| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pentamidine (isethionate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pentamidine (isethionate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.114091 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0766065 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0663532 |
| ENO1 | enolase 1, (alpha) | 0.0626859 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0577861 |
| MT2A | metallothionein 2A | 0.0575211 |
| CALR | calreticulin | 0.0565738 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.055744 |
| HLA-B | major histocompatibility complex, class I, B | 0.0557107 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0551505 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0540689 |
| MCL1 | myeloid cell leukemia 1 | 0.0489542 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.04728 |
| FTL | ferritin, light polypeptide | 0.0470321 |
| RPS12 | ribosomal protein S12 | 0.0463644 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0430778 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0414235 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0408029 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0395412 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0385004 |
| PLEC | plectin | 0.0378682 |
| UBC | ubiquitin C | 0.0378329 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0369166 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.036288 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0359611 |
| RPS3 | ribosomal protein S3 | 0.03555 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0352867 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0352425 |
| ADM | adrenomedullin | 0.0351186 |
| PRELID2 | PRELI domain containing 2 | 0.0348539 |
| RPS6 | ribosomal protein S6 | 0.0346794 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0346458 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0340416 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0333431 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0332585 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0331932 |
| PCBP2 | poly(rC) binding protein 2 | 0.0327455 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0326848 |
| LDHA | lactate dehydrogenase A | 0.0318344 |
| FAM13A | family with sequence similarity 13, member A | 0.0317168 |
| ASPH | aspartate beta-hydroxylase | 0.0316923 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0316279 |
| HLA-A | major histocompatibility complex, class I, A | 0.0308874 |
| TMEM165 | transmembrane protein 165 | 0.0308347 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0306652 |
| VIM | vimentin | 0.0300369 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0299326 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.029822 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0295595 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0292908 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0288282 |
| FMNL2 | formin-like 2 | 0.0284075 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0280799 |
| RPL9 | ribosomal protein L9 | 0.0280306 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0276542 |
| ZNF292 | zinc finger protein 292 | 0.0273662 |
| INTS6 | integrator complex subunit 6 | 0.0272709 |
| ACTN1 | actinin, alpha 1 | 0.0272676 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0271799 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.027082 |
| PTMA | prothymosin, alpha | 0.0269916 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0262491 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0262146 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0260906 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0260809 |
| TPM3 | tropomyosin 3 | 0.0259644 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0258926 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0253493 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0252697 |
| MED13L | mediator complex subunit 13-like | 0.0246898 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0244995 |
| CANX | calnexin | 0.0244837 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0244693 |
| RPL37A | ribosomal protein L37a | 0.0243316 |
| JUN | jun proto-oncogene | 0.0241908 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0240292 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0237746 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0236733 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0236536 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0229874 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0229375 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0226241 |
| RPS27A | ribosomal protein S27a | 0.0224795 |
| MYO10 | myosin X | 0.0223666 |
| RAI1 | retinoic acid induced 1 | 0.0222198 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0219807 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0219402 |
| CTBP2 | C-terminal binding protein 2 | 0.0218396 |
| PTK2 | protein tyrosine kinase 2 | 0.0217846 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0216264 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0215407 |
| RPL5 | ribosomal protein L5 | 0.0212492 |
| NBAS | neuroblastoma amplified sequence | 0.0211872 |
| NUP58 | nucleoporin 58 | 0.0210368 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0209726 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0209001 |
| SMYD3 | SET and MYND domain containing 3 | 0.020551 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0204132 |
