Pentoxifylline_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0697556
NCOR2 nuclear receptor corepressor 2 0.0512066
PCBP2 poly(rC) binding protein 2 0.0495754
MEIS2 Meis homeobox 2 0.0445116
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0432729
GOLGA4 golgin A4 0.0389358
MBNL2 muscleblind-like splicing regulator 2 0.038772
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0360091
RBM25 RNA binding motif protein 25 0.0346364
BIRC6 baculoviral IAP repeat containing 6 0.0340538
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0323988
FTO fat mass and obesity associated 0.0319278
USP34 ubiquitin specific peptidase 34 0.0306983
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0302984
ZMIZ1 zinc finger, MIZ-type containing 1 0.030014
ELP2 elongator acetyltransferase complex subunit 2 0.0298305
YEATS2 YEATS domain containing 2 0.0291449
NEK7 NIMA-related kinase 7 0.0290534
ZNF148 zinc finger protein 148 0.0285743
NUP58 nucleoporin 58 0.0276857
ZFC3H1 zinc finger, C3H1-type containing 0.0267067
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0265006
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0257725
PTPRK protein tyrosine phosphatase, receptor type, K 0.0257309
ADGRG6 adhesion G protein-coupled receptor G6 0.0252541
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0252217
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0251252
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0248154
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0247852
PELI1 pellino E3 ubiquitin protein ligase 1 0.0243054
CLINT1 clathrin interactor 1 0.0242033
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0241295
CABIN1 calcineurin binding protein 1 0.0238387
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0236752
MKI67 marker of proliferation Ki-67 0.0236067
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0234072
DPH6 diphthamine biosynthesis 6 0.0231668
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0231132
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0230375
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0226421
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.022334
SH3RF1 SH3 domain containing ring finger 1 0.0221877
AOPEP aminopeptidase O (putative) 0.0221258
KDM5A lysine (K)-specific demethylase 5A 0.0219639
TENT5A terminal nucleotidyltransferase 5A 0.0217494
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0217162
CD46 CD46 molecule, complement regulatory protein 0.0213033
DDIT4 DNA-damage-inducible transcript 4 0.0212583
CEP192 centrosomal protein 192kDa 0.0212314
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0212283
USP36 ubiquitin specific peptidase 36 0.0210688
METTL15 methyltransferase like 15 0.0209964
KDM4C lysine (K)-specific demethylase 4C 0.0209633
TBK1 TANK-binding kinase 1 0.0208927
FNDC3B fibronectin type III domain containing 3B 0.0208808
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0208261
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 0.0208124
UBA6 ubiquitin-like modifier activating enzyme 6 0.0206197
MEF2D myocyte enhancer factor 2D 0.0203761
NSUN6 NOP2/Sun domain family, member 6 0.0201311
NDRG1 N-myc downstream regulated 1 0.0200477
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0200158
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0198104
MTREX Mtr4 exosome RNA helicase 0.0197608
WDPCP WD repeat containing planar cell polarity effector 0.0195956
TOM1L2 target of myb1-like 2 (chicken) 0.0195506
BCLAF1 BCL2-associated transcription factor 1 0.0195279
AFDN afadin, adherens junction formation factor 0.0193889
IFI16 interferon, gamma-inducible protein 16 0.0193209
USP12 ubiquitin specific peptidase 12 0.0193124
VEZT vezatin, adherens junctions transmembrane protein 0.0192378
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0191505
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0191289
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0189999
VEGFA vascular endothelial growth factor A 0.0188407
PLAT plasminogen activator, tissue 0.0188167
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0188038
DOT1L DOT1-like histone H3K79 methyltransferase 0.0187484
HMGB2 high mobility group box 2 0.0185752
TRIM9 tripartite motif containing 9 0.0185665
FNBP4 formin binding protein 4 0.018541
RTN4 reticulon 4 0.0184766
FOXO3 forkhead box O3 0.0182756
IRF9 interferon regulatory factor 9 0.0182148
ARMC9 armadillo repeat containing 9 0.0181961
DCAF7 DDB1 and CUL4 associated factor 7 0.0181016
SREBF2 sterol regulatory element binding transcription factor 2 0.0180592
CDC27 cell division cycle 27 0.0180296
RC3H1 ring finger and CCCH-type domains 1 0.0179983
CSNK1A1 casein kinase 1, alpha 1 0.0179662
DCP1A decapping mRNA 1A 0.0178648
SEC24A SEC24 family member A 0.0178588
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0178092
PDGFC platelet derived growth factor C 0.0178031
RUNX1 runt-related transcription factor 1 0.0176987
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.017679
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0176658
