Pentamidine (isethionate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentamidine (isethionate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.133196
VIM vimentin 0.112924
PTMA prothymosin, alpha 0.100027
CXCL8 chemokine (C-X-C motif) ligand 8 0.0818271
TMSB10 thymosin beta 10 0.0728002
TMSB4X thymosin beta 4, X-linked 0.0701379
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0688713
RPL37A ribosomal protein L37a 0.0610364
TPT1 tumor protein, translationally-controlled 1 0.0601651
HLA-B major histocompatibility complex, class I, B 0.0594225
RPS12 ribosomal protein S12 0.0564676
VCL vinculin 0.0546148
RPS8 ribosomal protein S8 0.0502011
RPL31 ribosomal protein L31 0.0468111
FTL ferritin, light polypeptide 0.0450399
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0450131
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0425243
PLIN2 perilipin 2 0.0421168
PRELID2 PRELI domain containing 2 0.0416814
MT2A metallothionein 2A 0.0408427
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0406422
S100A10 S100 calcium binding protein A10 0.0401573
IFI6 interferon, alpha-inducible protein 6 0.0397574
IER3 immediate early response 3 0.0395348
SPDYA speedy/RINGO cell cycle regulator family member A 0.0391141
RPS29 ribosomal protein S29 0.0385862
RPL19 ribosomal protein L19 0.0385665
RPL23 ribosomal protein L23 0.0384127
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0380925
RPS3 ribosomal protein S3 0.0358511
INTS6 integrator complex subunit 6 0.0351441
GRB10 growth factor receptor-bound protein 10 0.0349861
RPL26 ribosomal protein L26 0.0336435
RPLP1 ribosomal protein, large, P1 0.0332992
RPL12 ribosomal protein L12 0.0325355
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0322745
RPL9 ribosomal protein L9 0.032267
IFI27 interferon, alpha-inducible protein 27 0.0321147
HILPDA hypoxia inducible lipid droplet-associated 0.0318598
RPL35A ribosomal protein L35a 0.0304674
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0300836
RPS23 ribosomal protein S23 0.0298576
ANGPTL4 angiopoietin-like 4 0.0293651
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0292719
HLA-A major histocompatibility complex, class I, A 0.0290433
GNAS GNAS complex locus 0.0286167
RPS21 ribosomal protein S21 0.027924
RPS17 ribosomal protein S17 0.0270608
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0267732
RRBP1 ribosome binding protein 1 0.0266682
RPS19 ribosomal protein S19 0.0262524
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0261915
RPS27A ribosomal protein S27a 0.0260683
RPS27 ribosomal protein S27 0.025654
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0250939
RPL11 ribosomal protein L11 0.0250153
BLZF1 basic leucine zipper nuclear factor 1 0.024633
LIMCH1 LIM and calponin homology domains 1 0.0242705
RAB7A RAB7A, member RAS oncogene family 0.0241346
RPL5 ribosomal protein L5 0.0239279
SQSTM1 sequestosome 1 0.0236957
CALR calreticulin 0.0235712
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0234789
RPL34 ribosomal protein L34 0.0234573
SEC61G Sec61 gamma subunit 0.0232783
ENO2 enolase 2 (gamma, neuronal) 0.0230707
UQCRB ubiquinol-cytochrome c reductase binding protein 0.022952
FLNB filamin B, beta 0.0227713
RPS24 ribosomal protein S24 0.0226169
RAD51B RAD51 paralog B 0.022394
C15ORF48 chromosome 15 open reading frame 48 0.0222791
TPM4 tropomyosin 4 0.0219249
RPS11 ribosomal protein S11 0.0218482
AEBP2 AE binding protein 2 0.0217912
ERRFI1 ERBB receptor feedback inhibitor 1 0.0217827
RPL36AL ribosomal protein L36a-like 0.0216692
PTPRF protein tyrosine phosphatase, receptor type, F 0.0215531
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0214577
RPL36 ribosomal protein L36 0.0213208
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0210649
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0210579
TMED9 transmembrane emp24 protein transport domain containing 9 0.0210101
RACK1 receptor for activated C kinase 1 0.0209787
MBD5 methyl-CpG binding domain protein 5 0.0209071
RPL13A ribosomal protein L13a 0.0206953
RPLP2 ribosomal protein, large, P2 0.0206582
LDHA lactate dehydrogenase A 0.0205759
VMP1 vacuole membrane protein 1 0.0203966
BASP1 brain abundant, membrane attached signal protein 1 0.0203255
RPL28 ribosomal protein L28 0.0203042
RPL37 ribosomal protein L37 0.0202894
RPS10 ribosomal protein S10 0.0200645
PGK1 phosphoglycerate kinase 1 0.0197749
RPL32 ribosomal protein L32 0.0196067
RPL8 ribosomal protein L8 0.0195812
RPL14 ribosomal protein L14 0.0190786
FUS FUS RNA binding protein 0.0190641
RPS14 ribosomal protein S14 0.0190195
PDE10A phosphodiesterase 10A 0.0189824
MCL1 myeloid cell leukemia 1 0.0189609

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.256699
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.174041
FN1 fibronectin 1 -0.17272
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.140741
