Pentoxifylline_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.123081
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0504777
PTMA prothymosin, alpha 0.0482856
LOC112694756 uncharaterized LOC112694756 0.0444005
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0411476
TMSB10 thymosin beta 10 0.0391364
FLNB filamin B, beta 0.038029
NDRG1 N-myc downstream regulated 1 0.0375148
ENO1 enolase 1, (alpha) 0.0338792
H1-0 H1.0 linker histone 0.0331166
LDHA lactate dehydrogenase A 0.0313911
PODXL podocalyxin-like 0.0312648
HSPG2 heparan sulfate proteoglycan 2 0.0305901
MT2A metallothionein 2A 0.0302531
FTH1 ferritin, heavy polypeptide 1 0.0297631
IGF2 insulin-like growth factor 2 0.0292585
RPS8 ribosomal protein S8 0.0291205
B2M beta-2-microglobulin 0.0271242
GNAS GNAS complex locus 0.0251325
KRT17 keratin 17, type I 0.0250004
TMSB4X thymosin beta 4, X-linked 0.0247805
TPT1 tumor protein, translationally-controlled 1 0.0238938
LAMA5 laminin, alpha 5 0.0236863
RPS6 ribosomal protein S6 0.0233736
RPS3 ribosomal protein S3 0.0227106
FTL ferritin, light polypeptide 0.0224068
ALCAM activated leukocyte cell adhesion molecule 0.022308
S100A10 S100 calcium binding protein A10 0.0217716
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0217658
RPS19 ribosomal protein S19 0.0217018
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.02138
ANXA1 annexin A1 0.0210139
ITGB4 integrin, beta 4 0.0207858
RPLP1 ribosomal protein, large, P1 0.0207736
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0202857
PGK1 phosphoglycerate kinase 1 0.0202782
BHLHE40 basic helix-loop-helix family, member e40 0.020154
LMNA lamin A/C 0.0200614
STC1 stanniocalcin 1 0.0199969
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0197708
EEF2 eukaryotic translation elongation factor 2 0.0188659
MKI67 marker of proliferation Ki-67 0.0186435
S100A11 S100 calcium binding protein A11 0.0184478
RPS21 ribosomal protein S21 0.0180325
RPL12 ribosomal protein L12 0.0176152
PKM pyruvate kinase, muscle 0.0173595
RPL37 ribosomal protein L37 0.0171059
MTSS1 metastasis suppressor 1 0.0169404
FLNA filamin A, alpha 0.0167771
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0167534
RACK1 receptor for activated C kinase 1 0.0165049
POTEF POTE ankyrin domain family, member F 0.0164539
PGAM4 phosphoglycerate mutase family member 4 0.016098
IFITM3 interferon induced transmembrane protein 3 0.0160599
YBX3 Y box binding protein 3 0.0160398
EZR ezrin 0.0159492
EGR1 early growth response 1 0.0154728
EFHD2 EF-hand domain family, member D2 0.0148286
ANLN anillin, actin binding protein 0.0146741
RPL26 ribosomal protein L26 0.0145549
RPL34 ribosomal protein L34 0.0144243
RPL11 ribosomal protein L11 0.0143331
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0141777
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0140246
TAGLN2 transgelin 2 0.0140102
HMGA1 high mobility group AT-hook 1 0.0138212
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0134998
RPL37A ribosomal protein L37a 0.0131204
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0128336
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0128181
RPL31 ribosomal protein L31 0.0126501
S100A2 S100 calcium binding protein A2 0.0124076
EMP1 epithelial membrane protein 1 0.0123991
SAMD9 sterile alpha motif domain containing 9 0.0122608
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0122252
RPL35 ribosomal protein L35 0.0122077
FSCN1 fascin actin-bundling protein 1 0.0120798
EEF1G eukaryotic translation elongation factor 1 gamma 0.0120468
TPX2 TPX2, microtubule-associated 0.0120012
SULF2 sulfatase 2 0.0119984
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0119961
NCOR2 nuclear receptor corepressor 2 0.0119514
RPL23 ribosomal protein L23 0.0117513
RPL36 ribosomal protein L36 0.0117341
RPS2 ribosomal protein S2 0.0115747
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0114112
EIF4A1 eukaryotic translation initiation factor 4A1 0.0112847
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0112011
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0111486
GUK1 guanylate kinase 1 0.0111417
RPS27 ribosomal protein S27 0.0111397
MYH9 myosin, heavy chain 9, non-muscle 0.011091
RPS14 ribosomal protein S14 0.0110884
DUSP6 dual specificity phosphatase 6 0.0110369
RPL30 ribosomal protein L30 0.0109586
WASF2 WAS protein family, member 2 0.0109502
TPI1 triosephosphate isomerase 1 0.0107733
IFITM1 interferon induced transmembrane protein 1 0.010696
RPL13A ribosomal protein L13a 0.0105809
RPL28 ribosomal protein L28 0.0105656

decreased expression

Symbol Name Standardized Value
FOXO1 forkhead box O1 -0.0277338
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0274866
MYOF myoferlin -0.0231324
NRIP1 nuclear receptor interacting protein 1 -0.0227505
SULF1 sulfatase 1 -0.0222647
PDE4D phosphodiesterase 4D, cAMP-specific -0.0194632