PCBP3 poly(rC) binding protein 3 0.0176615
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0176255
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0174988

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.203931
PTMA prothymosin, alpha -0.162033
ACTG1 actin gamma 1 -0.114164
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112693
LSAMP limbic system-associated membrane protein -0.107969
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0920634
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0903619
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.085906
EXT1 exostosin glycosyltransferase 1 -0.0853438
RPL23 ribosomal protein L23 -0.0852929
AKAP12 A kinase (PRKA) anchor protein 12 -0.0840547
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0839764
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0813828
NRG1 neuregulin 1 -0.0754914
IER3 immediate early response 3 -0.074917
ENO1 enolase 1, (alpha) -0.0739451
FMN1 formin 1 -0.0736402
RPLP1 ribosomal protein, large, P1 -0.0727415
VIM vimentin -0.0717713
THSD4 thrombospondin, type I, domain containing 4 -0.0660101
LINGO2 leucine rich repeat and Ig domain containing 2 -0.064991
LPP LIM domain containing preferred translocation partner in lipoma -0.0640071
RPS24 ribosomal protein S24 -0.062265
RPS6 ribosomal protein S6 -0.0584904
EGR1 early growth response 1 -0.0571991
TPM1 tropomyosin 1 (alpha) -0.0569348
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0568834
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.053962
MCL1 myeloid cell leukemia 1 -0.0537381
RPL31 ribosomal protein L31 -0.0535447
MSI2 musashi RNA-binding protein 2 -0.0526469
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0524835
NALF1 NALCN channel auxiliary factor 1 -0.051767
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0503751
TPT1 tumor protein, translationally-controlled 1 -0.0501602
AEBP2 AE binding protein 2 -0.049886
TPM4 tropomyosin 4 -0.0496971
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0489991
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0484893
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0480118
AHNAK AHNAK nucleoprotein -0.0478039
MBNL1 muscleblind-like splicing regulator 1 -0.0455565
IGFBP3 insulin-like growth factor binding protein 3 -0.0454222
CANX calnexin -0.0452889
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.043643
RPL38 ribosomal protein L38 -0.0431242
MYH9 myosin, heavy chain 9, non-muscle -0.043032
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0430032
RNF213 ring finger protein 213 -0.0426783
HELZ helicase with zinc finger -0.0424347
NPAS2 neuronal PAS domain protein 2 -0.0421163
FN1 fibronectin 1 -0.0416097
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.040968
KDM3A lysine (K)-specific demethylase 3A -0.0408909
RPL11 ribosomal protein L11 -0.0408449
COL3A1 collagen, type III, alpha 1 -0.0403322
CRABP2 cellular retinoic acid binding protein 2 -0.0398716
UNC5C unc-5 homolog C (C. elegans) -0.0398556
ZC3H11A zinc finger CCCH-type containing 11A -0.03972
SYT1 synaptotagmin I -0.0392031
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.039115
TRIB2 tribbles pseudokinase 2 -0.0388105
RPS19 ribosomal protein S19 -0.0386348
DLC1 DLC1 Rho GTPase activating protein -0.0382124
FBXO11 F-box protein 11 -0.0381009
RPL19 ribosomal protein L19 -0.037745
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0363298
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0358069
POTEF POTE ankyrin domain family, member F -0.0357217
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0355118
RPS3 ribosomal protein S3 -0.0353559
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0350154
GPATCH8 G patch domain containing 8 -0.0348729
RAB7A RAB7A, member RAS oncogene family -0.0346799
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0345562
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0344741
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0344569
PDLIM5 PDZ and LIM domain 5 -0.0343852
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0342238
RCOR1 REST corepressor 1 -0.0341644
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0340997
RPL32 ribosomal protein L32 -0.0340905
TAS2R14 taste receptor, type 2, member 14 -0.0338617
MAP1B microtubule-associated protein 1B -0.0337586
RAI14 retinoic acid induced 14 -0.0332573
CALR calreticulin -0.0330883
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0330056
KIF5B kinesin family member 5B -0.0327351
NAP1L1 nucleosome assembly protein 1-like 1 -0.0322089
RHOBTB3 Rho-related BTB domain containing 3 -0.0321505
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0318832
ZMYM2 zinc finger, MYM-type 2 -0.0314656
GREM2 gremlin 2, DAN family BMP antagonist -0.0313167
HMGA2 high mobility group AT-hook 2 -0.0309895
CALD1 caldesmon 1 -0.0309511
RPL12 ribosomal protein L12 -0.0309131
AHR aryl hydrocarbon receptor -0.0308005
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.03069
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0306465
CCND1 cyclin D1 -0.0305227