ITGA1 integrin, alpha 1 -0.114738
FNDC3B fibronectin type III domain containing 3B -0.0938859
NRG1 neuregulin 1 -0.0890652
AHR aryl hydrocarbon receptor -0.0811278
TMEM156 transmembrane protein 156 -0.0758715
TRIO trio Rho guanine nucleotide exchange factor -0.0686323
CLTC clathrin, heavy chain (Hc) -0.0588812
TXNIP thioredoxin interacting protein -0.0585911
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0578665
OSMR oncostatin M receptor -0.0563431
TMEM165 transmembrane protein 165 -0.0560942
SFTPA2 surfactant protein A2 -0.0553444
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0539359
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0530332
KMT2E lysine (K)-specific methyltransferase 2E -0.0530266
NRP1 neuropilin 1 -0.051882
ANKRD28 ankyrin repeat domain 28 -0.0518173
ELL2 elongation factor, RNA polymerase II, 2 -0.0516834
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0515196
CANX calnexin -0.0510538
PTK2 protein tyrosine kinase 2 -0.0504565
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0483153
GOLT1B golgi transport 1B -0.0460061
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0456292
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0449619
CD44 CD44 molecule (Indian blood group) -0.0445054
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0443364
MAP1B microtubule-associated protein 1B -0.0442255
CDCP1 CUB domain containing protein 1 -0.044047
SMAD3 SMAD family member 3 -0.0439918
UGCG UDP-glucose ceramide glucosyltransferase -0.0439673
EXT1 exostosin glycosyltransferase 1 -0.0438412
DOCK5 dedicator of cytokinesis 5 -0.043834
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0436862
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0435278
MCTP2 multiple C2 domains, transmembrane 2 -0.0428633
ETV1 ets variant 1 -0.04276
NEK7 NIMA-related kinase 7 -0.042393
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0421938
KLHL5 kelch-like family member 5 -0.0409632
ERBIN erbb2 interacting protein -0.0399067
NIPBL Nipped-B homolog (Drosophila) -0.0396097
RUNX2 runt-related transcription factor 2 -0.0395502
UBE2K ubiquitin-conjugating enzyme E2K -0.0391836
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0390441
TFPI2 tissue factor pathway inhibitor 2 -0.038751
JMJD1C jumonji domain containing 1C -0.0386901
CENPF centromere protein F, 350/400kDa -0.0383515
PRRC2C proline-rich coiled-coil 2C -0.0379958
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0377094
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0367506
PUM2 pumilio RNA-binding family member 2 -0.0364365
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0364032
ETV6 ets variant 6 -0.0363913
BICD1 bicaudal D homolog 1 (Drosophila) -0.0363147
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0360667
VEGFA vascular endothelial growth factor A -0.0340627
IL6ST interleukin 6 signal transducer -0.0339122
SNX9 sorting nexin 9 -0.0337605
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0332504
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0332216
WAC WW domain containing adaptor with coiled-coil -0.0331842
ETNK1 ethanolamine kinase 1 -0.0331133
SPAG9 sperm associated antigen 9 -0.0329562
DENND5B DENN/MADD domain containing 5B -0.0328887
RBM39 RNA binding motif protein 39 -0.0321925
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0320317
PAPOLA poly(A) polymerase alpha -0.0314805
CDC73 cell division cycle 73 -0.0309746
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0299201
FAM168B family with sequence similarity 168, member B -0.0294689
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0294501
ZFR zinc finger RNA binding protein -0.0294341
RO60 Ro60, Y RNA binding protein -0.029428
HMGA2 high mobility group AT-hook 2 -0.0292423
CAB39 calcium binding protein 39 -0.0291457
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0289965
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0289704
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0289562
SEPTIN9 septin 9 -0.0288506
UBC ubiquitin C -0.0286781
SRPK2 SRSF protein kinase 2 -0.0284568
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.028331
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0279511
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0279275
PDE4D phosphodiesterase 4D, cAMP-specific -0.0278549
FRY furry homolog (Drosophila) -0.027846
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0276641
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0276539
FOXP1 forkhead box P1 -0.0276309
APP amyloid beta (A4) precursor protein -0.0275111
NUP58 nucleoporin 58 -0.0275009
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0274549
MBNL1 muscleblind-like splicing regulator 1 -0.027217
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0271364
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0271244