Pentoxifylline_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pentoxifylline perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pentoxifylline_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBC ubiquitin C 0.164197
ASPH aspartate beta-hydroxylase 0.0887957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0683666
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0631042
ENO1 enolase 1, (alpha) 0.05149
HDLBP high density lipoprotein binding protein 0.0500341
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0499679
AHNAK AHNAK nucleoprotein 0.0471673
CANX calnexin 0.0467731
LOC112694756 uncharaterized LOC112694756 0.0438485
RPS27A ribosomal protein S27a 0.0435143
DSCAM Down syndrome cell adhesion molecule 0.0419468
MYH9 myosin, heavy chain 9, non-muscle 0.0408334
H1-0 H1.0 linker histone 0.0395146
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.039387
SOD2 superoxide dismutase 2, mitochondrial 0.0390514
SPAG9 sperm associated antigen 9 0.0386977
OGA O-GlcNAcase 0.0384296
ZC3H11A zinc finger CCCH-type containing 11A 0.0377311
LMO7 LIM domain 7 0.0373042
PCBP2 poly(rC) binding protein 2 0.0349681
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0347627
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0332971
USP9X ubiquitin specific peptidase 9, X-linked 0.0326992
KDM3A lysine (K)-specific demethylase 3A 0.0320002
GRAMD1B GRAM domain containing 1B 0.031689
HYOU1 hypoxia up-regulated 1 0.0307959
HOOK2 hook microtubule-tethering protein 2 0.029501
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0294287
NAMPT nicotinamide phosphoribosyltransferase 0.0291464
LAMC2 laminin, gamma 2 0.0289678
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0286313
PLEC plectin 0.0279046
CES1 carboxylesterase 1 0.027195
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0267747
SMAD3 SMAD family member 3 0.0266799
PKM pyruvate kinase, muscle 0.0262965
MACF1 microtubule-actin crosslinking factor 1 0.0261762
LAMB3 laminin, beta 3 0.0259882
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0257676
TOP1 topoisomerase (DNA) I 0.0251764
ZFC3H1 zinc finger, C3H1-type containing 0.0250226
CAMTA1 calmodulin binding transcription activator 1 0.0248161
ARRDC3 arrestin domain containing 3 0.0241413
GSK3B glycogen synthase kinase 3 beta 0.0240115
PDIA4 protein disulfide isomerase family A, member 4 0.023952
ANKRD10 ankyrin repeat domain 10 0.0238897
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023711
CTNND1 catenin (cadherin-associated protein), delta 1 0.0235708
HSPA8 heat shock 70kDa protein 8 0.0228941
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0228015
CSNK1A1 casein kinase 1, alpha 1 0.022503
NGLY1 N-glycanase 1 0.0224869
GIGYF2 GRB10 interacting GYF protein 2 0.0224662
YTHDC1 YTH domain containing 1 0.0222711
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0221807
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0221605
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0221483
SFPQ splicing factor proline/glutamine-rich 0.0220887
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0215707
FAM13A family with sequence similarity 13, member A 0.0213158
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0211492
EEF2 eukaryotic translation elongation factor 2 0.0209613
BRWD1 bromodomain and WD repeat domain containing 1 0.0205193
EIF4B eukaryotic translation initiation factor 4B 0.0204881
BCAR3 breast cancer anti-estrogen resistance 3 0.0204189
SEC31A SEC31 homolog A (S. cerevisiae) 0.0203742
PAPOLA poly(A) polymerase alpha 0.0200126
SENP5 SUMO1/sentrin specific peptidase 5 0.0194531
SPDYA speedy/RINGO cell cycle regulator family member A 0.0185191
ARGLU1 arginine and glutamate rich 1 0.0183934
NPTN neuroplastin 0.0183896
DSPP dentin sialophosphoprotein 0.0182058
ATP13A3 ATPase type 13A3 0.0181222
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0178702
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0177106
KCMF1 potassium channel modulatory factor 1 0.017665
ANO6 anoctamin 6 0.0176464
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0175692
TXNRD1 thioredoxin reductase 1 0.0175048
EIF4A2 eukaryotic translation initiation factor 4A2 0.017292
BIRC6 baculoviral IAP repeat containing 6 0.0170586
EP300 E1A binding protein p300 0.0169572
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0168129
PUM2 pumilio RNA-binding family member 2 0.016764
SLTM SAFB-like, transcription modulator 0.0165755
PDIA6 protein disulfide isomerase family A, member 6 0.0164574
USP34 ubiquitin specific peptidase 34 0.0164449
MYOF myoferlin 0.0164303
SRSF5 serine/arginine-rich splicing factor 5 0.0162818
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0162093
SDC4 syndecan 4 0.016119
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0161061
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0160529