BCAR3 breast cancer anti-estrogen resistance 3 -0.0185009
OSMR oncostatin M receptor -0.0184944
NEK7 NIMA-related kinase 7 -0.0169417
PRELID2 PRELI domain containing 2 -0.0163798
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0160467
BMAL2 basic helix-loop-helix ARNT like 2 -0.0156635
KIAA1217 KIAA1217 -0.015656
MEF2A myocyte enhancer factor 2A -0.0153684
SMYD3 SET and MYND domain containing 3 -0.0145041
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0144289
AOPEP aminopeptidase O (putative) -0.0142402
ATXN1 ataxin 1 -0.0141987
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0138862
RIN2 Ras and Rab interactor 2 -0.0132911
MBNL1 muscleblind-like splicing regulator 1 -0.0129173
CEMIP cell migration inducing protein, hyaluronan binding -0.0126396
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0123936
PICALM phosphatidylinositol binding clathrin assembly protein -0.0121807
FNDC3A fibronectin type III domain containing 3A -0.0121273
EGFR epidermal growth factor receptor -0.0120921
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0120851
NCOA3 nuclear receptor coactivator 3 -0.0119016
DPYD dihydropyrimidine dehydrogenase -0.0116399
PDLIM5 PDZ and LIM domain 5 -0.0113283
HM13 histocompatibility (minor) 13 -0.0111339
SMAD3 SMAD family member 3 -0.0110319
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0110134
FOXP1 forkhead box P1 -0.01076
BLCAP bladder cancer associated protein -0.0107331
SETX senataxin -0.0104407
ITGAV integrin, alpha V -0.0104126
AKAP13 A kinase (PRKA) anchor protein 13 -0.0103885
PTBP3 polypyrimidine tract binding protein 3 -0.0102988
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0102959
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0102642
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0101665
FRMD5 FERM domain containing 5 -0.00981691
RAD51B RAD51 paralog B -0.00940492
FNDC3B fibronectin type III domain containing 3B -0.00936492
ANKRD33B ankyrin repeat domain 33B -0.00927915
SLC45A4 solute carrier family 45, member 4 -0.0089686
ZFC3H1 zinc finger, C3H1-type containing -0.00892766
SBF2 SET binding factor 2 -0.00882907
ANKH ANKH inorganic pyrophosphate transport regulator -0.00865816
ATM ATM serine/threonine kinase -0.00864574
CTNND1 catenin (cadherin-associated protein), delta 1 -0.00862254
DGKH diacylglycerol kinase, eta -0.00860704
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.00856027
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.00853979
METTL15 methyltransferase like 15 -0.00847305
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.00846733
WARS1 tryptophanyl-tRNA synthetase 1 -0.00841431
ARB2A ARB2 cotranscriptional regulator A -0.00839484
MEF2C myocyte enhancer factor 2C -0.00839083
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.00836512
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.00830128
DOCK4 dedicator of cytokinesis 4 -0.00819129
COG5 component of oligomeric golgi complex 5 -0.00816521
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00810045
PDIA3 protein disulfide isomerase family A, member 3 -0.00809007
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00804327
NLRP1 NLR family, pyrin domain containing 1 -0.00804304
SLC38A6 solute carrier family 38, member 6 -0.00787142
TJP1 tight junction protein 1 -0.00787044
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.00778071
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.00774984
INTS6 integrator complex subunit 6 -0.00771575
RIGI RNA sensor RIG-I -0.0077078
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.00765487
CUL4B cullin 4B -0.00763148
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00762513
SOD2 superoxide dismutase 2, mitochondrial -0.00759564
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.00753991
PTK2 protein tyrosine kinase 2 -0.00745708
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.00738628
RASAL2 RAS protein activator like 2 -0.00737663
MECOM MDS1 and EVI1 complex locus -0.00735638
PHF20L1 PHD finger protein 20-like 1 -0.00735473
EHBP1 EH domain binding protein 1 -0.00723094
RB1CC1 RB1-inducible coiled-coil 1 -0.0072191
EXOC4 exocyst complex component 4 -0.00720467
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.00713256
EXOC6B exocyst complex component 6B -0.00707714
OXR1 oxidation resistance 1 -0.00702984
DOCK9 dedicator of cytokinesis 9 -0.00702554
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00701936
DENND4A DENN/MADD domain containing 4A -0.00698313
NCKAP5 NCK-associated protein 5 -0.00693172
LYST lysosomal trafficking regulator -0.0069141
LIFR leukemia inhibitory factor receptor alpha -0.00685801
CLU clusterin -0.00680513
UBE2H ubiquitin-conjugating enzyme E2H -0.0067794
LUZP1 leucine zipper protein 1 -0.00676997
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.00676967