4X ribosomal protein S4, X-linked -0.0243209
IFIH1 interferon induced with helicase C domain 1 -0.0242768
SFTPA2 surfactant protein A2 -0.0241889
RPLP0 ribosomal protein, large, P0 -0.024125
RAB7A RAB7A, member RAS oncogene family -0.0238957
SH3KBP1 SH3-domain kinase binding protein 1 -0.0236825
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0236724
ALCAM activated leukocyte cell adhesion molecule -0.0236372
KLF6 Kruppel-like factor 6 -0.0235458
MYL12B myosin, light chain 12B, regulatory -0.0235417