ELL2 elongation factor, RNA polymerase II, 2 0.0159832
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.0159783
RPL4 ribosomal protein L4 0.0159319
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0159127
KLC1 kinesin light chain 1 0.0157771
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0157173

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.244393
MT2A metallothionein 2A -0.173073
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0953697
NDRG1 N-myc downstream regulated 1 -0.0823479
TMSB10 thymosin beta 10 -0.0649612
RPL35A ribosomal protein L35a -0.0608177
FTL ferritin, light polypeptide -0.0502651
RPLP1 ribosomal protein, large, P1 -0.0494378
RPS6 ribosomal protein S6 -0.0463158
EGR1 early growth response 1 -0.0431376
RPS23 ribosomal protein S23 -0.0394721
TPT1 tumor protein, translationally-controlled 1 -0.0391338
CST3 cystatin C -0.0378416
RPLP0 ribosomal protein, large, P0 -0.0321537
EGFR epidermal growth factor receptor -0.0316949
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0313936
CAV1 caveolin 1, caveolae protein, 22kDa -0.0308454
MT1X metallothionein 1X -0.0304533
EIF1 eukaryotic translation initiation factor 1 -0.0301706
RPL11 ribosomal protein L11 -0.0300862
RPL37A ribosomal protein L37a -0.029406
B2M beta-2-microglobulin -0.0288584
CCNL1 cyclin L1 -0.0284263
RPS19 ribosomal protein S19 -0.0267136
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0264514
BLZF1 basic leucine zipper nuclear factor 1 -0.0258637
S100A10 S100 calcium binding protein A10 -0.0253577
RPS8 ribosomal protein S8 -0.0250662
SEC61G Sec61 gamma subunit -0.024099
RPS27 ribosomal protein S27 -0.023969
AREG amphiregulin -0.0230666
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0230588
RPLP2 ribosomal protein, large, P2 -0.0228602
RPL12 ribosomal protein L12 -0.0228342
S100A9 S100 calcium binding protein A9 -0.0217784
RPL19 ribosomal protein L19 -0.0211096
RPS21 ribosomal protein S21 -0.0210611
RPS25 ribosomal protein S25 -0.0210603
RPL7 ribosomal protein L7 -0.0208779
RPL36 ribosomal protein L36 -0.0206328
MCTP1 multiple C2 domains, transmembrane 1 -0.020407
RPS14 ribosomal protein S14 -0.0201849
RPS29 ribosomal protein S29 -0.0200794
RPL31 ribosomal protein L31 -0.0198823
RPL34 ribosomal protein L34 -0.0197264
S100A11 S100 calcium binding protein A11 -0.019481
BTG1 B-cell translocation gene 1, anti-proliferative -0.0194162
STC1 stanniocalcin 1 -0.0193638
S100P S100 calcium binding protein P -0.0188912
ANKRD12 ankyrin repeat domain 12 -0.0188235
ATF4 activating transcription factor 4 -0.0186038
RPS24 ribosomal protein S24 -0.0183375
VDAC1 voltage-dependent anion channel 1 -0.0177765
SLC38A1 solute carrier family 38, member 1 -0.0177682
RPS15 ribosomal protein S15 -0.0173647
RPL32 ribosomal protein L32 -0.0172005
CPE carboxypeptidase E -0.0170047
RPS16 ribosomal protein S16 -0.0168571
GUK1 guanylate kinase 1 -0.0168049
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0167892
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0164618
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0163185
CIB1 calcium and integrin binding 1 (calmyrin) -0.0162791
VIM vimentin -0.0162389
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0154289
RAB7A RAB7A, member RAS oncogene family -0.0154229
CCL20 chemokine (C-C motif) ligand 20 -0.0153307
RPL36A ribosomal protein L36a -0.0149679
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0148674
CAV2 caveolin 2 -0.0148129
IGFBP3 insulin-like growth factor binding protein 3 -0.0147954
RPL5 ribosomal protein L5 -0.0147727
RPS10 ribosomal protein S10 -0.0145417
IFI6 interferon, alpha-inducible protein 6 -0.0145306
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0145162
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0144742
RPL28 ribosomal protein L28 -0.0143285
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0141527
FOSL1 FOS-like antigen 1 -0.0141461
ACTG1 actin gamma 1 -0.0141457
RPL27 ribosomal protein L27 -0.014144
HLA-B major histocompatibility complex, class I, B -0.0141118
OSMR oncostatin M receptor -0.014068
RPL27A ribosomal protein L27a -0.014009
RACK1 receptor for activated C kinase 1 -0.0140072
KMT2E lysine (K)-specific methyltransferase 2E -0.0139769
RPL35 ribosomal protein L35 -0.0137807
RPL30 ribosomal protein L30 -0.0136976
TSC22D2 TSC22 domain family, member 2 -0.0136809
SLC38A2 solute carrier family 38, member 2 -0.0136531
RPL9 ribosomal protein L9 -0.0135765
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0135443
PFN1 profilin 1 -0.0134824
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0132714
CD163L1 CD163 molecule-like 1 -0.0130654
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0129381
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0128796
IER3 immediate early response 3 -0.0127974
EFNA5 ephrin-A5 -0.0127873
ANKRD37 ankyrin repeat domain 37 -0.0126885