Pentamidine (isethionate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentamidine (isethionate) perturbation in SW480 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pentamidine (isethionate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.073306
RPS12 ribosomal protein S12 0.0486921
RPS3 ribosomal protein S3 0.0458552
RPS8 ribosomal protein S8 0.0415939
RPL35A ribosomal protein L35a 0.0393491
RPL37A ribosomal protein L37a 0.0352232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0343325
RPL23 ribosomal protein L23 0.0327032
NKD1 naked cuticle homolog 1 (Drosophila) 0.0325886
RPL36A ribosomal protein L36a 0.0324759
RPL26 ribosomal protein L26 0.0304144
VIM vimentin 0.0302233
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0280049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0261587
RPS19 ribosomal protein S19 0.0252511
RPS25 ribosomal protein S25 0.0251628
RPLP1 ribosomal protein, large, P1 0.0250324
RPLP2 ribosomal protein, large, P2 0.0250284
RPL31 ribosomal protein L31 0.0247795
RPS17 ribosomal protein S17 0.0245357
RPL37 ribosomal protein L37 0.0234459
RPL11 ribosomal protein L11 0.0229991
RPL12 ribosomal protein L12 0.022817
MT2A metallothionein 2A 0.022575
RPS14 ribosomal protein S14 0.0222846
CD46 CD46 molecule, complement regulatory protein 0.0219571
AOPEP aminopeptidase O (putative) 0.0219404
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0219333
TXNIP thioredoxin interacting protein 0.0217719
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0212564
RPS13 ribosomal protein S13 0.0212539
RPL9 ribosomal protein L9 0.0203505
RPS27A ribosomal protein S27a 0.0198627
RACK1 receptor for activated C kinase 1 0.0191567
RPL7 ribosomal protein L7 0.0190255
RPL13A ribosomal protein L13a 0.0184142
RPL36 ribosomal protein L36 0.0172726
RPS29 ribosomal protein S29 0.0170315
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0166076
SET SET nuclear proto-oncogene 0.0165388
RPS2 ribosomal protein S2 0.0159668
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0156861
CEMIP2 cell migration inducing hyaluronidase 2 0.0155146
FOXP1 forkhead box P1 0.0151231
TPT1 tumor protein, translationally-controlled 1 0.015114
RPS27 ribosomal protein S27 0.0151109
PROX1 prospero homeobox 1 0.0142043
RPL34 ribosomal protein L34 0.014194
PERP PERP, TP53 apoptosis effector 0.0139363
NIPSNAP2 nipsnap homolog 2 0.0138543
S100A9 S100 calcium binding protein A9 0.0137809
RPS16 ribosomal protein S16 0.0137371
FTL ferritin, light polypeptide 0.0136956
B2M beta-2-microglobulin 0.0131686
TM7SF3 transmembrane 7 superfamily member 3 0.013045
EEF2 eukaryotic translation elongation factor 2 0.0127603
RPL18 ribosomal protein L18 0.0127588
RPL10A ribosomal protein L10a 0.0127319
OXR1 oxidation resistance 1 0.0126798
KIAA0319L KIAA0319-like 0.0124416
CDCP1 CUB domain containing protein 1 0.0123008
GCC2 GRIP and coiled-coil domain containing 2 0.0122652
UBE2B ubiquitin-conjugating enzyme E2B 0.0121637
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0119934
TMEM41B transmembrane protein 41B 0.0117679
EXOC1 exocyst complex component 1 0.0115964
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.0115644
MTDH metadherin 0.0114615
GPR155 G protein-coupled receptor 155 0.0114234
RPL5 ribosomal protein L5 0.0114109
NUCB2 nucleobindin 2 0.011352
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0110992
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0110023
RPS20 ribosomal protein S20 0.0109917
RPS23 ribosomal protein S23 0.0109027
RPLP0 ribosomal protein, large, P0 0.0108986
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0106929
PTMA prothymosin, alpha 0.0106817
KIZ kizuna centrosomal protein 0.0106413
ACBD3 acyl-CoA binding domain containing 3 0.0104757
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0103056
RPL15 ribosomal protein L15 0.0102472
RPS7 ribosomal protein S7 0.0102024
PLAUR plasminogen activator, urokinase receptor 0.0102012
ERRFI1 ERBB receptor feedback inhibitor 1 0.0101806
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0100954
BTBD9 BTB (POZ) domain containing 9 0.0100946
SOX4 SRY (sex determining region Y)-box 4 0.0100651
TTC3 tetratricopeptide repeat domain 3 0.0100522
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.00997725
OGA O-GlcNAcase 0.00989156
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.00983415
CHD9 chromodomain helicase DNA binding protein 9 0.0097736
ZNF292 zinc finger protein 292 0.00970181
TERF2IP telomeric repeat binding factor 2, interacting protein 0.00968873
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00956398
ZSWIM5 zinc finger, SWIM-type containing 5 0.00951965
RLF rearranged L-myc fusion 0.00947952
EIF1 eukaryotic translation initiation factor 1 0.00939346
RPL35 ribosomal protein L35 0.00937777

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.156401
