Pentoxifylline_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0341434
C3 complement component 3 0.027462
ARHGAP9 Rho GTPase activating protein 9 0.0222188
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0203791
FTH1 ferritin, heavy polypeptide 1 0.0183023
MRTFA myocardin related transcription factor A 0.0144913
LOC112694756 uncharaterized LOC112694756 0.0144751
SDC4 syndecan 4 0.0141112
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.013785
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.013287
BCL2L1 BCL2-like 1 0.0131987
FOXO1 forkhead box O1 0.0131971
MYH9 myosin, heavy chain 9, non-muscle 0.0125508
ICAM1 intercellular adhesion molecule 1 0.0121529
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0108124
ABTB3 ankyrin repeat and BTB domain containing 3 0.00999729
DLC1 DLC1 Rho GTPase activating protein 0.00985806
FZD5 frizzled class receptor 5 0.00973948
SYNJ2 synaptojanin 2 0.00879096
MKI67 marker of proliferation Ki-67 0.00812117
TF transferrin 0.00804358
NRIP1 nuclear receptor interacting protein 1 0.00803827
RNF11 ring finger protein 11 0.0078608
YAP1 Yes-associated protein 1 0.0078083
CFB complement factor B 0.00774698
TGOLN2 trans-golgi network protein 2 0.00761528
LUZP1 leucine zipper protein 1 0.00733734
SMAD7 SMAD family member 7 0.0072936
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.00722609
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0071792
LMCD1 LIM and cysteine-rich domains 1 0.00707043
PLAC8 placenta-specific 8 0.00703251
COL7A1 collagen, type VII, alpha 1 0.00682719
TPX2 TPX2, microtubule-associated 0.00662793
CRLS1 cardiolipin synthase 1 0.00659345
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00648145
NPTN neuroplastin 0.00626379
MED15 mediator complex subunit 15 0.00622104
ARHGAP5 Rho GTPase activating protein 5 0.00618157
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.00617747
HEG1 heart development protein with EGF-like domains 1 0.00615889
TAPT1 transmembrane anterior posterior transformation 1 0.00615748
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.00608473
SCAF8 SR-related CTD-associated factor 8 0.00605783
RBPMS RNA binding protein with multiple splicing 0.00601871
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 0.00600595
RAD23B RAD23 homolog B (S. cerevisiae) 0.0059882
CCN2 cellular communication network factor 2 0.00593051
FBLIM1 filamin binding LIM protein 1 0.00592599
FURIN furin (paired basic amino acid cleaving enzyme) 0.0058871
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.00569977
ETV4 ets variant 4 0.00568255
CASC3 cancer susceptibility candidate 3 0.00567723
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.00563641
RELL1 RELT-like 1 0.00559747
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.00551334
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.00551143
WDR43 WD repeat domain 43 0.00542449
TMEM41B transmembrane protein 41B 0.00540835
VCL vinculin 0.00538642
MARCHF3 membrane associated ring-CH-type finger 3 0.0053564
PELO pelota homolog (Drosophila) 0.00531475
EEF1G eukaryotic translation elongation factor 1 gamma 0.00530527
KLHL21 kelch-like family member 21 0.00518719
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00517605
DPP4 dipeptidyl-peptidase 4 0.00516255
CD68 CD68 molecule 0.0050898
PGAM4 phosphoglycerate mutase family member 4 0.00507941
LRRC59 leucine rich repeat containing 59 0.00505953
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.00495763
MT1X metallothionein 1X 0.00495484
TGFBI transforming growth factor, beta-induced, 68kDa 0.004859
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.00484725
MBD6 methyl-CpG binding domain protein 6 0.00483403
PGM1 phosphoglucomutase 1 0.00482055
APOB apolipoprotein B 0.00481239
FGA fibrinogen alpha chain 0.00479311
HSPG2 heparan sulfate proteoglycan 2 0.0047851
ZBTB17 zinc finger and BTB domain containing 17 0.00476449
PLXNB2 plexin B2 0.00475473
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0047524
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.00473864
JAG1 jagged 1 0.00473542
IL4R interleukin 4 receptor 0.0046946
AGFG2 ArfGAP with FG repeats 2 0.00468772
C1D C1D nuclear receptor corepressor 0.00468004
TBC1D22B TBC1 domain family, member 22B 0.0046339
SEC16A SEC16 homolog A (S. cerevisiae) 0.0046212
SMTN smoothelin 0.00460848
PRRC2B proline-rich coiled-coil 2B 0.00459682
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0045916
ASGR2 asialoglycoprotein receptor 2 0.00457699
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.00457036
TMEM37 transmembrane protein 37 0.00453939
RCL1 RNA terminal phosphate cyclase-like 1 0.00452522
PRPF8 pre-mRNA processing factor 8 0.00452229
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.00452227
EIF4B eukaryotic translation initiation factor 4B 0.00451733
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00448408
FLNA filamin A, alpha 0.0044791

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.389879
EHBP1 EH domain binding protein 1 -0.0642039
