Pentoxifylline_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.151076
TMSB10 thymosin beta 10 0.129292
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.122611
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.112414
VIM vimentin 0.107078
PTMA prothymosin, alpha 0.0750959
HMGA2 high mobility group AT-hook 2 0.0657375
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0608148
FTL ferritin, light polypeptide 0.0594337
ACTG1 actin gamma 1 0.0552276
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0535802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0534628
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0501523
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0500152
PCDH7 protocadherin 7 0.0487558
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0460978
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.044781
TPI1 triosephosphate isomerase 1 0.043139
NAP1L1 nucleosome assembly protein 1-like 1 0.0425948
YAP1 Yes-associated protein 1 0.0422752
ANKRD12 ankyrin repeat domain 12 0.0418308
ANXA1 annexin A1 0.0397167
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0390571
MYL12B myosin, light chain 12B, regulatory 0.037979
YBX3 Y box binding protein 3 0.0376963
NHSL1 NHS-like 1 0.0374567
MACF1 microtubule-actin crosslinking factor 1 0.0371706
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.036225
ENO1 enolase 1, (alpha) 0.0351915
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0340522
RPS8 ribosomal protein S8 0.0339353
HMGA1 high mobility group AT-hook 1 0.0339199
CALR calreticulin 0.0338921
H1-0 H1.0 linker histone 0.0334479
CNRIP1 cannabinoid receptor interacting protein 1 0.0332646
EHBP1 EH domain binding protein 1 0.0331252
HSPB1 heat shock 27kDa protein 1 0.0330121
MKI67 marker of proliferation Ki-67 0.0329535
RRM2 ribonucleotide reductase M2 0.0328681
ASPH aspartate beta-hydroxylase 0.0327239
RPS19 ribosomal protein S19 0.0322144
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0309889
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.030916
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0301179
SMC4 structural maintenance of chromosomes 4 0.0300096
RPL23 ribosomal protein L23 0.0284393
CANX calnexin 0.0277308
CUX1 cut-like homeobox 1 0.0277171
RPL36 ribosomal protein L36 0.027099
PDE4D phosphodiesterase 4D, cAMP-specific 0.0270018
RPLP1 ribosomal protein, large, P1 0.0265296
RPS3 ribosomal protein S3 0.0259262
DST dystonin 0.025851
TRIO trio Rho guanine nucleotide exchange factor 0.0257517
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.025647
RASAL2 RAS protein activator like 2 0.0254612
EGR1 early growth response 1 0.0252792
RPL37A ribosomal protein L37a 0.0250922
AHNAK AHNAK nucleoprotein 0.0249425
GNAS GNAS complex locus 0.0246857
PGK1 phosphoglycerate kinase 1 0.0246232
ADIPOR2 adiponectin receptor 2 0.0246207
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0243744
AKAP12 A kinase (PRKA) anchor protein 12 0.0241349
RIMS2 regulating synaptic membrane exocytosis 2 0.0239005
CMIP c-Maf inducing protein 0.023613
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0228519
HSPA8 heat shock 70kDa protein 8 0.0225257
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0225204
DLC1 DLC1 Rho GTPase activating protein 0.0224986
TPT1 tumor protein, translationally-controlled 1 0.0224604
PRDX1 peroxiredoxin 1 0.0219089
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0216218
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0215972
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0215231
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0213548
RPL19 ribosomal protein L19 0.0210979
RPS6 ribosomal protein S6 0.0210748
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0210613
S100A11 S100 calcium binding protein A11 0.0205795
RPS14 ribosomal protein S14 0.020501
MMP12 matrix metallopeptidase 12 0.0203378
PA2G4 proliferation-associated 2G4, 38kDa 0.0201528
RAB7A RAB7A, member RAS oncogene family 0.0198434
IFIH1 interferon induced with helicase C domain 1 0.0197961
TPM4 tropomyosin 4 0.0193586
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0192194
FTH1 ferritin, heavy polypeptide 1 0.0192118
HSPH1 heat shock 105kDa/110kDa protein 1 0.0190461
EIF4A1 eukaryotic translation initiation factor 4A1 0.0190253
RPS21 ribosomal protein S21 0.0188759
RPS12 ribosomal protein S12 0.0188516
BIRC3 baculoviral IAP repeat containing 3 0.0184765
PCDH9 protocadherin 9 0.0184588
TAS2R14 taste receptor, type 2, member 14 0.0183221
R3HDM2 R3H domain containing 2 0.0181645
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0181415
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0180977
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0179752
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0179751

decreased expression

Symbol Name Standardized Value
ZBTB20 zinc finger and BTB domain containing 20 -0.038867
CCNL1 cyclin L1 -0.0269212
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0243258
SLC38A2 solute carrier family 38, member 2 -0.0220942
TXNRD1 thioredoxin reductase 1 -0.0199236
