Pentoxifylline_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.106969
STC1 stanniocalcin 1 0.0854858
WWTR1 WW domain containing transcription regulator 1 0.0694821
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.069449
CD44 CD44 molecule (Indian blood group) 0.068435
TM4SF1 transmembrane 4 L six family member 1 0.0588741
UBC ubiquitin C 0.0459343
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.039291
SMAD3 SMAD family member 3 0.0383049
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0369264
LOXL2 lysyl oxidase-like 2 0.0352071
FTH1 ferritin, heavy polypeptide 1 0.0343434
AHNAK AHNAK nucleoprotein 0.0340322
MTSS1 metastasis suppressor 1 0.033689
DPYSL3 dihydropyrimidinase-like 3 0.0328637
HMGA2 high mobility group AT-hook 2 0.0318123
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0306547
INHBA inhibin, beta A 0.0296323
ERRFI1 ERBB receptor feedback inhibitor 1 0.0285573
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0279004
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0269123
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0266354
ECE1 endothelin converting enzyme 1 0.0265735
HAS2 hyaluronan synthase 2 0.0262912
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0257244
DUSP6 dual specificity phosphatase 6 0.0254086
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0251524
IFI6 interferon, alpha-inducible protein 6 0.0244431
COL1A1 collagen, type I, alpha 1 0.0238242
PLEC plectin 0.0233062
EXT1 exostosin glycosyltransferase 1 0.0227948
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224403
VMP1 vacuole membrane protein 1 0.0221383
DOCK5 dedicator of cytokinesis 5 0.0220537
COL6A3 collagen, type VI, alpha 3 0.0206991
MYH9 myosin, heavy chain 9, non-muscle 0.0203526
ENO1 enolase 1, (alpha) 0.0201569
OSMR oncostatin M receptor 0.020121
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0200815
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0194036
ANTXR2 anthrax toxin receptor 2 0.0192552
TIMP1 TIMP metallopeptidase inhibitor 1 0.0178571
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0178274
MX2 MX dynamin-like GTPase 2 0.0177361
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0175743
CD59 CD59 molecule, complement regulatory protein 0.0175345
VIM vimentin 0.0174411
SEPTIN9 septin 9 0.0171595
IGFBP7 insulin-like growth factor binding protein 7 0.0162457
NPC1 Niemann-Pick disease, type C1 0.015598
NRP1 neuropilin 1 0.0155769
LOC112694756 uncharaterized LOC112694756 0.0155319
ABLIM3 actin binding LIM protein family, member 3 0.0152133
SYNJ2 synaptojanin 2 0.0150886
NAV1 neuron navigator 1 0.0150176
ASPH aspartate beta-hydroxylase 0.0150129
IL6 interleukin 6 0.0148913
ZBTB38 zinc finger and BTB domain containing 38 0.0145077
PLAUR plasminogen activator, urokinase receptor 0.0142787
SOCS5 suppressor of cytokine signaling 5 0.0139271
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0137261
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0135097
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0133493
ADAM19 ADAM metallopeptidase domain 19 0.0132921
FAM20C family with sequence similarity 20, member C 0.0132496
KIAA1217 KIAA1217 0.0126963
EPN2 epsin 2 0.0126853
BACE2 beta-site APP-cleaving enzyme 2 0.01263
ANKRD12 ankyrin repeat domain 12 0.0125101
ITGB5 integrin, beta 5 0.0123547
NAV2 neuron navigator 2 0.01234
SENP5 SUMO1/sentrin specific peptidase 5 0.0122778
PLSCR1 phospholipid scramblase 1 0.0122031
SH3PXD2B SH3 and PX domains 2B 0.0121456
ATP13A3 ATPase type 13A3 0.0121422
KLF6 Kruppel-like factor 6 0.0118007
MYO9B myosin IXB 0.0117995
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.011711
SDC4 syndecan 4 0.0117001
ATXN10 ataxin 10 0.0116904
ARHGAP29 Rho GTPase activating protein 29 0.0115704
ANGPTL4 angiopoietin-like 4 0.0115383
NOTCH2 notch 2 0.0114988
FLNB filamin B, beta 0.0114881
PKM pyruvate kinase, muscle 0.011398
NRIP1 nuclear receptor interacting protein 1 0.0113254
CNOT12 CCR4-NOT transcription complex subunit 12 0.0112062
VEGFA vascular endothelial growth factor A 0.0112008
CLMP CXADR-like membrane protein 0.0111693
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0109925
HSPA8 heat shock 70kDa protein 8 0.0109041
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0108312
LDHA lactate dehydrogenase A 0.0108069
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0107957
BMERB1 bMERB domain containing 1 0.0105091
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0105087
LAMA5 laminin, alpha 5 0.0104084
TAPBP TAP binding protein (tapasin) 0.0102712
RASA3 RAS p21 protein activator 3 0.0101024
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0100328

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141106
IGFBP3 insulin-like growth factor binding protein 3 -0.133307