NAV2 neuron navigator 2 -0.127434
INTS6 integrator complex subunit 6 -0.115159
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0849352
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.072828
CDH13 cadherin 13 -0.0645989
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0633321
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0601981
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0598611
SLC38A2 solute carrier family 38, member 2 -0.0594426
CCND1 cyclin D1 -0.0585205
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0582776
LMO7 LIM domain 7 -0.056911
SDK1 sidekick cell adhesion molecule 1 -0.0548037
PDE4D phosphodiesterase 4D, cAMP-specific -0.0522226
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.052182
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0504697
EZR ezrin -0.0502901
MSI2 musashi RNA-binding protein 2 -0.0494695
ACTN4 actinin, alpha 4 -0.0494393
GMDS GDP-mannose 4,6-dehydratase -0.049394
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0492907
LOC102724023 ES1 protein homolog, mitochondrial -0.0471475
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0463887
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.044726
RCOR1 REST corepressor 1 -0.0446146
ACTN1 actinin, alpha 1 -0.0441382
PDLIM5 PDZ and LIM domain 5 -0.0433218
ANXA2 annexin A2 -0.0433013
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0426522
HDAC4 histone deacetylase 4 -0.0424501
ASPH aspartate beta-hydroxylase -0.0412154
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0406092
CDK6 cyclin-dependent kinase 6 -0.0400486
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0394976
MYH9 myosin, heavy chain 9, non-muscle -0.0372793
FLNB filamin B, beta -0.037155
KRT8 keratin 8, type II -0.0363084
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0363026
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0360369
ATXN1 ataxin 1 -0.0358253
RBM39 RNA binding motif protein 39 -0.0356749
UBAP2 ubiquitin associated protein 2 -0.0353902
AHNAK AHNAK nucleoprotein -0.0352302
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0351295
ACTG1 actin gamma 1 -0.0345883
OSBPL3 oxysterol binding protein-like 3 -0.034571
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0344939
VMP1 vacuole membrane protein 1 -0.0342259
TNS3 tensin 3 -0.0341549
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0338328
IARS1 isoleucyl-tRNA synthetase 1 -0.0335127
SYT1 synaptotagmin I -0.033269
LRPPRC leucine-rich pentatricopeptide repeat containing -0.032887
MYO1D myosin ID -0.0327168
MKI67 marker of proliferation Ki-67 -0.0326789
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0325761
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.032409
USP9X ubiquitin specific peptidase 9, X-linked -0.0321778
ECT2 epithelial cell transforming 2 -0.0321715
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0321135
TNIK TRAF2 and NCK interacting kinase -0.0319927
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0316894
DST dystonin -0.0316829
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0315486
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0313077
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0312407
LPP LIM domain containing preferred translocation partner in lipoma -0.0309448
KRT18 keratin 18, type I -0.0308153
EGR1 early growth response 1 -0.0306074
CMIP c-Maf inducing protein -0.0304883
STK24 serine/threonine kinase 24 -0.0304138
DOCK9 dedicator of cytokinesis 9 -0.0303728
EXOC4 exocyst complex component 4 -0.0302144
ITPRID2 ITPR interacting domain containing 2 -0.0301558
BCL2L1 BCL2-like 1 -0.0301031
KLF12 Kruppel-like factor 12 -0.0300993
WDR43 WD repeat domain 43 -0.0300239
CTBP2 C-terminal binding protein 2 -0.0299929
WNK1 WNK lysine deficient protein kinase 1 -0.0299805
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0298911
TMEM163 transmembrane protein 163 -0.0297007
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0296536
RAD51B RAD51 paralog B -0.029608
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0295368
SMAD3 SMAD family member 3 -0.0293118
RAB7A RAB7A, member RAS oncogene family -0.0291601
IGF1R insulin-like growth factor 1 receptor -0.0291213
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0290328
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0288112
COBL cordon-bleu WH2 repeat protein -0.028395
SKAP1 src kinase associated phosphoprotein 1 -0.0282253
RUNX1 runt-related transcription factor 1 -0.02817
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0281111
FLNA filamin A, alpha -0.0279765
GATAD2A GATA zinc finger domain containing 2A -0.0279357
ANLN anillin, actin binding protein -0.027805
TFRC transferrin receptor -0.0275225
ANKRD17 ankyrin repeat domain 17 -0.0275212
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0272745