ADAM17 ADAM metallopeptidase domain 17 -0.0187128
RB1CC1 RB1-inducible coiled-coil 1 -0.018452
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0181212
ARL5B ADP-ribosylation factor-like 5B -0.0181169
CHD1 chromodomain helicase DNA binding protein 1 -0.0179505
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0169466
SBF2 SET binding factor 2 -0.0165012
AKAP9 A kinase (PRKA) anchor protein 9 -0.015758
MEMO1 mediator of cell motility 1 -0.0156954
NEK7 NIMA-related kinase 7 -0.0155641
CEP95 centrosomal protein 95kDa -0.0154552
MON2 MON2 homolog (S. cerevisiae) -0.0147587
ADAM9 ADAM metallopeptidase domain 9 -0.0147026
CAMKMT calmodulin-lysine N-methyltransferase -0.0143847
COG5 component of oligomeric golgi complex 5 -0.0143771
ETNK1 ethanolamine kinase 1 -0.014211
CPOX coproporphyrinogen oxidase -0.0139152
TSC22D2 TSC22 domain family, member 2 -0.0138766
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0135273
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0134822
NCEH1 neutral cholesterol ester hydrolase 1 -0.0130973
KLHL24 kelch-like family member 24 -0.0129932
ARHGAP12 Rho GTPase activating protein 12 -0.0129021
DSCAM Down syndrome cell adhesion molecule -0.0125978
TNPO1 transportin 1 -0.0125865
BTBD10 BTB (POZ) domain containing 10 -0.0125506
FER fer (fps/fes related) tyrosine kinase -0.0124594
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0123136
STRN3 striatin, calmodulin binding protein 3 -0.0122906
BLTP1 bridge-like lipid transfer protein family member 1 -0.0121784
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0121256
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0121204
BRWD1 bromodomain and WD repeat domain containing 1 -0.0120221
AREG amphiregulin -0.0119593
NKTR natural killer cell triggering receptor -0.0119345
BIRC2 baculoviral IAP repeat containing 2 -0.0119239
RASA2 RAS p21 protein activator 2 -0.0119001
EXOC6B exocyst complex component 6B -0.0117753
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0117226
KIF5B kinesin family member 5B -0.0116562
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0114588
SLC49A4 solute carrier family 49 member 4 -0.0114171
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0113731
OGA O-GlcNAcase -0.0113529
COPA coatomer protein complex, subunit alpha -0.0112537
PTEN phosphatase and tensin homolog -0.0108461
FBXL20 F-box and leucine-rich repeat protein 20 -0.0106686
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0106454
RNF13 ring finger protein 13 -0.0106204
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0105867
CDK17 cyclin-dependent kinase 17 -0.0105035
PRKN parkin RBR E3 ubiquitin protein ligase -0.0104867
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0104842
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0104799
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0104139
CXADR coxsackie virus and adenovirus receptor -0.0103215
CCNG1 cyclin G1 -0.0102807
METTL15 methyltransferase like 15 -0.0102349
RHBDD1 rhomboid domain containing 1 -0.0102063
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0101994
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00998349
THOC1 THO complex 1 -0.00997071
PICALM phosphatidylinositol binding clathrin assembly protein -0.00991912
BCAS3 breast carcinoma amplified sequence 3 -0.00988779
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.00982201
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00972761
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00969957
FBXO11 F-box protein 11 -0.00955795
ECT2 epithelial cell transforming 2 -0.00952692
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.00952255
RIMKLB ribosomal modification protein rimK-like family member B -0.00948993
TBC1D32 TBC1 domain family, member 32 -0.00948379
ZFYVE16 zinc finger, FYVE domain containing 16 -0.00948023
RAB22A RAB22A, member RAS oncogene family -0.00937827
GASK1B golgi associated kinase 1B -0.00920468
JMJD1C jumonji domain containing 1C -0.00917216
PARD6B par-6 family cell polarity regulator beta -0.00911143
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00909897
ERBIN erbb2 interacting protein -0.00908604
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -0.00905473
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.00905404
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0090108
ICE1 interactor of little elongation complex ELL subunit 1 -0.00899264
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.00898782
THOC2 THO complex 2 -0.00897161
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.00897067
CCSER2 coiled-coil serine-rich protein 2 -0.00892587
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.00889572
TMEM131 transmembrane protein 131 -0.00874959
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.00866043
MBD5 methyl-CpG binding domain protein 5 -0.00861436
YTHDC1 YTH domain containing 1 -0.00857652
PHC3 polyhomeotic homolog 3 (Drosophila) -0.00853067
EPS15 epidermal growth factor receptor pathway substrate 15 -0.00852504
SP3 Sp3 transcription factor -0.00852306