| RPS8 | ribosomal protein S8 | 0.0202751 |
| PHF3 | PHD finger protein 3 | 0.01995 |
| Symbol | Name | Standardized Value |
|---|---|---|
| INHBA | inhibin, beta A | -0.254081 |
| FN1 | fibronectin 1 | -0.244994 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.179949 |
| COL6A3 | collagen, type VI, alpha 3 | -0.157562 |
| STC1 | stanniocalcin 1 | -0.127816 |
| COL1A1 | collagen, type I, alpha 1 | -0.12524 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.123827 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0784149 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0764639 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0749843 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0725745 |
| MMP1 | matrix metallopeptidase 1 | -0.0664003 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0642602 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0641853 |
| COL1A2 | collagen, type I, alpha 2 | -0.0618176 |
| EMP1 | epithelial membrane protein 1 | -0.0595953 |
| ACTG1 | actin gamma 1 | -0.0590978 |
| HMGA2 | high mobility group AT-hook 2 | -0.0584981 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0584093 |
| CD44 | CD44 molecule (Indian blood group) | -0.0572895 |
| LOXL2 | lysyl oxidase-like 2 | -0.0553368 |
| OSMR | oncostatin M receptor | -0.0551459 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0538714 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0510122 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0508666 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0484866 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0478899 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.047442 |
| ATP13A3 | ATPase type 13A3 | -0.046657 |
| SEPTIN11 | septin 11 | -0.046447 |
| TMSB10 | thymosin beta 10 | -0.0461319 |
| OXR1 | oxidation resistance 1 | -0.0444951 |
| PLPP3 | phospholipid phosphatase 3 | -0.0413123 |
| FRMD4A | FERM domain containing 4A | -0.0404533 |
| MEIS1 | Meis homeobox 1 | -0.0402882 |
| CALD1 | caldesmon 1 | -0.0389355 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0369888 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0368297 |
| CCND1 | cyclin D1 | -0.0355734 |
| DIAPH2 | diaphanous-related formin 2 | -0.0348537 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0344898 |
| RAI14 | retinoic acid induced 14 | -0.0340515 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0338344 |
| RRBP1 | ribosome binding protein 1 | -0.0337879 |
| COL4A1 | collagen, type IV, alpha 1 | -0.0335063 |
| GLG1 | golgi glycoprotein 1 | -0.033169 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0326906 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0322837 |
| NAV1 | neuron navigator 1 | -0.0320237 |
| INSIG1 | insulin induced gene 1 | -0.0307748 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0306707 |
| H1-0 | H1.0 linker histone | -0.0295418 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0294272 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0290357 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0287715 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0277676 |
| PDE8A | phosphodiesterase 8A | -0.0267452 |
| MAP1B | microtubule-associated protein 1B | -0.026736 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0267099 |
| HDLBP | high density lipoprotein binding protein | -0.0264337 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0262512 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0261083 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0258702 |
| COL5A2 | collagen, type V, alpha 2 | -0.0256856 |
| KIAA1549L | KIAA1549-like | -0.0249967 |
| ARF1 | ADP-ribosylation factor 1 | -0.0244326 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0244202 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0242015 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0240828 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0234589 |
| CDC27 | cell division cycle 27 | -0.023348 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0233304 |
| EGFR | epidermal growth factor receptor | -0.0232511 |
| CCDC102B | coiled-coil domain containing 102B | -0.0231773 |
| CLTC | clathrin, heavy chain (Hc) | -0.0231353 |
| CAVIN1 | caveolae associated protein 1 | -0.0230034 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0226492 |
| SEC24D | SEC24 family member D | -0.0224966 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0224076 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0222523 |
| TUBB6 | tubulin, beta 6 class V | -0.0221709 |
| FSTL1 | follistatin-like 1 | -0.0221052 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0220883 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0220804 |
| PRSS23 | protease, serine, 23 | -0.0219981 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0219571 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0218823 |
| EHD2 | EH-domain containing 2 | -0.0216733 |
| RNF213 | ring finger protein 213 | -0.0213932 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0209382 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0208891 |
| LOX | lysyl oxidase | -0.0207685 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0205842 |
| TUBB | tubulin, beta class I | -0.0204918 |
| HLA-C | major histocompatibility complex, class I, C | -0.0204399 |
| TAGLN2 | transgelin 2 | -0.0200399 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.019872 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0197715 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0196316 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0195955 |