AKAP12 A kinase (PRKA) anchor protein 12 -0.0614718
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0601476
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0548389
GPC6 glypican 6 -0.0536168
ASPH aspartate beta-hydroxylase -0.0527786
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0518539
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0512993
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0503796
GMDS GDP-mannose 4,6-dehydratase -0.0473378
FNDC3B fibronectin type III domain containing 3B -0.0449776
ATXN1 ataxin 1 -0.0449694
TPT1 tumor protein, translationally-controlled 1 -0.044776
ENO1 enolase 1, (alpha) -0.0435221
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0398346
ZBTB20 zinc finger and BTB domain containing 20 -0.0382058
IGFBP1 insulin-like growth factor binding protein 1 -0.0370269
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0369746
LRMDA leucine rich melanocyte differentiation associated -0.0369203
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0368581
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0368185
MAML2 mastermind-like 2 (Drosophila) -0.0351913
FMNL2 formin-like 2 -0.0340155
PARD3 par-3 family cell polarity regulator -0.0338236
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.031593
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0313094
FTL ferritin, light polypeptide -0.0312413
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0308078
DSPP dentin sialophosphoprotein -0.0307399
NDRG1 N-myc downstream regulated 1 -0.0300353
RPS6 ribosomal protein S6 -0.0299175
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0293575
APOA2 apolipoprotein A-II -0.0284184
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0279779
ZMYND8 zinc finger, MYND-type containing 8 -0.027753
DTNA dystrobrevin, alpha -0.0272623
RPS8 ribosomal protein S8 -0.0271357
EXT1 exostosin glycosyltransferase 1 -0.027067
GK glycerol kinase -0.0266823
SAMD4A sterile alpha motif domain containing 4A -0.0262859
PEG3 paternally expressed 3 -0.0255472
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0254479
DDIT4 DNA-damage-inducible transcript 4 -0.0254353
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253531
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0252021
SLC38A2 solute carrier family 38, member 2 -0.0251835
DST dystonin -0.0250479
RPL37A ribosomal protein L37a -0.0248699
NPAS2 neuronal PAS domain protein 2 -0.0247051
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0242726
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0241013
CP ceruloplasmin (ferroxidase) -0.023979
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0236009
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0234064
RNF213 ring finger protein 213 -0.0228615
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0226487
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.02237
SOX5 SRY (sex determining region Y)-box 5 -0.0221349
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0218205
ATP10A ATPase, class V, type 10A -0.0215954
RPL11 ribosomal protein L11 -0.021266
AHSG alpha-2-HS-glycoprotein -0.0212652
MBNL2 muscleblind-like splicing regulator 2 -0.0211864
INTS6 integrator complex subunit 6 -0.020822
NAP1L1 nucleosome assembly protein 1-like 1 -0.0207098
TM4SF1 transmembrane 4 L six family member 1 -0.020581
RUNX1 runt-related transcription factor 1 -0.0200276
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0198658
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0197446
SOS1 son of sevenless homolog 1 (Drosophila) -0.0196532
TRIO trio Rho guanine nucleotide exchange factor -0.0195511
DSCAM Down syndrome cell adhesion molecule -0.019449
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0193066
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0192639
ARFGEF3 ARFGEF family member 3 -0.0191204
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0191176
PTPRK protein tyrosine phosphatase, receptor type, K -0.0190261
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0187992
PLIN2 perilipin 2 -0.01879
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0187432
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0186422
PTK2 protein tyrosine kinase 2 -0.0186164
KIAA1217 KIAA1217 -0.0185802
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.01848
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0178662
APOA1 apolipoprotein A-I -0.0178606
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0177935
GOLGA4 golgin A4 -0.0176813
KDM3A lysine (K)-specific demethylase 3A -0.0176546
FRMD5 FERM domain containing 5 -0.0176063
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0175728
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0173285
TMSB10 thymosin beta 10 -0.0171455
SPAG9 sperm associated antigen 9 -0.0169642
CMIP c-Maf inducing protein -0.0169559
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0167729
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0166596
ZFAND3 zinc finger, AN1-type domain 3 -0.0165412
FAM135A family with sequence similarity 135, member A -0.0165097