CADM1 cell adhesion molecule 1 -0.120602
CDH13 cadherin 13 -0.105195
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102391
NDRG1 N-myc downstream regulated 1 -0.101876
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0851505
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0746216
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0626375
FTL ferritin, light polypeptide -0.0598868
RPS6 ribosomal protein S6 -0.0547622
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0519727
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.051421
RPS8 ribosomal protein S8 -0.0513393
NAMPT nicotinamide phosphoribosyltransferase -0.0503921
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0500146
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0493889
FNDC3B fibronectin type III domain containing 3B -0.0449852
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0445221
QKI QKI, KH domain containing, RNA binding -0.0444165
ZFAND3 zinc finger, AN1-type domain 3 -0.0415204
ACTG1 actin gamma 1 -0.0397558
NALF1 NALCN channel auxiliary factor 1 -0.0374947
MTDH metadherin -0.0369802
TMSB10 thymosin beta 10 -0.0368703
RPL35A ribosomal protein L35a -0.0353682
EGFR epidermal growth factor receptor -0.0351519
RAB2A RAB2A, member RAS oncogene family -0.0350776
PTMA prothymosin, alpha -0.0350512
TFG TRK-fused gene -0.0350035
IER3 immediate early response 3 -0.034423
CALD1 caldesmon 1 -0.0326003
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0324279
GARS1 glycyl-tRNA synthetase 1 -0.031743
TSC22D2 TSC22 domain family, member 2 -0.0309035
TGFBI transforming growth factor, beta-induced, 68kDa -0.0302945
RAB1A RAB1A, member RAS oncogene family -0.0298969
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0297938
FGFR1 fibroblast growth factor receptor 1 -0.0296516
YBX1 Y box binding protein 1 -0.0296158
ALCAM activated leukocyte cell adhesion molecule -0.0295149
EEF2 eukaryotic translation elongation factor 2 -0.0290736
FBN1 fibrillin 1 -0.0288782
ZNF292 zinc finger protein 292 -0.0284938
SQSTM1 sequestosome 1 -0.0284812
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0280188
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0278027
MT2A metallothionein 2A -0.0275739
ANKRD11 ankyrin repeat domain 11 -0.0272749
RPL11 ribosomal protein L11 -0.0268161
RPL5 ribosomal protein L5 -0.0266556
IARS1 isoleucyl-tRNA synthetase 1 -0.0266315
TRIO trio Rho guanine nucleotide exchange factor -0.0263408
TRAM1 translocation associated membrane protein 1 -0.0263375
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0263194
RPS19 ribosomal protein S19 -0.0262702
DSTN destrin (actin depolymerizing factor) -0.0258735
HILPDA hypoxia inducible lipid droplet-associated -0.0250243
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0249906
TPM4 tropomyosin 4 -0.0249585
RPS3 ribosomal protein S3 -0.0247615
RPLP1 ribosomal protein, large, P1 -0.0247268
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0246529
PDE10A phosphodiesterase 10A -0.0244063
RPL37A ribosomal protein L37a -0.0240151
RPL28 ribosomal protein L28 -0.023914
RPL7 ribosomal protein L7 -0.0237997
GOLGB1 golgin B1 -0.0237101
BHLHE40 basic helix-loop-helix family, member e40 -0.0236208
B2M beta-2-microglobulin -0.0235582
TTC3 tetratricopeptide repeat domain 3 -0.0235306
ADM adrenomedullin -0.0235132
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0234377
RYBP RING1 and YY1 binding protein -0.0233452
JARID2 jumonji, AT rich interactive domain 2 -0.0226883
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0225432
WSB1 WD repeat and SOCS box containing 1 -0.0224459
CD109 CD109 molecule -0.0223835
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0223405
CCNL1 cyclin L1 -0.0223165
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0221708
RPS20 ribosomal protein S20 -0.0221431
MATR3 matrin 3 -0.0221139
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0218338
USP3 ubiquitin specific peptidase 3 -0.0217737
MYL9 myosin, light chain 9, regulatory -0.0216955
COL6A1 collagen, type VI, alpha 1 -0.0214538
CSDE1 cold shock domain containing E1, RNA-binding -0.0211772
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0211644
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0211502
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0211495
RLF rearranged L-myc fusion -0.0211049
GOLGA4 golgin A4 -0.0210605
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0210428
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0209742
HYOU1 hypoxia up-regulated 1 -0.0209164
IRF1 interferon regulatory factor 1 -0.0208794
RPL12 ribosomal protein L12 -0.0208011
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0207776
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0205332